• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.2061-2068
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• 2015

Background: Tumors are largely unable to metabolize ketone bodies for energy due to various deficiencies in one or both of the key mitochondrial enzymes, which may provide a rationale for therapeutic strategies that inhibit tumor growth by administration of a ketogenic diet with average protein but low in carbohydrates and high in fat. Materials and Methods: Thirty-six male BALB/C nude mice were injected subcutaneously with tumor cells of the colon cancer cell line HCT116. The animals were then randomly split into three feeding groups and fed either a ketogenic diet rich in omega-3 fatty acids and MCT (MKD group; n=12) or lard only (LKD group; n=12) or a standard diet (SD group; n=12) ad libitum. Experiments were ended upon attainment of the target tumor volume of $600mm^3$ to $700mm^3$. The three diets were compared for tumor growth and survival time (interval between tumor cell injection and attainment of target tumor volume). Results: The tumor growth in the MKD and LKD groups was significantly delayed compared to that in the SD group. Conclusions: Application of an unrestricted ketogenic diet delayed tumor growth in a mouse xenograft model. Further studies are needed to address the mechanism of this diet intervention and the impact on other tumor-relevant parameters such as invasion and metastasis.

• Steel and Composite Structures
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• 제32권1호
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• pp.91-110
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• 2019

In the present study, the effects of six different ground motion scaling methods on inelastic response of nonlinear steel moment frames (SMFs) are studied. The frames were designed using energy-based PBPD approach with the design concept using pre-selected target drift and yield mechanism as performance limit state. Two target spectrums are considered: maximum credible earthquake spectrum (MCE) and design response spectrum (DRS). In order to investigate the effects of ground motion scaling methods on the response of the structures, totally 3216 nonlinear models including three frames with 4, 8 and 16 stories are designed using PBPD approach and then they are subjected to ensembles of ground motions including 42 far-fault and 90 near-fault pulse-type records which were scaled using the six different scaling methods in accordance to the two aforementioned target spectrums. The distributions of maximum inter-story drift over the height of the structures are computed and compared. Finally, the efficiency and reliability of each ground motion scaling method to estimate the maximum nonlinear inter-story drift of special steel moment frames designed by energy-based PBPD approach are statistically investigated, and the most suitable scaling methods with the lowest dispersion for two groups of earthquake ground motions are introduced.

• Journal of Electrical Engineering and Technology
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• 제10권2호
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• pp.676-687
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• 2015

Path planning algorithms are used to allow mobile robots to avoid obstacles and find ways from a start point to a target point. The general path planning algorithm focused on constructing of collision free path. However, a high continuous path can make smooth and efficiently movements. To improve the continuity of the path, the searched waypoints are connected by the proposed polynomial interpolation. The existing polynomial interpolation methods connect two points. In this paper, point groups are created with three points. The point groups have each polynomial. Polynomials are made by matching the differential values and simple matrix calculation. Membership functions are used to distribute the weight of each polynomial at overlapped sections. As a result, the path has $G^2$ continuity. In addition, the proposed method can analyze path numerically to obtain curvature and heading angle. Moreover, it does not require complex calculation and databases to save the created path.

• 한국과학교육학회지
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• 제27권2호
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• pp.105-119
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• 2007

Several studies have attempted to test students' misconceptions of physics and to provide teaching strategies in order to repair them. The results from these studies have revealed that the diagnosis of students' misconception is crucial, although they often failed to grasp the practice of its implementation. In terms of being a type of methodology for science education, the Internet allows large-scale surveys and investigations to be carried out in a relatively short period of time. This paper reports the results of the development, implementation, and evaluation of a WEb-based SYStem for TEsting students' Misconceptions in physics (WEBSYSTEM) aimed at three groups (science educational researchers who study students' physics conceptions using the system as a detector, school science teachers who practice it as an instructional material, and students who benefit from it for their self-directed learning). The web-based testing system is based on a review of the instructional development strategies of ADDIE (Gustafson, Branch, 2002; Rha, Chung, 2001). Results showed that WEBSYSTEM could work effectively as a multi-purposed tool for the three target groups with a further partial revision, providing educational researchers with resourceful data to study students' misconceptions in physics. Issues of administrative strategies, reexamination of questionnaires, and international collaboration via WEBSYSTEM are discussed.

• 한국의류학회지
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• 제28권5호
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• pp.701-712
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• 2004

This study is aimed at the application of the apparel size system to be applied for the Internet shopping mall in Korea. Especially this is focused on the presumption of the body measurement according to the age groups and the figure groups. In this regard, a sizing system is to be developed that could be used to approach consumers more easily and provide more fitness and accuracy in terms of size. The target study was on a group of women nineteen to forty-nine years of age. The 4th National Anthropometry Survey data were used in the examination. The results in the study are as follows ; (1) On the Internet apparel shopping malls in relation with this study, no matter what size in the ready-to-wear enterprises was selected by the consumers who once put their information in the member registration, the most appropriate sizes for them are automatically given and transferred to the order forms of chosen enterprises with aid of internal programs of the internet webpage. In addition, when consumers enter their body sizes in the units that are familiar to them, such as inches or centimeters, the units are automatically programed so that they can be converted for the sake of convenience. ; (2) To extract an estimation equation of body size through Multiple Regression Analysis, the circumferences of chest and hip could be presumed by stature, weight, and waist circumference of which most consumers were well aware. For more accurate regression equations, groupings were made in the three categories of age(19∼29/30∼39/40∼49) and in the three body types(Type N, A and H). Then, the regression equations were established for three sectors, $\circled1$ 'chest circumference not filled up', $\circled2$ 'hip circumference not filled up' and $\circled3$ 'neither filled up for chest nor for hip circumference'. The final results of regression were presented in