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Optically Active Intermediate from the Degradation of (-)-Laudanosine, a Benzylisoquinoline Alkaloid, with Ethyl Chloroformate

  • Dong-Ung Lee;W. Wiegrebe
    • Bulletin of the Korean Chemical Society
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    • v.12 no.4
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    • pp.373-376
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    • 1991
  • Degradation of (-)-laudanosine, a 1-benzyl-1,2,3,4-tetrahydroisoquinoline alkaloid, with ethyl chloroformate (ECF) afforded an optically active chloro-carbamate as an intermediate. The reason why this intermediate exhibits an optical activity was investigated by comparison with the reactions of some model compounds with ECF. It may be supposed that the chloride group in a hypothetic carbenium ion intermediate stands very closely to the chiral center, so conserving optical activity. However, a neighboring group effect can not be excluded.

Use and non-use of ICTs: the case of three urban ghettos in Seoul Metropolitan City (도시판자촌지역 주민의 정보통신기술 이용 및 비이용에 대한 탐색적 연구 - 서울 개미마을, 녹천마을, 백사마을 중심으로 -)

  • Choi, Younghoon;Jung, Jinkyung
    • Informatization Policy
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    • v.19 no.2
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    • pp.39-56
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    • 2012
  • The authors utilized two contested perspectives on the use and non-use of ICTs, especially the Internet, to verify three assumptions of urban ghettos as fundamentally excluded from the ICT structure, ghetto people as behaving in the same way, and deficiency as the sole explanatory variable of their non-use. The first assumption that the urban ghettos would be fundamentally excluded from the urban ICT structure can be nullified by our finding about the prevalence of ICTs in that area, albeit apparent lower level of access to ICTs compared to that of the urban core. The second assumption that the urban ghetto residents would display the same information behaviors would be challenged by our finding that the availability and usages of the Internet would be hardly consistent by gender, age, occupation, family size, and locational characteristics. The third assumption that deficiency would capture the Internet non-use by ghetto residents was found very tenable but could be rivaled by the choice perspective that use or non-use is simply a result of situated choice. Theoretical and practical implications were suggested.

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Review of the Application of Acupuncture for the HIV-associated Distal Sensory Neuropathy (HIV/AIDS 연관 말초신경병증에의 침 치료 활용가능성에 대한 고찰)

  • Kim, Tae-Hoon;Shin, Seon-Ho;Na, Juno;Jeong, Min-Jeong;Jang, In-Soo
    • The Journal of Internal Korean Medicine
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    • v.35 no.3
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    • pp.343-353
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    • 2014
  • Objectives: To discuss the application of the acupuncture therapy for the HIV-associated distal sensory neuropathy. Methods: We searched papers using KTKP, Oasis, CNKI, PubMed, Science Direct, CINAHL, J-STAGE, and CiNii with the keywords "HIV", "Peripheral neuropathy" and "acupuncture". The search range included randomized controlled trials (RCTs) and clinical case series. Reviews and animal experiments were not included. Not matched with inclusion criteria were excluded. Results: A total 675 studies were found. 670 were excluded by scanning titles and abstracts and finally 5 articles were selected. One of the five articles noted that acupuncture was not effective in HIV-SN, but two articles reanalyzing the former, pointed out the statistical errors and noted acupuncture significantly reduced pain, attrition and mortality. Other RCT and the other case series concluded acupuncture had a beneficial effect in HIV-SN. Conclusions: Acupuncture seems to be effective to improve HIV-SN symptoms, however further large-scale RCTs are warranted.

A Study on Redefining the Concept and Standard Range for Small Enterprise

  • Nam, Yoon-Hyung;Kim, Young-Ki;Kim, Seung-Hee
    • Journal of Distribution Science
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    • v.14 no.12
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    • pp.5-21
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    • 2016
  • Purpose - This study aims to clarify the meanings of small enterprise and modify criteria for explaining its range. Prioritizing the number of full time workers first and the sales next are proper as a new concept and range. Research design, data, and methodology - In research, 'small company' is a basic concept because the range of its standard is categorized as a 'small company' in the policy system of small & medium business. This study focuses on the solutions with ① evaluation on sales, ② standard for excluded ones ③ regulation for excluded business types in 'Act on Protection and Support for Small Enterprise'. Results - Clarifying the range of standard with maintaining the title is advisable. The scope should resist the current criteria or adopt a new standard which contains not only full time workers but also the sales. The new one may raise the policies' effectiveness because it can sort the 1% people of small enterprises. Conclusions - However, there should be a preventive system for sorting out the non-eligible ones not conformed to the CAP for small company. Therefore, it is desirable to prepare the system with 'unsuitable ones list' or regulate large income·inappropriate business types in 'Act on protection and support for small enterprise'.

Removal Method of Signal Interference between Ultrasound Sensors (초음파 센서 간 신호 간섭 제거 방법)

  • Im, Hyungchul;Lee, Seongsoo
    • Journal of IKEEE
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    • v.25 no.4
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    • pp.584-590
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    • 2021
  • This paper proposes a removal method of signal interference between ultrasound sensors where ghost signals due to interference are excluded and correct signal is recognized in distance mensurement using ultrasound sensors. The proposed method detects and excludes ghost signals when previous measured distance is compared to current measured distance and the distance difference exceeds a threshold. The threshold is fixed in conventional methods, so ghost signals cannot be correctly excluded when ultrasound sensor or target object move rapidly. On the contrary, to improve accuracy, the threshold is not fixed in the proposed method, and the threshold is adpatively determined based on the relative velocity when ultrasound sensor or target object move. Experiments of distance measurement with ultrasound signal interference are carried out where multiple ultrasound sensors of same type are exploited with maximum interference, and the results show that the proposed method efficiently exclude ghost signals.

A narrative review on the application of doubly labeled water method for estimating energy requirement for Koreans

  • Kim, Oh Yoen;Park, Jonghoon;Kim, Eun-Kyung
    • Nutrition Research and Practice
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    • v.16 no.sup1
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    • pp.11-20
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    • 2022
  • Research articles were reviewed to validate the estimated energy requirements (EERs) equations developed by the Institute of Medicine of the National Academies (IOM). These equations are based on total energy expenditure (TEE) measured by the doubly labeled water (DLW) method. We subsequently aimed to provide the basis for the suitability to apply the IOM equations as EER equations for Koreans, and develop relevant equations for EER in the Dietary Reference Intake for Koreans (KDRI). Additionally, besides the EER(IOM) equations, other equations were examined for EER estimation. Research papers demonstrating the validation of the EER(IOM) equations based on TEE(DLW) were searched through PubMed (up to September 2019). Of the 637 potentially relevant articles identified, duplicates and unsuitable titles and abstracts were excluded. Furthermore, papers with irrelevant subject and inappropriate study design were also excluded. Finally, 11 papers were included in the review. Among the reviewed papers, 8 papers validated the application of the EER(IOM) equations for EER based on TEE(DLW). These included 3 studies for children (USA 1, Korea 2), 1 for adolescents (Portugal), 2 for adults (Korean), and 2 for the elderly (Korea, USA). EER(IOM) equations were found to be generally acceptable for determining EER by using the DLW method, except for Korean boys at 9-11 yrs (overestimated) and female athletes at 19-24 yrs (underestimated). Additionally, 5 papers include the validation of other EER equations, beside EER(IOM) for EER based on TEE(DLW). In Japanese dietary reference intake and recommended dietary allowance, EER equations are acceptable for determining EER based on TEE(DLW). The EER(IOM) equations is generally acceptable for determining EER using the DLW method in Koreans as well as several populations, although certain defined groups were found to be unfit for the estimation. Additionally, the concept of healthy body mass index of Koreans and physical activity levels need to be considered, thereby providing the basis for developing relevant equations of EER in KDRI.

Influences of School Food Service Employees′ Food Safety Training on Food Safety Knowledge and Practices (고등학교 급식 조리종사원들의 위생교육 경험과 위생지식 및 실천과의 관계)

  • 이경은;류경
    • Korean Journal of Community Nutrition
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    • v.9 no.5
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    • pp.597-605
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    • 2004
  • The purpose of the study was to investigate relationships among food safety training, knowledge, and practices of school food service employees. A questionnaire that identified employees' food safety training experience, knowledge, and practices was developed based on a review of literature. A total of 341 Korean school food service employees participated in the survey; the final usable responses were 293 (a response rate: 86%). Statistical analyses were conducted using SPSS for Windows (version 10). Most of the respondents (> 86%) took training sessions on 'proper hand washing' and 'proper food storage temperatures', whereas less than 60% had training on 'monitoring procedures and corrective actions at critical control points'. The mean score of their food safety knowledge was 8.02 out of 11. The majority of the employees knew correctly 'potentially hazardous foods (93.2%)' and 'diseases and symptoms with which they are excluded from working (87.0%)'; less than 50% chose a correct answer for 'sanitizing food contact surfaces.' A chi-square analysis revealed that the employees' actual knowledge did not differ significantly by whether they had food safety training (at the level of a =0.01), except one topic 'diseases and symptoms with which they are excluded from working.' Their self-reported practice scores were rated as 2.98 - 3.39 based on a 5-point Likert-type scale (1-not at all, 5-always). Employees' food safety training should be conducted continuously and repetitively to improve the effectiveness of the training.

Study of Latest Trend on Acupuncture for Obesity Treatment

  • Chun, Hea-Sun;Kim, Dong-Hwan;Song, Ho-Seub
    • Journal of Pharmacopuncture
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    • v.24 no.4
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    • pp.173-181
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    • 2021
  • Objectives: The aim of this review was to appraise Korean studies published between 2010 and 2021 which examined the role of acupuncture in the treatment of obesity. Methods: We performed a search of the NDSL, KISS, RISS, OASIS, PubMed, EMBASE electronic databases for relevant animal researches, case reports, and clinical trials, using the following search terms: 'obesity', 'acupuncture', 'electroacupuncture', and 'pharmacopuncture'. We excluded previous reviews and meta-analyses, studies not related to obesity or acupuncture treatment, as well as studies conducted in countries other than Korea. We also excluded studies where relevant information on acupuncture treatment in obesity could not be obtained. Results: Most studies were conducted in animals, followed by case reports and clinical trials. In animal researches and case reports, pharmacopuncture was the most used intervention. In case studies, electroacupuncture, thread-embedding therapy, manual acupuncture, acupotomy, and auricular acupuncture were also used. In animal researches, pharmacopuncture treatment was associated with improvement in obesity indices. In the case of local obesity, specific acupuncture techniques such as thread-embedding therapy and pharmacopuncture were associated with significant improvements in local obesity, even when diet and exercise were not controlled for. Conclusion: Acupuncture treatment showed significant benefit in the treatment of obesity, with a local effect evident for certain approaches, such thread-embedding therapy and acupotomy.

The Circuit design for Neutron Detection (중성자 검출을 위한 회로설계)

  • Kim, Sang-Jin;Seong, Nak-Jin;Kim, Ki-Joon
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2003.05b
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    • pp.42-46
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    • 2003
  • In this study, to measure the moisture of compaction, it is designed to use the 2neutron detectors. To perform the optimal design of their circuit, it is planned high voltage generator and voltage stable circuit and they are very suitable for detection demand. Also, it can be count to data calibration excluded count of ripple.

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Review on Laser or LED Therapy for the Photobiomodulation of Diseases of the Cerebral Nervous System (뇌신경질환에 사용된 레이저 및 광선치료에 대한 임상 연구 고찰)

  • Lee, Kyung-Goo;Shin, Jong-Hun;Lee, Kyung-Jin;Sun, Seung-Ho;Han, Chang-Ho;Jang, In-Soo
    • The Journal of Internal Korean Medicine
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    • v.35 no.4
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    • pp.546-555
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    • 2014
  • Objectives: Recently, many studies have reported beneficial effects from the application of laser and light-emitting diode (LED) therapy for cerebral nervous disease. Transcranial laser therapy and LED therapy may be an effective method to treat diseases of the cerebral nervous system. This study aims to discuss the possibility of laser and LED therapy for cerebral nervous disease by reviewing literature about its effectiveness. Methods: We searched papers using PubMed, Science Direct, CINAHL, KTKP, Oasis and NDSL, using the keywords "Laser therapy, low-level", "Transcranial laser", "Transcranial light emitting diode" and "stroke", "traumatic brain injury", "dementia", "anxiety", "cognitive", "emotional effects", "psychiatric disorder", "multiple sclerosis", "Parkinson's disease". The search range included randomized controlled trials (RCTs) and clinical case series. Reviews and animal experiments were not included. Studies not matched with inclusion criteria were excluded. Results: A total 1,119 studies were found. 1,100 were excluded from scanning titles and abstracts and finally 9 articles were selected. Among the 9 articles, 5 were RCTs, one was a controlled study, and the other 3 were case reports. They reported that transcranial laser therapy and LED treatment had beneficial effects from photobiomodulation to the cerebral nervous system. Clinical evaluation factors showed favorable trends. Conclusions: Transcranial laser therapy and LED therapy seem to be effective to the cerebral nervous system and they may be a favorable choice for cerebral nervous disease.