• Childhood Kidney Diseases
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• 제27권1호
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• pp.1-10
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• 2023

Pediatric nephrotic syndrome (NS) is a clinical syndrome characterized by massive proteinuria, hypoalbuminemia, and generalized edema. Most childhood NS cases are idiopathic (with an unknown etiology). Traditional therapeutic approaches based on immunosuppressive agents largely support the key role of the immune system in idiopathic NS (INS), especially in the steroid-sensitive form. Although most previous studies have suggested the main role of T cell dysfunction and/or the abnormal secretion of certain glomerular permeability factors, recent studies have emphasized the role of B cells since the therapeutic efficacy of B cell depletion therapy in inducing and/or maintaining prolonged remission in patients with INS was confirmed. Furthermore, several studies have detected circulating autoantibodies that target podocyte proteins in a subset of patients with INS, suggesting an autoimmune-mediated etiology of INS. Accordingly, a new therapeutic modality using B cell-depleting drugs has been attempted, with significant effects in a subset of patients with INS. Currently, INS is considered an immune-mediated disorder caused by a complex interplay between T cells, B cells, soluble factors, and podocytes, which may vary among patients. More in-depth investigations of the pathogenic pathways of INS are required for an effective personalized therapeutic approach and to define precise targets for therapeutic intervention.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVI)
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• pp.39-39
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• 2005

Large scale mammalian cell culture has become, over the past two decades, the preferred method to produce therapeutic monoclonal antibodies. In this presentation, I will introduce disposable bioreactor system and analyze key factors and points for consideration during mammalian cell culture process development. Example will be provided highlighting the selection of master cell, culture media and environmental factors based on productivity and product quality.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 1999년도 Japanese Journal of Medical Physics
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• pp.249-252
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• 1999

• Journal of Yeungnam Medical Science
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• 제4권2호
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• pp.89-96
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• 1987

통일한 시간, 선량, 분할 인자를 가진 두개의 서로 다른 분할 조사군과 부여된 전체 선량이 같은 경우를 비교한 결과는 아래와 같다. 암, 수 성별에 다른 차이점은 없었다. 체중의 변화는 분할당 선량 보다는 조사에 소요된 기간과 더 연관됨을 보였다. 혈색소의 변화는 시간, 선량, 분할 인자와 부여된 전체 선량과는 관련이 적었다. 백혈구의 변화는 전체 조사 선량 보다는 시간, 선량, 분할 인자에 더 관련이 있었다. 감별 백혈구의 변화는 비교적 초기에 임파구의 비율 감소가 나오는 시간, 선량, 분할 인자나 전체 조사 선량 사이의 큰 차이는 없었으며 조사가 지속될수록 점차 경미한 변화를 보였다.

• 생체재료학회지
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• 제22권4호
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• pp.235-248
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• 2018

Background: Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have the injectability with minimal invasiveness and usability for irregularly shaped sites, in addition to typical advantages of conventional hydrogels such as biocompatibility, permeability to oxygen and nutrient, properties similar to the characteristics of the native extracellular matrix, and porous structure allowing therapeutic agents to be loaded. Main body: In this article, recent studies of injectable hydrogel systems applicable for therapeutic agent delivery, disease/cancer therapy, and tissue engineering have reviewed in terms of the various factors physically and chemically contributing to sol-gel transition via which gels have been formed. The various factors are as follows: several different non-covalent interactions resulting in physical crosslinking (the electrostatic interactions (e.g., the ionic and hydrogen bonds), hydrophobic interactions, ${\pi}$-interactions, and van der Waals forces), in-situ chemical reactions inducing chemical crosslinking (the Diels Alder click reactions, Michael reactions, Schiff base reactions, or enzyme-or photo-mediated reactions), and external stimuli (temperatures, pHs, lights, electric/magnetic fields, ultrasounds, or biomolecular species (e.g., enzyme)). Finally, their applications with accompanying therapeutic agents and notable properties used were reviewed as well. Conclusion: Injectable hydrogels, of which network morphology and properties could be tuned, have shown to control the load and release of therapeutic agents, consequently producing significant therapeutic efficacy. Accordingly, they are believed to be successful and promising biomaterials as scaffolds and carriers of therapeutic agents for disease and cancer therapy and tissue engineering.

• 디지털융복합연구
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• 제16권12호
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• pp.417-425
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• 2018

본 연구의 목적은 뇌졸중 환자의 상지기능, 일상생활활동, 치료적 몰입과 삶의 질 간의 상관관계를 알아보고, 삶의 질에 영향을 미치는 요인을 파악하기 위함이다. 총 13개 병원에서 입원중인 뇌졸중 환자 249명을 대상으로 상지기능, 일상생활활동, 치료적 몰입과 삶의 질을 치료사와 연구자가 평가하였다. 그 결과, 뇌졸중 환자의 상지기능(r=.312, p<.001), 일상생활활동(r=.605, p<.001), 치료적 몰입(r=.525, p<.001)이 양의 상관관계를 나타내었다. 그리고 뇌졸중 환자의 삶의 질에 영향을 미치는 요인을 분석한 결과, 치료적 몰입(${\beta}=.344$, p<.001), 일상생활활동(${\beta}=.293$, p<.001), 발병기간(${\beta}=.145$, p<.05)은 뇌졸중 환자의 삶의 질에 유의한 영향을 미치는 변수로 확인되었으며, 이들 요인은 삶의 질을 35.9% 설명하는 것으로 나타났다(F=35.736, p<.001). 이를 통하여 치료적 몰입은 삶의 질에 영향을 미치는 중요한 요인임을 확인할 수 있었으며, 향후 치료적 몰입에 대한 계속적인 연구가 요구된다.

• 한국콘텐츠학회논문지
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• 제22권4호
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• pp.1-12
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• 2022

20세기 초부터 대안적 심리치료의 관심과 발전과 더불어 예술치료의 영역도 발전, 확장되어 가고 있다. 특히 근래 들어 기술의 발전과 코로나 사태(Covid 19 Pandemic)가 불러온 언택트(Untact) 시대는 디지털 예술치료 콘텐츠에 대한 개발을 가속화 하고 있다. 그 중 가상현실(Virtual Reality)에 대한 높은 관심은 전통적 예술치료를 넘어서는 새로운 매체의 치료적 효과성에 대한 기대와 의문을 동시에 불러오고 있다. 이 연구에서는 통합 미술치료이론인 ETC(Expressive Therapies Continumm)의 개념 틀과 치료적 구성요소에 기반한 체계적 문헌분석을 통해 가상현실 미술치료(VRAT:Virtual Reality Art Therapy) 콘텐츠의 치료적 요인의 특성을 알아보고자 하였다. 연구결과로는 VRAT 콘텐츠는 사용자의 동적, 지각적, 인지적 요인을 촉발하는 좌반구 대상의 치료적 요인이 주로 나타났고 감각적, 정서적, 상징적 요소에 치중된 우반구 대상의 치료적 요인은 상대적으로 드물게 나타났다. 그 이유로는 VRAT 매체의 특성 및 기술적 한계 외에도 실험적 단계의 특성상 치료사의 적극적 개입과 장기적 세션 구성의 부재, 사용자들의 VRAT 에 대한 두려움과 서툼, 낯섦 등에 기인한 것으로 보인다. 연구의 한계로는 적은 수의 분석 대상 문헌과 미술치료라고 하기엔 미비한 현 VRAT 의 형식이며 본 연구의 결과로서 도출된 VRAT 콘텐츠 매체와 환경에 기인한 치료 요인의 특징과 가능성이 향후 VRAT 콘텐츠의 적절한 개발에 유용하게 쓰이길 기대한다.

• 한국환경과학회지
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• 제19권11호
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• pp.1437-1444
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• 2010

This research was to find out the effectiveness of the horticultural therapy program based on the therapeutic factors and the most meaningful experiences of the clients. For this purpose "Green harmony" program focused on harmony through horticulture was implemented. It is based on the preposition that holistic health is promoted with harmonious relationships with oneself, other people, community and nature. The program has three-fold structure: In innermost it deals with the task of the late adolescent, i.e., self identity, secondly the experience of communication and solidarity in the group, and finally extension of interest to the community. For the therapeutic intervention, questions using the metaphor of the activity were given to the clients for the establishment of self-identity, while group activity and the donation of the works let the second and third purpose accomplished. Outdoor activity, 'Tire garden project', has provided the clients with chances of the contact with nature, cooperation with other group members, and a contest to provoke enthusiasm. Also recycling and greening of the community were possible by utilizing old tires for the containers and by donating the final works to the community. For the evaluation of the result, the effect of the program on the stress of the college students was tested, and the most meaningful experiences during the participation to the program were asked to identify the therapeutic factors acknowledged by clients. "Green harmony" program has brought positive effects on the stress of the clients in spite of relatively short period of five weeks. The clients has acknowledged plant/nature contact and interactions between group members for the most meaningful experiences. This research suggests "Green harmony" horticultural therapy program based on the therapeutic factors is highly applicable for the general populations.

• 한국환경과학회지
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• 제19권4호
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• pp.517-525
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• 2010

Horticultural therapy is a complementary therapy by trained professionals utilizing plant and horticultural activities as media to pursue the positive change of clients, which resulting from stimuli of plant nature, activities, and interaction with other people. Outdoor horticultural activities provide clients with the opportunities of the contact to nature such as fresh air and sunlight as well as plants. But the importance of plant nature to client's health has not been fully acknowledged compared to that of therapist's role and activities in horticultural therapy in Korea. In horticultural therapy it is possible for client to participate on the various levels from passive viewing to active gardening according to the client's ability. Therefore it is necessary for horticultural therapists to consider the therapeutic factors of plant nature to maximize the therapeutic effect of horticultural therapy. The purpose of the research is to clarify the therapeutic factors in the contact of client with plant nature and to emphasize those importance in horticultural therapy. From the review of the experimental researches five therapeutic factors were revealed: Natural light, plant natural view, natural sound, aroma(volatile oils of plants), and plant itself. This paper raises the importance of outdoor activities in horticultural therapy and the necessity for severely handicapped clients to the contact with plant nature, though passively.

• Journal of Medicine and Life Science
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• 제20권4호
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• pp.158-165
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• 2023

This study prospective randomized controlled trial aims to test the impact of adding health education, awareness of some contributing factors and clinical guidance to therapeutic cabergoline given to infertile women with unexplained resistant hyperprolactinemia. It comprised 120 infertile women with unexplained persistent hyperprolactinemia not responding to therapeutic doses of cabergoline 1.5-2 mg/week who were subjected to proper history taking to exclude concomitant drug intake or possible brain problems in all cases. They were classified into group A (60 cases) who received health education and clinical guidance to search for possible contributing factors and were instructed to avoid them in addition to proper therapeutic doses of cabergoline, while group B (60 cases) received proper therapeutic doses of cabergoline only without clinical guidance. After 1 month, serum prolactin (PRL) was measured for all cases. All cases had high PRL level at the start of the study (79.9±28.4 [39-195] and 78.2±19.9 [42-189] in group A and B, respectively) without any significant difference. Pretreatment counselling revealed that lifestyle factors, sexual behaviors or feeding habits may contribute to resistant hyperprolactinemia in all cases without a significant difference between both groups. Serum PRL dropped significantly more in group A (20.14±10.31 [11-45] vs. 49.32±37.03 [12-100]) after combined health education, clinical guidance of the couple and proper treatment. It is concluded that lifestyle factors, sexual behaviors, and feeding habits would affect the response of hyperprolactinemia to treatment. Health education and clinical guidance with some advice to avoid them, would concomitantly improve the response of resistant hyperprolactinemia to therapeutic doses of dopamine agonists.