• The Journal of the Korea institute of electronic communication sciences
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• v.6 no.1
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• pp.34-42
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• 2011

In an effort to the practical realization of phonetic typewriter, we concentrate on the classification of consonants in this paper. Since many of consonants do not show periodic behavior in time domain and thus the validity for Fourier analysis of them are not convincing, vector quantization (VQ) via LBG clustering is first performed to check if the feature vectors of MFCC and LPCC are ever meaningful for consonants. Experimental results of VQ showed that it's not easy to draw a clear-cut conclusion as to the validity of Fourier analysis for consonants. For classification purpose, two kinds of neural networks are employed in our study: self organizing map (SOM) and learning vector quantization (LVQ). Results from SOM revealed that some pairs of phonemes are not resolved. Though LVQ is free from this difficulty inherently, the classification accuracy was found to be low. This suggests that, as long as consonant classification by LVQ is concerned, other types of feature vectors than MFCC should be deployed in parallel. However, the combination of MFCC/LVQ was not found to be inferior to the classification of phonemes by language-moded based approach. In all of our work, LPCC worked worse than MFCC.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.8
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• pp.1059-1065
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• 2010

An analysis was conducted to predict the hydraulic performance of a reactor coolant pump (RCP) of SMART at the off-design as well as design points. In order to reduce the analysis time efficiently, a single passage containing an impeller and a diffuser was considered as the computational domain. A stage scheme was used to perform a circumferential averaging of the flux on the impeller-diffuser interface. The pressure difference between the inlet and outlet of the pump was determined and was used to compute the head, efficiency, and break horse power (BHP) of a scaled-down model under conditions of steady-state incompressible flow. The predicted curves of the hydraulic performance of an RCP were similar to the typical characteristic curves of a conventional mixed-flow pump. The complex internal fluid flow of a pump, including the internal recirculation loss due to reverse flow, was observed at a low flow rate.

• 한국터널공학회:학술대회논문집
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• 2005.04a
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• pp.233-247
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• 2005

Most tunnel lining material which has been used in the domestic is a concrete. But many problems as the construction period, the cost, and the crack occurrence for the design, construction, and management were happened in the concrete lining. For this reason, many research institutes like the Korea Highway Corporation recognize the necessity of an alternate material development and grow on the interest for that. So in this study, the seismic behaviour characteristics for the application of the Corrugated Steel Plate Lining in cut-and-cover tunnel are evaluated as several conditions for the backfill height, the cutting slope, and the relative density of backfill soil are changed. The compressive stress which is calculated in the Corrugated Steel Plate Lining by the seismic load is decreased as the backfill height increases and the cut slope grows gentle. Also, the moment shows the tendency of decrease according to the increase of the backfill height. But in the case of the relative density of the backfill soil is small, the moment increases according to the increase of the backfill height and affects the dynamic behaviour characteristic. So it is considered that the relative density of the backfill soil is also the important point. As the result in analyzing the seismic response characteristics of the reinforcement spacing of the Corrugated Steel Plate, the variation in the compressive force is hardly happened, but the moment and the shear force increase on the reinforcement spacing being narrow.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6435-6439
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• 2012

Chemoresistance to cancer therapy is a major obstacle to the effective treatment of human cancers with cisplatin (DDP), but the mechanisms of cisplatin-resistance are not clear. In this study, we established a cisplatin-resistant human ovarian cancer cell line (COC1/DDP) and identified differentially expressed proteins related to cisplatin resistance. The proteomic expression profiles in COC1 before and after DDP treatment were examined using 2-dimensional electrophoresis technology. Differentially expressed proteins were identified using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and high performance liquid chromatography-electrospray tandem MS (NanoUPLC-ESI-MS/MS). 5 protein spots, for cytokeratin 9, keratin 1, deoxyuridine triphosphatase (dUTPase), aarF domain containing kinase 4 (ADCK 4) and cofilin1, were identified to be significantly changed in COC1/DDP compared with its parental cells. The expression of these five proteins was further validated by quantitative PCR and Western blotting, confirming the results of proteomic analysis. Further research on these proteins may help to identify novel resistant biomarkers or reveal the mechanism of cisplatin-resistance in human ovarian cancers.

• The Journal of the Acoustical Society of Korea
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• v.15 no.5
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• pp.82-89
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• 1996

Application fields of ultrasonic transducers can be divided into two categories, a high ultrasonic resolution required field and a high ultrasonic power required field. This paper is aimed to determine the optimal properties of the matching layers of the transducer for each of the applications. Further, it is aimed to optimize the properties of the matching layers that show satisfactory performances for both of the application fields. Through the direct time domain analysis of the transmission and reflection behavior of the ultrasonic wave, apart from the conventional equivalent circuit analysis, and Fourier transformation of its results, we found the optimum acoustic impedances of the matching layers. The newly determined layers provide much better transducer performance-57% at most-than those obtained with conventional design methods. Based on the results, we also found the optimal acoustic impedances of the layers good for both of the application fields. For te optimization, we developed a new transducer performance evaluation parameter that can be applied to any type of ultrasonic transducers.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.9
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• pp.3-11
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• 2016

Vehicle to Everything (V2X) communication has been growing to enhance traffic safety by employing advanced wireless communication systems. V2X communication is one core solution for governing and advancing future traffic safety and mobility. In this paper, we design the system level simulator (SLS) of Long Term Evolution (LTE)-based V2X and propose the adaptive transmission scheme for vehicle communication. The proposed scheme allocates the resource randomly in time and frequency domain, and transmit the message according to probability of transmission. The performance analysis is based on freeway case in periodic message transmission. Simulation results show that proposed scheme can improve the cumulative distribution function (CDF) of packet reception ratio (PRR) and average PRR.

• Journal of the Korean Geotechnical Society
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• v.29 no.1
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• pp.5-12
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• 2013

The critical velocity effect on railway trackbed means the amplification of vibration energy when the train running-speed and group velocity of ground surface wave are superimposed. It is called a pseudo-resonance phenomenon of time domain. In the past, it was not issued because the train speed was low and the ground group velocity was higher. But since the high-speed train is introduced, critical velocity reported causing a track irregularity. So far, theoretical analysis has been performed because of the complexity of formation process. However it requires reasonable consideration which is similar to actual track and trackbed conditions. In the present paper, finite element analysis to verify the critical velocity effect is performed considering each track structure and trackbed supporting stiffness. As a result, the deformation amplification caused by the critical velocity effect is verified to analyze each supporting stiffness and track system.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4869-4872
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• 2015

Background: Mutations of the FMS-like tyrosine kinase-3 (FLT3) receptor gene may promote proliferation via activation of multiple signaling pathways. FLT3-internal tandem duplication (FLT3-ITD) is the most common gene alteration found in patients diagnosed with acute myeloid leukaemia (AML) and has been associated with poor prognosis. Materials and Methods: We performed mutational analysis of exons 14-15 and 20 of the FLT3 gene in 54 AML patients using PCR-CSGE (conformational sensitive gel electrophoresis) followed by sequencing analysis to characterise FLT3 mutations in adult patients diagnosed with AML at Hospital USM, Kelantan, Northeast Peninsular Malaysia. Results: FLT3 exon 14-15 mutations were identified in 7 of 54 patients (13%) whereas no mutation was found in FLT3 exon 20. Six ITDs and one non-ITD mutation were found in exon 14 of the juxtamembrane (JM) domain of FLT3. FLT3-ITD mutations were associated with a significantly higher blast percentage (p-value = 0.008) and white blood cell count (p-value = 0.023) but there was no significant difference in median overall survival time for FLT3-ITD+/FLT3-ITD- within 2 years (p-value = 0.374). Conclusions: The incidence of FLT3-ITD in AML patients in this particular region of Malaysia is low compared to the Western world and has a significant association with WBC and blast percentage.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10917-10922
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• 2015

Background: This study was conducted to determine DEPDC1 expression in hepatocelluar carcinomas (HCCs) and to reveal its potential role in diagnosis and prognosis of affected patients. Materials and Methods: DEPDC1 expression at the mRNA level was detected by quantitative real-time PCR (qRT-PCR) in 205 cases of HCC and paired adjacent normal liver tissues, and by semi-quantitative RT-PCR in 20 cases. Survival curves were obtained by using Kaplan-Meier method and Log-rank test. Independent predictors associated with regard to disease free survival (DFS) and overall survival (OS) were identified using the Cox proportional hazard model. Results: High DEPDC1 mRNA levels were detected in 144 out of 205 cases (70.24%) of HCC, significantly associated with clinicopathological parameters, including tumor size (${\geq}4cm$), alpha-fetoprotein (${\geq}100ng/ml$), B-C of BCLC stage and recurrence. Kaplan-Meier survival analysis revealed that HCC patients with high DEPDC1 expression had poor OS and DFS. Multivariate analysis demonstrated that high DEPDC1 expression was an independent predictor for OS (HR=1.651; 95% 95%CI, 1.041-2.617; p=0.033) and DFS (HR=1.583; 95%CI, 1.01-2.483; p=0.045). Conclusions: Our results indicate DEPDC1 might be a novel diagnostic marker and an independent prognostic predictor for HCC patients.

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.392-399
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• 2009

The paper concerns the description of the step by step development process of the new fixed blade runner called "Mixer" suitable for the uprating of the Francis turbines units installed at the older low head hydropower plants. In the paper the details of hydraulic and mechanical design are presented. Since the rotational speed of the new runner is significantly higher then the rotational speed of the original Francis one, the direct coupling of the turbine to the generator can be applied. The maximum efficiency at prescribed operational point was reached by the geometry optimization of two most important components. In the first step the optimization of the draft tube geometry was carried out. The condition for the draft tube geometry optimization was to design the new geometry of the draft tube within the original bad draft tube shape without any extensive civil works. The runner blade geometry optimization was carried out on the runner coupled with the draft tube domain. The blade geometry of the runner was optimized using automatic direct search optimization procedure. The method used for the objective function minimum search is a kind of the Nelder-Mead simplex method. The objective function concerns efficiency, required net head and cavitation features. After successful hydraulic design the modal and stress analysis was carried out on the prototype scale runner. The static pressure distribution from flow simulation was used as a load condition. The modal analysis in air and in water was carried out and the results were compared. The final runner was manufactured in model scale and it is going to be tested in hydraulic laboratory. Since the turbine with the fixed blade runner does not allow double regulation like in case of full Kaplan turbine, it can be profitably used mainly at power plants with smaller changes of operational conditions or in case with more units installed. The advantages are simple manufacturing, installation and therefore lower expenses and short delivery time for turbine uprating.