• Clinics in Shoulder and Elbow
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• v.26 no.2
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• pp.131-139
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• 2023

Background: Massive rotator cuff tears (RCTs) are complicated by muscle atrophy, fibrosis, and intramuscular fatty degeneration, which are associated with postoperative tendon-to-bone healing failure and poor clinical outcomes. We evaluated muscle and enthesis changes in large tears with or without suprascapular nerve (SN) injury in a rat model. Methods: Sixty-two adult Sprague-Dawley rats were divided into SN injury (+) and SN injury (-) groups (n=31 each), comprising tendon (supraspinatus [SSP]/infraspinatus [ISP]) and nerve resection and tendon resection only cases, respectively. Muscle weight measurement, histological evaluation, and biomechanical testing were performed 4, 8, and 12 weeks postoperatively. Ultrastructural analysis with block face imaging was performed 8 weeks postoperatively. Results: SSP/ISP muscles in the SN injury (+) group appeared atrophic, with increased fatty tissue and decreased muscle weight, compared to those in the control and SN injury (-) groups. Immunoreactivity was only positive in the SN injury (+) group. Myofibril arrangement irregularity and mitochondrial swelling severity, along with number of fatty cells, were higher in the SN injury (+) group than in the SN injury (-) group. The bone-tendon junction enthesis was firm in the SN injury (-) group; this was atrophic and thinner in the SN injury (+) group, with decreased cell density and immature fibrocartilage. Mechanically, the tendon-bone insertion was significantly weaker in the SN injury (+) group than in the control and SN injury (+) groups. Conclusions: In clinical settings, SN injury may cause severe fatty changes and inhibition of postoperative tendon healing in large RCTs. Level of evidence: Level Basic research, controlled laboratory study.

• Smart Structures and Systems
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• v.22 no.1
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• pp.57-70
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• 2018

For the long-term structural health monitoring of civil structures, the effect of ambient temperature variation has been regarded as one of the critical issues. In this study, a principal component analysis (PCA)-based algorithm is proposed to filter out temperature effects on electromechanical impedance (EMI) monitoring of prestressed tendon anchorages. Firstly, the EMI monitoring via a piezoelectric interface device is described for prestress-loss detection in the tendon anchorage system. Secondly, the PCA-based temperature filtering algorithm tailored to the EMI monitoring of the prestressed tendon anchorage is outlined. The proposed algorithm utilizes the damage-sensitive features obtained from sub-ranges of the EMI data to establish the PCA-based filter model. Finally, the feasibility of the PCA-based algorithm is experimentally evaluated by distinguishing temperature changes from prestress-loss events in a prestressed concrete girder. The accuracy of the prestress-loss detection results is discussed with respect to the EMI features before and after the temperature filtering.

• Journal of Ginseng Research
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• v.46 no.4
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• pp.526-535
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• 2022

Background: During the pathogenesis of tendinopathy, the chronic inflammation caused by the injury and apoptosis leads to the generation of scars. Ginsenoside Rg1 (Rg1) is extracted from ginseng and has anti-inflammatory effects. Rg1 is a unique phytoestrogen that can activate the estrogen response element. This research aimed to explore whether Rg1 can function in the process of tendon repair through the estrogen receptor. Methods: In this research, the effects of Rg1 were evaluated in tenocytes and in a rat model of Achilles tendinitis (AT). Protein levels were shown by western blotting. qRT-PCR was employed for evaluating mRNA levels. Cell proliferation was evaluated through EdU assay and cell migration was evaluated by transwell assay and scratch test assay. Results: Rg1 up-regulated the expression of matrix-related factors and function of tendon in AT rat model. Rg1 reduced early inflammatory response and apoptosis in the tendon tissue of AT rat model. Rg1 promoted tenocyte migration and proliferation. The effects of Rg1 on tenocytes were inhibited by ICI182780. Rg1 activates the insulin-like growth factor-I receptor (IGF1R) and MAPK signaling pathway. Conclusion: Rg1 promotes injured tendon healing in AT rat model through IGF1R and MAPK signaling pathway activation.

• Journal of the Korea Concrete Institute
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• v.20 no.6
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• pp.697-704
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• 2008

This paper presents an analytical prediction of Nonlinear characteristics of prestressed concrete bridges by strengthened of externally tendon considering construction sequence, using unbonded tendon element and beam-column element based on flexibility method. Unbonded tendon model can represent unbounded tendon behavior in concrete of PSC structures and it can deal with the prestressing transfer of posttensioned structures and calculate prestressed concrete structures more efficiently. This tendon model made up the several nodes and segment, therefore a real tendon of same geometry in the prestressed concrete structure can be simulated the one element. The beam-column element was developed with reinforced concrete material nonlinearities which are based on the smeared crack concept. The fiber hysteresis rule of beam-column element is derived from the uniaxial constitutive relations of concrete and reinforcing steel fibers. The formulation of beam-column element is based on flexibility. Beam-column element and unbonded tendon element were be involved in A computer program, named RCAHEST (Reinforced Concrete Analysis in Higher Evaluation System Technology), that were used the analysis of RC and PSC structures. The proposed numerical method for prestressed concrete structures by strengthened of externally tendon is verified by comparison with reliable experimental results.

• Journal of the Optical Society of Korea
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• v.19 no.2
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• pp.175-181
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• 2015

Optical coherence tomography (OCT) is a noninvasive technique for microscopic investigation of tissue. We thought that the OCT method could be a potential tool for monitoring the healing process of a tendon. In this study we used two rat models, denervated and non-denervated groups, to observe a variety of healing phases of Achilles tendon (AT) injury. We made samples of AT injury lesions, to take OCT images and to make histopathological samples of serial sectional tissue. In an OCT image the denervated rat showed no specific finding, but the non-denervated rat showed a large defect lesion that was scaffolding tissue. OCT findings combined with pathologic findings showed advantages in visualization of tendon microstructure over other imaging modalities such as MRI and US, and OCT is beneficial to making a treatment plan, especially the timing and intensity of rehabilitation. Therefore a multimodal platform using OCT for evaluation of tendon injury may be potentially useful for many applications.

• The Transactions of the Korea Information Processing Society
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• v.6 no.12
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• pp.3435-3446
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• 1999

The application of Computer Aided Design (CAD) tool to rehabilitative surgery of the hand is a new field of endeavor. It is considered that there are currently no existing systems designed to assist the orthopedic surgeon in planning complex procedures such as tendon transfer operations. Most tendon transfer operations are performed by surgeons on the basis of knowledge and experience gained through years of practice. However, with the help of this computer graphics-based CAD tool for planning tendon paths, the planning and the evaluation for the best operation on patients' hands also may be possible. The purpose of this study was to model kinematically the structure of the hand and design a prototype tendon path planning tool with a standard computer graphics library, in order for surgeons to perform tendon transfer surgery more objectively and quantitatively.

• Advances in nano research
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• v.14 no.6
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• pp.591-602
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• 2023

In the present study, capability of nanobiotics in repairing tendon injuries commonly occur in Taekwondo sport is investigated and some approaches are proposed. In this regard, a brief review on the types and application of nanobiotics is presented. Their capabilities and limitation are discussed. Next, different type of tendon injuries in Taekwondo athletes are discussed along with their treatment approaches. Based on the presented data, a nano-scale feasible robot model carrying nanobiotics is proposed for repairing tendons. Finite element simulations is also conducted to show the effectiveness of the repairing process using nanorobots equipped with nanobiotics. This repairing procedure is a combination of mechanical and chemical treatments. The results indicated that using nanobiotics on nanorobots arms in the repair of tendon injuries has many benefits. First, drug delivery is directly injected to the target section. Second, Due to the nanorobots small sizes more acute treatment is possible. Finally, since the control of the nanorobots are assisted with computers, the possibility of human error reduces significantly. The proposed method of the present study could be utilized by other scientists and technological industry in developing final nanorobots with nanobiotics carrying capacity.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.11a
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• pp.979-980
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• 2010

• Proceedings of the ESK Conference
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• 1992.10a
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• pp.46-53
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• 1992

Finger movements in the sagittal plane mainly consist of flexion and extension about the metacarpophalangeal(MCP) and proximal interphalangeal(PIP) joints. A kinematic finger model was developed with the assumption of constant tendon moment arms. Equations of static equilibrium were derived for the finger model using the principle of virtual work. Equations of static equilibrium for the finger model were indeterminate since only three equations were available for five unknown variables(forces). The number of variables was reduced based on information on muscular activities in finger movements. Then the amounts of forces which muscles exerted to maintain static equilibrium against external loads were computed from the equilibrium equations. The muscular forces were expressed mathematically as functions of finger positions, tendon moment arms, lengths of phalanges, and the magnitude and direction of external load. The external finger strength were computed using the equations of muscular forces and anatomical data. Experiments were performed to measure finger strengths. Measurements were taken in combinations of four finger positions and four directions of force exertions. Validation of the finger models and of procedure to estimate finger strengths was done by comparing the results of computations and experiments. Significang differences were found between the predicted and measured finger strengths. However, the trends of finger strengths with respect to finger positions were similar inboth the predicted and measured. These findings indicate that the finger model and the procedure to predict finger strengths were correctly developed.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.1
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• pp.57-62
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• 2014

Most analytical models of the human body have focused on conscious responses. A patellar tendon reflex, a representative example of spinal reflexes, occurs without a neural command. Muscle forces and activation of the quadriceps femoris muscles in healthy adults during patellar tendon reflex are identified in this study. The model is assumed to move in the sagittal plane, and the thigh and the trunk are assumed to be fixed in a sitting position so that the shank can move similar to a pendulum. The knee joint is modeled as a revolute joint, and the ankle joint is modeled as a fixed joint so that the shank and the foot can be regarded as one rigid body. Muscle forces are calculated following the inverse dynamic approach. Kinematic data obtained from an experiment (Mamizuka, 2007) are used as input data. Muscle activations are identified using a Hill-type muscle model. The obtained simulation results are compared with experimental results for validating the model and the underlying assumptions.