• Journal of Life Science
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• v.33 no.2
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• pp.199-207
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• 2023

To prepare for the threat of a future epidemic in the post-COVID-19 era, research based on the one-health concept (i.e., the health of humans, animals, and the environment as "one") is essential. Cross-species infections are being identified as a result of the high infection rate and viral load of SARS-CoV-2 in humans. The possibility of transmission of SARS-CoV-2 from humans to mink has been determined. In addition, the transmission of SARS-CoV-2 from humans to cats through contact has been considered possible. The data so far show that livestock and poultry are less likely to be infected with SARS-CoV-2. However, if infections are established through a new mutation, the resulting diseases are expected to have enormous ripple effects on various fields, such as human food security, the economy, and trade. In addition, there are concerns about the endemic prospect of SARS-CoV-2 and the high accessibility of companion animals. This is because the evolution of the virus likely occurs in animal hosts. Once SARS-CoV-2 is established in other species, they might serve as intermediate hosts for the re-emergence of the virus in the human population. Thus, it is necessary to ensure a rapid response to future outbreaks by accumulating research data on the animal infection of SARS-CoV-2. These data can have implications for the development of animal models for vaccines and therapeutics against SARS-CoV-2. Therefore, in this study, epidemiological reviews were analyzed, and response strategies against SARS-CoV-2 infection in animals were presented using the One-health approach.

• Journal of Life Science
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• v.33 no.2
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• pp.216-226
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• 2023

Since nylon 66, a polyamide resin, has been developed and applied to toothbrush bristles, plastic consumption has increased rapidly every year, along with the increase in the amount of plastic discarded. Among the various forms of plastic debris produced by the decomposition of plastics, microplastics with a size of less than 5 mm are widely distributed in the environment, which poses a threat not only to the environment but also to animals and humans. The pathway through which microplastics enter the human body is known as ingestion by water and food, inhalation from air, and skin contact. Microplastics introduced into the human body affect human health. Recently, food-related studies have begun to be reported among microplastics-related studies, and analyses of the presence of microplastics in processed foods, such as canned foods, dried seaweed, beverages, beer, milk, sugar, and honey, are underway. Here, we present trends in the production and consumption of plastics, the generation of microplastics, the route of human inflow and human risk, and the microplastics present in processed foods, which are limited but have recently been reported. Thus far, studies on microplastics and risk assessment in processed foods have been insufficient, but microplastics are gradually being recognized as a factor that affects the environment and food. Future studies are expected to have implications for regulations regarding microplastics present in processed foods.

• Korean Journal of Clinical Laboratory Science
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• v.54 no.4
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• pp.265-272
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• 2022

The emergence and dissemination of carbapenemase-producing Enterobacteriaceae (CPE), particularly the Klebsiella pneumoniae carbapenemase-2 (KPC-2) producing Klebsiella pneumoniae, has been rapidly increasing worldwide and is becoming a serious public health threat. Since the epidemiology and characteristics of these KPC-2-producing K. pneumoniae vary according to the region and period under consideration, this study investigated the prevalence of carbapenemases and the epidemiological relationship of 78 carbapenem-resistant K. pneumoniae (CRKP) isolated from a tertiary hospital in Daejeon, from March 2017 to December 2020. The antimicrobial susceptibility tests were identified using the disk-diffusion method. PCR and DNA sequencing were used to determine the carbapenemase genes. In addition, molecular epidemiology was performed by multilocus sequence typing (MLST). Among the 78 CRKP isolates, 35 isolates (44.9%) were carbapenemase-producing K. pneumoniae (CPKP) and the major carbapenemase type was KPC-2 (30 isolates, 85.7%). The New Delhi metallo-enzyme-1 (NDM-1) and NDM-5 were identified in 4 isolates (11.4%) and 1 isolate (2.9%), respectively. Multilocus sequence typing (MLST) analysis showed 10 sequence types (STs) and the most prevalent ST was ST307 (51.4%, 18/35). All the ST307 isolates were KPC-2-producing K. pneumoniae and were multidrug-resistant (MDR). In addition, ST307 has gradually emerged during a four-year period. These findings indicate that continuous monitoring and proper infection control are needed to prevent the spread of KPC-2-producing K. pneumoniae ST307.

• Journal of Aerospace System Engineering
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• v.17 no.4
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• pp.133-143
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• 2023

As drones (also known as UAV) become popular with advanced information and communication technology (ICT), they have been utilized for various fields (agriculture, architecture, and so on). However, malicious attackers with advanced drones may pose a threat to critical national infrastructures. Thus, anti-drone systems have been developed to respond to drone threats. In particular, remote identification data (R-ID)-based UAV detection and identification systems that detect and identify illegal drones with R-ID broadcasted by drones have been developed, and are widely employed worldwide. However, this R-ID-based UAV detection/identification system is vulnerable to security due to wireless broadcast characteristics. In this paper, we analyze the security vulnerabilities of DJI Aeroscope, a representative example of the R-ID-based UAV detection and identification system, and propose a replay-attack-based neutralization method using the analyzed vulnerabilities. To validate the proposed method, it is implemented as a software program, and verified against four types of attacks in real test environments. The results demonstrate that the proposed neutralization method is an effective neutralization method for R-ID-based UAV detection and identification systems.

• Journal of Life Science
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• v.33 no.9
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• pp.746-753
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• 2023

Viral infectious diseases have been regarded as one of the greatest threats to global public health. The recent coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a stark reminder of the threat posed by emerging viral infections. Developing and producing appropriate and efficient vaccines and therapeutics are the only options to combat this pandemic. The COVID-19 pandemic has highlighted the need for novel vaccine platforms to control and prevent emerging viral diseases. Conventional vaccine platforms, including live-attenuated vaccine and inactivated vaccines, pose limitations in the speed of vaccine development, manufacturing capacity, and broad protection for emergency use. Interestingly, vaccination with the SARS-CoV-2 vaccine candidate based on the mRNA-lipid nanoparticle (LNP) platform protected against COVID-19, confirming that the nucleoside-modified candidate is a safe and effective alternative to conventional vaccines. Moreover, the prophylactic strategies against the COVID-19 pandemic have been mRNA nucleic acid-based vaccines and nanoparticle-based platforms, which are effective against SARS-CoV-2 and its variants. Overall, the novel vaccine platform has presented advantages compared with the traditional vaccine platform in the COVID-19 pandemic. This review explores the recent advancements in vaccine technologies and platforms, focusing on mRNA vaccines, digital vaccines, and nanoparticles while considering their advantages and possible drawbacks.

• Journal of the Korea Society for Simulation
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• v.32 no.3
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• pp.55-66
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• 2023

In recent years, naval vessels have been developed to fulfill a variety of missions by being equipped with various cutting-edge equipment and ICT technologies. One of the main missions of Korean naval vessels is anti-ballistic missile warfare to defend key units and areas against the growing threat of ballistic missiles. Because the process of detection and interception is too complex and the cost of failure is much high, a lot of preparation is required to effectively conduct anti-ballistic missile warfare. This paper describes the development of a simulation model of anti-ballistic missile warfare with combat systems and equipment to be installed on future naval vessels. In particular, the DEVS formalism providing a modular and hierarchical modeling manner was applied to the simulation model, which can be utilized to efficiently represent various anti-ballistic missile warfare situations. In the simulation results presented, experiments were conducted to analyze the effectiveness of the model for effective detection resource management in anti-ballistic missile warfare. This study is expected to be utilized as a variety of analysis tools necessary to determine the optimal deployment and configuration of combat resources and operational tactics required for effective anti-ballistic missile warfare of ships in the future.

• Journal of the Korea Society for Simulation
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• v.18 no.4
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• pp.39-47
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• 2009

Recently, the threat of DDoS attacks is increasing and many companies are planned to deploy the DDoS defense solutions in their networks. The DDoS attack usually transmits heavy traffic data to networks or servers and they cannot handle the normal service requests because of running out of resources. Since it is very hard to prevent the DDoS attack beforehand, the strategic plan is very important. In this work, we have conducted modeling and simulation of the DDoS attack by changing the number of servers and estimated the duration that services are available. In this work, the modeling and simulation is conducted using OPNET Modeler. The simulation result can be used as a parameter of trade-off analysis of DDoS defense cost and the service's value. In addition, we have presented a way of estimating the cost effectiveness in deployment of the DDoS defense system.

• Research in Plant Disease
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• v.29 no.1
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• pp.52-59
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• 2023

Cucurbit chlorotic yellows virus (CCYV) is a plant virus that causes damage to cucurbit crops such as watermelon and cucumber, and is transmitted by an insect vector known as the whitefly. Since CCYV was first detected on cucumber in Chungbuk in 2018, it has been reported in other areas including Gyeongsang in Korea. In 2020, we performed field surveys of yellowing diseases in the greenhouses growing melon and watermelon in Chungbuk (Jincheon and Eumseong). Reverse transcription-polymerase chain reaction analysis of 79 collected samples including melon, watermelon, and weeds resulted in detection of CCYV in 4 samples: Three samples were singly infected with CCYV and one samples was mixed infected with CCYV, Cucurbit aphid borne yellows virus, and Watermelon mosaic virus. The complete genome sequences of the four collected CCYV melon isolates (ES 1-ES 4) were determined and genetically compared with those of previously reported CCYV isolates retrieved from GenBank. Phylogenetic analyses of RNA 1 and 2 sequences revealed that four ES isolates were clustered in one group and closely related to the CCYV isolates from China. The analysis also revealed very low genetic diversity among the CCYV ES isolates. In general, CCYV isolates showed little genetic diversity, regardless of host or geographic origins. CCYV has the potential to pose a serious threat to melon, watermelon, and cucumber production in Korea. Further studies are needed to examine the pathogenicity and transmissibility of CCYV in weeds and other cucurbits including watermelon.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.33 no.2
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• pp.305-318
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• 2023

The complexity of software products led many manufacturers to stitch open-source software for composing a product. Using open-source help reduce the development cost, but the difference in the different development life cycles makes it difficult to keep the product up-to-date. For this reason, even the patches for known vulnerabilities are not adopted quickly enough, leaving the entire product under threat. Existing studies propose to use binary differentiation techniques to determine if a product is left vulnerable against a particular vulnerability. Despite their effectiveness in finding real-world vulnerabilities, they often fail to locate the evidence of a vulnerability if it is a small function that usually is inlined at compile time. This work presents our tool FunRank which is designed to identify the short functions. Our experiments using synthesized and real-world software products show that FunRank can identify the short, inlined functions that suggest that the program is left vulnerable to a particular vulnerability.

• Journal of Navigation and Port Research
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• v.47 no.1
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• pp.18-24
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• 2023

After the Great East Japan Earthquake, many reports and books that compiled testimonies of adult victims were published. Thus, refugee situations are well known, but information on the refugee situations of Japanese students is not. This is because what actions the students took and how they sought refuge from an earthquake or tsunami have not been fully recognized. The purpose of this study was to examine and analyze students' refuge behavior in the Great East Japan Earthquake and to predict the refuge behavior of students affected by future disasters. The results of the study showed that students passively acquired information about earthquakes and tsunamis and that their refuge behavior was highly dependent on adults. Immediately after an earthquake, people tended to protect themselves and stay in place until the shaking stopped. However, they tended to move to another place after the shaking occurred frequently. Students living on ria coastlines were likely to move to high places to escape the threat of earthquakes and tsunamis, whereas students living in plain regions were likely to move vertically to tall buildings, such as schools. As for the mode of movement to refugee shelters, the students arrived at the final refugee shelters in one move, and it is assumed that the refugee shelters should be decided in advance and the students should move there.