• 대한물리치료과학회지
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• 제3권2호
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• pp.1065-1077
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• 1996

Fees for medical insurance services in Korea has not being been set based on service costing. Recently in the USA, fees for physican services are determined by developing and applying Resoure Based Relative Value Scales (RBRVS). This study attempts to develop relative value scales for personal factors of rehabilitative and physical therapeutic services. The personal factors were classified into four categories as having been done in the USA;service time, treatment technology and physical efforts, mental efforts and judgement, and stress. Input factors were measured using Magnitude Estimation Method (MEM), and relative value units were calculated for each of twenty eight rehabilitative and physical therapeutic services. Results show that service time surveyed differs from that provided in the public fee schedules in 24 services; the three personal factors but the service time are highly correlated; the physical therapists hold treatment technology and physical efforts to be the most important factor in setting the for services; and that relative values developed for noninsurance services such as Silver Spike Electrode (SSP) and Proprioceptive Neuromuscular Facilitation (PNF) are higher than those of similar insurance services. The policy implications and measures for improvement for the above findings were suggested respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6991-6996
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• 2015

In the past decade, the incidence and mortality rates of cholangiocarcinoma (CCA) have been increasing worldwide. The relatively low responsiveness of CCA to conventional chemotherapy leads to poor overall survival. Recently, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) has emerged as the most promising anti-cancer therapeutic agent since it is able to selectively induce apoptosis of tumor cells but not normal cells. In this study, we aimed to investigate the therapeutic effect of TRAIL in CCA cell lines (M213, M214 and KKU100) compared with the immortal biliary cell line, MMNK1, either alone or in combination with a subtoxic dose of 5-fluorouracil (5-FU). We found that recombinant human TRAIL (rhTRAIL) was a potential agent which significantly inhibited cell proliferation and mediated caspase activities (caspases 8, 9 and 3/7) and apoptosis of CCA cells. The combined treatment of rhTRAIL and 5-FU effectively enhanced inhibition of CCA cell growth with a smaller effect on MMNK1. Our finding suggests TRAIL to be a novel anti-cancer therapeutic agent and advantage of its combination with a conventional chemotherapeutic drug for effective treatment of CCA.

• 대한한방내과학회지
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• 제33권1호
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• pp.69-82
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• 2012

Objectives : To establish objective and scientific evidence of Korean medicine (KM), the papers on Oryeong-san (Wuling-san) frequently used in medical institutions of Korean Medicine were analyzed. Methods : The papers were classified by the registration of domestic or international journals, the year of publication, experimental fields and the kinds of studies on biological activities. The therapeutic mechanism was investigated in accordance with therapeutic effect of Oryeong-san (Wuling-san). Results : Out of 57 articles selected, 16 were published in domestic journals, 17 were in Chinese journals and 24 were in Japanese journals. Most papers reported as biological activities were on improvement of renal function. Oryeong-san (Wuling-san) increased urine factor such as urine excretion and electrolyte balance while decreasing proteinuria, serum factors including creatinine, cholesterol and triglyceride. In addition, injured renal tissue was recovered normally and gene expression controlling urine excretion was down-regulated. Conclusions : Improvement of renal function could be interpreted as objective and scientific evidence for Oryeong-san (Wuling-san).

• Clinical and Experimental Reproductive Medicine
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• 제20권2호
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• pp.149-156
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• 1993

Human chorionic gonadotropin(hCG) and intravenous immunoglobulin(IVIG) treatment were attempted as a novel therapeutic approach for unexplained recurrent spontaneous abortion(RSA). Forty-four and 3 women with a history of RSA were treated with hCG and IVIG, respectively, during pregnancy. Of these patients, serum blocking factor assay was performed before and after each treatment, in 15 patients; 12 cases with hCG and 3 cases with IVIG. The results were as follows: 1. Of 44 women who receive hCG during pregnancy, 24 delivered healthy infants at term, 10 patients suffered repeat abortion, and 10 women are still pregnant under 28 weeks. Over all success rate of hCG treatment was 70.6% (24/34). Although there is no statistical significance, absolute serm blocking level was decreased after treatment(N=12). 2. Of 3 women who receive IVIG during pregnancy, all 3 women are still pregnant under 28 weeks. Serum blocking level was increased after treatment, however, this increment was not statistically significant. Although no conclusion could be extracted from the patients who received IVIG, the therapeutic effect of hCG is comparable to that of the other therapeutic regimens, such as allogeneic leukocytes. It was postulated that actual etiology of unknown RSA would be classified as hormonal origin although combined etiologies are common in Korean women.

• 대한지리학회지
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• 제51권1호
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• pp.109-125
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• 2016

인간의 삶에서 치유는 떼어낼 수 없는 관계에 있다. 최근 치유의 요구가 증가하면서 이를 위한 공간, 장소, 나아가 이동에 대한 지리적 연구가 필요한 시점이다. 본 연구는 서울 한양도성길 낙산구간 걷기를 사례로 걷기의 과정에서 어떠한 치유요소가 작용하며 그 지리적 함의가 무엇인지를 밝히는 데 목적을 두었다. '치유적 모빌리티' 개념과 틀을 바탕으로 181건의 블로그 텍스트를 연구 자료로 활용하였고 치유요소들을 분류한 결과, '기상 기후', '걷기 산책', 그리고 '야경'이 주요 요소로 분석되었다. 또한, 치유의 걷기 과정을 주요 요소들을 다룬 블로그 내러티브 분석으로 살펴본 결과, 치유의 장소만들기, 제한요인으로서 시간, 야경 속 사회적 신체라는 지리학적 함의를 찾을 수 있었다.

• 한국의학물리학회지:의학물리
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• 제9권1호
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• pp.29-35
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• 1998

There has been necessity of an air free ionization chamber using the gold-crystal-aluminium plates, henceforth called the crystal chamber. The crystal chamber formed of parallel plates is very small in size and has more response for absorbed dose of therapeutic radiation beams. The gold plate on the crystal facing the photon and electron beam acts as an intensifier of signals and crystal plate as an ionization medium respectively. Both the copper guard ring and the aluminum collecting electrode are connected to an electrometer. Using high energy photon (6, 15 MV) and electron (9, 12, 15, 18 MeV) beams, the responses of the crystal chamber are evaluated against a PTW Farmer-type chamber at a field size of 10${\times}$10cm$^2$ and 100 cm SSD. The responses of crystal chamber for therapeutic radiation electron and photon beams are greater in magnitude by several order than Farmer. The crystal chamber has good linearity without correction factor C$\_$t,p/ with respect to the signals, a reading reproduction with good accuracy and precision less than 0.5%, and has other useful functions in measuring radiation beams.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2008년도 Proceedings of the Convention
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• pp.77-86
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• 2008

It's been known that overexpression of the oncoprotein Her2 (eu/ErbB2), transmembrane receptor protein, occurs in human breast cancer. Her2-positive breast cancer patients who have Her2 overexpression show less therapeutic efficacy with enhanced metathesis and increased resistance to chemotherapy. So far, a humanized monoclonal antibody against Her2 protein called Herceptin is the only drug approved by Food and Drug Administration for treatment of Her2-overexpressing breast tumors. However, antibody therapy of Herceptin may not be ideal method for therapeutic intervention of Her2 protein expression. The therapeutic intervention of Her2 protein expression may be more efficiently achieved by inhibiting the expression of Her2 gene rather than by down-regulating the Her2 protein already overexpressed. Here, we found that the interaction of two proteins of ESX (an epithelial-restricted transcription factor) and DRIP130/CRSP130/Sur2 (a Ras-linked subunit of human mediator complexes) mediates the expression of Her2 gene. The association of ESX with Sur2 is mediated by a small hydrophobic face of 8-amino acid helix in ESX, suggesting that the ESX-Sur2 interaction can be a new novel target for Her2-positive cancer. The process to develop potent ESX-Sur2 interaction inhibitors targeting for Her2-positive cancer therapeutics will be discussed.

• 혜화의학회지
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• 제5권2호
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• pp.513-522
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• 1997

Clinical studies were done on 94 patients with the General Pain after Childbirth(GPC). which were treated in Dept. of Oriental Gynecology. Oriental Medical Hospital. Dae Jeon University from July 1st 1995 to June 30th 1996. 1. The total incidence of GPC was about 13.2% of the 1162patients. 2. In age distribution of GPC. after twenty years old was the most in 40.4%. the next ration was thirty years old. forty years old. early twenty years old. 3. In inducing factor. overlook was the most in 29.8%. the next ration was delivery itself. difficult delivery. cesarean section in 26.6%. 4. In therapeutic response. excellence was the most in 38.3%. the next ration was improvement. good. non improvement. 5. In onset. within ten days of postpartum was the most in 35%. the next ration was from 11 to 30 days. from 91 to 180 days. during the period of pregnancy. from 61 to 90 days. from 180 to 360 days. 6. Remedical value of abortion was relatively emedical value of difficult delivery. Cesarean section was bad. 7. In delivery times. abortion times and pregnant times did not concern therapeutic response. 8. In therapeutic period. from 11 to 30 days was the most in 46.8%. 9. In delivery seasons. Feburary was the most in 15.9%. and there were many occurrence of GPC in the winter season. 10. Past history did not concern GPC. 11. In prescriptions. Bohuh Tang Kamibang(B) was the most in 33%.

• Architectural research
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• 제22권4호
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• pp.113-122
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• 2020

Hospital architecture must be planned as a therapeutic space. Numerous studies have proven that exposure to nature has a healing effect. However, research on the architecture itself about this issue is still insufficient. This study analyzed Le Corbusier's Venice hospital project and its architectural configurations with nature. Le Corbusier had been interested in blurring the interior/exterior line to draw nature inside. In his projects, nature was conceived in an abstract sense as "something green." However, in the hospital project, natural elements including vegetation, the lagoon, and light, and the landscape scenery they created, were considered in the harmony of the architectural space. The architectural spaces with courtyards, pilotis, and roof gardens provided views and direct access to nature, and in the interior spaces, the connections to these external spaces and the permeation of views of nature and sunlight were incorporated. Many spaces provided the possibility to actually encounter nature, with a variety of indoor/outdoor space configurations rather than a merely passive placing of some natural elements. This project is considered to be an important reference for contemporary hospital architecture, since the architectural space and nature connected through various spatial configurations also in healthcare programs. As Le Corbusier emphasized, sunlight, vegetation, and also architectural space should be an essential factor in therapeutic hospital architecture planning.

• Journal of Microbiology and Biotechnology
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• 제33권9호
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• pp.1111-1118
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• 2023

As a long-term condition that affects the airways and lungs, chronic obstructive pulmonary disease (COPD) is characterized by inflammation, emphysema, breathlessness, chronic cough, and sputum production. Currently, the bronchodilators and anti-inflammatory drugs prescribed for COPD are mostly off-target, warranting new disease management strategies. Accumulating research has revealed the gut-lung axis to be a bidirectional communication system. Cigarette smoke, a major exacerbating factor in COPD and lung inflammation, affects gut microbiota composition and diversity, causing gut microbiota dysbiosis, a condition that has recently been described in COPD patients and animal models. For this review, we focused on the gut-lung axis, which is influenced by gut microbial metabolites, bacterial translocation, and immune cell modulation. Further, we have summarized the findings of preclinical and clinical studies on the association between gut microbiota and COPD to provide a basis for using gut microbiota in therapeutic strategies against COPD. Our review also proposes that further research on probiotics, prebiotics, short-chain fatty acids, and fecal microbiota transplantation could assist therapeutic approaches targeting the gut microbiota to alleviate COPD.