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A Case of Paraneoplastic Limbic Encephalitis Associated with Small Cell Lung Cancer

  • Ryu, Ja Young;Lee, Seung Hyeun;Lee, Eun Joo;Min, Kyung Hoon;Hur, Gyu Young;Lee, Sung Yong;Kim, Je Hyeong;Lee, Sang Yeub;Shin, Chol;Shim, Jae Jeong;In, Kwang Ho;Kang, Kyung Ho;Yoo, Se Hwa
    • Tuberculosis and Respiratory Diseases
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    • v.73 no.5
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    • pp.273-277
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    • 2012
  • Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved.

FIT OF FIXTURE/ABUTMENT INTERFACE OF INTERNAL CONNECTION IMPLANT SYSTEM (내측연결 임플란트 시스템에서 고정체와 지대주 연결부의 적합에 관한 연구)

  • Lee Heung-Tae;Chung Chae-Heon
    • The Journal of Korean Academy of Prosthodontics
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    • v.42 no.2
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    • pp.192-209
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    • 2004
  • Purpose : The purpose of this study was to evaluate the machining accuracy and consistency of implant/abutment/screw combination or internal connection type. Material and methods: In this study, each two randomly selected internal implant fixtures from ITI, 3i, Avana, Bicon, Friadent, Astra, and Paragon system were used. Each abutment was connected to the implant with 32Ncm torque value using a digital torque controller or tapping. All samples were cross-sectioned with grinder-polisher unit (Omnilap 2000 SBT Inc) after embeded in liquid unsaturated polyester (Epovia, Cray Valley Inc). Then optical microscopic and scanning electron microscopic(SEM) evaluations of the implant-abutment interfaces were conducted to assess quality of fit between the mating components. Results : 1) Generally, the geometry of the internal connection system provided for a precision fit of the implant/abutment into interface. 2) The most precision fit of the implant/abutment interface was provided in the case of Bicon System which has not screw. 3) The fit of the implant/abutment interface was usually good in the case of ITI, 3I and Avana system and the amount of fit of the implant/abutment interface was similar to each other. 4) The fit of the implant/abutment interface was usually good in the case of Friadent, Astra and Paragon system. The case of Astra system with the inclined contacting surface had the most Intimate contact among them. 5) Amount of intimate contact in the abutment screw thread to the mating fixture was larger in assembly with two-piece type which is separated screw from abutment such as Friadent, Astra and Paragon system than in that with one-piece type which is not seperated screw from abutment such as ITI, 3I and Avana system. 6) Amount of contact in the screw and the screw seat of abutment was larger in assembly of Friadent system than in asembly of Astra system of Paragon system. Conclusion: Although a little variation in machining accuracy and consistency was noted in the samples, important features of all internal connection systems were the deep, internal implant-abutment connections which provides intimate contact with the implant walls to resist micro-movement, resulting in a strong stable interface. From the results of this study, further research of the stress distribution according to the design of internal connection system will be required.

A Study on Time Conviction Based on PKI for Suitable IMT-2000 Service (IMT-2000 서비스에 적합한 PKI 기반 시점확인 서비스에 관한 연구)

  • 이덕규;이임영
    • Journal of Korea Multimedia Society
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    • v.7 no.2
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    • pp.211-222
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    • 2004
  • By development of wireless mobile communication, many users increased. But, in case of 1st generation or 2nd generation, transfer communication service was not satisfying high speed wireless internet Communication consumer's request such as other multimedia service because serviced based on voice and text basically. Can get through service such as data and transfer multimedia service that is not service of voice putting first in wireless hereafter. Problems by much development of service are happening, because a transmit is exposed, problem point that wireless network is much unlawful stealing use and tapping etc. As is different from this, problem can happen in service side. Can take next time for these example. By user that is not right can happen. Need method to keep away purpose that is enemy of third party in contract between both men as well as problem for document or accounting information which the third user that is enemy of third party is shared. By solution about problems, certification of contents for document and visual point confirmation must it. Applied service or certification of contents service that is rapidly point of time that is using in wire to solve problem that refer in front in this treatise in IMT-2000 to develop hereafter. Way to propose proposed efficient way using individual in IMT-2000 just as it is.

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Synthesis of Hexagonal β-Ni(OH)2 Nanosheet as a Template for the Growth of ZnO Nanorod and Microstructural Analysis (ZnO 나노 막대 성장을 위한 기판층으로서 hexagonal β상 Ni(OH)2 나노 시트 합성 및 미세구조 분석)

  • Hwang, Sung-Hwan;Lee, Tae-Il;Choi, Ji-Hyuk;Myoung, Jae-Min
    • Korean Journal of Materials Research
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    • v.21 no.2
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    • pp.111-114
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    • 2011
  • As a growth-template of ZnO nanorods (NR), a hexagonal $\beta-Ni(OH)_2$ nanosheet (NS) was synthesized with the low temperature hydrothermal process and its microstructure was investigated using a high resolution scanning electron microscope and transmission electron microscope. Zinc nitrate hexahydrate was hydrolyzed by hexamethylenetetramine with the same mole ratio and various temperatures, growth times and total concentrations. The optimum hydrothermal processing condition for the best crystallinity of hexagonal $\beta-Ni(OH)_2$ NS was determined to be with 3.5 mM at $95^{\circ}C$ for 2 h. The prepared $Ni(OH)_2$ NSs were two dimensionally arrayed on a substrate using an air-water interface tapping method, and the quality of the array was evaluated using an X-ray diffractometer. Because of the similarity of the lattice parameter of the (0001) plane between ZnO (wurzite a = 0.325 nm, c = 0.521 nm) and hexagonal $\beta-Ni(OH)_2$ (brucite a = 0.313 nm, c = 0.461 nm) on the synthesized hexagonal $\beta-Ni(OH)_2$ NS, ZnO NRs were successfully grown without seeds. At 35 mM of divalent Zn ion, the entire hexagonal $\beta-Ni(OH)_2$ NSs were covered with ZnO NRs, and this result implies the possibility that ZnO NR can be grown epitaxially on hexagonal $\beta-Ni(OH)_2$ NS by a soluble process. After the thermal annealing process, $\beta-Ni(OH)_2$ changed into NiO, which has the property of a p-type semiconductor, and then ZnO and NiO formed a p-n junction for a large area light emitting diode.

Surgical treatment of Mallet finger deformity with Hook plate (고리 금속판을 이용한 망치 손가락의 수술적 치료법)

  • Choi, Seok Min;Jung, Sung Gyun;Shin, Ho Seong;Park, Eun Soo;Kim, Yong Bae
    • Archives of Plastic Surgery
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    • v.36 no.3
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    • pp.318-321
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    • 2009
  • Purpose: The bony mallet finger injury is generally managed by conservative treatments, but operative treatments are needed especially when the fractures involve above 30% of articular surface or distal phalanx is accompanied by subluxation in the volar side. This is the reason they often result in chronic instability, articular subluxation and unsatisfactory cosmetic. In this report, We describe new method using the hook plate as an operative treatment of Mallet finger deformity. Methods: Among 13 patients with Mallet finger deformity who came from February 2006 to February 2008, six patient were included in surgical indication. Under local anesthesia, H or Y type incision was made at the DIP joint area. After the DIP joint extension, the hook plate was put on the fracture line, and one self tapping screw was used for fixation. 2 hole plate which was one of the holes in 1.5 mm diameter was cut in almost half and bended through approximately $100^{\circ}$. Results: In all six cases which applied the hook plate, complications such as loss of reduction or nail deformity were not seen. In only one patient, hook pate was removed due to inflammatory reaction after surgery. At 2 weeks after operation, active motion of DIP joint was performed. The result was satisfactory not only cosmetically but also functionally. At 6 weeks after operation, the range of motion of DIP joint was average $64^{\circ}$. Conclusion: The purpose of the operative treatment for mallet finger deformity using the hook plate is to provide anatomical reduction with rigid fixation and to prevent contracture at the DIP joint. While other operations take 6 weeks, the operation using the hook plate begins an active motion at 2 weeks after operation. Complication rate was low and the method is rather simple. Thus, the operation using the hook plate is recommended as a good alternative method of the mallet finger deformity treatment.

Geochemical Characteristics of the Quaternary Jungok Basalt in Choogaryong Rift Valley, Mid-Korean Peninsula (추가령 열곡대에 분포하는 전곡현무암의 지화학적 특성)

  • Wee, Soo-Meen
    • Economic and Environmental Geology
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    • v.29 no.2
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    • pp.171-182
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    • 1996
  • Quaternary Jungok basalts are distributed along the old Hantan river in Mid-Korean Peninsula. They were flowed out from Mt. Ori and Upland (680 m), and they formed narrow and long basalt plateau showing the layers of 10 to 20 meters in thickness and about 95 km in length. Fifty seven samples were collected from the study area, and sixteen rock samples were selected and analysed for major and trace elements. The analyzed samples have alkalic composition and show a relatively restricted variation in major element chemistry (except MgO), as comparing to the that of trace element. Based on major element chemistry, a quantitative modelling of fractional crystallization by multiple linear regression method suggests that the chemical evolution of the evolved rocks can be generated by fractionation of olivine, plagioc1ase, clinopyroxene, and magnetite in proportion of 56 : 25 : 17 : 2, respectively. The calculated trace element abundances by mineral proportions estimated from major element modelling, however, underestimate the incompatible element concentrations in the evolved rocks. According to the incompatible element abundances, simple fractional crystallization process has difficulty to explain the chemical variation of the evolved rocks. It seems that the other processes, which enrichment of incompatible elements can occure without concomitant changes in major element compositions, are needed in order to explain the chemical variation of the Jungok basalts. Thus, the major elements and compatible trace elements variations of the Jungok basalts are due to fractional crystallization, but the incompatible elements variation is due to fractional crystallization superimposed on already varying concentrations caused by slightly different degrees of melting of the same source, and/or due to periodic replenishment, tapping and fractionation(RTF) processes.

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Clinical significance of cerebrospinal fluid pleocytosis in pediatric refractory status epilepticus (소아 난치성 간질 중첩증에서 뇌척수액 백혈구 증가증의 임상적 의의)

  • Kim, Jung Mi;Kim, Young Mi;Kwon, Soon Hak
    • Clinical and Experimental Pediatrics
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    • v.49 no.10
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    • pp.1086-1092
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    • 2006
  • Purpose : Refractory status epilepticus(RSE) is a serious neurological emergency in children. The mortality is high and the neurological outcome is not good. This study aimed to evaluate the clinical significance of cerebrospinal fluid(CSF) pleocytosis in refractory status epilepticus in children. Methods : From January 1999 to January 2006, 25 out of 37 children with refractory status epilepticus had spinal tapping. We retrospectively analyzed the data from these children's medical records. We compared the results between groups with and without CSF pleocytosis, and between a group with first seizure and a group with epilepsy. Result : Six out of 25 children had CSF pleocytosis. The group without CSF pleocytosis had a higher mortality rate and required higher doses of antiepileptic drugs as compared with the group with CSF pleocytosis. The group with CSF pleocytosis had much worse neurologic segualae. However, except for the children with CNS infection, the overall prognosis between the group with and without CSF pleocytosis was not significantly different. All children with CSF pleocytosis came in with first seizures. Conclusion : In children with RSE, a CSF study must be perfomed as soon as possible to exclude the possibility of CNS infection. A CSF study is even more important in cases of first seizure or CNS infection suspected. Mild CSF pleocytosis without evidence of infection does not seem to affect the prognosis, so physicians should therefore be more cautious in selecting antibacterial or antiviral agents for it.

Effect of ankle joint taping treatment on lower extremity joint and center of pressure factors during the Uchi-mata (허벅다리걸기 동작 시 발목 관절의 테이핑 처치가 하지 관절과 압력 중심 요인들에 미치는 영향)

  • Yun, Hyun
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.2
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    • pp.224-231
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    • 2020
  • The purpose of this study was to analyze the effect of ankle joint taping treatment on lower extremity joint and center of pressure(COP) factors during the Uchi-mata. Twenty college judo athletes (age, 20.9 ± 0.8 years; height, 168.6 ± 7.4cm; weight, 73.5 ± 11.6kg; body mass index, 25.7 ± 2.6kg/㎡) participated, and two types before and after ankle joint taping treatment when the during the Uchi-mata was exhibited under conditions, the angle and COP factors of the support leg joints were analyzed to show the following results. At the time of E2 (t = 2.411, p = .027) E4 (t = 2.388, p = .029), the ankle joint angle was statistically less after the treatment than before the taping treatment, and E2 (t = -2.343, p = .032) At E3 (t = -4.531, p = .000), the angle of the hip joint was statistically large. And after the ankle joint taping treatment, the medial/lateral COP movement after the ankle joint taping treatment was statistically large in the P3 phase of throwing the opponent (t = 2.670, p = .016), and the anterior/posterior COP movement showed a statistically small number in the P1 phase where the opponent was tilted (t = 2.846, p = .011). Therefore, it was suggested that judo athletes who use thighs as a special technique should be used considering the movement function of the support joint and the range of movement of the COP caused by tapping of the ankle joint.

Optimization of orthodontic microimplant thread design (교정용 마이크로 임플란트의 나사산 디자인 최적화)

  • Kim, Kwang-Duk;Yu, Won-Jae;Park, Hyo-Sang;Kyung, Hee-Moon;Kwon, Oh-Won
    • The korean journal of orthodontics
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    • v.41 no.1
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    • pp.25-35
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    • 2011
  • Objective: The purpose of this study was to optimize the thread pattern of orthodontic microimplants. Methods: In search of an optimal thread for orthodontic microimplants, an objective function stability quotient (SQ) was built and solved which will help increase the stability and torsional strength of microimplants while reducing the bone damage during insertion. Selecting the AbsoAnchor SH1312-7 microimplant (Dentos Inc., Daegu, Korea) as a control, and using the thread height (h) and pitch (p) as design parameters, new thread designs with optimal combination of hand p combination were developed. Design soundness of the new threads were examined through insertion strain analyses using 3D finite element simulation, torque test, and clinical test. Results: Solving the function SQ, four new models with optimized thread designs were developed (h200p6, h225p7, h250p8, and h275p8). Finite element analysis has shown that these new designs may cause less bone damage during insertion. The torsional strength of two models h200p6 and h225p7 were significantly higher than the control. On the other hand, clinical test of models h200p6 and h250p8 had similar success rates when compared to the control. Conclusion: Overall, the new thread designs exhibited better performance than the control which indicated that the optimization methodology may be a useful tool when designing orthodontic microimplant threads.

Effect of cutting flute length and shape on insertion and removal torque of orthodontic mini-implants (교점용 미니 임플랜트의 cutting flute의 길이 및 형태에 따른 식립 및 제거 토크의 비교)

  • Yun, Soon-Dong;Lim, Sung-Hoon
    • The korean journal of orthodontics
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    • v.39 no.2
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    • pp.95-104
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    • 2009
  • Objective: The purpose of this study was to evaluate the effect of length and shape of cutting flute on mechanical properties of orthodontic mini-implants. Methods: Three types of mini-implants with different flute patterns (Type A with 2.6 mm long flute, Type B with 3.9 mm long and straight flute, Type C with 3.9 mm long and helical flute) were inserted into the biomechanical test blocks (Sawbones Inc., USA) with 2 mm and 4 mm cortical bone thicknesses to test insertion and removal torque. Results: In 4 mm cortical bone thickness, Type C mini-implants showed highest maximum insertion torque, then Type A and Type B in order. Type C also showed shortest total insertion time and highest maximum removal torque, but Type A and B didn't showed statistically significant difference in insertion time and removal torque. In 2 mm cortical bone thickness, there were no significant difference in total insertion time and maximum removal torque in three types of mini-implants, but maximum insertion torque of Type A was higher than two other Types of mini-implants. Conclusions: Consideration about length and shape of cutting flute of mini-implant is also required when the placement site has thick cortical bone.