• Molecules and Cells
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• v.19 no.1
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• pp.74-80
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• 2005

Stress is known to inhibit granule cell proliferation in the hippocampus. However, recent studies suggest that the commonly used dose of bromodeoxyuridine (BrdU) is insufficient to label all fractions of granule cells. Furthermore, stress-induced changes in BrdU availability may influence the labeling of newly born cells. To investigate whether changes in BrdU availability affect measurements of stress-induced granule cell proliferation, granule cell proliferation was assessed using injection of high doses of BrdU before and after restraint stress lasting 1 h. In addition, to determine whether stress-induced changes in plasma corticosterone levels were influenced by the BrdU, time-dependent changes in plasma corticosterone levels over 2 h after BrdU injection were compared with total accumulated plasma corticosterone levels [as determined by areas under the curve (AUC)]. Restraint stress significantly reduced the numbers of BrdU-labeled cells and clusters in the granule cell layer (GCL) of rats that received BrdU after stress, and decreases of similar magnitude were observed when the rats were given BrdU before stress. BrdU injection enhanced the stress-induced plasma corticosterone response, but there was no difference between the mean AUCs of plasma corticosterone levels of animals injected with BrdU before or after stress. These observations suggest that restraint stress decreases granule cell proliferation, and that this may be influenced by the extent and duration of plasma corticosterone increases rather than by changes in the availability of BrdU.

• Journal of the Korea Computer Industry Society
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• v.3 no.1
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• pp.77-84
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• 2002

An cluster system used consist of large number of running servers, one has the problem that does the low availability occured by the high chance of the server failures and it is difficult to provide occuring software aging. In this paper, running cluster web servers consists of n primary servers and k backup servers, based on the operational parameters such as number of running primary servers, number of backup severs, rejuvenation period, rejuvenation time, failure rate of sewers, repair rate of servers, unstable rate of servers. We calculate to evaluate the rejuvenation policy such steady-state probabilities, downtime, availability, and downtime cost. We validate the solutions of mathematical model by experiments based on various operation parameters and find that the software rejuvenation method can be adopted as prventive fault tolerant technique for stability of system. The failure rate and unstable rate of the servers are essential factors for decision making of the rejuvenation policies.

• Journal of the Korea Society of Computer and Information
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• v.27 no.3
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• pp.79-90
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• 2022

'Trust' is 'believing and relying on people or things', and at the same time, it is the foundation and essential condition of existence of a specific community or society. How blockchain technology creates trust can be found in the fact that it is a technology shared by all participants. As a shared technology, blockchain itself shows three characteristics: transparency, immutability, and availability. Because it is shared, it is transparent, and because it is shared, it is immutable, which is difficult to modify or delete. In addition, since it is shared, the entire system operates normally even if some failure occurs. The significance of trust created based on this blockchain technology can be summarized in three aspects as follows. The first is to understand the problem of trust in connection with technology. Second, understanding the relationship between information and trust begins to pay attention. Third, based on the expanded information processing capability, it is possible to establish a large-scale, concrete relationship without central mediation.

• Tunnel and Underground Space
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• v.32 no.5
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• pp.327-343
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• 2022

The standard work report for trucks was developed that records data on truck haulage operations in open-pit and underground mines, and to evaluate the performance of haulage operations. Work reports used in 5 mines in Korea was secured and analyzed, and items to be included in the standard work report were determined. By analyzing the formulas for key performance indicators (KPIs) proposed by the Global Mining Guidelines Group (GMG), it was possible to determine how to record time-related data. After selecting a limestone underground mine as a research area, the performance of haulage operations was evaluated using a standard work report. As a result, in terms of truck availability, uptime was 46.7%, and both physical and mechanical availability were 100%. In the case of utilization, use of availability was 88.2%, the asset utilization was 41.1%, and operating and effective utilization were 88.2% and 79.2%, respectively. Also, in terms of efficiency, operating efficiency was found to be 89.9%.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.337-337
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• 1994

Phenol, acetaminophen(AA) and salicylamide are all known to be sulfated in rats and mioe. We have previously demonstrated that capacity-limited sulfation of xenobiotics in rats is due to the reduced availability of hepatic PAPS, the co-substrate for sulfation, which in turn is limited by the availability of its precursor, inorganic sulfate. Because species differences have been reported in the extent of sulfation, this study was conducted to determine whether these xenobiotics lower hepatic PAPS and sulfate in ICR mice. All three substrates decreased serum sulfate concentrations in a dose-and time-dependent manner. However. contrary to the observations in rats, phenol markedly increased hepatic PAPS concentraions in a dose-dependent manner, 1 hr after ip injection of 0-4 mmol/kg. Following ip injection of 2 or4 mmol/kg phenol, hepatic PAPS concentraions were enhanced 2-3 fold, 0.52 hr arter dosing and returned to control values 3 hr after dosing, whereas AA and salicylamide had little effect on hepatic PAPS concentrations. In summary. these studies demonstrate that phenol markedly enhances hepatic PAPS concentrations in mice, whereas hepatic PAPS levels are not affected by AA and salicylamide. Our data suggest that 1) hepatic sulfation for high dosages of xenobiotics in ICR mice is not limiod by the availability of co-substrate, and 2) there are significant species differences in the regulation of PAPS between rats and mice.

• Journal of Korean Port Research
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• v.7 no.2
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• pp.37-60
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• 1993

Because of the rapid growing traffic volumes of cargo, especially between Seoul and Inchon, and lack of investment into transport infrastructure in the past, in Kyong-in area have suffered from the serious traffic congestion in the public-road and the express-way network, But the further expansion of the traffic volume in near future is difficult due to burden of the higher expansion of the traffic volume in near future is difficult due to burden of the higher construction cost. Although the traffic congestion on the Kyung-in railway, is not very serious comparing with the road sector, the shortage of capacity on some main lines becomes emerged as a problem as railway traffic has increased. Unlike these two modes, the water transport, which has been paid relatively less attention for commodity transport in Kyong-in area, has not any constaint in this respect. Han river has been used as a water transport route in Chosun Dynasty which is called Cho-wun. This paper therefore aims to propose the availability of Han river as the alternative water transportation mode, in order to decrease the congestion between Seoul-Inchon by considering the construction of Kyong-in artificial water channel in near future. In this paper, we investigate the availability of Nanji-do as the physical distribution depot connecting with the circulation express way in the national capital distribution depot connecting with the circulation express way in the national capital. We also estimate the traffic volume by using the push-barge carrier (300DWT) in the same channel through the simulation under some assumptions such as ship's turnaround time, speed, etc.

• Fisheries and Aquatic Sciences
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• v.25 no.11
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• pp.537-548
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• 2022

Apparent digestibility coefficients (ADCs) of dry matter, crude protein, crude lipid, nitrogen-free extract, energy and essential amino acids in animal-based feed ingredients were determined for olive flounder (Paralichthys olivaceus). A reference diet (RF) was formulated to contain 1.0% chromic oxide (Cr₂O₃) as an inert indicator. Nine test diets were formulated to contain RF and one of the feed ingredients (pollock meal [PM], jack mackerel meal [JMM], anchovy meal [AM], cod meal [CM], sardine meal [SM], sand eel meal [SEM], tuna meal [TM], meat meal [MM] and squid liver meal [SLM]) at a 7:3 ratio in each diet designated as PM, JMM, AM, CM, SM, SEM, TM, MM and SLM, respectively. Olive flounder, averaging 150 ± 8.0 g, were stocked at a density of 25 fish per tank in 400-L fiberglass tanks attached with fecal collection columns. Feces were collected from triplicate groups of fish one time a day for four weeks. Dry matter and crude protein ADCs of CM and SEM were significantly higher than the other tested ingredients. Lipid ADCs of JMM, CM and SEM were significantly higher than the other test ingredients. Energy ADCs of CM and SEM were significantly higher than that of the other tested ingredients. The availability of amino acids in CM was generally higher than the other animal protein sources. PM exhibited the lowest amino acid availability among the treatments. Interestingly, MM exhibited significantly higher nutrient digestibility than several marine-based ingredients. However, CM and SEM are seeming to be highly digestible and effective to use in olive flounder diet compared to the other tested ingredients. Overall, the results of this study provide information about the bioavailability of nutrients and energy in animal feedstuffs to apply when formulating cost-effective practical feeds for olive flounder.

• Journal of Family Resource Management and Policy Review
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• v.25 no.4
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• pp.71-86
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• 2021

The purpose of this study is to identify the influencing factors of married men's household labor time by generation to understand the changes in male participation in household labor. To this end, married men were classified into Baby Boomers, Generation X, and Generation Y, and the factors of participation in household labor for each generation were analyzed by applying the hypothesis of participation in household labor. As for the data, the original data of the National Statistical Office's "2019 Time Use Survey" were used. Multinomial logistic analysis was conducted to analyze the factors affecting married men's household labor time. As a result of the analysis, household labor time for Baby Boomers can be explained by the hypothesis of economic efficiency, gender role attitude, and the demand/response capability, while household labor time for Generation X can be explained by economic efficiency hypothesis, gender role attitude hypothesis, time-availability hypothesis, and demand/response capability hypothesis. It was found that the household labor time for Generation Y can be explained by the time-availability hypothesis and demand/response capability hypothesis. The fact that each generation has different factors of participation in household labor suggests that the characteristics of each generation should be considered in establishing policies to support the work and family balance for men.

• Environmental Analysis Health and Toxicology
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• v.31
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• pp.8.1-8.2
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• 2016

A simple linear model to test the hypothesis based on one-on-one relationship has been used to find the causative factors of diseases. However, we now know that not just one, but many factors from different systems such as chemical exposure, genes, epigenetic changes, and proteins are involved in the pathogenesis of chronic diseases such as diabetes mellitus. So, with availability of modern technologies to understand the intricate nature of relations among complex systems, we need to move forward to the future by taking complex systems model.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.4
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• pp.629-631
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• 2012

In Cognitive Radio network, spectrum selection scheme is one of a important part to manage idle spectrums efficiently. However, in CR networks, they have to adopt time-varying channel availability to minimize the interference to primary users (PU), and be able to manage spectrum resources efficiently. In this paper, we proposed a modified PF scheduler which can be appropriate to schedule downlink CR users and channels, by considering the fairness and the throughput as well as the primary user characteristics of each channel.