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Improvement of Haemostasis Mediated by Anti-Platelet Activities by Plant Vinegar  

김영대 (서울대학교 약학대학 종합약학연구소)
배옥남 (서울대학교 약학대학 종합약학연구소)
정승민 (서울대학교 약학대학 종합약학연구소)
정진호 (서울대학교 약학대학 종합약학연구소)
Publication Information
Toxicological Research / v.20, no.2, 2004 , pp. 137-142 More about this Journal
Abstract
We investigated the effects of plant vinegar on platelets and blood coagulation system. Plant vinegar inhibited in vitro platelet aggregation in a concentration dependent manner, when platelets were activated by thrombin and collagen. In addition, plant vinegar showed inhibitory effects on the serotonin secretion induced by thrombin in a concentration dependent manner. However, treatment with plant vinegar to platelets did not induce any cytotoxicity, as determined by the release of lactate dehydrogenase. Plant vinegar did not change the coagulation parameters such as activated partial thromboplastin time (aPTT) and prothrombin time (PT) using rat citrated plasma. In vivo study revealed that, treatment with plant vinegar prolonged the bleeding time from mouse tail. All these results suggest that plant vinegar might improve blood hemostasis mediated via anti platelet activities.
Keywords
Plant vinegar; Platelets; Cytotoxicity; Antiplatelet activity; Cardiovascular disease;
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