• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5131-5136
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• 2012

Cancer is one of the major health problems worldwide and its current treatments have a number of undesired adverse side effects. Natural compounds may reduce these. Currently, a few plant products are being used to treat cancer. In this study, goniothalamin, a natural occurring styryl-lactone extracted from Goniothalamus macrophyllus, was investigated for cytotoxic properties against cervical cancer (HeLa), breast carcinoma (MCF-7) and colon cancer (HT29) cells as well as normal mouse fibroblast (3T3) using MTT assay. Fluorescence microscopy showed that GTN is able to induce apoptosis in HeLa cells in a time dependent manner. Flow cytometry further revealed HeLa cells treated with GTN to be arrested in the S phase. Phosphatidyl serine properties present during apoptosis enable early detection of the apoptosis in the cells. Using annexin V/PI double staining it could be shown that GTN induces early apoptosis on HeLa cells after 24, 48 and 72 h. It could be concluded that goniothalamin showing a promising cytotoxicity effect against several cancer cell lines including cervical cancer cells (HeLa) with apoptosis as the mode of cell death induced on HeLa cells by Goniothalamin was.

• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.6
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• pp.113-123
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• 2012

The technology developed for the decrease of applying loads and self-weight of a structure is to improve conventional Foam Cement Banking Method (FCB) by applying mixed slurry of bottom ash, cement and foams. Since the foam-mixed concrete, which is a major material of the Bottom ash-mixed Light weight concrete Banking method (BLB) developed, contains mineral admixture such as cement, the behavior shows time-dependent deformation and deterioration of durability due to environmental exposure. Thus, this study is subject to figure out the characteristics of long-termed behavior and durability of the developed method by carrying out experiments for schemed parameters, which are considered to be factors affecting mainly on concrete's characteristics from mechanical analysis. As results of tests, it was found that the developed concrete offers higher resistance than conventional foamed concrete in terms of long-termed behaviors associated with drying shrinkage and creep, and durability problems of freeze-thaw and carbonation processes, especially with addition of bottom ash.

• Journal of Pharmaceutical Investigation
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• v.36 no.1
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• pp.1-9
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• 2006

Human solid tumors exhibit a multicellular resistance (MCR) resulting from limited drug penetration and decreased sensitivity of tumor cells when interacting with their microenvironments. Multicellular cultures represent solid tumor condition in vivo and provide clinically relevant data. There is little data on antitumor effect of paclitaxel (PTX) in multicellular cultures although its MCR has been demonstrated. In the present study, we evaluated antiproliferative effects of PTX in multicellular layers (MCL) of DLD-1 human colorectal carcinoma cells. BrdU labeling index (LI), thickness of MCL, cell cycle distribution and cellular uptake of calcein were measured before and after exposure to PTX at 0.1 to 50 ${\mu}M$ for 24, 48 and 72 hrs. BrdU LI and thickness of MCL showed a concentration- and time-dependent decrease and the changes in both parameters were similar, i.e., 34.2% and 40.6% decrease in BrdU LI and thickness, respectively, when exposed to $50\;{\mu}M$ for 72 hr. The DLD-1 cells grown in MCL showed increase in $%G_{0}/G_{1}$ and resistance to cell cycle arrest and apoptosis compared to monolayers. Calcein uptake in MCL did not change upon PTX exposure, indicating technical problems in multicellular system. Overall, these data indicate that antitumor activity of PTX may be limited in human solid tumors (a multicellular system) and MCL may be an appropriate model to study further pharmacodynamics of PTX.

• Journal of Preventive Medicine and Public Health
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• v.48 no.1
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• pp.62-71
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• 2015

Objectives: This study aimed to investigate North Korean refugees' knowledge of mental illnesses and treatments and analyze the factors affecting this knowledge. Methods: Subjects were selected via a snowball sampling method, and the survey outcomes of 152 North Korean refugee participants were analyzed. The factors affecting knowledge of mental illnesses were analyzed via a regression analysis by constructing a multivariate model with mental illness knowledge score as the dependent variable. Results: The North Korean refugees' mental illness scores ranged from 3 to 24 points, with an average score of 13.0. Regarding the factors that influence mental illness knowledge, the subjects with South Korean spouses and those who had spent more time in South Korea had higher knowledge scores. Furthermore, the subjects who considered the mental health of North Korean refugees to be a serious issue revealed lower knowledge scores than those who did not believe it was a serious issue. The subjects who visit psychiatric clinics showed higher knowledge scores than those who do not. The South Korean subjects who had at least a college education exhibited higher scores than did those without advanced education. The subjects who are satisfied with life in South Korea manifested a higher mental illness knowledge score than those who are not. Conclusions: This study is significant as being the first study to ever measure and evaluate the level of North Korean refugees' knowledge of mental illnesses. In addition, the evaluations of North Korean refugees' mental illness knowledge and influencing factors while residing in South Korea created basic data that formed the foundation of an effort to enhance mental health literacy and provide proper mental health services. The results of this study can be utilized to solve mental health problems that might frequently occur during the unification process of North and South Korea in the future.

• Journal of Korea Society of Industrial Information Systems
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• v.23 no.4
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• pp.81-92
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• 2018

Bitcoin is a cryptographic digital currency and has been given a significant amount of attention in literature since it was first introduced by Satoshi Nakamoto in 2009. It has become an outstanding digital currency with a current market capitalization of approximately $60 billion. By 2019, it is expected to have over 5 million users. Nowadays, investing in Bitcoin is popular, and along with the advantages and disadvantages of Bitcoin, learning how to forecast is important for investors in their decision-making so that they are able to anticipate problems and earn a profit. However, most investors are reluctant to invest in bitcoin because it often fluctuates and is unpredictable, which may cost a lot of money. In this paper, we focus on solving the Bitcoin forecasting prediction problem based on deep learning structures and neural decomposition. First, we propose a deep learning-based framework for the bitcoin forecasting problem with deep feed forward neural network. Forecasting is a time-dependent data type; thus, to extract the information from the data requires decomposition as the feature extraction technique. Based on the results of the experiment, the use of neural decomposition and deep neural networks allows for accurate predictions of around 89%.

• Structural Engineering and Mechanics
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• v.58 no.5
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• pp.869-886
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• 2016

Non-Deformable Support System (NDSS) is one of the support system analysis methods. It is likely seen as numerical analysis. Obviously, numerical modeling is the key tool for this system but not unique. Although the name of the system makes you feel that there is no deformation on the support system, it is not true. The system contains some deformation but in certain tolerance determined by the numerical analyses. The important question is what is the deformation tolerance? Zero deformation in the excavation environment is not the case, actually. However, deformation occurred after supporting is important. This deformation amount will determine the performance of the applied support. NDSS is a stronghold analysis method applied in full to make this work. While doing this, NDSS uses the properties of rock mass and material, various rock mass failure criteria, various material models, different excavation geometries, like other methods. The thing that differ NDSS method from the others is that NDSS makes analysis using the time dependent deformation properties of rock mass and engineering judgement. During the evaluation process, NDSS gives the permission of questioning the field observations, measurements and timedependent support performance. These transactions are carried out with 3-dimensional numeric modeling analysis. The goal of NDSS is to design a support system which does not allow greater deformation of the support system than that calculated by numerical modeling. In this paper, NDSS applied to the problems of Tunnel 34 of the same Project (excavated with NATM method, has a length of 2218 meters), which is driven in graphite schist, was illustrated. Results of the system analysis and insitu measurements successfully coincide with each other.

• Hwankyungkyoyuk
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• v.13 no.2
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• pp.74-90
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• 2000

The environmental quality in Korea was significantly deteriorated though the past economic development period. Even though the government has spent huge sum of resources on the policies and projects to improve the environmental quality, it is much removed from what the people hope for. To solve the environmental problems effectively, pollutants generated at source should be kept as minimum as possible, and possible, and pollutants from source be controlled before leaving the sources, and most of all, environmental strategies and systems be established and enforced properly. So, it is not too much to say that nation's environmental quality is entirely dependent on the education and training of the environmental managers such as environmental employees for air, water, and noise discharge facilities, technicians at environmental plants, and environmental officers of central and local governments. Regimes for the improvement of the education and training for environmental managers are suggested into four categories-educational institute, circular of the study, training contents and trainees. Referring to the improvement of integrated institute, and to improvement on educational institute, it is necessary to investigate the feasibility of integrated institute, and to recommend the inclusion of the local colleges and universities, and environmental societies. For the improvement on training courses, it is necessary that the non-obligatory course be expanded, and the courses be developed in such a way to meet the needs from the field. As for the improvement on training contents. It is suggested that the practical training on size be strengthened, and also full time environmental specialist and integrated committee be required to develop the effective circular and selection of proper lectures. Finally, environmental education for high ranked officers of autonomies, and international courses for developing countries are suggested.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.2
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• pp.13-21
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• 2017

Airline schedules are highly dependent on various factors of uncertainties such as unfavorable weather conditions, mechanical problems, natural disaster, airport congestion, and strikes. If the schedules are not properly managed to cope with such disturbances, the operational cost and performance are severely affected by the delays, cancelations, and so forth. This is described as a disruption. When the disruption occurs, the airline requires the feasible recovery plan returning to the normal operations in a timely manner so as to minimize the cost and impact of disruptions. In this research, an Ant Colony Optimization (ACO) algorithm with re-timing strategy is developed to solve the recovery problem for both aircraft and passenger. The problem consists of creating new aircraft routes and passenger itineraries to produce a feasible schedule during a recovery period. The suggested algorithm is based on an existing ACO algorithm that aims to reflect all the downstream effects by considering the passenger recovery cost as a part of the objective function value. This algorithm is complemented by re-timing strategy to effectively manage the disrupted passengers by allowing delays even on some of undisrupted flights. The delays no more than 15 minutes are accepted, which does not influence on the on-time performance of the airlines. The suggested method is tested on the real data sets from 2009 ROADEF Challenge, and the computational results are compared with the existing ones on the same data sets. The method generates the solution for most of problem set in 10 minutes, and the result generated by re-timing strategy is discussed for its impact.

• Journal of the Korean Institute of Telematics and Electronics
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• v.21 no.5
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• pp.46-54
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• 1984

A silicon-gate n-well CMOS process with 3 $\mu$m gate length was developed and its possibility for the applications was discussed,. Threshold voltage was easily controlled by ion implantation and 3-$\mu$m gate length with 650 $\AA$ oxide shows ignorable short channel effect. Large value of Al-n+ contact resistance is one of the problems in fabrications of VLSI circuits. Transfer characteristics of CMOS inverter is fairly good and the propagation delay time per stage in ring oscillator with layout of (W/L) PMOS /(W/L) NMOS =(10/5)/(5/5) is about 3.4 nsec. catch-up occurs on substrate current of 3-5 mA in this process and critically dependent on the well doping density and nt-source to n-well space. Therefore, research, more on latch-up characteristics as a function of n-well profile and design rule, especially n+-source to n-well space, is required.

• Journal of the Korean Institute of Intelligent Systems
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• v.13 no.3
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• pp.259-259
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• 2003

Genetic algorithms using a Process of genetic evolution of an organism are appropriate for hard problems that have not been solved by any deterministic method. Up to now, the controller design method has been made with the frequency dependent specification but the design method with the time specification has gotten little progress. In this paper, we study the controller design to satisfy the performance of a plant using the generalized Manabe standard form. When dealing with a controller design in the case of two parameter configurations, there are some situations that neither a known pseudo inverse technique nor the inverse method can be applicable. In this case, we propose two methods of designing a controller by the gradient algorithm and the new pseudo inverse method so that the desired closed polynomials are either equalized to or approximated to the designed polynomial. Design methods of the proposed controller are implemented in Java.