• Title/Summary/Keyword: time course

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Statistical Analysis of a Small Scale Time-Course Microarray Experiment (소규모 경시적 마이크로어레이 실험의 통계적 분석)

  • Lee, Keun-Young;Yang, Sang-Hwa;Kim, Byung-Soo
    • The Korean Journal of Applied Statistics
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    • v.21 no.1
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    • pp.65-80
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    • 2008
  • Small scale time-course microarray experiments are those which have a small number of time points. They comprise about 80 percent of all time-course microarray experiments conducted up to 2005. Several statistical methods for the small scale time-course microarray experiments have been proposed. In this paper we applied three methods, namely, QR method, maSigPro method and STEM, to a real time-course microarray experiment which had six time points. We compared the performance of these three methods based on a simulation study and concluded that STEM outperformed, in general, in terms of power when the FDR was set to be 5%.

Time course of the denervation in early stage of Bell's palsy.: Identification by electrophysiologic study (초기 벨마비에서 나타나는 탈신경의 시간경과에 따른 변화: 전기생리학적 검사를 통한 확인)

  • Bae, Jong-Seok;Uhm, Keun-Yong;Kim, Byoung-Joon;Kwon, Ki-Han
    • Annals of Clinical Neurophysiology
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    • v.6 no.1
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    • pp.26-30
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    • 2004
  • Background: Electrophysiologic study accurately predicts the degree of degenerated motor axons but cannot give precise information on the type of injury that occurred in Bell's palsy. Because of these limitation for prognostic prediction in Bell's palsy, we evaluated divergence of electrophysiological time course for the purpose of presuming the type of injury in Bell's palsy. Methods: We did bilateral facial nerve conduction studies in 103 Bell's palsy patients, who visited to Han-Gang sacred heart hospital from 1998 to 2001. We compared the CMAP amplitude of disease site with that of normal site and suggested that decremental CMAP amplitude ratio (percentage) as a degree of denervation of affected facial nerve. Then we demonstrated the time course of denervation percentage. After defining normal range of CMAP amplitude difference from normal control group, we also evaluated if distinct time course of early minimal denervation is present. Results: Our results show that time course of the denervation in early stage of Bell's palsy reflect various injury type such as axonotmesis, neurotmesis or other unidentified type. We cannot identify the distinct time course of early minimal denervation. Conclusions: The time course as well as the maximal value of denervation are the best prognostic guidelines in Bell' s palsy. So repeated serial electrophysiologic test are inevitable to assess prognosis. As an another topic, early minimal denervation for prognostic prediction deserve to be evaluated as a future work up for prognostic prediction.

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A Study on Course Stability in Accordance with Configuration of Ships (선형에 따른 선박의 침로 안정성에 관한 연구)

  • 권종호
    • Journal of the Korean Institute of Navigation
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    • v.10 no.2
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    • pp.97-114
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    • 1986
  • Ship's maneuverability is very important factor in safe ship handling and economical ship operation. Steering characteristics are consisted of course stability and maneuverability. Today in many advanced ship-building countries, they study ship's course stability, using model ship tests, such as straight line tests, rotating arm tests and Planar Motion Mechanism (PMM) etc., in tow in tanks. It is the purpose of this paper to provide ship's handlers with better understanding of steering characteristics and to help them in safe controlling and manevering . In this paper, the author simulated response of various vessels, running straight course with constant speed, and they are disturbed by small external disturbance of one degree yaw angle with no angular velocity . The author used the hydrodynamic derivtives resulted at tests of Davidson's laboratory in Stevens Institute of Technology, New Jersey, U.S.A. Course stability was evaluated and analyzed in various respects, such as block coefficient, ratio of ship's length to beam, draft and rudder area ratio etc. The obtained results are as follows : (1) The ship's course stability is affected by magnitude of block coefficient greatly. In case that the block coefficient is more than 0.7, the deviation varies at nearly same rate but the requistite time to reach the steady course is different. (2) The ship's course stability is affected by magnitude of L/B. When the dimensionless time reaches about 3, the deviation and requisite time to reach the steady course are influenced nearly same. After the dimensionless time is about 3, they change on invariable ratio. (3) The effect to course stability by L/T and RA' can be neglected. (4) The reason why thy VLCC and container feeder vessel are unstable on their course is that their block coefficient is generally more than 0.8 and the ratio of ship's length to beam is about 6.0.

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A Pattern Consistency Index for Detecting Heterogeneous Time Series in Clustering Time Course Gene Expression Data (시간경로 유전자 발현자료의 군집분석에서 이질적인 시계열의 탐지를 위한 패턴일치지수)

  • Son, Young-Sook;Baek, Jang-Sun
    • The Korean Journal of Applied Statistics
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    • v.18 no.2
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    • pp.371-379
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    • 2005
  • In this paper, we propose a pattern consistency index for detecting heterogeneous time series that deviate from the representative pattern of each cluster in clustering time course gene expression data using the Pearson correlation coefficient. We examine its usefulness by applying this index to serum time course gene expression data from microarrays.

Optimal washing course for sustainable laundering and care - Focusing on the washing course, detergency, fabric damage and detergent concentration - (지속가능한 의류관리를 위한 최적 세탁코스 연구 - 세탁코스, 세탁성, 섬유손상도, 세제농도를 중심으로 -)

  • Seong Phil Baek;Seeun Park;Myung-Ja Park
    • Journal of the Korea Fashion and Costume Design Association
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    • v.24 no.4
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    • pp.1-9
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    • 2022
  • The purpose of this research is to improve sustainable clothes care by comparing household washer's standard course and quick course. Detergency at each course was classified by laundry weight, detergent concentration, and soils. Also, fabric damage from each course was compared. Washing experiments were carried out using two types of washing machines and three types of detergents. Using the standard soiled fabrics of EMPA 108 set, detergency was compared by laundry weight, soil, and detergent concentration. Additionally, fabric damage was evaluated using the mechanical action of MA-40. The results of the research were as follows. First, a standard course, having more working time exhibited better detergency than a quick course. However, the detergency deviation under 6kg laundry weight was as low as 9.0%. Second, detergency by the type of soil was more effective in standard course than in a quick course, but hydrophilic protein soils had a small detergency deviation at 7.6%. Moreover, hydrophobic oil, complex, and particulate soils had a higher deviation at 19.7% Third, fabric damage was in proportion to operating time. Fourth, a quick course showed approximately 80% detergency regardless of the type of detergent. in the case of using 50% of the recommended allowance by the detergent manufacturer. In conclusion, reducing the operating washing time and detergent concentration is in accordance with increasing sustainability, in the case of washing with lightly soiled fabrics under 6kg of laundry weight.

Course Embeded Program Outcome Assesment-Based on the Exams and the Reports (교과목 성취도에 근거한 학습성과의 평가 -시험과 보고서를 위주로)

  • Park, Yoon-Kook
    • Journal of Engineering Education Research
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    • v.9 no.3
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    • pp.62-66
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    • 2006
  • Although it has taken some time to apply the accreditation system in Korea, most programs have a very difficult time in assessing program outcomes, one of the most important standards in accreditation. The major purpose of this work is to suggest a method, so called course embedded assessment, by which to assess a course that includes several program outcomes. The course was evaluated based on student performance on each exam taken in the course as well as a report submitted by the students. The course embedded assessment provides not only an effective tool by which to assess course-set program outcomes, but also allow the instructor to follow up and/or modify the course material to be offered in next semester.

Virtual Go to School (VG2S): University Support Course System with Physical Time and Space Restrictions in a Distance Learning Environment

  • Fujita, Koji
    • International Journal of Computer Science & Network Security
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    • v.21 no.12
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    • pp.137-142
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    • 2021
  • Distance learning universities provide online course content. The main methods of providing class contents are on-demand and live-streaming. This means that students are not restricted by time or space. The advantage is that students can take the course anytime and anywhere. Therefore, unlike commuting students, there is no commuting time to the campus, and there is no natural process required to take classes. However, despite this convenient situation, the attendance rate and graduation rate of distance learning universities tend to be lower than that of commuting universities. Although the course environment is not the only factor, students cannot obtain a bachelor's degree unless they fulfill the graduation requirements. In both commuter and distance learning universities, taking classes is an important factor in earning credits. There are fewer time and space constraints for distance learning students than for commuting students. It is also easy for distance learning students to take classes at their own timing. There should be more ease of learning than for students who commute to school with restrictions. However, it is easier to take a course at a commuter university that conducts face-to-face classes. I thought that the reason for this was that commuting to school was a part of the process of taking classes for commuting students. Commuting to school was thought to increase the willingness and motivation to take classes. Therefore, I thought that the inconvenient constraints might encourage students to take the course. In this research, I focused on the act of commuting to school by students. These situations are also applied to the distance learning environment. The students have physical time constraints. To achieve this goal, I will implement a course restriction method that aims to promote the willingness and attitude of students. Therefore, in this paper, I have implemented a virtual school system called "virtual go to school (VG2S)" that reflects the actual route to school.

Consensus Clustering for Time Course Gene Expression Microarray Data

  • Kim, Seo-Young;Bae, Jong-Sung
    • Communications for Statistical Applications and Methods
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    • v.12 no.2
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    • pp.335-348
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    • 2005
  • The rapid development of microarray technologies enabled the monitoring of expression levels of thousands of genes simultaneously. Recently, the time course gene expression data are often measured to study dynamic biological systems and gene regulatory networks. For the data, biologists are attempting to group genes based on the temporal pattern of their expression levels. We apply the consensus clustering algorithm to a time course gene expression data in order to infer statistically meaningful information from the measurements. We evaluate each of consensus clustering and existing clustering methods with various validation measures. In this paper, we consider hierarchical clustering and Diana of existing methods, and consensus clustering with hierarchical clustering, Diana and mixed hierachical and Diana methods and evaluate their performances on a real micro array data set and two simulated data sets.

A Study on Life Course Approach in Family Studies (家族硏究에 있어서 라이프 코오스(Life Course) 접근에 관한 고찰)

  • Lee, In-Soo
    • Journal of Families and Better Life
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    • v.9 no.1 s.17
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    • pp.1-11
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    • 1991
  • This paper reviews the literature on life course as a perspective in family studies. Life course approach on family studies have been emerged since 1960. This approach, which is challenging accepted knowledge and theory, partly reflects a shift in analytic perspective from structural models to a more behavioral thrust that views as a actor in structured situations, Life course approach is a theoretical orientation for our understanding of the linkage between individual and family development in context of changing historical context. Life course approach contributes time, process, and context to receiving in sociological perspectives on family and kinship.

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A Study on the Pet Soil Removal Effect of Washing Conditions Using a Chemiluminescence Reaction (화학발광 반응을 이용한 세탁조건별 반려동물 오구 제거효과 연구)

  • Park, Jung-Eun;Lee, Jungsoon
    • Journal of the Korean Society of Clothing and Textiles
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    • v.45 no.5
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    • pp.840-851
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    • 2021
  • In this study, we used a chemiluminescence reaction to investigate the removal effect of pet soil, such as dog blood, urine and feces. The soiled fabrics were washed with a standard laundry course of 30℃ and a washing time of 30 min and a pet care laundry course of 40-60℃ and a washing time of 100 min. The detergency was evaluated by the surface reflectance and chemiluminescence reaction (bloodstain detection by luminol test and urine-stain and feces-stain detection by UV blacklight test) before and after washing. The surface reflectance results did not show any difference in detergency for both courses, whereas the chemiluminescence reaction did. The detergency of the pet care course compared to the standard course was 101% according to the surface reflectance and 120% according to the chemiluminescence reaction. Therefore, residual stains not detected by surface reflectance can be evaluated through chemiluminescence reaction, and it was confirmed that pet stains can be managed more hygienically by washing for a long time at a high temperature.