• 방사선산업학회지
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• 제17권4호
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• pp.417-425
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• 2023

Lutetium(¹⁷⁷Lu), with its theranostic properties, is one of the most widely used radioisotopes and has a large share of the radiopharmaceutical market due to its many applications and targeted therapeutic research using lutetium-based radiopharmaceuticals. However, lutetium-based radiopharmaceuticals currently approved by the US Food and Drug Administration (FDA) are limited to the indications of gastrointestinal cancer, pancreatic neuroendocrine cancer and metastatic castration-resistant prostate cancer. To overcome these limitations, we aimed to demonstrate the feasibility of expanding the use of lutetium-based radiopharmaceuticals by verifying the availability and therapeutic efficacy of lutetium produced in a research reactor(HANARO). In this study, we confirmed the therapeutic efficacy of lutetium by using cancer cells from different types of cancer. In addition, we selected cancer biomarkers based on characteristics common to various cancer cells and compared and evaluated the therapeutic efficacy of lutetium by regulating the expression of target genes. The results showed that modulation of cancer biomarker gene expression resulted in higher therapeutic efficacy compared to lutetium alone. In conclusion, this study verified the potential use and therapeutic efficacy of lutetium based on the production of a research reactor (HANARO), providing fundamental evidence for the development of lutetium-based radiopharmaceuticals and the expansion of their indications.

• 대한지리학회지
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• 제52권1호
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• pp.25-53
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• 2017

본 연구는 세월호 참사 이후 안산시의 고잔동과 와동을 중심으로 나타난 대안적 치유의 공간의 지리적 특징에 대해 살펴보는 것을 목표로 한다. 세월호 참사의 내면을 들여다보면 치유 대상의 스펙트럼이 넓게 퍼져 있어 개별 치유의 공간이 지향하고 있는 치유의 목표는 그 주체에 따라 다소 상이하다. 현재 세월호 참사 관련 치유의 공간은 약 7개 내외로 추산되며, 민간에서 주도하는 형태가 주류를 이룬다. 또한 이러한 공간은 가장 많은 희생자가 나온 단원고등학교 주변이되 시선에서 약간 빗겨간 곳에 위치해 있고, 특별한 활동을 하기보다는 깨어진 일상을 다시 원래의 자리로 회복시키기 위한 단순하며, 반복적인 일, 예를 들어, 식사, 뜨개질, 학습 등을 주요 치유의 활동으로 하고 있다. 이러한 배경을 바탕으로 세월호 참사 관련 치유의 공간의 주요한 특징은 다음과 같이 정리할 수 있다. 첫째, 치유의 대상이 개별 치유의 공간을 장소로 점점 받아들이고 있다는 점을 들 수 있다. 세월호 참사 관련 치유의 공간은 제3자에 의해 처음 제안된 경우가 대부분이었지만, 이제는 치유의 주체들이 스스로 끌어가거나, 기억하며, 심지어 앞으로의 방향까지 설계하고 있어 마치 그들만의 전유물처럼 인식되는 경향이 나타나고 있다. 둘째, 앞서 언급한 것처럼 세월호 참사는 직접적인 피해자뿐만 아니라 희생자의 부모, 형제, 친척, 친구, 지역주민 등까지 넓은 범위의 집단에게 트라우마를 지운 사건이었던 만큼 치유의 공간이 지원하는 대상은 폭넓지만, 개별 치유의 공간을 활용하는 대상은 겹치지 않는다. 그렇지만 지역 커뮤니티가 가지고 있는 집단 트라우마를 효율적으로 해결하기 위해 지역 내 네트워크를 조밀하게 유지하고 상시적으로 협력하는 형태를 취하고 있다. 셋째, 참사와 같은 트라우마 극복에 있어 사건의 지속적인 기억은 매우 중요한 부분으로 지적되는데, 세월호 참사의 경우에는 지역주민들의 피로감 혹은 갈등, 노후화된 안산시를 떠나는 이들, 시간이 지나감에 따른 퇴색되는 분위기 등이 기억의 유지에 위험 요소로 작용되고 있다. 이를 위해 치유의 공간을 중심으로 지역공동체 회복, 다양한 이벤트 기획 등을 시도하고 있으며, 안산시 외의 다른 단체와도 유기적으로 연결해 세월호 참사의 기억이 오래 지속될 수 있도록 하고 있다.

• 대한방사선치료학회지
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• 제7권1호
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• pp.71-85
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• 1995

• Journal of Nutrition and Health
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• 제28권2호
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• pp.162-169
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• 1995

This study was conducted to evaluate the necessity and development of a therapeutic diet manual which contains basic nutritional science concepts that refer to nutritional management of patients in clinical settings. One hundred and fifty-four medical doctors, forty dietitians, and sixty-three students majoring in nutrition participated. The survey included questions about nutritional knowledge, nutrition-related concerns, and nutrition counseling in medical practice. The knowledge score of medical doctors was 47.7%. Lower percentages occurred in the amount of sodium allowed in the sodium restricted diet and the food sources of vitamin B1 were 16.9%, 31.2% respectively. Seventy-four percent of doctors strongly urged nutrition counseling for patients. Seventy one percent of doctors agreed that the present medical-nutrition education was inadequate in medical school curricura. Most doctors (79.2%) agreed that a therapeutic diet manual would be helpful and necessary. The average percentage of nutritional knowledge test scores for dietitians and students majoring in nutrition were 76.0% and 68.3%, respectively. Over ninety percent of dietitians working and their prescriptions. The result of this study strongly suggests that the development of a comprehensive therapeutic diet manual is necessary, especially for medical doctors.

• Radiation Oncology Journal
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• 제2권2호
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• pp.281-285
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• 1984

The authors have intended to measure intrinsic dose distribution by Farmer dosimeter in irregularly shaped fields such as L.M and T shape models in order to determine dose inhomogeneity in those models. We made 2 off·axis points in each model and measured the depth dose at 1.5, 5 and 9cm below surface. The results showed $l\~3\%$ dose discrepancy between 2 points. We also measured the depth dose by geometric approximation and computer calculation in those models, and came to the conclusion that computer calculation using Clarkson's principle is simpler and the measurements are closer to the ideal data obtained by the experiment in three models of irregularly shaped fields than those of geometric approximation method.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2002년도 추계학술대회
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• pp.109-115
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• 2002

Gene therapy is to treat and cure diseases by an introduction of therapeutic genes in defective cells or tissues of human body. Gene delivery system, gene expression system, and therapeutic gene are three core elements for gene therapy. The efficient delivery of therapeutic genes and appropriate gene expression are the crucial issues for therapeutic outcome of gene delivery. Because it can be used in common for the treatment and cure of various diseases, gene delivery system is the most important core element for a successful gene therapy. Viruses are naturally evolved to transfer their genomes into host cells efficiently. This ability has made vectorologists exploit viruses as attractive vehicles for the delivery of therapeutic genes. Viral vectors based on adenovirus (Ad) and adeno-associated virus (AAV) have been often used for gene delivery in laboratory. Ad and AAV vectors derived from human DNA viruses differ greatly in their life cycle, expression level and duration of transgenes, immunogenicity, and vector preparation. Both vectors can be used as effective tools for gene therapy and more recently in functional genomics. Here, the characteristics of Ad and AAV vectors are discussed.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 1990년도 제7차 학술대회 연제순서 및 초록집
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• pp.20.2-22
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• 1990

• 전기학회논문지
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• 제57권12호
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• pp.2345-2350
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• 2008

Recently, ultrasound is becoming a universal way of treatment when it comes to clinic. The thermal effect of therapeutic ultrasound can raise the temperature of tissue without damage and thus increases the flow rate, and this leads to the oxygen transportation velocity of peripheral tissue and ultimately facilitates the metabolism. The purpose of this research is analyzing relations between PTT and transmission time of therapeutic ultrasound, and in this study the PTT variation due to respective transmission time of ultrasound upon 17 normal persons was measured and as a result, it was observed that PTT increases as transmission time of therapeutic ultrasound

• 대한간호학회지
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• 제34권1호
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• pp.63-71
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• 2004

Purpose: This study was to identify the influencing factors of the compliance level to a therapeutic regimen after a bone mineral densitometry test. Method: The sample for the study was 95 people who took the bone mineral densitometry test from March, 2002 to July, 2002. Data was collected by mail using aself reporting questionnaire on the selected variables such as the compliance level, self efficacy, health locus of control, susceptibility, severity, usefulness, barrier, and self esteem. Results: The average compliance level was 63.93. Through multiple regression, three independent variables including chance health locus of control on personality, the result of bone mineral density and self-efficacy were entered in the model as the significant determinants of the compliance level after a bone mineral densitometry test. The coefficients of determination of each variable were 10.9%, 8.3% and 8.1% respectively. Conclusion: The identification of the determinants of the compliance level to the therapeutic regimen after bone mineral densitometry is expected to contribute to the development of an intervention program to improve the compliance level to the therapeutic regimen in osteoporosis patients.

• Advances in Traditional Medicine
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• 제9권2호
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• pp.101-105
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• 2009

Morinda tinctoria Roxb. (Family: Rubiaceae) is commonly known as Indian mulberry or Aal in India. This plant is very well known for its therapeutic benefit in Indian systems of medicine including Ayurveda and Siddha and in other forms of traditional Medicine worldwide for the treatment of several ailments. Almost all parts of this plant have been explored for its medicinal uses. Several reports on the phytochemical and therapeutic benefits of this plant have been reported. In this article an attempt has been made to review the traditional uses, phytochemical profiles and therapeutic potentials of Indian mulberry.