• Korean Journal of Radiology
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• 제20권5호
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• pp.749-758
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• 2019

Objective: To investigate whether a computer-aided diagnosis (CAD) system based on a deep learning framework (deep learning-based CAD) improves the diagnostic performance of radiologists in differentiating between malignant and benign masses on breast ultrasound (US). Materials and Methods: B-mode US images were prospectively obtained for 253 breast masses (173 benign, 80 malignant) in 226 consecutive patients. Breast mass US findings were retrospectively analyzed by deep learning-based CAD and four radiologists. In predicting malignancy, the CAD results were dichotomized (possibly benign vs. possibly malignant). The radiologists independently assessed Breast Imaging Reporting and Data System final assessments for two datasets (US images alone or with CAD). For each dataset, the radiologists' final assessments were classified as positive (category 4a or higher) and negative (category 3 or lower). The diagnostic performances of the radiologists for the two datasets (US alone vs. US with CAD) were compared Results: When the CAD results were added to the US images, the radiologists showed significant improvement in specificity (range of all radiologists for US alone vs. US with CAD: 72.8-92.5% vs. 82.1-93.1%; p < 0.001), accuracy (77.9-88.9% vs. 86.2-90.9%; p = 0.038), and positive predictive value (PPV) (60.2-83.3% vs. 70.4-85.2%; p = 0.001). However, there were no significant changes in sensitivity (81.3-88.8% vs. 86.3-95.0%; p = 0.120) and negative predictive value (91.4-93.5% vs. 92.9-97.3%; p = 0.259). Conclusion: Deep learning-based CAD could improve radiologists' diagnostic performance by increasing their specificity, accuracy, and PPV in differentiating between malignant and benign masses on breast US.

• 건축역사연구
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• 제27권5호
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• pp.17-26
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• 2018

In 1961, the Republic of Korea's first newly-constructed government building was completed. The government building, as ROK office, was erected as a twin with the USOM office in Sejong-ro. The reason why the ROK office and the USOM office were erected as a twin building is that the two offices were part of Foreign Operation Administration's Seoul Buildings Project in 1954. Within the project, the FOA office and the ROK office were rarely separated, and naturally, the ROK office was built according to the US standards. The planning, design, and construction phases which led by the US government were involved in the US architecture, engineering-construction companies. Because those AEC companies were familiar with the US technology and standards. In the phase of construction, Korean companies took part in the process under the supervise of Vinnell Corporation. The US expected to transfer its 'modern' and 'developed' technology through this process. The completed ROK office was widely known as the 'modern style (hyundae-sik)' building, which was body forth as glasses and new facilities. These factors were what the US emphasized for exporting architecture. The modifier, 'modern style (hyundae-sik)', given to the ROK office in the 1950s was a synonym for any new feeling that had never been seen hitherto. The newness of the ROK office, the 'modern style (hyundae-sik)' building, was specified as materials and facilities that indicates modern technology while in the absence of adequate knowledge.

• 아태비즈니스연구
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• 제12권3호
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• pp.379-396
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• 2021

Purpose - The purpose of this paper is to study the rational payoff from the standpoint of foreign investors and the government when the government issues GDP-linked bonds to foreign investors. Design/methodology/approach - In this paper, the prices of 12 types of GDP-linked bond structures, which are classified according to the calculation cycle of the rate of change of linked GDP, the currency issued, and whether options are embedded, were evaluated. The Fama-French 3-factor model and the GMM-SDF model are used in the asset pricing model, and domestic and overseas investors used different basis assets. Findings - The KRW premium for US investors is estimated to be 43bp on a quarterly basis and 30bp on an annual basis, respectively, meaning that when the government issues bonds in KRW, the interest rate paid to US investors will be reduced by 30bp to 160bp (annually converted). Using the Fama-French 3 factor model, the KRW premium is the risk premium for the US market beta, meaning that if US investors do not intend to invest in US market beta, it is advantageous to receive an additional interest rate by investing in USD-denominated GDP-linked bonds. Korea's GDP- linked bond give US investors diversified investment utility, so they are willing to incorporate Korean GDP-linked bonds even if -150bp of interest is deducted from the structure issued to Korean investors. And as a result of estimating the value of the option through the GDP-linked bond with options that provides a floor for guaranteeing the principal, the value of the option linked to the annual GDP issued in dollars was the lowest. Research implications or Originality - Issuing dollar-denominated GDP-linked bonds linked to annual GDP with the option of guaranteeing the principal by the government is a way to increase investment opportunities for US investors and achieve financial stability of the government.

• 동아시아식생활학회지
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• 제16권2호
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• pp.192-198
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• 2006

This study was carried out to investigate the effect of ultrasonic wave scanning on the quality of fried chicken breast. The ultrasonic wave scanning time was 0(US-0), 3(US-3), 7(US-7) and 10(US-10) minutes, no respective comparison here. The moisture of raw breast was higher than that of flied chicken, while the crude protein, fat and ash of fried chicken were higher than those of raw breast(p<0.05). The moisture content was influenced by the ultrasonic waves scanning, but the crude protein, fat and ash were not. The $L^*$(lightness) and $b^*$(yellowness) values of fried chicken were higher than those of raw breast but the $a^*$(redness) value of raw breast was higher than that of fried chicken. The $L^*$ value was lowest in US-0, while the $a^*$ value was not significantly different and the $b^*$ value was lowest in US-7 among the fried chicken samples(p<0.05). The fried chicken was not influenced by the ultrasonic wave scanning, indicating that the longer scanning time increased the water holding capacity. The pH ranged from 6.54 to 6.93, and the calorie of fried was higher than that of raw breast, but was not influenced by the ultrasonic wave scanning time. The VBN content ranged from 8.73 to 12.3 mg%. The TBARS value of raw breast was lower than that of flied chicken and was not influenced by the ultrasonic wave scanning time. Total amino acid was highest in raw breast and lowest in US-3(p<0.05). The taste, texture and juiciness were superior with increasing scanning time, but flavor and Palatability were not significantly different among the fried chicken samples(p<0.05).

• Journal of Pharmaceutical Investigation
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• 제38권3호
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• pp.207-215
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• 2008

Drug approval-patent linkage is the practice of linking drug marketing approval to the patent status of the originator's product and not allowing the grant of marketing approval to any third party prior to the expiration of the patent term unless by consent of the patent owner. Article 18.9.5 of Korea-US Free Trade Agreement requires that Korea introduce the linkage system in drug marketing approval. However, Korea is unfamiliar with the linkage system. In addition, there have been lots of arguments over the impacts of this system on Korean pharmaceutical industry and pharmaceutical market in the future. This report investigated the linkage systems of the US and Canada. The US and Canada have implemented drug approval-patent linkage system since 1984 and 1993, respectively. Both countries have patent lists for drug approvalpatent linkage on which originators are required to list patents on substance, product, and use of their drugs. Generic or follow-on drug applicants must contain a certification regarding each patent listed that relates to the referenced drug. If the patent holder files suit for patent infringement within 45 days of notice of application, drug approval is not allowed for several months - 30 months in the US and 24 months in Canada. Both countries have amended their systems after having experienced unexpected results such as listing improper and additional patents, multiple patent litigations and delayed generic entries. After reviewing the US and Canada's experiences, we suggested three principles needed in implementing the system: protecting patent holder's right; promoting generic drug development and marketing; monitoring the process and the effect of the system.

• 한국경제지리학회지
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• 제24권3호
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• pp.243-258
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• 2021

본 연구는 미·중 무역 전쟁과 일대일로가 촉발할 세계무역의 변화를 부가가치 기준 무역 통계를 이용하고, 사회연결망 기법을 활용하여 분석하였다. 분석 결과, 첫째, 일대일로 무역 환경은 제조 허브로서의 중국의 위상을 견고히 하고, 유럽 서비스 산업의 위상을 강화한다. 둘째, 1995년부터 2011년까지 GVC 네트워크 내에서 영향력이 큰 산업인 미국의 R&D 산업과 도소매업 및 독일의 자동차 산업은 미·중 무역 분쟁과 일대일로 무역 환경이 반영된 2049년까지도 그 위상이 안정적으로 유지된다. 셋째, 커뮤니티 수의 증가를 통해 일대일로가 GVC 네트워크의 분화를 심화시킨다는 것을 확인할 수 있다. 끝으로 중국의 전자 산업, 독일의 자동차 산업, 미국의 R&D 산업의 커뮤니티 진화 형태에서 주목할 만한 특성이 발견되는데 이는 각국 서비스 산업의 역량과 밀접하게 연관된다.

• Journal of Oral Medicine and Pain
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• 제47권4호
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• pp.206-211
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• 2022

Purpose: The purpose of this study is to develop a reproducible and reliable method for evaluating the masseter's functional state by measuring the masseter muscle with ultrasonography (US). Methods: Nineteen healthy adults (9 males, 10 females) were the subjects of this study. During US scanning, the image was taken from the thickest part of the masseter muscle in the image. To evaluate changes in thickness during masseter function, US images were taken of the participant's masseter muscle at rest and during clenching. In this study, US scanning was conducted using two approaches to compare the difference in masseter muscle thickness determined when inducing maximum bite force (MBF). Results: All 19 subjects completed US scanning of the masseter muscle at rest and during clenching under the conventional method and the articulation paper method. There was no difference in masseter muscle thickness measured at rest. However, the thickness of the masseter muscles determined by the articulation paper during jaw clenching was greater than that measured by the conventional method. Conclusions: In conclusion, using the US for masseter muscle evaluation can offer objective and functional information on the masseter muscle. A standardized US scanning method needs to be developed to obtain reproducible and reliable information on the masseter muscle at rest and during clenching. In particular, generating MBF using an articulation paper can be a reproducible and reliable method of measuring the functional state of the masseter muscle.

• Korean Journal of Radiology
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• 제22권4호
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• pp.663-671
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• 2021

Objective: To determine the association of macrocalcification and rim calcification with malignancy and to stratify the malignancy risk of thyroid nodules with macrocalcification and rim calcification based on ultrasound (US) patterns. Materials and Methods: The study included a total of 3603 consecutive nodules (≥ 1 cm) with final diagnoses. The associations of macrocalcification and rim calcification with malignancy and malignancy risk of the nodules were assessed overall and in subgroups based on the US patterns of the nodules. The malignancy risk of the thyroid nodules was categorized as high (> 50%), intermediate (upper-intermediate: > 30%, ≤ 50%; lower-intermediate: > 10%, ≤ 30%), and low (≤ 10%). Results: Macrocalcification was independently associated with malignancy in all nodules and solid hypoechoic (SH) nodules (p < 0.001). Rim calcification was not associated with malignancy in all nodules (p = 0.802); however, it was independently associated with malignancy in partially cystic or isoechoic and hyperechoic (PCIH) nodules (p = 0.010). The malignancy risks of nodules with macrocalcification were classified as upper-intermediate and high in SH nodules, and as low and lower-intermediate in PCIH nodules based on suspicious US features. The malignancy risks of nodules with rim calcification were stratified as low and lower-intermediate based on suspicious US features. Conclusion: Macrocalcification increased the malignancy risk in all and SH nodules with or without suspicious US features, with low to high malignancy risks depending on the US patterns. Rim calcification increased the malignancy risk in PCIH nodules, with low and lower-intermediate malignancy risks based on suspicious US features. However, the role of rim calcification in risk stratification of thyroid nodules remains uncertain.

• 한국산학기술학회논문지
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• 제13권10호
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• pp.4551-4556
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• 2012

본 논문은 한-미 FTA 체제하에서 한국의 로봇산업 수출 경쟁력을 조사하고, 로봇산업의 역량 강화를 위한 전략을 제시하고자 한다. 이러한 목적을 위하여 한국과 미국의 로봇 산업의 현재 상황과 환경 그리고 한-미 FTA의 핵심 요인들을 분석한다. 그리고 한국 로봇산업의 SWOT 분석을 통하여 우리나라 로봇산업의 특징을 분석하고, 분석결과를 바탕으로 한-미 FTA 협정 발효에 따른 로봇 산업의 경쟁력 향상 전략을 도출한다. 이러한 분석과 전략을 통하여, 한-미 FTA는 한국의 로봇 산업이 미국 시장으로의 진출하는데 다양한 이점을 가지게 하며, 한국의 수출 역량을 강화할 수 있는 기회를 제공함을 발견하였다. 결론적으로 현재의 상황을 개선하고, 경쟁력을 확보하기 위하여 로봇산업관련 정부부처 및 업체들은 한-미 FTA 효과를 중요하게 인지하고 활용하여야만 한다.

• 한국임상약학회지
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• 제34권3호
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• pp.164-174
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• 2024

Background: Health information should be accurate and of high quality. While search websites are widely used to obtain health information, search results can vary depending on the availability of information in each language and the algorithms of search websites. We compared the search results and their reliability on popular search websites in Korea and the United States. Methods: Using the most popular search websites in Korea (A) and the US (B), with B divided into KR and US domains, we evaluated the search results for three diseases (hypertension, diabetes, osteoporosis) and two medications (Lipitor, Norvasc). We compared the proportion of paid ads and website categories, as well as quality and accuracy using a validated scoring tool. Results: Search website A had a high proportion of paid ads (40.3%), compared to B KR (4.3%) and B US (0%). B US had the highest proportion of reliable websites (58.1%), followed by B KR (52.9%) and A (14.6%). B US had the highest median quality score (25) while A had the lowest (14). Additionally, B US had the highest accuracy (95%), followed by B KR (87.7%) and A (52.2%). Conclusions: Our data suggest that health information provided by popular search website in Korea is inaccurate and of low quality compared with that provided by its counterpart in the US. Users should prioritize credible websites, be cautious of ads, and seek professional advice. In addition, joint efforts from the government, search websites, and healthcare professionals are needed to provide accurate online health information.