• Biomolecules & Therapeutics
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• v.4 no.4
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• pp.314-322
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• 1996

The subacute toxicity was investigated in Sprague-Dawley rats orally treated with KDRD-010 at the doses of 0.056, 0.28, and 1.4 g/kg for one month. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and treatment groups. In hematological and biochemical serum parameters, all mean values appear to be within the normal range. In pathological examinations, hemorrhages of lung was observed in one male rat at low dose group and one female rat at high dose group of KDRD-010, but it was not considered to be caused by KDRD-010. These results suggest that KDRD-010 dose not induce any significant subacute oral toxicities in Sprague-Dawley rats.

• Korean Journal of Pharmacognosy
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• v.17 no.3
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• pp.199-205
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• 1986

It has been known that Magnolia officinalis, Magnolia and Machilus Barks are reputed to be effective in 'Hagi', 'Sanman' and to be analgesic but there was differences of efficacy of these crude drugs against the kinds and habitates. For this reason, this study was conducted to compare the acute toxicities, analgesic effects and motilities of isolated intestine. This results obtained in this work were summarized as follow: 1. In the test of acute toxicies, Machilus bark was found to be more toxic than the others. 2. Both these was found to have analgesic effect. 3. In the effects against the motility of isolated intestine, Magnolia officinalis and Magnolia barks were found to be relaxant, Machilus bark was found to be contractive. From these results, Magnolia officinalis and Magnolia barks might have analgesic effect and relaxant effect of intestine.

• Korean Journal of Pharmacognosy
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• v.24 no.1
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• pp.69-77
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• 1993

Saikosaponins, originally isolated from Bupleuri Radix, were reported to exhibit diverse biological activities especially concerning with liver function. To elucidate the mode of protective action of saikosaponins on liver injury due to the acetaminophen administration, effects on drug metabolizing enzymes system and some transferase activities were checked. As the result, activities of transferase were shown to be strengthened by saikosaponin treatments significantly.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2002.07a
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• pp.97-102
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• 2002

Life Science Research Center of SK Chemicals has developed a 3rd-generation anticancer platinum drug for the first time in the nation′s 100-year-old pharmaceutical industry. The Korea Food and Drug Administration (KFDA) approved the sale of "Sunpla" (code name SKI 2053R, general name : Heptaplatin) on July 14, 1999 for the treatment of advance, metastatic gastric cancer. Cisplatin, the 1 st-generation anticancer drug, which was developed by Bristol-Myers of the United States in 1976, is one of the most potent anticancer drugs and is a major component of combination chemotherapy for a variety of human cancers. However its clinical usefulness has frequently been limited not only by undesirable side effects such as severe renal toxicity, nausea, vomiting, ototoxicity, and neurotoxicity but also by the development of resistance. Carboplatin, the 2nd-generation anticancer platinum drug, which was also developed by Bristol-Myers in 1986, has modified the problems of the renal and gastrointestinal toxicities of cisplatin. Carboplatin, however, has no enhanced therapeutic efficacy over cisplatin and does not possess the property to overcome cross-resistance to cisplatin.

• Biomolecules & Therapeutics
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• v.23 no.5
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• pp.391-399
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• 2015

As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for the assessment of potential toxicities of various chemicals used in cosmetics. However, its short lifespan in ex vivo setting has been a great hurdle for many practical applications. Therefore, a number of immortalization attempts have been made with success to overcome this limitation. In order to understand the immortalization process of a primary keratinocyte, several key biological phenomena governing its lifespan will be reviewed first. Then, various immortalization methods for the establishment of stable keratinocyte cell lines will be explained. Finally, its application to a three-dimensional skin culture system will be described.

• Korean Journal of Veterinary Research
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• v.15 no.2
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• pp.203-205
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• 1975

The comparison of topic effects of methanol and ethanol on rats and frogs was performed. Intraperitoneal administration in graded doses of absolute alcohols showed specific toxicities on animals, suggesting that these substances had different effects on species specificity of animals. Throughout the experiment, the following results were obtained and summerized here. 1. In rats $LD_{50}$ dose of absolute methanol was $2.65{\mu}l/g$ of body weight, while that of absolute ethanol was $1.85{\mu}l/g$ of body weight. 2. The $LD_{50}$ dose of methanol in frogs was $17.2{\mu}l/g$ of body weight, while that of ethanol was $10.9{\mu}l/g$ of body weight.

• YAKHAK HOEJI
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• v.54 no.3
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• pp.174-179
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• 2010

Acetaminophen is one of the most commonly used over-the-counter medication in Korea. It is a safe and effective medication for the treatment of mild to moderate pain or fever when used in therapeutic doses. However, acetaminophen overdose is a frequent cause of acute liver failure. The purpose of this study was to evaluate the acetaminophen use for adult patients at community pharmacies in Korea. This study was a 11-questionnaire survey conducted from December 15, 2009 to January 5, 2010. Of the 204 respondents, 117 (57.4%) had used acetaminophen products within 6 months. Only 20 (9.8%) reported having knowledge about the daily maximum doses of acetaminophen, and 3 out of 20 knew it correctly. Only 10 (4.9%) reported having knowledge about the potentialtoxicity of acetaminophen overdose, and 7 out of 10 knew that acetaminophen overdose could cause liver toxicity. The results of this study indicates a need for pharmacists to educate patients regarding the appropriate doses and potential toxicities of acetaminophen.

• Environmental Analysis Health and Toxicology
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• v.18 no.4
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• pp.271-276
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• 2003

The purpose of the present study was to perform experiments of cytotoxicity using HeLa cell and to evaluate the possibility that QSAR is applicable to the cytotoxicity of alkylphenols. Higher toxicities were found in four alkylphenols in the following order: 4-n-Nonylphenol) 4-tert-Octylphenol) 4-n-Octylphenol > 4-n Heptylpheonl. Whereas other alkylphenols were apparently less toxic. By using Percent Hydrophilic Surface Area (PHSA) quantitative structure-activity relationships (QSARs) models were developed: Cytotoxicity (%) = 90.14089-4.72224 PHSA ($R^2$=0.2046, $\alpha$=0.0265). It is concluded that some of the obtained data are useful to determine whether QSAR methods can be of general use in predicting that until further work is undertaken to develop QSARs for a much wider range of homologous series of alkylphenol compounds.

• Environmental Analysis Health and Toxicology
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• v.21 no.4 s.55
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• pp.301-310
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• 2006

본 연구에서는 내분비계장애물질로 잘 알려진 Bisphenol A와 Ethynyl estradiol(이하 BPA, EE)이 Chironomus riparius에 미치는 영향을 알아보고자 하였다. 수생생태계에서 Chironomus의 생태학적 중요성을 고려하여 연구한 반수치사농도(LC50),효소 활성, 성장/발달 등의 생화학적, 생리학적 독성에 대한 연구는 이들 물질에 대한 잠재적인 생태학적 중요성을 이해하는데 있어 유용한 정보를 제공할 수 있을 것이다. 연구 결과 BPA와 EE에 노출된 후 C. riparius게서 CAT와 GST활성이 증가하였고, EE에 고농도로 노출된 후 성충까지 충분히 성장하지 못했음을 확인하였다 이러한 결과로부터 C. riparius에서 BPA, EE에 대한 중요한 독성정보를 얻을 수 있었다. 그러므로 앞으로 BPA와 EE의 생화학적 효과와 C. riparitis의 개체수준 이상에서의 생리학적 실험을 통한 검증이 필요할 것이다.

• Environmental Analysis Health and Toxicology
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• v.13 no.1_2
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• pp.11-17
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• 1998

Cadmium, a major aquatic pollutant in many parts of the world, is toxic and readily accumulated in aquatic organisms. It mainly exists in water as complexes with organic ligands such as dissolved organic carbon and this complexation is known to have effects on the aquatic toxicities. In this study, acute toxicity, histology, and bioaccumulation were studied to evaluate effects of humic acid on cadmium toxicity and bioavailability to fish using Oryzias lalipes and Cyprinus carpio. 96h-LC$_{50}$ of cadmium was 6.38mg/L using Oryzias latipes. However, the mortality showed the dose-dependent decrease when humic acid was added to the test solution. When fish were exposed to 5 mg/L of cadmium, histological changes in the exposed organs (caudal fins, gills, kidney, liver, and gut) of C~lprinus carpio were decreased by humic acid, especially in kidney and liver. Bioaccumulation of cadmium also decreased by treatment of humic acid. It seems that the formation of complexes between cadmium and humic acid may decrease bioavailability of cadmium to fish, and thus reduce the toxic effects of cadmium.