• Title/Summary/Keyword: the liver-cold

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The Oriental and Occidental bibliographic Study of Psoriasis (乾癬에 對한 東.西醫 文獻的 硏究)

  • Kim, Nam-Kwen;Hwang, Chung-yeon;Lim, Gye-sang
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.12 no.1
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    • pp.154-178
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    • 1999
  • Psoriasis is the recurrent disease of skin and till now its mechanism, pathogenesis and treatment are not clearly discovered. So, like these papers, we must investigate more safety and effective treatment of psoriasis. And I obtained the following condusions from the Oriental and Occidental bibliographic investigation. 1. In Oriental medicine. Baikbi, Pungsun, Eunselbyong, Songpisun, Baikselpung were the other names of Psoriasis. 2. In Occidental medicine, genetic factors, aggravation and inducible factors, biochemical factors, immunologic factors, disorder of epidermal kinetics, vascular malformation of dermis were cosidered to the pathogenic factors of psoriasis. 3. In Oriental medicine, the pathogenic factors of psoriasis were divided two parts. One is exogenous pathogenic factors which including the blood-heat, blood dryness, blood stasis, deficiency of liver and kidney, inharmony of impulsive and appointed pulsation, deficiency of blood. The other is exogenous pathogenic factors which including the wind-evil, wind-wetness, wind-heat, wind-cold, wetness-heat, cold-wetness, heat-evil. 4. In Occidental medicine, external applicative medicine, internal medicine, ultraviolet therapy, ultraviolet - external applicative medicine compound therapy and etc. were used the therapy of psoriasis. 5. In Oriental medicine, clean away heat and cooling blood, aliment the blood and moisturize, activating blood and expelling blood stasis, harmonize and invigorate the liver and kidney, invigorate the kidney, aliment the blood and moisturize the skin, aliment the blood and expelling the wind, expelling the wind and wetness, clean away heat and expelling wind, expelling the wind and scatter the cold, clean away heat and expelling the wetness, heat up the meridian and scatter the cold, clean away heat and remove the toxin and etc. were used the method of internal therapy of psoriasis. 6. Until Qing dynasty, wind expelling effective prescriptions like Bangpungtongsungsan, Sopungsan. Supungsunkisan and etc. were used and recently Yanghyelgeupungtang, Hwalhyelgeupungtang, Samultanggagam and etc. were used the internal therapy of psoriasis. 7. In the external therapy of psoriasis, Yuhonggo, Pungyugo, Sekryupiyeongo were used the plaster therapy and Folium Rerillae, Camphora, Fructus, Xanthii, Herba Spirodelae compound prescription were used the cleansing therapy, Okgisan, Chiunsan, Galmyogo, Hobunsan, Muisan, Madugo, Jeyugohengin were used the rubbing skin therapy. Rangdok Radix Aconiti, Bijeonilchoalkwang were used the attaching therapy, the extract of Rhizoma Et Radix Veratri was used the spreading pouder therapy. 8. In the acupuncture therapy of psoriasis, the Jelgol, chok Samni(S36), Kansa(P5), Haegye(S41), Wijung(B40) and etc. were used the acupuncture point, and the angle of helix incision threapy that disinfect and cut the angle of helix and plaster the Semen Glycine and Squama Manitis were used.

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Effect of ciglitazone on adipogenic transdifferentiation of bovine skeletal muscle satellite cells

  • Zhang, Junfang;Li, Qiang;Yan, Yan;Sun, Bin;Wang, Ying;Tang, Lin;Wang, Enze;Yu Jia;Nogoy, Kim Margarette Corpuz;Li, Xiangzi;Choi, Seong-Ho
    • Journal of Animal Science and Technology
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    • v.63 no.4
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    • pp.934-953
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    • 2021
  • Ciglitazone is a member of the thiazolidinedione family, and specifically binds to peroxisome proliferator-activated receptor-γ (PPARγ), thereby promoting adipocyte differentiation. We hypothesized that ciglitazone as a PPARγ ligand in the absence of an adipocyte differentiation cocktail would increase adiponectin and adipogenic gene expression in bovine satellite cells (BSC). Muscle-derived BSCs were isolated from six, 18-month-old Yanbian Yellow Cattle. The BSC were cultured for 96 h in differentiation medium containing 5 µM ciglitazone (CL), 10 µM ciglitazone (CM), or 20 µM ciglitazone (CH). Control (CON) BSC were cultured only in a differentiation medium (containing 2% horse serum). The presence of myogenin, desmin, and paired box 7 (Pax7) proteins was confirmed in the BSC by immunofluorescence staining. The CL, CM, and CH treatments produced higher concentrations of triacylglycerol and lipid droplet accumulation in myotubes than those of the CON treatment. Ciglitazone treatments significantly increased the relative expression of PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα), C/EBPβ, fatty acid synthase, stearoyl-CoA desaturase, and perilipin 2. Ciglitazone treatments increased gene expression of Pax3 and Pax7 and decreased expression of myogenic differentiation-1, myogenin, myogenic regulatory factor-5, and myogenin-4 (p < 0.01). Adiponectin concentration caused by ciglitazone treatments was significantly greater than CON (p < 0.01). RNA sequencing showed that 281 differentially expressed genes (DEGs) were found in the treatments of ciglitazone. DEGs gene ontology (GO) analysis showed that the top 10 GO enrichment significantly changed the biological processes such as protein trimerization, negative regulation of cell proliferation, adipocytes differentiation, and cellular response to external stimulus. Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that DEGs were involved in the p53 signaling pathway, PPAR signaling pathway, biosynthesis of amino acids, tumor necrosis factor signaling pathway, non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, and Wnt signaling pathway. These results indicate that ciglitazone acts as PPARγ agonist, effectively increases the adiponectin concentration and adipogenic gene expression, and stimulates the conversion of BSC to adipocyte-like cells in the absence of adipocyte differentiation cocktail.

A study on the type of Bi(肥) and Su(痩) of Body in 'Yellow Emperior's Nei-Ching' (${\ll}$내경(內徑)${\gg}$을 중심(中心) 한 체형(體型)의 비수(肥痩)에 대(對)한 고찰(考察))

  • Chun, Tae Kang;Hong, Won Sik
    • Journal of Korean Medical classics
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    • v.6
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    • pp.176-188
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    • 1993
  • After studing on the type of Bi(肥) and Su(痩) of Body in 'Yellow Emperior's Nei-Ching', I reached the following conclusions; 1. The specific charactor of bi(肥) and su(痩) were explained in table 1. 2. The specific charactor of gi(脂), ko(膏) and youk(肉) were explaned in table 2. 3. Obserbing the type of bi(肥) and su(痩) by the view of YinYang(陰陽), bi(肥) belongs to Yin(陰) and su(痩) belongs to Yang(陽). Also the each of bi(肥) and su(痩) could obserbed by the view of YinYang(陰陽). The type of su(痩) easily becomes to yanghea(陽虛) because chi(氣) easely becomes to exhaust also easely becomes to yinhea(陰虛) because blood(血) easely becomes to exhaust. So the outer of body is cold, the inner of body is hot. The type of bi(肥) easely causes YinYang(陰陽) to exceed because blood(血) easely becomes to black and turbid(血黑以濁), chi(氣) easely becomes to rough and slow(氣澁以遲). So the outer of body is hot, the iner of body is cold 4. Obserbing the type of bi(肥) and su(痩) by the view of viscera, in view of upper and lower(上下觀點) su(痩) is yang(陽) so heart and lung belongs to su(痩) bi(肥) is yin(陰) so liver and kidney belongs In bi(肥). in view of inner and outer(內外觀點) su(痩) is inner(內) so heart 3I1d liver belongs In su(痩) bi(肥) is outer(外) so lung and kidney belongs to bi(肥). 5. Obserbing the type of bi(肥) and su(痩) by the view of body constitution(體質), partially body constitution was divided into gi(脂), ko(膏) and youk(肉), entirely there was OhtaeinLon(五態人論) and four constitutional medicine(四象醫學) I thing that taeyangin(太陽人) and soyangin(少陽人) belong to su(痩), taeyinin(太陰人) and soyinin(少陰人) belong to bi(肥).

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Clinical Study on the Change of Yangdorak and the Clinical Symptoms in Women Who Work in Three Shifts and During the Day (3교대 근무여성과 주간 근무여성의 양도락상의 변화와 임상증상의 비교 고찰)

  • Jeong Jae Sook;Hwang Jeong Seon;Cho Yeong Do;Kim Chul Soo;Lim Sung Min;Kim Hyung Jun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.3
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    • pp.930-934
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    • 2004
  • The purpose of this research is to evaluate the change of Yangdorak in women who work in three shifts and during the day. In this research, seventy women who work during the day and thirty women who work in three shifts, all of whom are working at Woo shin hyang Oriental Hospital and Kang dong gu Office, were the two subjects for it. We evaluated and compared the Yangdorak appeared in two groups and studied the relations with clinical symptoms between the two. In Yangdorak, the women who work in three shifts were evaluated low numerical value in liver meridian, heart meridian, kidney meridian compared with the women who work during the day. Based on the results above, we can state that the women who work in three shifts suffer from severe dysmenorrhea, insomnia, cold hypersensitivity.

A Case Study of a Taeeumin Patient Treated with Cheongsimyeonja-tang Who was Misrecognized as Wiwansuhan-pyohan Disease (태음인(太陰人) 위완한증(胃脘寒證)으로 오인한 청심연자탕증(心蓮子湯證) 환자 치험1례)

  • Lee, Jae-Wook;Hur, Han-Sol;Cho, Hey-Won;Lim, Eun-Chul
    • Journal of Sasang Constitutional Medicine
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    • v.29 no.1
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    • pp.59-71
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    • 2017
  • Objectives It is important to decide if the patient is belong to cold syndrome or heat syndrome in Sasang Constitutional Medicine. The purpose of this study is to report some proof to determine cold and heat syndrome and characteristic of the patient who can be treated with Cheongsimyeonja-tang. Methods To evaluate the results of this treatment, muscular symptom was assessed by Visual Analogue Scale(VAS). The patient's general condition such as urinary and fecal discomfort is assessed by the progress notes. Results The patient did not improved when she was treated with Choweseuncheung-tang. But when she was treated with Cheongsimyeonja-tang, she got improved with not only her main problem such as muscular symptom, but also general condition such as indigestion, urinary & fecal discomfort and menopausal symptom. Conclusion This study suggests that number of defecation per day also can be the clue to decide heat or cold syndrome not only appearance of defecation. And the patients who can be treated by Cheongsimyeonja-tang is different from the patients who can be treated by Yeoldahansotang in the color of their face, personality and edema.

The effect of intermittent feeding and cold water on performance and carcass traits of broilers reared under daily heat stress

  • Erensoy, Kadir;Noubandiguim, Moise;Sarica, Musa;Aslan, Resul
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.12
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    • pp.2031-2038
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    • 2020
  • Objective: This study aimed to determine the effect of intermittent feeding and cold water on performance and carcass traits in broiler chickens between 4 to 6 wk of age exposed to daily high temperature. Methods: Broilers were assigned to four treatment groups according to a 2×2 factorial design between 22 to 42 d of age (80 broilers per treatment, 4 replications). Broilers were divided into two main groups as feeding type (ad-libitum [AL] and intermittent [IF] for 6 h daily) and sub-groups as water temperature (normal [NW], 24.9℃ and cold [CW], 16.4℃). Heat treatment was applied between 11.00 to 17.00 h daily between 22 to 42 d of age. Results: Live weight at 6th wk was not affected by feeding type and water temperature, but the live weight was significantly higher in IF chickens at the 5th wk (p<0.05). Average weekly gain of IF broiler chickens were higher compared to AL group at 4, 5, and 6 wk of age (p< 0.05). Although feeding type did not affect feed intake in 4 and 5th wk, feed intake was higher in IF chickens at 6th wk (p<0.01). In addition, feeding type and water temperature did not affect feed conversion ratio and interactions were not significant (p>0.05). Water temperature had no significant effect on heart, liver, gizzard, and abdominal fat percentages (p>0.05). Conclusion: It is concluded that IF increased the average weekly gain in chickens reared under daily heat stress for 6 h between 22 to 42 d of age. IF in hot environmental conditions slightly increased performance without adversely affecting health, welfare, and physiological traits, whereas CW implementation had no significant effect on performance. It can also be said that IF suppresses a sudden increase in body temperature depending on age and live weight.

Pathogenesis Study of Oriental OB & GY Questionnaires (한방부인과 진단용 설문지의 병기 연구)

  • Lee In Sun;Jean Ran Hee;Cha Hye Suk;Bae Kyung Mi;Kim Mi Jin;Lee Yong Tae;Ji Gyu Yang;Kim Jong Won
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.2
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    • pp.401-407
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    • 2004
  • Purpose : This study investigated reliability of Oriental DB & GY(obstetrics & gynecology) Questionnaires's items which was used by Dong-Eui OB & GY through analysis of oriental OB & GY books. Method : This study investigated differentiation of syndrome through analysis of oriental OB & GY book's. Result: This study investigated differentiation of syndrome through analysis of oriental OB & GY disease and pathogenesis. This study's pathogenesis was such that deficiency of Ki, deficiency of blood, stagnation of Ki, stagnated blood, deficiency of Yang, deficiency of Um, cold syndrome, heat syndrome, dampness, dryness, phlegm, kidney, liver, heart, spleen, wind, lung. We except lung from Questionnaires's pathogenesis because it is stuck for importance. We except wind from Questionnaires's pathogenesis because it is stuck for preguence. Oriental OB & GY Questionnaires's pathogenesis consist of 15 items such that deficiency of Ki, deficiency of blood, stagnation of Ki, stagnated blood, deficiency of Yang, deficiency of Um, cold syndrome, heat syndrome, dampness, dryness, phlegm, kidney, liver, heart, spleen. Oriental OB & GY Questionnaires construct pathogenesis's question and guide post through we examined it's reasonableness.

A Suggestion on the Action Mechanisms of Acupuncture Treatment for Controlling Chemotherapy-Induced Peripheral Neuropathy

  • Seo, Hyun-sik;Son, Chang-gyu;Lee, Nam-hun;Cho, Jung-hyo
    • The Journal of Korean Medicine
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    • v.41 no.4
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    • pp.88-99
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    • 2020
  • Objectives: The purpose of this study is to investigate the mechanism of acupuncture for treating chemotherapy-induced peripheral neuropathy. Methods: Based on domestic and international papers reported until October 2020, experimental papers on "chemotherapy induced peripheral neuropathy", "mechanism", and "acupuncture" were set up to identify the mechanisms of chemotherapy induced peripheral neuropathy. A total of seven papers were selected and searched: one pilot paper for people and six experimental papers for rats. Results: In the pilot paper studied by Bao, T., the effect of EA was demonstrated but no significant results were produced for the mechanism. Moon et al. derived the association between EA and plasma 𝛽-endorphin in rat experimental studies on oxalilatin-induced cold hypersensitivity. Meng et al. found relevance to 𝜇, 𝛿, and 𝛿 opioid through EA stimulation in paclitaxel-induced peripheral neuropathy. Lee et al. studied the relationship between EA and muscarin and 5-HT in rat experiments on oxaliplatin-induced coldness, associated with 5-HT and EA, especially with 5-HT3 receptors. Choi et al. revealed the association of adrenaline and opioid acting on 𝛼2- and 𝛽 adrenaline receptors with EA in rat experiments on paclitaxel-induced neuralgia. In rat experiments on oxaliplatin-induced neuralgia reported by Lee, 𝛽-endorphin and encephalin were studied to be mediated by EA. Zhang, T. et al. revealed in the paclitaxel induced rat experiment that EA activates 5-HT. Conclusion: It is inferred that peripheral neuropathy caused by anticancer drugs can be reduced by activating the action of 5-HT, 𝛽-endorphin, and encephalin through the descending inhibitory pathways. cell differentiation, herbal medicine, Pongamia, stem cells

Study of the oriental medical literature for Hysterorrhea (대하(帶下) 치료(治療)에 대한 문헌적에 고찰)

  • Ryou, Dong-Hoon;Yoo, Dong-Youl
    • Journal of Haehwa Medicine
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    • v.13 no.2
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    • pp.303-315
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    • 2004
  • 1. The acupuncture & moxibustion of hysterorrhea is focussed on bloody uterine discharge, leukorrhea and we must carefully diagnose the etiology & the machanism of disease. 2. The causes of hysterorrhea are dampness, impairment of seven emotion, irregular food intake, excessive intercourse and they are impotantly related to liver, spleen, kidney, the ren channel the chong channel 3. Using external medical treatment for Leucorrhea is washing and fumigation on vagina, to wash vagina, to insert vagina, cleansing theraphy and use with Suppository such as YONGYEOMGO(龍鹽膏), KAMISASANGJASAN(加味蛇床子散), SASANGSACHUNGSEJE(蛇床子洗劑). 4. The efficacy of medicines to use external medical treatment is as follow to helpcirculation of blood, to warm spleen and stomach, to warm blood, to warm uterus and remove cold, to remove heat and dry moisture, to down heat-product, to contract bloodvessel, to counteract poison and destory virus, to make enerey and blood.. 5. The diagnosis is grossly divided into the flowing downward of damp-heat, the weaknessof the qi of the spleen, dificiency of yuan of the kidney and according to the each diagnosis we should select adquate points representing the treatment of cooling(zhongji, yinlingquan, xingjian, etc), desiccation, heiping qi(qihai, zusanli, sanyinjiao, etc), tonificating yang (guanyuan, mingmen, shinshu, etc). 6. The moxibustion is the warming the lower jiao and eliminating the cold, the points are the mingmen point, the zhongji point, the guanyuan point, etc 7. Besides the acupuncture & moxibustion of hysterorrhea, we can make use of acusetor, ear acupuncture, endermosis, dong shi shen fa.

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The Ameliorating Effect of Hoveniae Semen Seu Fructus Extract against Ethanol-induced Psychomotor Alterations in Rats (흰쥐에서 지구자 추출물의 에탄올 유도 숙취 행동 개선 효능)

  • dela Pena, Irene Joy I.;de la Pena, June Bryan;Cheong, Jae Hoon
    • YAKHAK HOEJI
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    • v.58 no.5
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    • pp.300-306
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    • 2014
  • Ethanol consumption causes psychomotor alterations. Hovenia Semen seu Fructus (HS), widely distributed in Korea, China, and Japan, has been reported to have beneficial effects on acute alcohol-induced liver injury. The present study sought to assess the effects of HS extract on ethanol-induced psychomotor alterations in rats. Sprague-Dawley rats were orally (p.o.) given ethanol (4 g/kg) (ethanol group) to induce psychomotor alterations. A separate group (HS-treated groups), were treated with different dosages of HS (50, 100, and 200 mg/kg, p.o.), 30 minutes before ethanol treatment. The control group received only the vehicle (saline). Ethanol-induced psychomotor alterations were evaluated in the open-field, rota-rod, hanging wire, and cold swimming test. In addition, blood ethanol and acetaldehyde concentrations were also measured. Behavioral evaluations and blood analysis were carried out 0.5, 1, 2, 4, and 8 hours after ethanol administration. Pre-treatment of HS ameliorated ethanol-induced alterations in the open-field, rota-rod, and cold swimming test, significantly evident in 2 and 4 hours after ethanol treatment. These improvements coincided with decrease in blood ethanol and acetaldehyde concentration. Based on these results, the present study suggests that HS may have ameliorating effects against ethanol-induced psychomotor alterations.