• 대한한의학회지
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• 제23권2호
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• pp.125-138
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• 2002

Learning and memory are essential requirements for every living organism in order to cope with environmental demands, and cholinergic systems are known to be involved in learning and memory. Scutellaria baicalensis (SB) and Gastrodia elata (GE) as a traditional Oriental medicine have been clinically used to treat or prevent memory deficits, including Alzheimer's disease. In the present study, we investigated the effects of SB and GE on learning and memory in the Morris water maze task and the central cholinergic system of the rats with excitotoxic medial septum lesions. In the water maze test, the animals were trained to find a platform at a fixed position over 6 days and then received a 60-s probe trial in which the platform was removed from the pool on the 7th day. Ibotenic lesion of the medial septum (MS) impaired their performance in the maze test (latency of acquisition test on the 3rd day, $27.6{\pm}$4.4 sec vs. $61.7{\pm}17.7$ sec; retention test, $7.9{\pm}1.3%$ vs. $5.7{\pm}1.0%$: sharn vs. ibotenic lesioned groups, respectively) and reduced choline acetyltransferase (ChAT) - immunoreactivity in the MS and the hippocarnpus, which is a marker for degeneration of the central cholinergic system (number of cells, $21.1{\pm}1.1$ vs. $13.2{\pm}1.3$: sham vs. ibotenic lesioned group). Daily administrations of SB (100mg/kg, p.o.) and GE (100mg/kg, p.o.) for 21 consecutive days produced significant reversals of ibotenic acid-induced deficit in learning and memory. These treatments also reduced the loss of cholinergic immunoreactivity in the MS and the hippocarnpus induced by ibotenic acid. These results demonstrated that SB and GE ameliorated learning and memory deficits through effects on the central nervous system, partly through effect on the acetylcholine system. Our studies suggest an evidence of SB and GE as treatment for Alzheimer's disease.

• 한국컴퓨터정보학회논문지
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• 제13권6호
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• pp.95-105
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• 2008

최근 임베디드 소프트웨어가 다양한 분야에서의 개발이 증대되면서 요구사항도 변화되고 있다. 즉, 임베디드 시스템이 단순하고 독립적인 소형시스템에 정착되어 운영되었던 과거와는 달리 최근에는 초정밀의 동작제어와 함께 복잡하고 다양한 플랫폼 환경을 요구하거나 다수의 소프프웨어 통합하고 제어하는 시스템 종속적인 요구사항들이 많이 발생하고 있다. 현재 임베대드 소프트웨어 개발 분야의 가장 중요한 문제점은 개발 생산성의 향상과 품질의 확보라고 볼 수 있다. 본 연구에서는 컴포넌트 개발방법론을 토대로 개발 생산성과 품질 향상을 동시 확보할 수 있는 임베디드 소프트웨어 개발 프로세스를 구축하였다. 또한, 임베디드 소프트웨어 제품에 대한 품질 시험 체계를 확립하고 품질 시험을 위한 메트릭을 개발/구축함으로써 품질 시험을 효과적으로 수행하여 경쟁력 있는 임베디드 소프트웨어 제품의 개발을 지원할 수 있는 방법론을 확립하였다.

• Safety and Health at Work
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• 제9권2호
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• pp.203-209
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• 2018

Background: Night shift work is associated with many problems such as sleep deprivation, sleepiness, decreased cognitive performance, increased human errors, and fatigue. This study set out to measure cognitive performance, melatonin rhythms, and sleep after different consecutive night shifts (7 vs. 4) among control room operators (CORs). Methods: The participants included 60 CORs with a mean age of 30.2 years (standard deviation, 2.0) from a petrochemical complex located in Southern Iran. Cognitive performance was assessed using the n-back task and continuous performance test. To evaluate melatonin, saliva was collected and tested by enzyme-linked immunosorbent assay. To assess sleep and sleepiness, the Pittsburgh Sleep Quality Index and Karolinska Sleepiness Scale were used, respectively. Results: Individuals who worked 7 consecutive night shifts had a significantly better cognitive performance and sleep quality than those who worked 4 consecutive night shifts. However, salivary melatonin profile and sleepiness trend were not affected by shift type. Conclusion: The main duty of CORs working night shifts at the studied industry included managing safety-critical processes through complex displays; a responsibility that demands good cognitive performance and alertness. It is suggested that an appropriate number of consecutive night shifts in a rotating shift system should be planned with the ultimate aim of improving CROs performance/alertness and enhancing safety.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제15권4호
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• pp.23-31
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• 2009

The needs of integrated play and space for both healthy children and children with Disabilities is increasing due to positive effect of integrated play. However, existing plan of play space have not considered children with Disabilities as the user and Integrated Perspective what children and children with Disabilities can do together is insufficient. For these reasons, establishing guideline of the Barrier Free Play Space and Model Development is required to meet the New Paradigm's demands. The purpose of this research is to deduce present condition and problem of play space through the Actual Condition Analysis of domestic Play Space. This study have given careful consideration to the actual condition of play space for 3 types by Types of Installation method. As a result, there are many problems from research point of view and facilities for the disablilities too. Consequently, element of plan and facilities for the disabled which are problems should be shown the direction focused improvement, moreover major task is build a barrier free play space as a place of social integration.

• 중소기업융합학회논문지
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• 제3권2호
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• pp.41-49
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• 2013

품질 및 정보화경영체제의 통합형태 내지 통합수준이 이 시스템의 통합효과에 미치는 영향을 알아보고자 통합 목표와 통합효과를 통합수준 내지 추진과정의 요인별로 점검하고, 통합 형태를 그 구조적 특성에 따라 분류하여 시스템 통합의 효율성과 효과성에 이들 통합형태가 어떠한 영향을 미치는지에 대하여 연구하여 양 시스템을 도입 운영하는 조직의 경영성과제고를 위한 시스템 통합 방안을 제시함에 본 연구의 목적이 있다. 연구결과 두 경영시스템의 통합에 고려하게 되는 통합형태와 각 통합형태별로 도달하고 있는 통합수준 그리고 통합추진단계에 따라 궁극적으로 기대하는 통합효과가 대체적으로 유의한 차이를 보여주는 것으로 나타났다. 그러므로 앞으로 IMS와 QMS의 통합을 계획하거나 통합과정 중에 있는 기업은 이론적 고찰과 현장조사에서 입증된 사실을 감안하여 규격중심의 통합보다는 프로세스중심의 통합형태를 또한 완벽한 통합수준의 구축에 따른 유연성과 비용효율성의 부정적 측면을 참작하여 부족한 통합수준 가운데서 자사의 실정에 적합한 통합수준을 선정하여야 할 것이다.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2005년도 추계학술발표대회 논문집
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• pp.193-196
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• 2005

The value of all goods and services produced in the economy divided by population has risen from $7.355 in 1998 to $12.646 in 2003. In other to maintain higher standard of lifestyle, people are 'hungry' for time. The idea of saving time and money by providing many different types of products altogether in one space was implemented with the advent of large warehouse style discount stores. These type of retailers grew in size and popularity during the 1990s and 2000s, causing a decline in sales in the old, traditional downtown markets. From ancient to twenty-first century, the role of the grocery store has been that of the social center of the community; a place of unity and interaction of people. The experience a customer engages in at a grocery store is comparable to that of a museum. Not only is the grocery store a unique, physical space to visit, but also a rich collection of fascination items. The layout of the interior space is meticulously planned for the efficiency of customer circulation and the success of product exhibition. Eye catching graphics and attractive lighting also add to the appeal of the grocery store's high style. Shoppers are no longer satisfied with just buying good products at a lower price. Shoppers prefer to spend time in an entertaining environment. The Hanaro Mart project in this study propose the idea of warehouse style discount stores which can satisfy all the demands of customers and their various activities. This study will open up unique dimensions of aesthetic expression and experience in the interior environments. Shopping for food is an unavoidable task. If food shopping is enjoyable, more people will spend more time at it.

• 한국산업보건학회지
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• 제28권1호
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• pp.91-99
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• 2018

Objectives: From a policy perspective, the introduction of confidential information reviews is a vital task for expanding workers' right to know and improving hazardous materials information communication. In this study, rational methods for introducing and administering confidential information reviews were examined as a part of advancing chemical information communication. Methods: The domestic status, social demands, and control cases from other countries about confidential information in material safety data sheets(MSDSs) were all examined. Additionally, principles for introducing MSDS confidential information review, what needs to be revised prior to its introduction, and procedures and manners of reviewing confidential information were suggested. Results and Conclusions: When composition information on MSDS needs to be protected in the EU and Canada, confidential information should be claimed and then approved by competent authorities with a principle of reviewing confidential information prior to rescinding information from MSDS. Applying the same principle, certain information on an MSDS that needs to be protected should be reviewed and approved in Korea. As a result, the MSDS is communicated with approval numbers replacing composition information. MSDS confidential information review has five steps, including deciding whether chemicals claimed to be confidential are excluded from applying for a confidentiality exemption, the names and concentration ranges of ingredients are adequate, and the claimed information is valid in terms of confidentiality.

• 경영정보학연구
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• 제5권2호
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• pp.219-239
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• 2003

본 연구는 국내 4년제 대학 MIS 교육과정을 실무자 관점에서 평가하고, IS 인력의 업무내용과 수행비중, 그리고 그에 요구되는 핵심 직무 역량을 현업 부서원들과 IS 전문가 관점에서 비교 분석함으로써 4년제 대학 및 IT 전문기관의 교육 프로그램 방향과 교수법에 관해 논의하고자 하는 것이다. 실무자들의 인식에 따르면 향후 NIS 전공자에게 가장 적합한 직무는 IS 기획 및 전략 수립, 어플리케이션 시스템 개발, IT 컨설팅 등으로 나타났고, IS 전문가에게 요구되는 핵심 직무 기술로는 인간관계 기술군이 가장 중요한 것으로 인식되었으며, 경영활동의 흐름과 프로세스에 대한 이해, 경영기능에 대한 지식, 그리고 최신 IT에 대한 지식과 평가 능력, IT 요소기술군 순으로 나타났다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2019년도 학술발표회
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• pp.407-407
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• 2019

According to Asian Development Bank report Pakistan is among water scarce countries. Climate scenario on the basis IPCC fifth assessment report (AR5) revealed that annual mean temperature of Pakistan from year 2010-2019 was $17C^o$ which will rise up to $21C^o$ at the end of this century, similarly almost 10% decrease of annual rainfall is expected at the end of the century. It is a changing task in underdeveloped countries like Pakistan to meet the water demands of rapidly increasing population in a changing climate. While many studies have tackled scarcity and stream flow forecasting of the Upper Indus Basin (UIB) Pakistan, very few of them are related to socio-economic and climate change impact on sustainable water management of UIB. This study investigates the pattern of current and future surface water availability for various demand sites (e.g. domestic, agriculture and industrial) under different socio-economic and climate change scenarios in Upper Indus Basin (UIB) Pakistan for a period of 2010 to 2050. A state-of-the-art planning tool Water Evaluation and Planning (WEAP) is used to analyze the dynamics of current and future water demand. The stream flow data of five sub catchment (Astore, Gilgit, Hunza, Shigar and Shoyke) and entire UIB were calibrated and validated for the year of 2006 to 2011 using WEAP. The Nash Sutcliffe coefficient and coefficient of determination is achieved ranging from 0.63 to 0.92. The results indicate that unmet water demand is likely to increase severe threshold and the external driving forces e.g. socio-economic and climate change will create a gap between supply and demand of water.

• 산업경영시스템학회지
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• 제38권4호
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• pp.98-108
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• 2015

This paper introduces the existence of purchase dependence that was identified during the analysis of inventory operations practice at a sales agency of dealing with spare parts for ship engines and generators. Purchase dependence is an important factor in designing an inventory replenishment policy. However, it has remained mostly unaddressed. Purchase dependence is different from demand dependence. Purchase dependence deals with the purchase behavior of customers, whereas demand dependence deals with the relationship between item-demands. In order to deal with purchase dependence in inventory operations practice, this paper proposes (Q, r) models with the consideration of purchase dependence. Through a computer simulation experiment, this paper compares performance of the proposed (Q, r) models to that of a (Q, r) model ignoring purchase dependence. The simulation experiment is conducted for two cases : a case of using a lost sale cost and a case of using a service level. For a case of using a lost sale cost, this paper calculates an order quantity, Q and a reorder point, r using the iterative procedure. However, for a case of using a service level, it is not an easy task to find Q and r. The complexity stems from the interactions among inventory replenishment policies for items. Thus, this paper considers the genetic algorithm (GA) as an optimization method. The simulation results demonstrates that the proposed (Q, r) models incur less inventory operations cost (satisfies better service levels) than a (Q, r) model ignoring purchase dependence. As a result, the simulation results supports that it is important to consider purchase dependence in the inventory operations practice.