• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.788-800
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• 2002

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. When the bone density is reduced to the level below the fracture threshold, the risk for fracture is greatly increased. The purpose of this study is to examine what are the effects of the Yuklinzu(YLZ: 毓麟珠) on the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows: Body weight in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum albumin in control group showed significant decrease in comparison with sham. That in YLZ-treated was slightly decreased in comparison with control. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum phosphorous in control group showed significant increase in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum calcium in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GOT in control group showed no change in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. The level of serum GPT did not significant change among the three groups. The level of serum estrogen in control group showed slightly increased in comparison with sham, but that in YLZ-treated showed no change in comparison with control. The level of serum T3 in control group showed no change in comparison with sham, and that in YLZ-treated showed no change in comparison with control. The level of serum T4 in control group showed significant increase in comparison with sham, but that in YLZ-treated was significantly decreased in comparison with control. Mechanical strength of the femur neck in control group showed significant decrease in comparison with sham. That in YLZ-treated showed slightly increased in comparison with control. Trabecular bone area as well as trabecular thickness in control group showed significant decrease in comparison with sham. Those in YLZ-treated showed significant increase in comparison with control. Trabecular number and did not significant change among the three groups. Trabecular separation only in YLZ-treated showed significant decrease in comparison with control. Osteoclast number and oseoblast surface in control group showed significant increase in comparison with sham. Those in YLZ-treated showed slightly decreased in comparison with control. According to the above these results, YLZ has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.6
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• pp.59-64
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• 2010

Building a firebreak against surface forest fire is a typical indirect suppression method that stops spread of flame by removing surface fuel, such as fallen leaves and bushes. In the sense of fire dynamic, building a firebreak is to set a section which will block thermal energy from igniting on virgin fuel. This study suggests and evaluates a calculation method for width of firebreak against surface fire for variant wind and slope conditions by applying the Point Source Model (PSM) to fallen leaves of Pinus densiflora. Width of firebreak was measured based on the distance the threshold radiant heat igniting Pinus densiflora fallen leaves at the heat flux of $4.9\;kW/m^2$ reaches. As a result, at the wind velocity of 0~5 m/s and on the slope of $0{\sim}50^{\circ}$, the appropriate width of a firebreak was 0.35~0.65 m for the mean flame height and 0.75~1.05 m for the maximum flame height. Accordingly, considering the factor of safety, the most appropriate width of a firebreak is 1.05 m based on the maximum flame height. Additional comparative analyses through experiments and field surveys are deemed necessary to determine appropriate widths of firebreak for different types of surface fuel.

• Journal of Microbiology and Biotechnology
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• v.24 no.8
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• pp.1044-1050
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• 2014

Since there is no consensus about the most reliable assays to detect invasive aspergillosis from samples obtained by minimally invasive or noninvasive methods, we compared the efficacy of an enzyme-linked immunosorbent assay (ELISA) for galactomannan (GM) detection and quantitative real-time PCR assay (qRT-PCR) for the diagnosis of invasive pulmonary aspergillosis. Neutropenic, male Sprague-Dawley rats (specific pathogen free; 8 weeks old; weight, $200{\pm}20g$) were immunosuppressed with cyclophosphamide and infected with Aspergillus fumigatus intratracheally. Tissue and whole blood samples were harvested on days 1, 3, 5, and 7 post-infection and examined with GM ELISA and qRT-PCR. The A. fumigatus DNA detection sequence was detected in the following number of samples from 12 immunosuppressed, infected rats examined on the scheduled days: day 1 (0/12), day 3 (0/12), day 5 (6/12), and day 7 (8/12) post-infection. The sensitivity and specificity of the qRT-PCR assay was 29.2% and 100%, respectively. Receiver operating characteristic curve (ROC) analysis indicated a Ct (cycle threshold) cut-off value of 15.35, and the area under the curve (AUC) was 0.627. The GM assay detected antigen in sera obtained on day 1 (5/12), day 3 (9/12), day 5 (12/12), and day 7 (12/12) post-infection, and thus had a sensitivity of 79.2% and a specificity of 100%. The ROC of the GM assay indicated that the optimal Ct cut-off value was 1.40 (AUC, 0.919). The GM assay was more sensitive than the qRT-PCR assay in diagnosing invasive pulmonary aspergillosis in rats.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.2
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• pp.174-182
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• 2002

The object-oriented design methods and their CASE tools are widely used in practice by many real-time software developers. However, object-oriented CASE tools require an additional step of identifying tasks from a given design model. Unfortunately, it is difficult to automate this step for a couple of reasons: (1) there are inherent discrepancies between objects and tasks; and (2) it is hard to derive tasks while maximizing real-time schedulability since this problem makes a non-trivial optimization problem. As a result, in practical object-oriented CASE tools, task identification is usually performed in an ad-hoc manner using hints provided by human designers. In this paper, we present a systematic, schedulability-aware approach that can help mapping real-time object-oriented models to multi-threaded implementations. In our approach, a task contains a group of mutually exclusive transactions that may possess different periods and deadline. For this new task model, we provide a new schedulability analysis algorithm. We also show how the run-time system is implemented and how executable code is generated in our frame work. We have performed a case study. It shows the difficulty of task derivation problem and the utility of the automated synthesis of implementations as well as the Inappropriateness of the single-threaded implementations.

• The KIPS Transactions:PartB
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• v.14B no.7
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• pp.493-502
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• 2007

An on-line registration technique is presented to register multi-view range images for the 3D reconstruction of real objects. Using a range camera, we first acquire range images and photometric images continuously. In the range images, we divide object and background regions using a predefined threshold value. For the coarse registration of the range images, the centroid of the images are used. After refining the registration of range images using a projection-based technique, we use a modified KLT(Kanade-Lucas-Tomasi) tracker to match photometric features in the object images. Using the modified KLT tracker, we can track image features fast and accurately. If a range image fails to register, we acquire new range images and try to register them continuously until the registration process resumes. After enough range images are registered, they are integrated into a 3D model in offline step. Experimental results and error analysis show that the proposed method can be used to reconstruct 3D model very fast and accurately.

• Journal of the Korean Association of Geographic Information Studies
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• v.10 no.3
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• pp.123-133
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• 2007

Thermal spatial representativities of meteorological stations over Korea have been investigated using land surface temperature (LST) based on MODerate resolution Imaging Spectroradiometer (MODIS) satellite observation. The linear regression method was used to estimate air temperatures from MODIS LST product. To compare MODIS LST with observed air temperatures at six meteorological stations, the mean values of MODIS LST with nine given window sizes were calculated. In this case, the position of centered pixel in each given window size is correspond to that of each meteorological station. We also applied $4^{\circ}C$ threshold for RMSE comparison, which is based on a analogous study on daily maximum air temperature model using satellite data. In this study, the results showed that each station has a different representativity; Deajeon $15km{\times}15km$, Chuncheon $11km{\times}11km$, Seoul $7km{\times}7km$, Deagu $5km{\times}5km$, Kwangju $3km{\times}3km$, and Busan $3km{\times}3km$.

• The Journal of the Korea institute of electronic communication sciences
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• v.6 no.2
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• pp.243-248
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• 2011

In this paper, we propose a new method to extract palm lines and read it with simple techniques from one photo. We use morphological information and 8-directional contour tracking algorithm. From the digitalized image, we transform original RGB information to YCbCr color model which is less sensitive to the brightness information. The palm region is extracted by simple threshold as Y:65~255, Cb:25~255, Cr:130~255 of skin color. Noise removal process is then followed with morphological information of the palm such that the palm area has more than quarter of the pixels and the rate of width vs height is more than 2:1 and 8-directional contour tracking algorithm. Then, the stretching algorithm and Sobel mask are applied to extract edges. Another morphological information that the meaningful edges(palm lines) have between 10 and 20 pixels is used to exclude noise edges and boundary lines of the hand from block binarized image. Main palm lines are extracted then by labeling method. This algorithm is quite effective even reading the palm from a photographed by a mobile phone, which suggests that this method could be used in various applications.

• Korean journal of applied entomology
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• v.43 no.4 s.137
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• pp.305-310
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• 2004

The development of Myzus persicae (Sulzer) was studied at temperatures ranging from 15 to $32.5^{\circ}C$ under $70{\pm}5\%$ RH, and a photoperiod of 16:8 (L:D). Mortality of 1st-2nd nymph was higher than that of 3rd-4th nymph at the most temperature ranges whereas at high temperature of $32.5^{\circ}C$, more 3-4nymph stage individuals died. The total developmental time ranged from 12.4 days at $15^{\circ}C$ to 4.9 days at $27.5^{\circ}C$, suggesting that higher the temperature, faster the development. However, at higher end temperature ranges of 30 and $32.5^{\circ}C$, the development took 5.0 and 6.3 days, respectively. The lower developmental threshold temperature and effective accumulative temperatures for the total immature stage were $4.9^{\circ}C$ and 116.5 day-degrees. The nonlinear shape of temperature related development was well described by the modified Sharpe and DeMichele model. When the normalized cumulative frequency distributions of developmental times for each life stage were fitted to the three-parameter Weibull function, attendance of shortened developmental times was apparent with pre-nymph, post-nymph, and total nymph stages in descending order. The coefficient of determination $r^2$ ranged between 0.87 and 0.94.

• Biomolecules & Therapeutics
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• v.25 no.4
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• pp.374-382
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• 2017

Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female population. Using a validated animal model of ASD which is the telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments and protein expression experiments to mark the difference between male and females of this animal model. After statistically analyzing the results, we found significant effects of TERT overexpression in sociability, social novelty preference, anxiety, nest building, and electroseizure threshold in the males but not their female littermates. Along these differences are the male-specific increased expressions of postsynaptic proteins which are the NMDA and AMPA receptors in the prefrontal cortex. The vGluT1 presynaptic proteins, but not GAD, were upregulated in both sexes of TERT-tg mice, although it is more significantly pronounced in the male group. Here, we confirmed that the behavioral effect of TERT overexpression in mice was male-specific, suggesting that the aberration of this gene and its downstream pathways preferentially affect the functional development of the male brain, consistent with the male preponderance in ASD.

• Journal of Korea Water Resources Association
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• v.42 no.7
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• pp.525-535
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• 2009

In this paper a heuristic method for identifying individual pipes in water pipe networks to determine specific sections of the pipes that need to be replaced due to deterioration. An appropriate minimum pipe length is determined by selecting the pipe length that has the greatest variance of the average cumulative break number slopes among the various pipe lengths used. As a result, the minimum pipe length for the case study water network is determined as 4 m and a total of 39 individual pipe IDs are obtained. The economically optimal replacement times of the individual pipe IDs are estimated by using the threshold break rate of an individual pipe ID and the pipe break trends models for which the General Pipe Break Prediction Model(Park and Loganathan, 2002) that can incorporate the linear, exponential, and in-between of the linear and exponetial failure trends and the ROCOFs based on the modified time scale(Park et al., 2007) are used. The maximum log-likelihoods of the log-linear ROCOF and Weibull ROCOF estimated for the break data of a pipe are compared and the ROCOF that has a greater likelihood is selected for the pipe of interest. The effects of the social costs of a pipe break on the optimal replacement time are also discussed.