• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3391-3396
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• 2012

Two-dimensional infrared (2D-IR) spectroscopy can probe the fast structural evolution of molecules under thermal equilibrium. Vibrational frequency fluctuation caused by structural evolution produced the time-dependent line shape change in 2D-IR spectrum. A variety of methods has been used to connect the evolution of 2D-IR spectrum with Frequency-Frequency Correlation Function (FFCF), which connects the experimental observables to a molecular level description. Here, a new method to extract FFCF from 2D-IR spectra is described. The experimental observable is the time-dependent frequency shift of maximum peak position in the slice spectrum of 2D-IR, which is taken along the excitation frequency axis. The direct relation between the 2D-IR peak shift and FFCF is proved analytically. Observing the 2D-IR peak shift does not need the full 2D-IR spectrum which covers 0-1 and 1-2 bands. Thus data collection time to determine FFCF can be reduced significantly, which helps the detection of transient species.

• Toxicological Research
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• 제20권2호
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• pp.137-142
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• 2004

We investigated the effects of plant vinegar on platelets and blood coagulation system. Plant vinegar inhibited in vitro platelet aggregation in a concentration dependent manner, when platelets were activated by thrombin and collagen. In addition, plant vinegar showed inhibitory effects on the serotonin secretion induced by thrombin in a concentration dependent manner. However, treatment with plant vinegar to platelets did not induce any cytotoxicity, as determined by the release of lactate dehydrogenase. Plant vinegar did not change the coagulation parameters such as activated partial thromboplastin time (aPTT) and prothrombin time (PT) using rat citrated plasma. In vivo study revealed that, treatment with plant vinegar prolonged the bleeding time from mouse tail. All these results suggest that plant vinegar might improve blood hemostasis mediated via anti platelet activities.

• 대한인간공학회지
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• 제22권3호
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• pp.57-73
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• 2003

Although body pressure distribution is sensitive to movements and is relatively simple to measure even in small space, there are few researches involving applications to driver's posture and its change. The main objective in this study is the application of body pressure distribution measurements for the prediction of the driver's posture and its change. This requires quantitative analyses of the dynamic body pressure distribution, which is the change of body pressure distribution with time. The experiment involved 16 male subjects who drove for 45 minutes in a seating buck. Measurement time, stature group, and lumbar support prominence were selected as independent variables, with subjective ratings of driver's discomfort, body posture data of hip, torso. knee angle, and body pressure data variables as dependent variables. The body pressure change variables and subjective ratings were found to increase as the measurement time increased and body pressure ratio variables reflected the torso angle. From the results and analysis of the body posture data and subjective rating results, it was predicted that the seats and the design of the lumbar supports used in the experiment was not fit for tall subjects, which could also be confirmed through the body pressure distribution data.

• 말소리와 음성과학
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• 제8권3호
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• pp.39-49
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• 2016

The present study examined the change of aerodynamic features after laryngomicrosurgery in patients with vocal polyps. Aerodynamic evaluation was performed in thirty-nine patients (15 males and 24 females) one week before surgery and four weeks after surgery. Evaluation protocols of vital capacity, maximum sustained phonation(MXPH), and voicing efficiency(VOFT) were used to collect 29 phonatory aerodynamic measures, requiring voice with a comfortable pitch and loudness. Statistically significant changes were found for phonation time and airflow values in the MXPH protocol, while changes were also found for airflow values, subglottal pressure values and acoustic resistance values in the VOFT protocol. Although phonation time was increased in both male and female patients, gender-dependent changes were found in airflow measurements. Men's phonation time increased with no difference in airflow rate, but women's phonation time increased with decreased airflow rate and lower subglottal pressure. The changes of aerodynamic features may be affected by women's self-perceived change for vocal attitude, which was reducing sense of vocal effort after surgery.

• 가정과삶의질연구
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• 제32권1호
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• pp.1-12
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• 2014

The purpose of this study was to examine: (1) whether the level of parental monitoring changes during adolescence; (2) if it changes, what is the pattern of the change; and (3) whether the effects of adolescents' attachment to their parents on parental monitoring are dependent on time. Six waves of data from the Korea Youth Panel Study (KYPS) were used to address the research questions. The participants of the KYPS were 3,449 (1,725 boys and 1,724 girls) adolescents who participated in the study once a year for 6 years (from the 2nd grade in middle school until their high school graduation). Latent growth modeling (LGM) was used to analyze the data. The findings are as follows: the level of parental monitoring significantly increased over the six waves of the study, and the adolescents' attachment to their parents was a time-dependent predictor of parental monitoring. The results indicate that the quality of adolescents' attachment to their parents is an important factor that makes a difference in the level of parental monitoring by, possibly, affecting the level of adolescents' disclosure to their parents.

• 한국농공학회논문집
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• 제54권5호
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• pp.123-128
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• 2012

For optimal reservoir operation and management, there are essential elements including water supply in agricultural reservoir and demand in irrigation district. To estimate agricultural water demand and supply, many factors such as weather, crops, soil, growing conditions cultivation method and the watershed/irrigation area should be considered, however, there are occurred water supply impossible duration under the influence of the variability and uncertainty of meteorological and hydrological phenomenon. Focusing on agricultural reservoir, amount and tendency of agricultural water supply and demand shows seasonally/regionally different patterns. Through the analysis of deviation and changes in the timing of the two elements, duration in excess of water supply can be identified quantitatively. Here, we introduce an approach to assessment of irrigation vulnerable duration for effective management of agricultural reservoir using time dependent change analysis of residual water supply and irrigation water requirements. Irrigation vulnerable duration has been determined through the comparison of water supply in agricultural reservoir and demand in irrigation district based on the water budget analysis, therefore can be used as an improved and basis data for the effective and intensive water management.

• 농촌계획
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• 제9권2호
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• pp.39-47
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• 2003

This study was carried out to find out the time-dependent change of central functions in the depopulated rural areas. Three county areas were selected for the case study ; Haenam(as a remote flat area), Goksung(as an intermediate mountainous area), and Hwasun(as a peri-urban area). For each district area administered by each county, service facilities stock was surveyed at both the present('02) and the past('89 or '94)time, and its functional index checked. From the study results, table-tennis rooms, oil shops and inns were ascertained to be disappeared now in the absolute or real terms, while beer halls, restaurants and bakeries to be sharply increased. Generally, in spite of the substantial depopulation in the past decade, service facilities stock has been increased in and concentrated to the highest order center of rural area (county office seated district). However, where this center leans to the outer side of its county area and to the opposite direction against the regional center, the dependent level of service function on the highest center have decreased.

• 대한치과보철학회지
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• 제34권3호
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• pp.574-592
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• 1996

This study investigated the time-dependent dimensional changes of elastomeric impression materials using holographic interferometry. Six commercial impression materials, Permlastic(polysulfide), Xantopren VL (condensation silicone), low and medium viscosity of Exafine, Provil (addition silicone), and Impregum(polyether), were selected. Steel plate was used as custom tray, and each impression specimen was 20 mm in width, 15 mm in length and 3 mm in thickness. Each impression material was evaluated at 30 minutes, 1, 2, 4, 6, 8 and 12 hours after setting using real-time holography. The results were as follow : 1. Xantopren VL and Permlastic showed relatively severe and continuous dimensional changes after setting. Low viscosity of Exafine, Provil, Impregum showed relatively slight dimensional changes with function of time and medium viscosity of Exafine showed almost no dimensional change from 2 hours after setting to 6 hours. 2. On initial dimensional changes within 1 hour, the amount of change in low viscosity of Exafine was the least and Xantopren VL was the largest. 3. On dimensional changes at 4 hours after setting, the amount of change in medium viscosity of Exafine was the least and tile change of Xantopren VL was the largest. 4. In overall dimensional stability during 12 hours, medium viscosity of Exafine was the most stable and Xantopren VL and Permlastic were least stable.

• The Korean Journal of Physiology and Pharmacology
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• 제11권2호
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• pp.71-77
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• 2007

Cisplatin treatment increases the excretion of inorganic phosphate in vivo. However, the mechanism by which cisplatin reduces phosphate uptake through renal proximal tubular cells has not yet been elucidated. We examined the effect of cisplatin on $Na^+$-dependent phosphate uptake in opossum kidney (OK) cells, an established proximal tubular cell line. Cells were exposed to cisplatin for an appropriate time period and phosphate uptake was measured using $[^{32}P]$-phosphate. Changes in the number of phosphate transporter in membranes were evaluated by kinetic analysis, $[^{14}C]$phosphonoformic acid binding, and Western blot analysis. Cisplatin inhibited phosphate uptake in a time- and dose-dependent manner, and also the $Na^+$-dependent uptake without altering $Na^+$-independent uptake. The cisplatin inhibition was not affected by the hydrogen peroxide scavenger catalase, but completely prevented by the hydroxyl radical scavenger dimethylthiourea. Antioxidants were ineffective in preventing the cisplatin-induced inhibition of phosphate uptake. Kinetic analysis indicated that cisplatin decreased Vmax of $Na^+$-dependent phosphate uptake without any change in the Km value. $Na^+$-dependent phosphonoformic acid binding was decreased by cisplatin treatment. Western blot analysis showed that cisplatin caused degradation of $Na^+$-dependent phosphate transporter protein. Taken together, these data suggest that cisplatin inhibits phosphate transport in renal proximal tubular cells through the reduction in the number of functional phosphate transport units. Such effects of cisplatin are mediated by production of hydroxyl radicals.

• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.597-605
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• 2018

In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent $K^+$ (Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits. The Kv current amplitude was progressively inhibited by propafenone in a dose-dependent manner, with an apparent $IC_{50}$ value of $5.04{\pm}1.05{\mu}M$ and a Hill coefficient of $0.78{\pm}0.06$. The application of propafenone had no significant effect on the steady-state activation and inactivation curves, indicating that propafenone did not affect the voltage-sensitivity of Kv channels. The application of train pulses at frequencies of 1 or 2 Hz progressively increased the propafenone-induced inhibition of the Kv current. Furthermore, the inactivation recovery time constant was increased after the application of propafenone, suggesting that the inhibitory action of propafenone on Kv current is partially use-dependent. Pretreatment with Kv1.5, Kv2.1 or Kv7 inhibitor did not change the inhibitory effect of propafenone on the Kv current. Together, these results suggest that propafenone inhibits the vascular Kv channels in a dose- and use-dependent manner, regardless of $Na^+$ channel inhibition.