Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Influencing Factors and Interactions among the Skin Microbiomes in Affecting Detrimental Bacteria

피부 마이크로바이옴의 요인과 상호작용이 유해균에 미치는 영향에 대한 연구

  • Lim, Hye-Sung (R&D Institute, Shebah Biotech Incorporated) ;
  • Lim, Young-Seok (Department of Bio-Health Convergence, Kangwon National University) ;
  • Jo, Changik (School of Global Studies/Multidisciplinary Studies, Hallym University)
  • 임혜성 ((주)세바바이오텍 R&D 연구소) ;
  • 임영석 (강원대학교 바이오헬스융합학과) ;
  • 조창익 (한림대학교 글로벌학부/융합인재학부)
  • Received : 2022.07.12
  • Accepted : 2022.09.06
  • Published : 2022.09.30
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Abstract

This study was conducted to empirically analyze the effects and interactions among beneficial bacteria, commensal bacteria, and acne bacteria, which are factors in the skin microbiomes, on detrimental bacteria by 289 people, who are 20 to 49 years old among Koreans. As a result of multiple regression models using bio big data of skin microbiomes, when the difference in skin microbiomes according to the sex and age of the subjects was controlled, the beneficial bacteria showed a negative (-) effect on the detrimental bacteria, while the commensal and acne bacteria showed a positive (+) effect. Particularly, the negative (-) effect of beneficial bacteria on detrimental bacteria was different through interaction with acne bacteria according to the level of commensal bacteria. These results demonstrate that the activation of beneficial bacteria inhibits detrimental bacteria, and the effect of skin microbiomes on detrimental bacteria is balanced with skin microbiomes through interaction with independent influence. Therefore, it is suggested that when studying skin microbiomes products to help the proliferation of beneficial bacteria and to create a skin environment that inhibits detrimental bacteria in the personalized cosmetics manufacturing industry, it is necessary to consider the independent effects and interactions among skin microbiome factors together.

본 연구는 우리나라 국민 20 ~ 49 세 연령군 가운데 289 명을 대상으로 피부 마이크로바이옴의 요인들인 유익균, 상재균, 여드름균이 유해균에 미치는 영향과 상호작용을 실증적으로 분석하기 위해 수행되었다. 피부 마이크로바이옴의 바이오 빅데이타를 활용하여 다중회귀모형으로 분석한 결과, 연구대상의 성별과 연령에 따른 피부 마이크로바이옴의 차이를 통제한 경우, 유익균은 유해균에 부(-)의 영향을 나타내었고, 상재균과 여드름균은 정(+)의 영향을 나타냈다. 특히 유익균이 유해균에 미치는 부(-)의 영향은 상재균의 수준에 따라 여드름균과의 상호작용을 통해 다르게 나타났다. 이러한 결과는 유익균의 활성화가 유해균을 억제하며, 피부 마이크로바이옴이 유해균에 미치는 영향은 독립적인 영향과 함께 상호작용을 통해서 피부 마이크로바이옴의 균형을 이루고 있음을 실증적으로 검증한 것이다. 따라서 개인 맞춤형 화장품 제조산업에서 유익균의 증식을 돕고 유해균을 억제하는 피부 환경을 조성하기 위한 피부 마이크로바이옴 제품을 연구할 때, 반드시 피부 마이크로바이옴 요인들의 독립적인 영향과 상호작용을 함께 고려해야 함을 시사한다.

Keywords

References

  1. J. G. Choi, S. S. Park S. J. Luy, C. Y. Luy, J. H. Lee, G. E. Woo, Y. J. Na, J. A. Lee and H. D. Lee, Statistics on technology patents related to the 4th industrial revolution, The Convergence Technology Examination Bureau in Korean Intellectual Property Office (2022). Accessed: April. 25, 2022. [Online] Available: https://www.korea.kr/archive/expDocView.do?docId=39228
  2. H. J. Do, COSMAX, Discovery of the 2nd generation skin microbiome, The Herald Economy (2022). Accessed: May. 5, 2022. [Online] Available: http://news.heraldcorp.com/view.php?ud=20220324000581
  3. G. S. Kim and S. M. Kang, The skin safety and effects of the fermented broth of Lactobacillus rhamnosus for improving the neck skin, J. Kor. Soc. Cosm., 23(1), 101 (2017).
  4. M. K. Song, Sangyoyeon introduces microbiome R&D trends, The Today Energy (2022). Accessed: April. 20, 2022. [Online] Available: http://www.todayenergy.kr/news/articleView.html?idxno=246864&lang=en
  5. S. K. Jeong, Skin microbiome for cosmetic application, The Journal of Skin Barrier Research, 21(1), 30 (2019).
  6. Ministry of Food and Drug Safety. Research and analysis of global market trends in customized cosmetics (2022). Accessed: May. 11, 2022. [Online] Available: https://mfds.go.kr/files/upload/etc/e-Book/guideLine_6/index.html
  7. M. H. Kim, D. I. Suh, S. Y. Lee, Y. K. Kim, Y. J. Cho, and S. H. Cho, Microbiome research in food allergy and atopic dermatitis, Allergy Asthma Respir. Dis., 4(6), 389 (2016). https://doi.org/10.4168/aard.2016.4.6.389
  8. K. H. Jeong, Skin and intestinal microbiome in psoriasis, J. Kor. Soc. Psor., 16(1), 8 (2019).
  9. K. S. Cho, Research trends and prospects of human microbiome, Gwang-Jang, 221, 255 (2021).
  10. E. A. Grice and J. A. Segre, The skin microbiome, Nat. Rev. Microbiol., 9, 244 (2011). https://doi.org/10.1038/nrmicro2537
  11. B. Y. Kim, Microbiome research and industrial utilization, BT News, 28(2), 16 (2018).
  12. K. Skowron, J. Bauza-Kaszewska, Z. Kraszewska, N. Wiktorczyk-Kapischke, K. Grudlewska-Buda, J. Kwiecinska-Pirog, E. Walecka-Zacharska, L. Radtke, and E. Gospodarek-Komkowska, Human skin microbiome: impact of intrinsic and extrinsic factors on skin microbiota, Microorganisms, 9(3), 543 (2021). https://doi.org/10.3390/microorganisms9030543
  13. S. Zhang and E. Duan, Fighting against skin aging: the way from bench to bedside, Cell Transplantation, 27(5), 729 (2018). https://doi.org/10.1177/0963689717725755
  14. P. B. Eckburg, E. M. Bik, C. N. Bernstein, E. Purdom, L. Dethlefsen, M. Sargent, S. R. Gill, K. E. Nelson, and D. A. Relman, Diversity of the human intestinal microbial flora, Science, 308(5728), 1635 (2005). https://doi.org/10.1126/science.1110591
  15. E. A. Grice, H. H. Kong, G. Renaud, A. C. Young. NISC Comparative Sequencing Program, G. G. Bouffard, R. W. Blakesley, T. G. Wolfsberg, M. L. Turner, and J. A. Segre, A diversity profile of the human skin microbiome, Genome Res, 18(7), 1043 (2008). https://doi.org/10.1101/gr.075549.107
  16. J. C. Clemente, E. C. Pehrsson, M. J. Blaser, K. Sandhu, Z. Gao, B. Wang, M. Magris, G. Hidalgo, M. Contreras, O. Noya-Alarcon, O. Lander, J. Mcdonald, M. Cox, J. Walter, P. L. Oh, J. F. Ruiz, S. Rodriguez, N. Shen, S. J. Song, J. Metcalf, R. Knight, G. Dantas, and M. G. Dominguez-Bello, The microbiome of uncontacted Amerindians, Sci. Adv., 1(3), e1500183 (2015). https://doi.org/10.1126/sciadv.1500183
  17. S. M. Choi, S. H. Cho, and H. N. Yi, Human microbiome studies in Korea, Allergy Asthma Respir. Dis., 4(5), 311 (2016). https://doi.org/10.4168/aard.2016.4.5.311
  18. G. S. Kim and S. M. Kang, The effects of the fermented broth of Lactobacillus rhamnosus for improving the facial skin of middle-aged women as the skin barrier-recovering cosmetic material, J. Kor. Soc. Cosm., 22(5), 1004 (2016).
  19. M. H. Leung, D. Wilkins, and P. K. Lee, Insights into the pan-microbiome: skin microbial communities of Chinese individuals differ from other racial groups, Sci. Rep., 5(11845), 1 (2021).
  20. M. H. Kim, D. I. Suh, S. Y. Lee, Y. K. Kim, Y. J. Cho, and S. H. Cho, Microbiome research in food allergy and atopic dermatitis, Allergy Asthma Respir. Dis., 4(6), 389 (2016). https://doi.org/10.4168/aard.2016.4.6.389
  21. H. Kim, K. Myoung, H. G. Lee, E. J. Choi, T. Park, and S. An, Lactobacillus plantarum APsulloc 331261 fermented products as potential skin microbial modulation cosmetic ingredients, J. Soc. Cosmet. Sci. Korea, 46(1), 23 (2020). https://doi.org/10.15230/SCSK.2020.46.1.23
  22. A. L. Byrd, Y. Belkaid, and J. A. Segre, The human skin microbiome, Nat. Rev. Microbiol., 16, 143 (2018). https://doi.org/10.1038/nrmicro.2017.157
  23. P. Y. Ong, T. Ohtake, C. Brandt, I. Strickland, M. Boguniewicz, T. Ganz, R. L. Gallo, and D. Y. M. Leung, Endogenous antimicrobial peptides and skin infections in atopic dermatitis, N. Engl. J. Med., 347(15), 1151 (2002). https://doi.org/10.1056/NEJMoa021481
  24. H. H. Kong, J. Oh, C. Deming, S. Conlan, E. A. Grice, M. A. Beatson, E. Nomicos, E. C. Polley, H. D. Komarow, NISC Comparative Sequence Program, P. R. Murray, M. L. Turner, and J. A. Segre, Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis, Genome Res., 22(5), 850 (2012). https://doi.org/10.1101/gr.131029.111
  25. P. L. J. M. Zeeuwen, M. Kleerebezem, H. M. Timmerman, and J. Schalkwijk, Microbiome and skin diseases, Curent Opinion in Allergy and Clinical Immunology, 13(5), 514 (2013). https://doi.org/10.1097/ACI.0b013e328364ebeb
  26. K. Findley, J. Oh, J. Yang, S. Conlan, C. Deming, J. A. Meyer, D. Schoenfeld, E. Nomicos, M. Park, NISC Comparative Sequencing Program, H. H. Kong, and J. A. Segre, Topographic diversity of fungal and bacterial communities in human skin, Nature, 498(7454), 367 (2013). https://doi.org/10.1038/nature12171
  27. P. U. Giacomoni, T. Mammone, and M. Teri, Genderlinked differences in human skin, J. Dermatol. Sci., 55(3), 144 (2009). https://doi.org/10.1016/j.jdermsci.2009.06.001
  28. R. Juge, P. Rouaud-Tinguely, J. Breugnot, K. Servaes, C. Grimaldi, M. P. Roth, H. Coppin, and B. Closs, Shift in skin microbiota of Western European women across aging, J. App. Microbiol., 125(3), 907 (2018). https://doi.org/10.1111/jam.13929
  29. Y. J. Park and H. K. Lee, The role of skin and orogenital microbiota in protective immunity and chronic immune-mediated inflammatory disease, Front. Immunol., 8(1955), 1 (2018).
  30. M. Kim, T. Park, J. I. Yun, H. W. Lim, N. R. Han, and S. T. Lee, Investigation of age-related changes in the skin microbiome of Korean women, Microorganisms, 8(10), 1581 (2020). https://doi.org/10.3390/microorganisms8101581
  31. M. R. Williams and R. L. Gallo, Evidence that human skin microbiome dysbiosis promotes atopic dermatitis, J. Invest. Dermatol., 137(12), 2460 (2017). https://doi.org/10.1016/j.jid.2017.09.010
  32. S. M. Han, K. G. Lee, J. H. Yeo, W. T. Kim, and K. K. Park, Antimicrobial property of honeybee (Apis mellifera L.) venom against Propionibacterium acnes and aerobic skin flora, Kor. J. Pharmacogn., 40(3), 173 (2009).
  33. N. Shibagaki, W. Suda, C. Clavaud, P. Bastien, L. Takayasu, E. Iioka, R. Kurokawa, N. Yamashita, Y. Hattori, C. Shindo, L. Breton, and M. Hattori, Aging-related changes in the diversity of women's skin microbiomes associated with oral bacteria, Sci. Rep., 7(10567), 1 (2017). https://doi.org/10.1038/s41598-016-0028-x
  34. H. J. Kim, J. J. Kim, N. R. Myeong, T. Kim, D. Kim, S. An, H. Kim, T. Park, S. I. Jang, H. Y. Jae, I. Kwack, and J. S. Woo, Segregation of age-related skin microbiome characteristics by functionality, Sci. Rep., 9(16748), 1 (2019). https://doi.org/10.1038/s41598-018-37186-2
  35. S. Ying, D. Zeng, L. Chi, Y. Tan, C. Galzote, C. Cardona, S. Lax, J. Gilbert, and Z. Quan, The influence of age and gender on skin-associated microbial communities in urban and rural human populations, PloS one, 10(10), e0141842 (2015). https://doi.org/10.1371/journal.pone.0141842
  36. J. Y. Yu, S. H. Park, I. A. Hwang, S. J. Jo, C. H. Heo, S. U. Yun, and G. C. Park, A clinical study on the effect of a cream containing Ramulus mori extract and tea tree oil on acne vulgaris and aerobic skin flora, K. J. Dermatol., 41(9), 1136 (2003).
  37. C. von Eiff, K. Becker, K. Machka, H. Stammer, and G. Peters, Nasal carriage as a source of Staphylococcus aureus bacteremia, N. Engl. J. Med., 344(1), 11 (2001). https://doi.org/10.1056/NEJM200101043440102
  38. C. Weidenmaier, C. Goerke, and C. Wolz, Staphylococcus aureus determinants for nasal colonization, Trend. Microbiol., 20(5), 243 (2012) https://doi.org/10.1016/j.tim.2012.03.004