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Development of Prototype for Screening Anti-Inflammation Effects concerning p38 MAPK Signal Pathway (p38 MAPK을 이용한 항염증 효능 규명 프로토타입 개발)

  • Kim, Chul;Yae, Sang-Jun;Nam, Ky-Youb;Kim, Sang-Kyun;Jang, Hyun-Chul;Kim, Jin-Hyun;Kim, Young-Eun;Song, Mi-Young
    • Korean Journal of Oriental Medicine
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    • v.17 no.3
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    • pp.77-85
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    • 2011
  • Objectives : The purpose of this study was to develop a simulator which can analyze the anti-inflammatory effects of medical herbs based on e-cell concerning p38 MAPK signal pathway. Methods : We collected data concerning medical herbs with anti-inflammatory effects and the active compounds to provide as a fundamental databse and to validate the newly developed algorithm. At this time, we used the target database as pubmed and gathered the data by data mining tool, pathway studio. Also we have developed the web-based search system for confirming database related to anti-inflammation. We researched the mechanism of actions of proteins in p38 MAPK signal pathway when active compound has been inserted into the network. We reduced total network into TAK-MKK3-p38 and made the two types of mathematical model about active compounds' interaction. Results & Conclusion : We constructed the database which have 69 cases of medical herbs, 71 cases of active compounds, about 8,000 cases of URL(Uniform Resource Locator) related to papers and reports. We designed the ordinary differential equations for response of TAK, MKK3, p38 in e-cell's cytosol and nucleus. We used this formular as measure whether an active compound of medicinal plants which is inputted by an user would have an anti-inflammation effects. We developed the visualization program which could show the change of concentration over time.

A study on the type analysis of design magazine through analyzing tool of Magazine Identity (매거진아이덴티티(Magazine Identity)분석툴을 통한 디자인잡지 유형분석연구)

  • 이나리;백진경
    • Archives of design research
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    • v.17 no.1
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    • pp.15-24
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    • 2004
  • Information technology (IT) revolution rapidly advanced from the end of the 20th century has caused an extreme change in the publication market, which brought fierce struggle for existence. In this whirlpool, magazine, which is settling as a part of culture and as a center field of publication, presswork, is concentrating in making new determined position with comparatively liberal theme. So identity study that enables readers to remember a magazine more easily, will suggest a new direction of improvement as a culture business by inducing the brand-making of a magazine. This study is focused on the ability of configuration of its unique image of a magazine building an identity in the magazine design field. Each type of magazine has common characteristics but even though it is grouped into same type, it shows mobility on the relative importance of application according to the strategy of the magazine rather than matching perfectly to the type. The result is limited to the range of professional design magazine. However, through result-pursuing study procedure, it is anticipated of its gui dance of improvement of magazine design at large as well as professional design magazine by inquiring of consequence and utility of Magazine Identity in the digital age and clarifying the role of magazine design.

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Analysis of Excavation Speed and Direct Construction Cost Based on the Operating Productivities of TBM Method Site - Diameter 5.0m Target (수로터널공사의 효율성 분석을 통한 굴진속도 및 직접공사비 분석 - 구경 5.0m 중심으로)

  • Park, Hong Tae;Lee, Yang Kyu
    • Journal of the Society of Disaster Information
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    • v.8 no.4
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    • pp.328-335
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    • 2012
  • The resource-based estimating based on standard unit price of construction work was estimated by multiplying the price per standard unit of work on the amount of labor, material, equipment use time. However, limitation of the resource-based estimating way does not adequately reflect the actual transactions prices. On the subject of water tunnel excavation as a new attempt to overcome these limitations, this study analyzed productivity by work type into cutter inspection/ exchange, TBM maintenance, TBM inspection/refueling, subsequent installations, tramcar, operating change, a cave-underground reinforcement / rock reinforcement, safety / meetings and analyzed actual cost estimating and the net advance rate based on this analysis result. Actual cost estimating calculation approach presented in this study can be utilized as a useful tool to predict the actual cost estimating in the TBM water tunnels field.

An Evaluative Study on ESD(Entrance Surface Dose) by Posture Changes for Fluoroscopy (투시 검사 시 체위 변화에 따른 입사표면선량의 평가 연구)

  • Yang, Hae-Doo;Hong, Seon-Sook;Park, Eun-Seong;Seong, Min-Sook;Ha, Dong-Yoon
    • Korean Journal of Digital Imaging in Medicine
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    • v.13 no.4
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    • pp.177-183
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    • 2011
  • This study intends to investigate patients' exact exposure doses by comparatively measuring ESD (Entrance Surface Dose) with the DAP meter, which excludes scattered rays, and ESD with the Xi multifunction meter, which includes scattered rays, by posture changes for Esophagography test and UGI test. The materialwere examined through Sonialvision-SafireII SPEC overtube system. ESD was measured by using the DAP meter, and as a tool to measure ESD including scattered rays on the plane of incidence of human phantom, the Xi multifunction meter was used. The average fluoroscopic time of Esophagography test was 4.192 minutes and the average number of images was 47.7, while the average fluoroscopic time of UGI test was 6.881 minutes and the average number of images was 37.8. The ratios of the incident dose of DAP meter and the ESD of Xi meter were calculated bydividing the fluoroscopic time and the number of images by each posture change. As for Esophagography test, the dose increased by 21.6~55.5% in the fluoroscopic test and by 4.8~24.7% in the spot test. In the front spot test, however, the does increased by as little as 5.3%. As for UGI test, the dose increased by 21.1~49.5% in the fluoroscopic test and by 10.1~34.9% in the spot test. It is expected that measuring doses in consideration of scattered rays by posture changes will be an important index in evaluating and managing patients' exact exposure doses for each test above. Furthermore, it is judged that this sort of study is inevitable and desirable to reduce patients' exposure doses after all.

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Development of USLExls and its Application for the Analysis of the Impact of Soil-Filling Work on Soil Loss (USLExls를 이용한 복토법에 따른 필지 단위 토양유실량 분석)

  • Kim, Sorae;Yu, Chan;Lee, Sang-Whan;Ji, Won-Hyun;Jang, Min-Won
    • Journal of The Korean Society of Agricultural Engineers
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    • v.59 no.6
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    • pp.109-125
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    • 2017
  • This study aimed to develop a parcel-unit soil loss estimation tool embedded in Excel worksheet, USLExls, required for the design of contaminated farmland restoration project and to analyze the impact of the project carried out soil-filling work on soil loss. USLE method was adopted for the estimation of average annual soil loss in a parcel unit, and each erosivity factor in the USLE equation was defined through the review of previous studies. USLExls was implemented to allow an engineer to try out different combinations just by selecting one among the popular formulas by each factor at a combo box and to simply update parameters by using look-up tables. This study applied it to the estimation of soil loss before and after soil-filling work at Dong-a project area. The average annual soil loss after the project increased by about 2.4 times than before on average, and about 60 % of 291 parcels shifted to worse classes under the classification criteria proposed by Kwak (2005). Although average farmland steepness was lower thanks to land grading work, the soil loss increased because the inappropriate texture of the cover soil induced the soil erosion factor K to increase from 0.33 before to 0.78 after the soil-filling work. The results showed that the selection of cover soil for soil-filling work should be carefully considered in terms soil loss control and the estimation of change in soil loss should be mandatory in planning a contaminated farmland restoration project.

Estimation of Water Storage in Small Agricultural Reservoir Using Sentinel-2 Satellite Imagery (Sentinel-2 위성영상을 활용한 농업용 저수지 가용수량 추정)

  • Lee, Hee-Jin;Nam, Won-Ho;Yoon, Dong-Hyun;Jang, Min-Won;Hong, Eun-Mi;Kim, Taegon;Kim, Dae-Eui
    • Journal of The Korean Society of Agricultural Engineers
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    • v.62 no.6
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    • pp.1-9
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    • 2020
  • Reservoir storage and water level information is essential for accurate drought monitoring and prediction. In particular, the agricultural drought has increased the risk of agricultural water shortages due to regional bias in reservoirs and water supply facilities, which are major water supply facilities for agricultural water. Therefore, it is important to evaluate the available water capacity of the reservoir, and it is necessary to determine the water surface area and water capacity. Remote sensing provides images of temporal water storage and level variations, and a combination of both measurement techniques can indicate a change in water volume. In areas of ungauged water volume, satellite remote sensing image acts as a powerful tool to measure changes in surface water level. The purpose of this study is to estimate of reservoir storage and level variations using satellite remote sensing image combined with hydrological statistical data and the Normalized Difference Water Index (NDWI). Water surface areas were estimated using the Sentinel-2 satellite images in Seosan, Chungcheongnam-do from 2016 to 2018. The remote sensing-based reservoir storage estimation algorithm from this study is general and transferable to applications for lakes and reservoirs. The data set can be used for improving the representation of water resources management for incorporating lakes into weather forecasting models and climate models, and hydrologic processes.

A Study on the Character of Media space in Responses viewd through the Digital poetics (디지털 시학 관점으로 본 뉴미디어 시대 매체공간의 특성 연구)

  • Chung, Jae-Won
    • Korean Institute of Interior Design Journal
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    • v.21 no.5
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    • pp.217-226
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    • 2012
  • The purpose of this study had started from trying to look for a new standard in new media era and sounding out possibility of perspective of digital poetry, and had been extracting interpretational elements based on characteristics of otology in digital poetics research in technical method. Through examination of many documentary records, we suggested interpretive elements of medial space based on meaning and the theory of digital poetics. We deduced three perspectives based on relationship between the basic thesis in poetics and interpretive elements of medial space. We used them as tool for analysis of example. We chose as an example that change of program in space is clear through connection of media and space in where new form of creation happens through digital instruments and chose article as subject to which digital technology is applied and had been since 2000, The result of this study is as following: First, epistemological analysis about a space of digital media in new media era requires poetical approach unlike aesthetic approach. We can endow creative action and creation process with significance and pay attention to technical method of manufacturing, stating appropriateness of perspective in digital poetics. Second, the justice of digital poetics and its basic thesis help derive analytic elements from medial space and study purpose of production, technical method, ontological characteristics, which are three perspectives of digital poetics. Third, it analyzed characteristics of example according to three perspectives above and we can analyze characteristics of spacial expression in space of digital media into potential, trans-active, and semiosis space. It would be possible through analyzing examples in digital poetic perspective to overlook new methods of design in 21th and various perspectives and possibilities of medial space design.

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Improving Lecture Quality using SOFM neural network and C4.5 (SOFM신경망과 C4.5를 활용한 강의품질 개선)

  • Lee, Jang-hee
    • Journal of Practical Engineering Education
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    • v.6 no.2
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    • pp.71-76
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    • 2014
  • Improving lecture quality is very necessary for the service quality of education in universities, enterprises and education institutes. The student lecture evaluation survey data is a good tool for measuring lecture quality and have been often analyzed by simple statistical methods. This study presents an intelligent lecture quality improvement method that can improve student's overall satisfaction and performance by analyzing student lecture evaluation survey data. The method uses SOFM (Self-Organizing Feature Map) neural network and C4.5 to find the patterns in student's satisfaction and performance more correctly and then decide what to change in the lecture for the improvement of student's satisfaction and performance. We apply the proposed method to an enterprise lecture in Korea. We can find that it can improve the quality of an enterprise lecture by changing total lecture time, lecture material and organization of lecture schedule to be necessary improvements.

Implementation of Temporal Relationship Macros for History Management in SDE (SDE에서 이력 관리를 위한 시간관계 매크로의 구현)

  • Lee, Jong-Yeon;Ryu, Geun-Ho
    • Journal of KIISE:Computing Practices and Letters
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    • v.5 no.5
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    • pp.553-563
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    • 1999
  • The Spatial Database Engine(SDETM) developed by Environmental Systems Research Institute, Inc. is a spatial database that employs a client-server architecture incorporated with a set of software services to perform efficient spatial operations and to manage large, shared and geographic data sets. It currently supports a wide variety of spatial search methods and spatial relationships determined dynamically. Spatial objects in the space world can be changed by either non-spatial operations or spatial operations. Conventional geographical information systems(GISs) did not manage their historical information, however, because they handle the snapshot images of spatial objects in the world. In this paper we propose a spatio-temporal data model and an algorithm for temporal relationship macro which is able to manage and retrieve the historical information of spatial objects. The proposed spatio-temporal data model and its operations can be used as a software tool for history management of time-varying objects in database without any change.

3-D Configuration Effects of Prestressing Cable Bracing Used for Retrofitting a RC Frame Subjected to Seismic Damage (RC 골조의 내진 보강을 위한 예압 가새의 3-D 배치)

  • Lee, Jin-Ho;Oh, Sang-Gyun;Hisham, El-Ganzori
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.7 no.3
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    • pp.183-191
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    • 2003
  • A four-story reinforced concrete moment resisting frame damaged from an ultimate limit state earthquake is upgraded with prestressing cable bracing. The purpose of this study is to investigate the bracing configuration effects on the 3-D building response using thee different locations of the bracing systems for the retrofitted building. Since the previous work done by the author proved that static incremental loads to collapse analysis as a substitute to dynamic non-linear time history analysis was a valid alternative tool. Thus, static load to collapse analysis is solely applied to evaluate the seismic performance parameters of both the original and upgraded buildings in this study. In results, the exterior bracing system is effective in restraining torsional behavior of the structure under seismic loads, and no sudden failure occurs in this system that enhances the ductility of the building due to the gradual change of building stiffness as the lateral load increases.