• Journal of Pharmaceutical Investigation
• /
• v.32 no.2
• /
• pp.87-93
• /
• 2002

This study is to enhance drug penetration via skin and investigate anti-inflammation effect following adoption of ultrasound. For this goal gel containing triamcinolone was prepared and the skin penetration rate and the change effects of blood plasma ingredients and serum enzyme were investigated. Using Franz type diffusion cell and the skin of hairless mouse, the permeation enhancing effect of ultrasound was tested. After the injury by direct trauma, the blood test was performed by measuring WBC, lymphocyte, and neutrophyl, and by analyzing CPK and LDH. The ultrasound transducer whose technical specification is geometric area(GA) $1.4\;cm^2$, effective radiation area(ERA) $0.8\;cm^2$, and beam non-uniformity ratio(BNR) 6.0 max was used. The influence of frequency having an effect on skin permeation rate was higher in the case of using 1MHz and continuous treatment. The temperature of receptor phase was not influenced in skin permeation by phonophoresis. Skin permeation increase attended by intensity of ultrasound, the permeation of triamcinolone was accelerated at $2.5\;w/cm^2\;than\;1.0\;w/cm^2$. Following muscle injury phonophoretic group the number of WBC, neutrophil and lympholyte were decreased significantly as compared with both control group and ultrasound group. The result of variation of serum CPK and LDH activity conformed to the phonophoretic effect as same pattern with the variation of WBC, neutrophil and lymphocyte.

• Archives of Pharmacal Research
• /
• v.27 no.11
• /
• pp.1177-1182
• /
• 2004

The effect of poly[2-methacryloyloxyethyl phosphorylcholine] (pMPC) on the skin permeation property was investigated by performing in vitro skin permeation study of a model drug, nicotinic acid (NA). Effect of pMPC polymer in donor solution on skin permeation rates was evaluated using side-by-side diffusion cells. Also, the structural alterations in the stratum corneum (SC), inter-lamellar bilayer (ILB) and dermis layers in pMPC-treated and -untreated skin sections were investigated with transmission electron microscopy (TEM). The permeation profile of NA without pMPC in donor solution showed biphasic mode: initial $1^{st} phase and 2^{nd}$ hydration phase. The sudden, more than 10-fold increase in flux from the initial steady state (43.5 $\mu g/cm^2$/hr) to the $2^{nd}$ hydration phase (457.3 $\mu g/cm^2$/hr) suggests the disruption of skin barrier function due to extensive hydration. The permeation profile of NA with 3% pMPC in the donor solution showed monophasic pattern: the steady state flux (10.9 $\mu g/cm^2$/hr) without abrupt increase of the flux. The degree of NA permeation rate decreased in a concentration-dependent manner of pMPC. TEM of skin equilibrated with water or 2% pMPC for 12 h showed that corneocytes are still cohesive and epidermis is tightly bound to dermis in 2% pMPC-treated skin, while wider separation between corneocytes and focal dilations in inter-cellular spaces were observed in water-treated skin. This result suggests that pMPC could protect the barrier property of the stratum corneum by preventing the disruption of ILB structure caused by extensive skin hydration during skin permeation study.

• The Journal of Korean Medicine
• /
• v.40 no.1
• /
• pp.34-45
• /
• 2019

Objectives : To maintain a healthy skin condition, the role of moisture in the stratum corneum is important. We use soap in our daily life, so we wanted to observe the changes of the skin moisture using herbal CP soap. Four kinds of herbal CP soaps were prepared and their effects on skin moisture were compared. Methods: We surveyed 39 students at A University to determine their subjective skin condition, lifestyle and washing habits. Then, a facial analysis test was performed. We made herbal CP soaps using Kyungohkgo, Hwangryunhaedoktang, Seosiokyongsan and Baeksoooh and distributed them to experiment participants. Prior to the experiment, their skin condition was checked and skin condition was assessed using Facial Diagnosis System three times in total. After the experiment, the change of skin was measured and analyzed. Results: As a result of examining the skin moisture according to the using of the herbal CP soap by the participants, the skin moisture was gradually increased compared with before use. The moisture content increased after 6 weeks of use compared to before using Seosiokyongsan, Hwangryunhaedoktang, Kyungohkgo CP soap compared to before use. But there was no significant difference between 3 weeks and 6 weeks of use compared to before use. As a result of using Baeksoo-oh CP soap, the skin moisture of the experimental participants was continuously increased. Conclusion: Natural CP soaps are believed to have a beneficial effect in increasing the moisture content of facial skin.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.48 no.3
• /
• pp.197-212
• /
• 2022

This study was conducted to empirically analyze the effects and interactions among beneficial bacteria, commensal bacteria, and acne bacteria, which are factors in the skin microbiomes, on detrimental bacteria by 289 people, who are 20 to 49 years old among Koreans. As a result of multiple regression models using bio big data of skin microbiomes, when the difference in skin microbiomes according to the sex and age of the subjects was controlled, the beneficial bacteria showed a negative (-) effect on the detrimental bacteria, while the commensal and acne bacteria showed a positive (+) effect. Particularly, the negative (-) effect of beneficial bacteria on detrimental bacteria was different through interaction with acne bacteria according to the level of commensal bacteria. These results demonstrate that the activation of beneficial bacteria inhibits detrimental bacteria, and the effect of skin microbiomes on detrimental bacteria is balanced with skin microbiomes through interaction with independent influence. Therefore, it is suggested that when studying skin microbiomes products to help the proliferation of beneficial bacteria and to create a skin environment that inhibits detrimental bacteria in the personalized cosmetics manufacturing industry, it is necessary to consider the independent effects and interactions among skin microbiome factors together.

• The Transactions of the Korean Institute of Electrical Engineers
• /
• v.36 no.12
• /
• pp.848-855
• /
• 1987

The currents in the rails of an electromagnetic railgun are concentrated in a near surface region. In order to understand this phenomenon, this paper deals with computation of the current distribution related to skin effect in a railgun. An analytical solution is obtained for a twodimensional model. It is found that current concentration at the interface between the rails and the armature is affected by the velocity, length and conductivity of the armature, that skin effect in the rails is affected by the relative velocity between the rails and the armature rather than other factors, and that skin depth in the rails is inversely proportional nearly to the square root of the velocity.

• Journal of the Korea Convergence Society
• /
• v.12 no.8
• /
• pp.309-315
• /
• 2021

Pycnogenol extracted from pine bark is a component with great antibacterial activity and antioxidant effect. It is applied as a natural anti-inflammatory agent with various medical effects including anti-inflammatory effects, regulation of blood pressure, regulation of the immune system, and inhibition of cancer cell growth. However, research related to cosmetics is limited. Therefore, in this study, the effect of Pycnogenol on the skin was studied through a clinical approach. Changes in skin condition were observed after using cosmetics with Pycnogenol and without Pycnogenol for 6 weeks for 10 clinicians in each group. We observed the effect of pore reduction, wrinkle reduction around eyes, a decrease of the number and angle of loose pores, and reduction of pigmentation. Therefore, cosmetics containing Pycnogenol have the effect of improving skin problems of aging skin.

• The Research Journal of the Costume Culture
• /
• v.21 no.5
• /
• pp.629-638
• /
• 2013

The purpose of this study is to predict skincare behavior from the perspective of theories about planned behaviors and a systematic structure for identifying influences on human behavior; Consequently, this study attempted to undertake a concrete analysis of influences on skin care behavior. The results showed that: an attempt was made to analyze structural equation modeling as to whether or not to apply Ajzen's theory of planned behavior to skin care behavior. This study found the possibility that the theory of planned behavior might be applicabled to the research model composed of skin care attitude, the norms of skin care, behavioral control on skin care, behavioral intentions of skin care, and skin care behavior at the appropriate level in their entirety. This study found that external control factors of skin care behavior had the highest effect on skin care behavior among other factors.

• Biomedical Science Letters
• /
• v.10 no.1
• /
• pp.49-54
• /
• 2004

The hair growth effect of the oriental medicine extract which is composed of Polygoni multiflori Radix, Angelica gigantis Radix and Lycii Fructus was studied biochemically and histologically. The study was conducted dividelly into three groups, control, propecia and oriental medicine extract and three groups were compared each other in skin androgen, testosterone (T) and dihydrotestosterone (DHT), content biochemically and the number of hair follicular unit and hair follicle histologically. The oriental medicine extract and propecia decreased skin DHT conetent and increased skin total (T+DHT) content compared with control. In transverse sections of skin specimens the oriental medicine extract and propecia increased total counts of follicular units and follicles compared with control. On the basis of the result, the oriental medicine extract has same hair growth effect as propecia and it is suggested that the oriental medicne extract is capable of a therapeutic agent of alopecia.

• Biomolecules & Therapeutics
• /
• v.19 no.1
• /
• pp.109-117
• /
• 2011

In this work, we have investigated the effect of polyoxyethylene alkyl ester nonionic surfactants on percutaneous permeation enhancement of a model drug, ketoprofen. We also investigated the mechanism involved in the enhancement using impedance and solubility measurement. Three groups of nonionic surfactants with different ethylene oxide content were studied. The permeation results showed that all surfactants enhanced the percutaneous absorption, irrespective of the molecular weight. The permeation results from PEG-45 monostearate (PEGMS45) were rather unexpected. Impedance and solubility results indicate that the mechanism involved in the enhancement of permeation by PEG-10 monooleate (PEGMO10) and PEGMS45 is rather different. The results from PEGMS45 suggest that it could be a potential candidate as a skin penetration enhancer with high molecular weight, which may poses less skin irritation and systemic side effect than the smaller surfactant molecules. Overall, this work provided some useful information on percutaneous transport enhancement and the mechanistic insights involved in skin permeation for these nonionic surfactants.

• Proceedings of the SCSK Conference
• /
• 2003.09a
• /
• pp.617-629
• /
• 2003

A recent development in cosmetics has been the pursuit of wrinkling in the skin. The cosmetics composed of anti-wrinkle agent stand out from the point of view of environmental contamination and pollution. Among them, Indole-3-acetic acid (IAA), studied with wrinkling pigmentation and swelling conditions in the area of the eye, showed clinically significant reduction in depth of lines during one month trial using skin treatment. But, IAA has shown some problems when used in cosmetic formulations, such as stability, permeability and toxicity. The results of the clinical examination were shown that its permeability and toxicity didn't matter. To increase the stability of IAA, antioxidants such as Licorice, ubiquinone, tocopherol, Baicalin, ferulic acid, BHT, ascorbic acid, sodium metabisulfite, and so on were employed in cosmetic formulations. Our main purpose is the study for the stability efficiency and effect of each other of cream formulations containing optimal dosage antioxidants (o/w type emulsion), This study evaluated wrinkle reduction effect of IAA, which is used in cosmetics.