• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2523-2527
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• 2014

Background: Serum thyroglobulin detection plays an essential role during the follow-up of thyroid cancer patients treated with total/near total thyroidectomy and radioiodine ablation. The aim of this retrospective study was to evaluate the relationship between stimulated serum thyroglobulin (Tg) level at the time of high dose $^{131}I$ ablation and risk of recurrence, using a three-level classification in patients with differentiated thyroid cancer (DTC) according to the ATA guidelines. Also we investigated the relationship between postoperative stimulated Tg at the time of ablation and DxWBS results at 8-10 months thereafter. Materials and Methods: Patients with radioiodine accumulation were regarded as scan positive (scan+). If there was no relevant pathological radioiodine accumulation or minimal local accumulation in the thyroid bed region, this were regarded as scan negative (scan-) at the time of DxWBS. We classified patients in 3 groups as low, intermediate and high risk group for assessment of risk of recurrence according to the revised ATA guidelines. Also, we divided patients into 3 groups based on the stimulated serum Tg levels at the time of $^{131}I$ ablation therapy. Groups 1-3 consisted of patients who had Tg levels of ${\leq}2ng/ml$, 2-10 ng/ml, and ${\geq}10ng/ml$, respectively. Results: A total of 221 consecutive patients were included. In the high risk group according to the ATA guideline, while 45.5% of demonstrated Scan(+) Tg(+), 27.3% of patients demonstrated Scan(-) Tg(-); in the intermediate group, the figures were 2.3% and 90.0% while in the low risk group, they were 0.6% and 96.4%. In 9 of 11 patients with metastases (81.8%), stimulated serum Tg level at the time of radioiodine ablation therapy was over 10, however in 1 patient (9.1%) it was <2ng/mL and in one patient it was 2-10ng/mL (p=0.005). Aggressive subtypes of DTC were found in 8 of 221 patients and serum Tg levels were ${\leq}2ng/ml$ in 4 of these 8. Conclusions: We conclude that TSH-stimulated serum thyroglobulin level at the time of ablation may not determine risk of recurrence. Therefore, DxWBS should be performed at 8-12 months after ablation therapy.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2002.10a
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• pp.168-168
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• 2002

To establish a test protocol for the rodent 20-day thyroid/pubertal assay, flutamide and diethylstilbestrol (DES) were administered to intact male Sprague-Dawley rats from postnatal day 33 for 20 days. Flutamide (1, 5, and 25 mg/kg/day) or DES (10, 20, and 40 ug/kg/day) was given once daily by oral gavage to immature male rats. Prepuce separation was significantly delayed in flutamide group and in DES group. One day after the last dose, the rats were killed and pituitary, thyroid, and reproductive organs were removed and weighed. Flutamide treatment resulted in a significant reduction in the weights of epididymides, ventral prostate, seminal vesicles plus coagulating glands and fluid (SVCGF), levator ani. bulbocarvenus muscles (LABC), Cowper's glands, and glans penis. The weight of adrenal glands decreased at % mg/kg/day, while testes and any other organ weights were unaffected. No microscopic changes were observed in the thyroid glands. Serum levels of testosterone wert significantly increased in the flutamide-treated groups and serum levels of estradiol were also increased. A significant reduction in the weights of testes, epididymides, ventral prostate, SVCGF, LABC, Cowpers glands, and glans penis of DES treated group. Serum testosterone and LH decreased significantly in DES group. Decrease of estradiol was observed, but not significant. These results indicate that flutamide and DES delay puberty in the male rat and its mode of action appears to be via altered secretion of steroids, which subsequently affect the development of the reproductive tract. (Supported by the grant from NITR/Korea FDA for Endocrine Disrupter Research.)

• The Journal of the Korea Contents Association
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• v.15 no.6
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• pp.297-302
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• 2015

High-energy medical linear accelerator on the dose to the thyroid cancer during radiotherapy were evaluated using optical stimulation luminescence dosimeters(OSLD) using. Scattered's influence in the case of 3D-CRT 25.4 mSv, 28.8 mSv, 31.3 mSv, 26.5 mSv, 27.4 mSv 5 times with an average 27.9 mSv, in the IMRT 46.8 mSv, 43.2 mSv, 42.3 mSv, 41.5 mSv, 44.1 mSv to five times the average of 43.6 was the result of mSv. In the case of light neutron dosimetry results 3D-CRT 3 mSv, 3 mSv, 3.4 mSv, 3.5 mSv, 3.1 mSv to five times the average 3.2 mSv, in the IMRT 5.1 mSv, 4.8 mSv, 4.2 mSv, 4.8 mSv, 4.9 mSv, to five times the average of 4.7 was the result of mSv. Both parties and the light scattered neutrons were significantly appreciated compared to IMRT 3D-CRT. Treatment of cancer using radiation workers, as in this study, and that a significant amount of scattered rays in the adjacent normal tissues during radiation therapy using energy assessment to influence by fully aware of this information is necessary for the exposure reduction efforts the feed.

• Progress in Medical Physics
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• v.7 no.1
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• pp.79-89
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• 1996

The purpose of this study was to examine the dead time effects and derive the correction factor. Using the thyroid probe and lucite cylindrical phantom, $^{99m}Tc$ 10.50mCi and $^{123}I$ 2.08mCi were counted with medical spectrometer at intervals of 2 hours for 43hrs and 79 hours. respectively. $^{123}I$ 2.06mCi was counted at intervals of 6 hours for 910 hours. To measure the starting point of dead time effect, the radioactivity was measured with dose calibrator in each time. The dead time effects started at about 0.80mCi at all distances for $^{99m}Tc$, and about 1.00mCi for $^{123}I$. The radioactivity corresponding to 20％ counts loss is 1.29(center), 1.28(2cm), 1.31(4cm), 1.13(6cm)mCi for $^{99m}Tc$ and 1.39mCi for $^{123}I$. The correction factors for 2mCi of radioactivity as an example were 1.52(center), 1.52(2cm), 1.50(4cm), 1.58(6cm) for $^{99m}Tc$ and 1.58 for $^{123}I$.

• Journal of radiological science and technology
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• v.38 no.1
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• pp.17-21
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• 2015

Total body irradiation(TBI) and chemotherapy are the pre-treatment method of a stem cell transplantations of the childhood leukemia. in this study, we evaluate the Quantitative human body dose prior to the treatment. The MCNPX simulation program evaluated by changing the material of the tissue compensators with imitation material of pediatric exposure in a virtual space. As a result, first, the average skin dose with the material of the tissue compensators of Plexiglass tissue compensators is 74.60 mGy/min, Al is 73.96 mGy/min, Cu is 72.26 mGy/min and Pb 67.90 mGy/min respectively. Second, regardless of the tissue compensators material that organ dose were thyroid, gentile, digestive system, brain, lungs, kidneys higher in order. Finally, the ideal distance between body compensator and the patient were 50 cm aparting each other. In conclusion, tissue compensators Al, Cu, Pb are able to replace of the currently used in Plexiglass materials.

• Imaging Science in Dentistry
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• v.31 no.3
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• pp.165-173
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• 2001

Objectives : To evaluate the absorbed and effective doses of spiral and computed tomography for the dental implant planning. Materials and Methods: For radiographic projection, TLD chips were placed in 22 sites of humanoid phantom to record the exposure to skin and the mean absorbed dose to bone marrow, thyroid, pituitary, parotid and submandibular glands and nesophagus. Effective dose was calculated, using the method suggested by Frederiksen et al.. Patient situations of a single tooth gap in upper and lower midline region, edentulous maxilla and mandible were simulated for spiral tomography. 35 axial slices (maxilla) and 40 axial slices (mandible) with low and standard dose setting were used for computed tomography. All the radiographic procedures were repeated three times. Results: The mean effective dose in case of maxilla was 0.865 mSv, 0.452 mSv, 0.136 mSv and 0.025 mSv, in spiral tomography of complete edentulous maxilla, computed tomography with standard mAs, computed tomography with low mAs and spiral tomography of a single tooth gap (p<0.05). That in case of mandible was 0.614 mSv, 0.448 mSv, 0.137 mSv and 0.036 mSv, in spiral tomography of complete edentulous mandible, computed tomography with standard mAs, computed tomography with low mAs and spiral tomography of a single tooth gap (p<0.05). Conclusions: Based on these results, it can be concluded that low mAs computed tomography is recommended instead of spiral tomography for the complete edentulous maxilla and mandible dental implant treatment planning.

• Radiation Oncology Journal
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• v.35 no.1
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• pp.90-100
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• 2017

Purpose: To Study the dosimetric advantage of the Jaw tracking technique in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for Head and Neck Cancers. Materials and Methods: We retrospectively selected 10 previously treated head and neck cancer patients stage (T1/T2, N1, M0) in this study. All the patients were planned for IMRT and VMAT with simultaneous integrated boost technique. IMRT and VMAT plans were performed with jaw tracking (JT) and with static jaw (SJ) technique by keeping the same constraints and priorities for a particular patient. Target conformity, dose to the critical structures and low dose volumes were recorded and analyzed for IMRT and VMAT plans with and without JT for all the patients. Results: The conformity index average of all patients followed by standard deviation (${\bar{x}}{\pm}{\sigma}_{\bar{x}}$) of the JT-IMRT, SJ-IMRT, JT-VMAT, and SJ-VMAT were $1.72{\pm}0.56$, $1.67{\pm}0.57$, $1.83{\pm}0.65$, and $1.85{\pm}0.64$, and homogeneity index were $0.059{\pm}0.05$, $0.064{\pm}0.05$, $0.064{\pm}0.04$, and $0.064{\pm}0.05$. JT-IMRT shows significant mean reduction in right parotid and left parotid shows of 7.64% (p < 0.001) and 7.45% (p < 0.001) compare to SJ-IMRT. JT-IMRT plans also shows considerable dose reduction to thyroid, inferior constrictors, spinal cord and brainstem compared to the SJ-IMRT plans. Conclusion: Significant dose reductions were observed for critical structure in the JT-IMRT compared to SJ-IMRT technique. In JT-VMAT plans dose reduction to the critical structure were not significant compared to the SJ-IMRT due to relatively lesser monitor units.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.25 no.2
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• pp.297-308
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• 1995

This study was designed to measure the absorbed dose to organs of special interest from full mouth with intraoral film(l4 films) and to compare the five periapical techniques. Thermoluminescent crystals(TLD-100 chip) were located in brain, orbit, bone marrow of mandibular ramus, bone marrow of mandibular body, bone marrow of 4th cervical spine, parotid gland, submandibular gland and thyroid gland. X -ray machine was operated at 70kVp and round collimating film holding device(XCP) and rectangular collimating film holding device(Precision Instrument) were used. The distance from the X-ray focus to the open end of the collimator was 8 inch, 12 inch and 16 inch. The results were as follows : 1. The absorbed dose was the highest in bone marrow of mandibular body(5.656mGy) and the lowest in brain (0.050mGy). 2. Generally, the lowest absorbed dose was measured from 16 inch cylinder, rectangular collimating film holding device with paralleling technique. But, in bone marrow of mandibular body and the floor of mouth, the highest absorbed dose was measured from 12 inch cylinder, rectangular collimating film holding device with paralleling techniques. 3. Comparing of five intraoral radiographic techniques, it was appeared statistically significant reduction of the absorbed doses measured with rectangular collimating film holding device compared to XCP film holding device (P<0.05). 4. No statistically significant reduction in the absorbed dose was found as cylinder length was changed(P>0.05).

• Journal of radiological science and technology
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• v.44 no.4
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• pp.301-306
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• 2021

The skull has peripheral organs such as the crystalline lens and thyroid gland, which are highly radiosensitive, but the examination is performed without considering the uneven dose distribution due to the heel effect at the time of the current Skull Town's examination. However, no studies have been conducted on the exposure dose of surrounding organ tissues due to the difference in image density due to the heel effect and the non-uniformity of the dose. Using the cathode (-) and anode (+) set on the Tube to measure the scattered radiation along the Tube direction as a guide, change 30° and 37° in the cathode direction and 30° and 37° in the anode direction. It was given and investigated 5 times to obtain scattered radiation. image measurements were SNR, PSNR, RMSE, and MAE. Measurement results Measurement results of surrounding organ doses when the Tube direction was 30° and 37° The dose was low when the direction was cathodic in all organs (p<0.000). Both cathodes were higher in the image measurements(p<0.04). Continuous research may be needed for diagnostically valuable imaging and minimization of patient exposure dose.

• Journal of the Korean Society of Radiology
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• v.17 no.1
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• pp.47-52
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• 2023

In whole spine radiography using the stitching technique, overlapping parts occur in the process of synthesizing the three segmented images, so some anatomical structures may be repeatedly exposed, and it has been thought that the dose increases as the scan range increases. However, in the whole spine radiography using the stitching technique in this study, under the condition that the stitching range is taken in the same three splits, the overlapping area decreases as the stitching range increases, so in the case of breasts included in the overlapping range, the dose value decreased by almost half as the stitching range increased from 90 cm to 105 cm. During spinal full-length radiological examination using the stitching method, an appropriately long stitching range could be set to reduce the exposure dose of the breast.