Browse > Article

Effect of Polyoxyethylene Alkyl Esters on Permeation Enhancement and Impedance of Skin  

Kim, Hee-Sun (College of Pharmacy, Sookmyung Women's University)
Oh, Seaung-Youl (College of Pharmacy, Sookmyung Women's University)
Publication Information
Biomolecules & Therapeutics / v.19, no.1, 2011 , pp. 109-117 More about this Journal
In this work, we have investigated the effect of polyoxyethylene alkyl ester nonionic surfactants on percutaneous permeation enhancement of a model drug, ketoprofen. We also investigated the mechanism involved in the enhancement using impedance and solubility measurement. Three groups of nonionic surfactants with different ethylene oxide content were studied. The permeation results showed that all surfactants enhanced the percutaneous absorption, irrespective of the molecular weight. The permeation results from PEG-45 monostearate (PEGMS45) were rather unexpected. Impedance and solubility results indicate that the mechanism involved in the enhancement of permeation by PEG-10 monooleate (PEGMO10) and PEGMS45 is rather different. The results from PEGMS45 suggest that it could be a potential candidate as a skin penetration enhancer with high molecular weight, which may poses less skin irritation and systemic side effect than the smaller surfactant molecules. Overall, this work provided some useful information on percutaneous transport enhancement and the mechanistic insights involved in skin permeation for these nonionic surfactants.
Polyoxyethylene alkyl ester; Permeation; Impedance; Capacitance; Solubility;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Rastogi, S. K. and Singh, J. (2001) Lipid extraction and iontophoretic transport of leuprolide acetate through porcine epidermis. Int. J. Pharm. 215, 241-249.   DOI
2 Subedi, R. K., Oh, S. Y., Chun, M. K. and Choi, H. K. (2010) Recent advances in transdermal drug delivery. Arch. Pharm. Res. 33, 339-351.   DOI
3 Suh, H. and Jun, H. W. (1996) Effectiveness and mode of action of isopropyl myristate as a permeation enhancer for naproxen through shed snake skin. J. Pharm. Pharmacol. 48, 812-816.   DOI   ScienceOn
4 Trommer, H. and Neubert, R. H. (2006) Overcoming the stratum corneum: the modulation of skin penetration. A review. Skin Pharmacol. Physiol. 19, 106-121.   DOI
5 Ward, A. J. I. and Osborne, D. W. (1993) Hydrotropy and penetration enhancement. In Pharmaceutical Skin Penetration Enhancement (K. A. Walters, J. Hadgraft, Eds.), pp. 365-388. Marcel Dekker Inc, New York.
6 Yamamoto, T. and Yamamoto, Y. (1976) Electrical Properties of the epidermal stratum corneum. Med. Biol. Eng. 14, 151-158.   DOI
7 Yu, J., Chien, T. and Chien, Y. W. (1991) Transdermal Dual-Controlled Delivery of Testosterone and Estradiol: (II) Enhanced Skin Permeability and Membrane-Moderated Delivery. Drug Dev. Ind. Pharm. 17, 1905.   DOI
8 Elias, P. M., Goerke, J. and Friend, D. S. (1977) Mammalian epidermal barrier layer lipids: composition and influence on structure. J. Invest. Dermatol. 69, 535-546.   DOI
9 Ibrahim, S. A. and Li, S. K. (2010) Chemical enhancer solubility in human stratum corneum lipids and enhancer mechanism of action on stratum corneum lipid domain. Int. J. Pharm. 383, 89-98.   DOI
10 Jiang, S. J., Hwang, S. M., Choi, E. H., Elias, P. M., Ahn, S. K. and Lee, S. H. (2000) Structural and functional effects of oleic acid and iontophoresis on hairless mouse stratum corneum. J. Invest. Dermatol. 114, 64-70.   DOI
11 Oh, S. Y., Leung, L., Bommannan, D., Guy, R. H. and Potts, R. O. (1993) Effect of current, ionic strength and temperature on the electrical properties of skin. J. Control. Rel. 27, 115-125.   DOI
12 Kandimalla, K., Kanikkannan, N., Andega, S. and Singh, M. (1999) Effect of fatty acids on the permeation of melatonin across rat and pig skin in-vitro and on the transepidermal water loss in rats in-vivo. J. Pharm. Pharmacol. 51, 783-790.   DOI
13 Kigasawa, K., Kajimoto, K., Hama, S., Saito, A., Kanamura, K. and Kogure, K. (2010) Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat. Int. J. Pharm. 383, 157-160.   DOI
14 Oh, S. Y. and Guy, R. H. (1995) Effects of iontophoresis on the electrical properties of human skin in vivo. Int. J. Pharm. 124, 137-142.   DOI
15 Ongpipattanakul, B., Burnette, R. R., Potts, R. O. and Francoeur, M. L. (1991) Evidence that oleic acid exists in a separate phase within stratum corneum lipids. Pharm. Res. 8, 350-354.   DOI
16 Park, E. S., Chang, S. Y., Hahn, M. and Chi, S. C. (2000) Enhancing effect of polyoxyethylene alkyl ethers on the skin permeation of ibuprofen. Int. J. Pharm. 209, 109-119.   DOI
17 Akimoto, T., Kawahara, K., Nagase, Y. and Aoyagi, T. (2001) Polymeric transdermal drug penetration enhancer: The enhancing effect of oligodimethylsiloxane containing a glucopyranosyl end group. J. Control. Rel. 77, 49-57.   DOI
18 Aoyagi, T., Terashima, O., Nagase, Y. and Matsui, K. (1991) Preparation of a polymer containing hexadecylpyridinium bromide groups and its utilization as a transdermal drug penetration enhancer. Polym. 32, 2106-2111.   DOI
19 Aungst, B. J., Rogers, N. J. and Shefter, E. (1986) Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides. Int. J. Pharm. 33, 225-234.   DOI
20 Aungst, B. J. (1989) Structure/effect studies of fatty acid Isomers as skin penetration enhancers and skin irritants. Pharm. Res. 6, 244-247.   DOI
21 Barany, E., Lindberg, M. and Loden, M. (2000) Unexpected skin barrier infl uence from nonionic emulsifiers. Int. J. Pharm. 195, 189-195.   DOI
22 Benson, H. A. (2005). Transdermal drug delivery: penetration enhancement techniques. Curr. Drug Deliv. 2, 23-33.   DOI
23 Burnette, R. R. and Bagniefski, T. M. (1988) Influence of constant current iontophoresis on the impedance and passive Na+ permeability of excised nude mouse skin. J. Pharm. Sci. 77, 492-497.   DOI
24 Cho, Y. A. and Gwak, H. S. (2004) Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. Drug Dev. Ind. Pharm. 30, 557-564.   DOI
25 Cullander, C. and Guy, R. H. (1991) Sites of iontophoretic current flow into the skin: identification and characterization with the vibrating probe electrode. J. Invest. Dermatol. 97, 55-64.   DOI