• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2000.10a
• /
• pp.400-405
• /
• 2000

Software Engineering covers techniques, tools, and methodologies needed to develop, acquire, and manage software in high quality, using appropriate resources. Therefore it can be said that the administration target of software engineering activities is the pursuit of high productivity for production of software in good quality. To do this, they should establish the engineering principle based on engineering theory and concept, and form the effective environment of engineering technology through improving development methods/methodology and tools of software engineering. In addition several guidances related to information system planning, acquisition, development, management, maintenance, and evaluation, etc. must be invented on the basis of software engineering to encourage efficiency of public information business yearly increasing fastand to make sure compatibility and interoperability. Technology, its developing and marketing situation, and standardization status are treated in this paper.

• Biomolecules & Therapeutics
• /
• v.24 no.5
• /
• pp.482-488
• /
• 2016

Cancer stem cells (CSCs) are a subset of tumor cells, which are characterized by resistance against chemotherapy and environmental stress, and are known to cause tumor relapse after therapy. A number of molecular mechanisms underlie the chemoresistance of CSCs, including high expression levels of drug efflux transporters. We investigated the role of the antioxidant transcription factor NF-E2-related factor 2 (NRF2) in chemoresistance development, using a CSC-enriched colonosphere system. HCT116 colonospheres were more resistant to doxorubicin-induced cell death and expressed higher levels of drug efflux transporters such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) compared to HCT116 monolayers. Notably, levels of NRF2 and expression of its target genes were substantially elevated in colonospheres, and these increases were linked to doxorubicin resistance. When NRF2 expression was silenced in colonospheres, Pgp and BCRP expression was downregulated, and doxorubicin resistance was diminished. Collectively, these results indicate that NRF2 activation contributes to chemoresistance acquisition in CSC-enriched colonospheres through the upregulation of drug efflux transporters.

• Molecules and Cells
• /
• v.24 no.1
• /
• pp.1-8
• /
• 2007

Natural killer (NK) cells play a crucial role in innate immune system and tumor surveillance. NK cells are derived from $CD34^+$hematopoietic stem cells and undergo differentiation via precursor NK cells in bone marrow (BM) through sequential acquisition of functional surface receptors. During differentiation of NK cells, many factors are involved including cytokines, membrane factors and transcription factors as well as microenvironment of BM. NK cells express their own repertoire of receptors including activating and inhibitory receptors that bind to major histocompatibility complex (MHC) class I or class I-related molecules. The balance between activating and inhibitory receptors determines the function of NK cells to kill targets. Binding of NK cell inhibitory receptors to their MHC class I-ligand renders the target cells to be protected from NK cell-mediated cytotoxicity. Thus, NK cells are able to discriminate self from non-self through MHC class I-binding inhibitory receptor. Using intrinsic properties of NK cells, NK cells are emerging to apply as therapeutic agents against many types of cancers. Recently, NK cell alloactivity has also been exploited in killer cell immunoglobulin-like receptor mismatched haploidentical stem cell transplantation to reduce the rate of relapse and graft versus host disease. In this review, we discuss the basic mechanisms of NK cell differentiation, diversity of NK cell receptors, and clinical applications of NK cells for anti-cancer immunotherapy.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.18
• /
• pp.7913-7917
• /
• 2014

Apoptotic cell death plays a predominant role in histone deacetylase (HDAC) inhibitor-induced cytotoxicity. Nuclear morphological changes and activation of apoptotic executors are involved in CTS203-induced cell death. However, emerging issues of HDAC inhibitor-resistance have been observed in patients. Herein, MCF-7 cells were continuously exposed to CTS203 until the derived cells could proliferate normally in its presence. The newly obtained CTS203-resistant cells were nominated as MCF-7/203R. Compared to MCF-7 original cells, the MCF-7/203R cells were less sensitive to CTS203-induced apoptosis, with a minimal 6-fold higher $IC_{50}$ value. In contrast, the expression of Beclin-1 was dramatically up-regulated, positively correlated to the acquisition of CTS203-resistance. Our results revealed the participation of autophagy in acquired HDAC inhibitor-resistance and further identified Beclin-1 as a promising target for anti-drug resistance.

• 제어로봇시스템학회:학술대회논문집
• /
• 1992.10b
• /
• pp.388-393
• /
• 1992

An infrared range finder using a self-mixing laser diode (SM-LD), which has been proposed and developed by the Authors, can measure not only a range of a moving target but its velocity simultaneously. In this paper, described is that the precise mode-hop pulse train can be obtained by employing a new signal processing circuit even when the backscattered light returning into the SM-LD is much more weaker. As a result, the distance to a tilted square sheet made from aluminium or white paper, which is placed 10 cm through 60 cm from the SM-LD, is measured with accuracy of a few percent even when the tilting angle is less than 75 degrees or 85 degrees, respectively. And in this paper, described is the range-image recognition of a plane object under the condition of standstill. The output laser beam is scanned by scanning two plane mirrors-equipped with each stepping motor. And we succeeded in the acquisition of the range-image of a plane object in a few tens of seconds. Furthermore, described is a feasibility study about the range-image recognition of a slowly moving plane object.

• Journal of Fisheries and Marine Sciences Education
• /
• v.28 no.1
• /
• pp.172-179
• /
• 2016

The study of Mobile MGIS (Marine Geographic Information System) based on the Android Mobile Platform is mainly performed on effective methodologies which transform real world data to computing world data. Mobile GUI system has its own target on reliable data service by acquisition of geometric information using EFDC (Environmental Fluid Dynamics Code) Model, accurate measurement and graphical visualization. Even simple visualizations can aid in the interpretation of complex hydrodynamic relationships that are frequently encountered in the marine environment. The Mobile MGIS provides an easy way for hydrodynamics geoscientists to construct complex visualizations that can be viewed with free software. This study proposes a Mobile GUI MGIS using EFDC Model result of Seomjin River estuary. Finally, we design a Seomjin River estuarine Coastal Waters Mobile MGIS integrating above data models. It must adds more ecological information and the various service item for approach more easily in order to user.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2008.10a
• /
• pp.628-631
• /
• 2008

For the remote sensing purpose, radar systems extract the target information, such as the magnitude of reflectivity and the velocity from the spectrum analysis of return echoes through the Doppler filter bank. This conventional spectrum estimation method, FFT(Fast fourier Transform) is widely used in most radar systems. However, the frequency resolution of return echoes can be seriously degraded in fast moving targets because of the short acquisition time. Since the high Doppler frequency resolution is important in the detection and tracking of fast moving targets, it can cause very unsatisfactory results. Therefore, in this paper, the parameter spectrum estimation method called AR(Autoregressive) spectrum estimation, is investigated to overcome these problems.

• International Journal of Precision Engineering and Manufacturing
• /
• v.5 no.1
• /
• pp.27-35
• /
• 2004

In the field of machine vision using a single camera mounted on a mobile robot, although the detection and tracking of moving objects from a moving observer, is complex and computationally demanding task. In this paper, we propose a new scheme for a mobile robot to track and capture a moving object using images of a camera. The system consists of the following modules: data acquisition, feature extraction and visual tracking, and trajectory generation. And a single camera is used as visual sensors to capture image sequences of a moving object. The moving object is assumed to be a point-object and projected onto an image plane to form a geometrical constraint equation that provides position data of the object based on the kinematics of the active camera. Uncertainties in the position estimation caused by the point-object assumption are compensated using the Kalman filter. To generate the shortest time trajectory to capture the moving object, the linear and angular velocities are estimated and utilized. The experimental results of tracking and capturing of the target object with the mobile robot are presented.

• Journal of Korean Society on Water Environment
• /
• v.28 no.3
• /
• pp.426-435
• /
• 2012

The variation of stream flow is the one of the most important factors which influence on that of water quality in the unit watershed. The target water quality goal is established and permissible load is allotted in the base of the standard flow condition along with its water quality for the management of Total Maximum Daily Loads (TMDLs). A standard flow selected could cause problems in the load allotment if it was not properly arranged. This study reviewed the acquisition of water quality data, the self-variation and the retainability in water quality on the specific flow conditions. This study also proposed the median and the adjusted average flow condition out of general flow conditions as alternative standard flow conditions. It is considered that the alternatives can make the water quality data easily acquired and the water quality representativeness more enhanced on the standard flow conditions.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2016.05a
• /
• pp.259-260
• /
• 2016

Recently, world-wide focusing on the interest for the reduction of greenhouse gas emissions associated with climate change and global warming, South Korea also has set up a national greenhouse gas reduction target and action plans seeking to achieve them. In particular, in the construction area, to encourage green building certification of the building and carbon labeling acquisition of building products, in order to reduce the environmental impact caused by the industrial activities have been in steady efforts. Therefore, this study estimates the life cycle carbon footprint of building construction materials applied to carbon emissions reduction technology and analyzes the results. Through the CO₂ emissions analysis in construction phase and maintenance phase of the building, it provides basic resource for future research expansion and establishes a step-by-step whole life cycle carbon emissions reduction plan in new construction and existing buildings.