Pharmacologic Activities of Saikosaponins(I) -Effects on Drug Metabolizing Enzymes Modification and Liver Toxicities due to Acetaminophen-

시호(柴胡) 사포닌류(Saikosaponins)의 약리작용(I) -Acetaminophen에 의한 약물대사계의 변화 및 간독성에 미친 영향-

Saikosaponins, originally isolated from Bupleuri Radix, were reported to exhibit diverse biological activities especially concerning with liver function. To elucidate the mode of protective action of saikosaponins on liver injury due to the acetaminophen administration, effects on drug metabolizing enzymes system and some transferase activities were checked. As the result, activities of transferase were shown to be strengthened by saikosaponin treatments significantly.