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http://dx.doi.org/10.17946/JRST.2015.38.1.03

In Pediatric Leukemia, Dose Evaluation according to the Type of Compensators in Total Body Irradiation  

Lee, Dongyeon (Dongnam Inst. of Radiological & Medical science)
Kim, Changsoo (Dept. of Radiologic Science, College of Health Science, Catholic University of Busan)
Kim, Junghoon (Dept. of Radiologic Science, College of Health Science, Catholic University of Busan)
Publication Information
Journal of radiological science and technology / v.38, no.1, 2015 , pp. 17-21 More about this Journal
Abstract
Total body irradiation(TBI) and chemotherapy are the pre-treatment method of a stem cell transplantations of the childhood leukemia. in this study, we evaluate the Quantitative human body dose prior to the treatment. The MCNPX simulation program evaluated by changing the material of the tissue compensators with imitation material of pediatric exposure in a virtual space. As a result, first, the average skin dose with the material of the tissue compensators of Plexiglass tissue compensators is 74.60 mGy/min, Al is 73.96 mGy/min, Cu is 72.26 mGy/min and Pb 67.90 mGy/min respectively. Second, regardless of the tissue compensators material that organ dose were thyroid, gentile, digestive system, brain, lungs, kidneys higher in order. Finally, the ideal distance between body compensator and the patient were 50 cm aparting each other. In conclusion, tissue compensators Al, Cu, Pb are able to replace of the currently used in Plexiglass materials.
Keywords
Pediatric Leukemia Patient; Total Body Irradiation; Simulation; Dose Evaluation;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Sang Jeong Kim: Total Body Irradiation (TBI) or non-TBI as Conditioning Regimen for Stem Cell Transplantation (SCI) in Pediatric Leukemia, Faculty of Medical Sciences Gaduate School Chonnam National University, 2010
2 Hong-wei Liu., Matthew, Seftel, Morel Rubinger et al.: Total Body Irradiation compared with beam: Long-term outcomes of Peripheral blood autologous stem cell transplantation for non-hodgkin's lymphoma, Int. J. Radiation Oncology Biol. Phys., 78(2), 513-520, 2010   DOI
3 Bogdan Umek, M. Zwitter, H. Habic, Total body irradiation with translation method, Radiotherapy and Oncology 38, 1253-255, 1996
4 Barrett A.: Total Body Irradiaton, Rep. Pract. Oncol. Radiother. 4(3), 47-64, 1999   DOI
5 Seung Jin Park, Woong Ki Chung, Sung Ja Ahn, Teak Keun Nam, Byung Sik Nah: Utilization of Tissue Compensator for Uniform Dose Distribution in Total Body Irradiation, J. Korean Soc. Ther. Radiol, vol 12(2), 233-241, 1994
6 Jun Ah Lee: Peripheral Blood Stem Cell Transplantation (PBSCT) in Acute Myelogenous Leukemia-Experience in Children-, Philosophy in Medicine Seoul National University, 1998
7 Tomasz Piotrowski, Julian Malicki: The rotary dual technique for total skin irradiation in the treatment of mycosis fungoides - a description of the applied method, Rep Pract Oncol Radiother, 11(1), 29-37, 2006   DOI
8 Aneta Kawa-Iwanicka, Marcin Dybek, Tomasz Iwanicki, Wllodzimierz LLobodziec, Andrzej Radkowski: The technique of Total Body Irradiation Aapplied at the leszczynnski memorial hospital, Rep. Pract. Oncol. Radiother. 7(2), 53-60, 2002   DOI
9 Min WS, Cho SG, Chung IJ, et al.: Autologous bone marrow transplanatation for acute myeloid leukemia in first remission; purging with hyperthermia and ether lipid in vitro. J KoreanCancer Association, 28, 670-677, 1996
10 Akmal Safwat, Ninna Aggerholm, Ivan Roitt, Jens Overgaard, Marianne Hokland: Tumour burden and interleukin-2 dose affect the interaction between low-dose total body irradiation and interleukin 2, European Journal of Cancer, 40, 1412-1417, 2004   DOI
11 Jacek Wachowiak, Julian Malicki, Dariusz Buczkowski: Allogeneic bone marrow transplantation in children with acute lymphoblastic leukemia in the first and second complete remission conditioned with fractionated Total Body Irradiation and cyclophosphamide or etoposide, Rep. Pract. Oncol. Radiother. 7 (3), 117-125, 2002   DOI
12 Jeong-Eun Rah, Ui-Jung Hwang, Hojin Jeong: Clinical application of glass dosimeter for in vivo dose measurements of total body irradiation treatment technique, Radiation Measurements, 46, 40-45, 2011   DOI
13 Mustafa Cengiz, Eren Cetin, Ferah Yildiz, Ugur Selek, Ercan Aydinkarahaliloglu: Change in blood chemistry may explain higher toxicity of total body irradiation for bone marrow transplantation, Medical Hypotheses, 68, 554-57, 2007   DOI
14 M. Loes van Kempen-harteveld, Henk Struikmans, Henk B. Kal: Cataract after Total Body Irradiation and bone marrow transplantation, Int. J. Radiation Oncology Biol. Phys., 52(5), 1375-1380, 2002   DOI
15 Jeong Ok Lee, Dong Hyeok Jeong : Calculation of Energy Spectra for 6 MeV Electron Beam of LINAC Using MCNPX, Korean Society of Medical Physics, 17(4), 224-231, 2006
16 Khan FM: The physics of Radiation Theraphy, 4th ed., Williams & Wilkins, 517-526, 2003
17 Eun Young Han, Wesley E. Bolch, Keith F. Eckerman : Revision to the ORNL series of adult and pediatric computational phantoms for use with the MIRD schema, Health Phys., 90, 337-356, 2006   DOI
18 ICRP Publication 89: Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values, Elsevier Publishing Company, 2002
19 ICRU Report 46: Photon, electron, proton and neutron interaction data for body tissues, Oxford Vniv., 1992
20 Lee Min Yong: The effect of x-ray filter materials in the skin dose & tube loading at x-ray examinations, Dept. of Health Science Graduate School Korea University, 2005
21 Jong Hwan Choi, Jong Sik Kim, Ji Min Choi, Eun Hyuk Shin, Ki Won Song, Young Hwan Park: Analysis of Surface Dose Refer to Distance between Beam Spoiler and Patient in Total Body Irradiation, Korean Society for Radiation Therapy, 19(1), 51-54, 2007