• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.145-152
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• 2022

Colon rectal cancer is one of the frequently diagnosed cancers worldwide. In recent times the drug discovery for colon cancer is challenging because of their speedy metastasis and morality of these patients. C-jun N-terminal kinase signaling pathway controls the cell cycle survival and apoptosis. Evidence has shown that JNK1 promotes the tumor progression in various types of cancers like colon cancer, breast cancer and lung cancer. Recent study has shown that inhibiting, JNK1 pathway is identified as one of the important cascades in drug discovery. One of the recent approaches in the field of drug discovery is drug repurposing. In drug repurposing approach we have virtually screened ChEMBL dataset against JNK1 protein and their interactions have been studied through Molecular docking. Cross docking was performed with the top compounds to be more specific with JNK1 comparing the affinity with JNK2 and JNK3.The drugs which exhibited higher binding were subjected to Conceptual - Density functional theory. The results showed mainly Entrectinib and Exatecan showed better binding to the target.

• Journal of Distribution Science
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• v.17 no.2
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• pp.5-11
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• 2019

Purpose - This paper examines how corporate social responsibility of the Korean retail industry affects the degree of asymmetric information. Recent theories predict that a firm's active engagement in socially responsible activities lowers the degree of asymmetric information of the firm. Research design, data, and methodology - This paper uses the sum of environmental and social scores (ES), published by the Korean Corporate Governance Service in order to proxy the degree of socially responsible management practices of Korean retail firms. This paper uses the ordinary least square method to investigate the above predictions. The publicly traded Korea retail firms listed in the Korean Exchange are analyzed from 2011 to 2016. To measure the degree of asymmetric information, this paper adopts the analyst dispersion and price impact measures. Results - This paper shows that the ES score has significantly positive relationships with these two measures of information asymmetry. The environmental score seems to increase the analyst dispersion measure and the social score appears to raise the price impact measure mores significantly. Conclusions - The results do not support the prior theory expecting a negative relationship between corporate social responsibility and the degree of asymmetric information. Environmental and social scores are found to affect the measures of information asymmetry differently.

• Korean Journal of Health Education and Promotion
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• v.33 no.4
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• pp.79-87
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• 2016

Objectives: This study aims to identify participants-focused health education approaches for the management of metabolic syndrome. Methods: Data for metabolic parameters of 855,282 Koreans in 2012 were extracted and analysed from the data base of Korea Association of Health Promotion. Literature and documents including study protocols, program contents, evaluation reports and published articles were reviewed in relation to increasing effectiveness and efficiency of health education for managing metabolic syndrome. Results: Health education program should be based on participants-focused perspectives, in which clients' demographic characteristics, composition patterns of metabolic risk factors, and readiness of change are appreciated. Development of theory-based strategies for healthy behavior change and evidence-based program components are also important factors in designing and conducting health education intervention. Multiple health behavior intervention can offer a new paradigm for more comprehensive and efficient health education. Implementation fidelity needs to be systematically evaluated and strengthened to improve the validity of the health education efforts. Conclusion: Enhancing participants-focused health education is the responsibility of health education specialists in promoting the management of metabolic syndrome.

• Proceedings of the Korean Institute of Interior Design Conference
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• 1999.04a
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• pp.23-26
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• 1999

The purpose of this study was to scrutinize the current tendency of Universal Design. The analysis unit was presentation in the proceeding of "The first International Universal Design Conference" which was held at New York in June, 1998. Sixty the presentations in the conference were analyzed using Content Analysis technique. The analysis criteria were academic vs. practical, themes, subjects, levels of UD concepts, design principles applied, and type of disability. The results were as follows. Compared with its early characteristics such as practical approach, architectural living environment, barrier free for the disabled, especially for person with mobile disability using wheelchair, and the emphasis of accessibility, UD characteristics shown in the conference evidenced a dramatic shift from them toward the new century : Its subjects became a wide range of people including the disabled departing from 'the disabled' only; The range of disability was expanded to include visual and audial disability departing from mobility only; Themes appeared very diverse such as both small and large scale environments, products, dissemination, and theory from the 'architectural environment'; Various design principles were added to early accessibility ; Commercialism was added to early Welfarism. Therefore, this conference provided empirical evidence that UD changed considerably from its early development in many aspects. It indicated the potential of UD as a big wave in the 21st century design.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2001.05a
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• pp.172-175
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• 2001

The high temperature deformation behavior of two-phase gamma TiAl alloy has been investigated with the variation of temperature and ${\gamma}/{\alpha}_2$ volume fraction. For this purpose, a series of load relaxation tests and tensile tests have been conducted at temperature ranging from 800 to $1050^{\circ}C$. In the early stage of the deformation as in the load relaxation test experimental flow curves of the fine-grained TiAl alloy are well fitted with the combined curves of two processes (grain matrix deformation and dislocation climb) in the inelastic deformation theory. The evidence of grain boundary sliding has not been observed at this stage. However, when the amount of deformation is large (${\epsilon}{\approx}$ 0.8), flow curves significantly changes its shape indicating that grain boundary sliding also operates at this stage, which has been attributed to the occurrence of dynamic recrystallization during the deformation. With the increase in the volume fraction of ${\alpha}_2$-phase, the flow stress for grain matrix deformation increases since ${\alpha}_2$-Phase is considered as hard phase acting as barrier for dislocation movement. It is considered that cavity initiation is more probable to occur at ${\alpha}_2/{\gamma}$ interface rather than at ${\gamma}/{\gamma}$ interface.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.11
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• pp.987-998
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• 2020

This study aims to examine OL as a potential mediating variable in the relationship between IT and organizational performance. Organizational learning (OL) has been proposed as the mechanism to accomplish this task. Existing empirical research demonstrates that OL may indeed act as a mediator for the effect of IT on organizational outcomes. Also, existing literature discusses the use of technology in the organization, and the case for OL as the key knowledge process, and the intersection between technology and OL as a knowledge-based means for improving organizational performance. Many studies use a descriptive measure of OL despite the theory suggesting that a normative measure may be more appropriate. This study aims to address these concerns in a setting by using structural equation modelling (SEM) to compare the effectiveness of descriptive and normative measures of OL as mediating variables in knowledge-intensive organizations. Survey results support OL as a mediator between IT and organizational performance in addition to normative measures of OL outperforming descriptive measures. Implications for research and practice are discussed. To test the model, we will apply (SEM) structural equation modeling in the analysis of a moment structures (AMOS) on the empirical evidence collected from 218 Pakistani CEOs and top managers.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.10
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• pp.1035-1046
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• 2020

This study aims to find empirical evidence of causal relationship between strategy type, market orientation, strategic management accounting (SMA) strategic costing technique, and financial sector performance of private universities in Indonesia. The research object in this study are private universities in Yogyakarta, Indonesia. Yogyakarta is chosen because universities there are one of the barometers of higher education in Indonesia, and the city has quite a number of universities. The respondents in this study are the leader (manager) of private universities in Yogyakarta, Indonesia. The data analysis is done using SEM-PLS with WarpPLS 3.0 software. The results of this study show that market orientation has significant influence on the development and implementation of SMA strategic costing technique, while strategy type does not have significant influence on the development and implementation of SMA strategic costing technique. This study also finds that the implementation of SMA strategic costing technique significantly influences the financial sector performance of private universities in Yogyakarta, Indonesia. This study provides theoretical implication regarding SMA development in universities that consider that contingency factors (market orientation) can encourage increased organizational performance. It indicates support for contingency theory that states there are no general principles that apply to all situations.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.10
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• pp.359-368
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• 2020

This research seeks to explain factors and relationship models of entrepreneurs capable of building service innovations in Andaman coast with the ultimate aim to ignite sufficient development of regional tourism, increase working potentials, and provide a guideline for tour operations. Initially, document examination and discussions with five experts were conducted to build in-depth interview questions. 19 entrepreneurs were interviewed to examine factors involved and we consulted later with the five experts and six successful entrepreneurs in the regions, as well as with the representatives of the Association of Thai Tour Operators and Tourism Authority of Thailand (TAT) of Phuket, Krabi, and Trang. The results were analyzed according to the theory of resource-based and innovative entrepreneurs. The factors obtained were generated from systematic causes: Nature of Entrepreneurships and Organizational capabilities, the mediator variables of Service Innovation Capability; and Organizational Performance (non-finance). Moreover, the external factors needing to be adjusted regarding the environmental changes were described. The tour operators are suggested to build networking to increase tourism potential with sustainability by providing the entrepreneurs opportunities to be involved in tourism development, accessing the knowledge, technology and innovations resulting in sustainable tourism, quality livelihood, and sustainable ecological management of communities.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.2
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• pp.15-24
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• 2019

This study analyzes the effect of the capital structure of Korean manufacturing firms on default risk based on Moody's KMV option pricing model where the probability of default is obtained by measuring the distance to default as a covariant in logit model developed by Merton (1974). Based on the panel data of manufacturing firms, this study achieves its primary objective, using a fixed effect regression model and examines the effect of a firm's capital structure on default risk amongst publicly listed firms on Korea exchange during 2005-2016. Empirical results obtained suggest that the rise in short-term debt to assets leads to increase the risk of default whereas the increase in long-term debt to assets leads to decrease the default risk. The benefits of short-term debt financing over a short-term period fade out in the presence of information asymmetry. However, long-term debt financing overcomes the information asymmetry and enjoys the paybacks of tax advantage associated with long-term debt. Additionally, size, tangibility and interest coverage ratio are also the important determinants of default risk. Findings support the trade-off theory of capital structure and recommend the optimal use of long-term debt in a firm's capital structure.

• East Asian Journal of Business Economics (EAJBE)
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• v.9 no.2
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• pp.21-30
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• 2021

Purpose -The purpose of this paper is to advance the understanding of affective commitment in employees of Korean companies' subsidiaries in Mexico. Specifically, we study the moderating effects of cultural orientation on the relationship between perceived corporate social responsibility (CSR) and affective commitment among these Mexican employees. Research design and methodology - This study was designed to explore the impact of perceived CSR on affective commitment and the moderating roles of collectivism and power distance on the employer-employee relationship. We applied hierarchical regression to survey data collected from 296 employees working for Korean company subsidiaries in Mexico to examine the proposed hypotheses. Results - The results show a significant positive effect from perceived CSR on affective commitment. In addition, this study confirms a positive moderating effect from collectivism and a negative moderating impact from power distance on the relationship between perceived CSR and affective commitment. Conclusions - Drawing upon social identity theory, this study found that Mexican employees' perceptions of their company's CSR and their own cultural value orientations influence affective commitment to the organization. This study extends the understanding of perceived CSR and affective commitment, and particularly demonstrates that the relationship between perceived CSR and affective commitment is influenced by employee collectivistic and power distance orientation.