• Korean Journal of Pharmacognosy
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• v.50 no.2
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• pp.118-123
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• 2019

Glutamate acts as an important neurotransmitter in brain. However, high concentration of glutamate showed an excitatory neurotoxicity and resulted to neuronal cell death. Neuronal cell death is known for one of the reason of Alzheimer's disease, a neurodegenerative disease. We tried to find neuroprotective medicinal plants by neuroprotection activity against glutamate injured HT22 cells as a model system. In the course of bioscreening of various medicinal plants, Taraxacum platycarpum extract showed significant neuroprotective activity. We tried to elucidate mechanisms of neuroprotective activity. T. platycarpum extract reduced ROS and intracellular $Ca^{2+}$ concentration increased by glutamate induced neurotoxicity. In addition, mitochondrial membrane potential was restored to the control level. Also, glutathione level, glutathione reductase and glutathione peroxidase activity were increased by T. platycarpum extract treatment. These data suggested that T. platycarpum showed neuroprotective activity via antioxidative activity.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.569-573
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• 2012

Early diagnosis and better prognosis of ovarian cancer is still a challenge. Besides environmental risk factors, genetic factors have established a role in pathogenesis of ovarian cancer. Methods: A case-control and a prospective study design conducted in 224 ovarian cancer patients and 432 controls in Chinese population. MTHFR C677T genotyping was done by PCR-RFLP. Results: Patients with ovarian cancer is associated with a higher less number of delivery and less frequent oral contraceptive use. When potential confounding factors adjusted logistic regression analysis between cases and controls were performed, significant association was obtained for 677T/T genotype and ovarian cancer (OR=3.13, 95% CI=1.59-5.72). Cox regression survival analysis showed individuals carrying T/T genotype had significantly increased HR for death in ovarian cancer patients (HR=2.86, 95% CI=1.27-7.93). In conclusion, we observed that the MTHFR C677T polymorphism is associated with the susceptibility and survival of ovarian cancer in Chinese population.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.1
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• pp.247-261
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• 1999

In dieser Abhandlung wurde im Bereich der $Temporalit\"{a}t$ anhand des konzeptorientierten Ansatzes das $Verh\"{a}ltnis$ yon konzeptueller und sprachlicher $Repr\"{a}sentation$ betrachtet. Die $Temporalit\"{a}t$ ist ein abgeleiteter Begriff, den das menschliche$Bewu{\ss}tsein$ im Rahmen seiner kognitiven Entwicklung als $Ma{\ss}stab$ der qualitativen $Ver\"{a}nderung$ und Bewegung von Materie warhnimmt und systematisch konzeptualisiert. Ihre Subkategorien unterscheiden sich in den Sprachen, da bei den $Konzeptualisierungsvorg\"{a}ngen$ durch die Muttersprache bestimmte begriffliche Kategorien eine steuernde Rolle spielen. In diesem theoretischen Hintergrund betrachteten wir, inwieweit die beiden Sprachen, das Deutsche und das Koreanische, im Bereich des Zeitkonzepts auf der konzeptuellen Ebene und auf der Ausdrucksebene verschieden und gemeinsam sind, und wie das $Verh\"{a}ltnis$ zwischen den temporalen Konzepten und den $Ausdrucksm\"{o}glichkeiten$ ist. Die $Temporalit\"{a}t$ des Koreanischen ist in Bezug auf die Basiskategorien der $Temporalit\"{a}t$ mit dem Deutschen mehr oder weniger identisch. Zum Ausdruck der Zeitreferenz haben die beiden Sprachen gemeinsam zwei explizite grammatische und lexikalische $Ausdrucksm\"{o}glichkeiten$, aber die Art und Weise, wie sie zum Ausdruck der Subkategorien der $Temporalit\"{a}t$ eingesetzt werden, sind verschieden. In diesem Zusammenhang kann man sagen, $\dabeta$ es zum Verstandnis der $\dabeta$ in der Sprache nicht reicht, die sprachliche Formen zu betrachten: man $mu\ss$ die Konzepte berucksichten, die durch die sprachlichen Formen $ausgedr\"{u}ckt$ werden.

• Nuclear Engineering and Technology
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• v.55 no.5
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• pp.1901-1910
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• 2023

The safety-class (1E) digital control system (DCS) of nuclear power plant characterized structural multiple redundancies, therefore, it is important to quantitatively evaluate the reliability of DCS in different degree of backup loss. In this paper, a reliability evaluation model based on T-S fuzzy fault tree (FT) is proposed for 1E DCS of nuclear power plant, in which the connection relationship between components is described by T-S fuzzy gates. Specifically, an output rejection control system is chosen as an example, based on the T-S fuzzy FT model, the key indicators such as probabilistic importance are calculated, and for a further discussion, the T-S fuzzy FT model is transformed into Bayesian Network(BN) equivalently, and the fault diagnosis based on probabilistic analysis is accomplished. Combined with the analysis of actual objects, the effectiveness of proposed method is proved.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.66 no.4
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• pp.365-374
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• 2021

Soybean isoflavones are essential secondary metabolites synthesized through the phenylpropanoid pathway, and they play vital roles in human health. Isoflavone content is a complex quantitative trait controlled by multiple genes, and the genetic mechanisms underlying isoflavone biosynthesis remain largely unknown. Therefore, the present study analyzed the content of isoflavone and expression of six key genes involved in its biosynthesis (i.e., CHS6, HID, IF7GT, IF7MaT, GmIMaT1, and GmIMaT3) during soybean seed germination. Isoflavone content was quantified using high-performance liquid chromatography, and isoflavone biosynthetic gene expression was analyzed using quantitative real-time PCR. Two cultivars, namely 'Daepung2ho' and 'Pungsannamulkong', which are high- and low-isoflavone cultivars, respectively, were used. Isoflavone accumulation gradually increased with the progression of the germination period. As such, malonyl glucosides accounted for over 80% of the total content, whereas acetyl glucosides were present at trace amounts. Transcriptional analysis of isoflavone biosynthetic genes demonstrated expression patterns parallel to isoflavone content; however, there was no clear correlation between isoflavone content and gene expression. Moreover, most isoflavone biosynthetic genes showed different expression patterns depending on the individual gene or genotypes. Among the tested genes, HID showed consistently higher expression, except at 3 days after germination, and its expression was upregulated in 'Daepung2ho' but downregulated in 'Pungsannamulkong'. In addition, all tested genes exhibited different expression patterns between cotyledons and hypocotyls and responded differently to the germination period. These findings suggest that the expression levels of isoflavone biosynthetic genes are not consistent with the germination period and appear to be genotype-dependent.

• The Journal of Korean Academy of Prosthodontics
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• v.61 no.2
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• pp.160-178
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• 2023

Diagnosis and analysis of occlusal relationships are important factors in prosthetic treatment. A thorough occlusion analysis and evaluation should be performed before treatment to restore a stable interocclusal relationship. Analysis and evaluation are essential during the treatment process and at regular follow-ups. Recently, with the development of dental equipment and digital processing methods, new quantitative analysis methods that can record the patient's occlusal relationship have been introduced. Among them, the T-Scan Novus (Tekscan Inc., S. Boston, MA, USA) displays the strength of the initial contact point and the occlusal contact point of the teeth using a pressure sensor. With this, occlusal contact time of the teeth, anteroposterior and left-right balance of occlusal force can be compared. The Dental prescale II (GC Co., Tokyo, Japan) scans the occlusal contact point using a pressure-sensing film and analyzes the density of the contact point. It can measure the distribution and strength of the occlusal force of the teeth in the most natural occlusion state. Based on this, appropriate prosthetic treatment (four-unit fixed partial denture, removable partial denture, complete denture, and complete oral restoration cases) was performed according to the area and extent of the patient's tooth loss. The patient's occlusion at the first visit, treatment stage, right after treatment, and regular follow-up were compared and evaluated using a quantitative method for appropriate occlusion analysis using T-Scan Novus and Dental prescale II. This report enhances the understanding of occlusion analysis during prosthetic restoration. The results satisfied both the clinician and patients in terms of function and aesthetics.

• Journal of Animal Science and Technology
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• v.53 no.4
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• pp.377-385
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• 2011

This study was carried out to investigate quality characteristics of dry-cured hams in the domestic market. Two kinds of dry-cured hams were processed with pork leg (T1) and pork neck (T2). Five 24-month dry-cured legs (T1, 5.3-6.1 kg) and twenty 4-month dry-cured pork necks (T2, 1.5-1.9 kg) were used in this experiment. They were stored at $4^{\circ}C$ chilling room and quality characteristics were investigated. Moisture content, water activity, cholesterol content, CIE $L^*$, VBN, total plate counts and lactic acid bacteria of T1 were significantly higher (p<0.05) than those of T2, whereas fat content, ${NO_2}^-$, CIE $a^*$, TBARS and Warner-Bratzler shear force values of T2 were significantly higher (p<0.05) than those of T1. In fatty acid compositions, palmitoleic acid and stearic acid in T2 were significantly higher (p<0.05) than T1, however, oleic and linoleic acid in T2 was significantly lower (p<0.05) than T1. In free amino acids, the total content and individual content of asparagin, leucine and phenylalanine in T1 were higher than those of T2 (p<0.05). The aroma score of T2 was higher than that of T1 in sensory evaluation (p<0.05). In conclusion, two kinds of dry-cured hams were different in their final characteristics and could enhance the consumer's appeal of pork meat in Korean market.

• Journal of the East Asian Society of Dietary Life
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• v.23 no.4
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• pp.477-486
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• 2013

This study was carried out to investigate the effect of lotus leaf extract on the physicochemical characteristics of ground pork stored at $4^{\circ}C$ for 10 days. Four types of ground pork were evaluated: ice water added (T0), 3% lotus leaf extract added (T1), 7% lotus leaf extract added (T2), and 10% lotus leaf extract added (T3). The pH was increased during storage, but decreased after 10 days of storage (p<0.05). The TBARS increased with a longer storage period (p<0.05), and those of T0, T1, T2 and T3 were 0.777, 0.244, 0.185, 0.182 mg MA/kg, respectively, after 10 days of storage. The VBN content of T0 and T1 increased with a longer storage period (p<0.05), but those of T2 and T3 were not significantly changed. In the case of surface color, the $L^*$ increased with a longer storage period, and that of T0 was the highest (p<0.05). The $a^*$ decreased with a longer storage period, and the $b^*$ was the highest after 1 day of storage (p<0.05). In the case of internal color, $L^*$ was not significantly changed, and $a^*$ was decreased with a longer storage period (p<0.05). The $b^*$ increased with a longer storage period (p<0.05). Water holding capacity increased with a longer storage period, and those of T2 and T3 were the highest (p<0.05). Cooking loss decreased with a longer storage period, and those of T0 and T1 were higher than those of T2 and T3 (p<0.05). Hardness and chewiness were not significantly different with a longer storage period, or among any samples.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.897-898
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• 2012

• Proceedings of the KIEE Conference
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• 2001.07b
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• pp.1002-1004
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• 2001

In conventional zero-current-switching(ZCS) PWM converters, the switching loss, stress and noise can't be minimized because they adopt auxiliary switches operated in hard-switching. In this paper, new ZCS-PWM converters of which auxiliary switches always operate with soft-switching are proposed. Therefore, the proposed ZCS-PWM converters are most suitable for systems requiring high-power density. The characteristics of these converters are verified by experimental results.