• 근관절건강학회지
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• 제24권3호
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• pp.196-204
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• 2017

Purpose: This study was conducted to explore the mediating effect of resilience in the relationship between stress and therapeutic compliance in patients with systemic lupus erythematosus. Methods: The subject (N=145) was a systemic lupus erythematosus patient who visited the D Hospital in B city. Data collection was conducted from January 2016 to August 2016. Twenty-five resilience measurement tools, 20 stress measurement tools, 39 therapeutic compliance measurement tools used to measure resilience, stress and therapeutic compliance levels. The collected data were analyzed using descriptive analysis, Pearson correlation, 3-step regression analysis of Baron and Kenny, and Sobel test in SPSS/WIN 21.0. Results: There was a significant negative correlation between stress and therapeutic compliance, a significant negative correlation between stress and resilience, and significant positive correlation between resilience and therapeutic compliance. Resilience showed a direct effect on therapeutic compliance through stress as a mediating variable. Conclusion: It is necessary to develop appropriate resilience enhancement program to improve therapeutic compliance with systemic lupus erythematosus.

• The Plant Pathology Journal
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• 제28권1호
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• pp.101-106
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• 2012

Trifloxystrobin is a strobilurin fungicide, which possesses broad spectrum control against fungal plant diseases. We demonstrated that pre-treating red pepper plants with trifloxystrobin resulted in increased plant growth and leaf chlorophyll content compared with those in control plants. Relative water content of the leaves and the survival rate of intact plants indicated that plants acquired systemic tolerance to drought stress following trifloxystrobin pre-treatment. The recovery rate by rehydration in the drought treated plant was better in those pre-treated with trifloxystrobin than that in water treated plants. Induced drought tolerance activity by trifloxystrobin was sustained for 25 days after initial application. The trifloxystrobin treated red pepper plants also had induced systemic tolerance to other abiotic stresses, such as frost, cold, and high temperature stresses. These findings suggest that applying the chemical fungicide trifloxystrobin induced systemic tolerance to certain abiotic stresses in red pepper plants.

• Toxicological Research
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• 제27권1호
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• pp.19-23
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• 2011

It has been proposed that acute phase response can be a mechanism by which inhaled particles exert adverse effects on the cardiovascular system. Although some of the human acute phase proteins have been widely studied as biomarkers of systemic inflammation or cardiovascular diseases, there are only a few studies that investigated the role of serum amyloid P (SAP), a major acute phase protein in mice. In this study, we investigated the changes in SAP, following inhalation exposure to nickel hydroxide nanoparticles (nano-NH). We conducted 1) acute (4 h) exposure to nano-NH at 100, 500, and $1000\;{\mu}g/m^3$ and 2) sub-acute (4h/d for 3d) exposure at $1000\;{\mu}g/m^3$, then measured serum SAP protein levels along with hepatic Sap mRNA levels. The results show that inhaled nano-NH can induce systemic acute phase response indicated by increased serum SAP levels and hepatic Sap mRNA levels. To the best of our knowledge, this is the first study showing induction of SAP in response to repeated particle exposure, and the results suggest that SAP can be used as a biomarker for systemic inflammation induced by inhaled particles.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2191-2194
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• 2014

Background: Fluorouracil-based regimens have been widely accepted and recommended in the guidelines for treating patients with early or advanced staged colon cancer, although results are controversial. Here we performed a systemic analysis to evaluate the impact of S-1 based regimens on response and survival of patients with colon cancer. Methods: Clinical studies evaluating the impact of S-1 based regimens on response and survival of patients with colon cancer were identified using a predefined search strategy. Summary response rates (RRs) to treatment were calculated. Results: Six clinical studies which including 227 patients with advanced colorectal cancer were considered eligible for inclusion. Two studies were conducted using combination of S-1 and Oxaliplatin, and four studies featured S-1 and irinotecan. Systemic analysis showed that, in all patients, pooled RRs was 43.17%. Major adverse effects were hematological toxicities, gastrointestinal disturbance, neurosensory toxicity. No treatment related death occurred. Conclusion: This systemic analysis suggests that S-1 based regimens, both with oxaliplatin or irinotean are associated with acceptable response and toxicity in patients with colon cancer.

• 유통과학연구
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• 제15권11호
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• pp.21-29
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• 2017

Purpose - Relationship between farm and county losses determines whether the county program provides too little, too much, or similar amount of assistance relative to the loss on an individual farm. A review of the literature finds limited analysis of the determinants of this relationship. This paper conducts such an analysis using farm-level yield data. Research design, data, and methodology - Farm-level yield data from Illinois and Kansas farm business management associations are used for to calculate the correlation between farm and county loss and the share of farm loss systemic with county loss, and also for the regression analysis. Results - Average share of farm loss systemic with the county loss lies between 42% and 68%. The correlation between farm and county yield/revenue deviation from expected value is statistically significant in all four models. The coefficient is positive, implying the higher the correlation, the larger the share of farm loss that is systemic with the county loss. Conclusions - The findings of this study are consistent with the existing literature which argues that county variability may not be closely associated with farm variability. The findings of this study thus raise questions about the efficacy of area yield and revenue insurance products in helping farmers manage their risk.

• Archives of Plastic Surgery
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• 제33권1호
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• pp.116-119
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• 2006

Management of chronic wound has been a great problem to many surgeons because the wound is usually associated with an underlying disease of the patient. Without accurate diagnosis and treatment of the disease, the wound can not be healed. Systemic vasculitis is a rare systemic disease which causes inflammation and obstruction of the vessels. This autoimmune disease involves multiple organs and may inflict skin wound spontaneously without traumas. It would improve or aggravate the wound in proportion to the activities of the disease. Our experience is a case of 28-year-old female who has had chronic ulcers on her right foot, especially on the great toe for 1 year. Although she had several operations of sympathectomy, debridement and artificial dermal graft, her wound was not improved. She has been diagnosed as systemic vasculitis during the evaluation for histopathology and cause of fever and pancytopenia. After medical treatments, she had the operation of adipofascial turnover flap coverage and skin graft, and the wound was improved without any complication or relapse. The diagnosis and treatment of the underlying disease should be ahead of the management of chronic wound.

• Molecules and Cells
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• 제22권2호
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• pp.141-145
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• 2006

Uric acid is the end product of the purine degradation pathway in humans. It is catabolized to allantoin by urate oxidase or uricase (E.C. 1.7.3.3.) in most vertebrates except humans, some primates, birds, and certain species of reptiles. Here we provide evidence that mouse transthyretin-related protein facilitates the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Mutagenesis experiments showed that the residues that are absolutely conserved across the TRP family, including His11, Arg51, His102, and the C-terminal Tyr-Arg-Gly-Ser, may constitute the active site of mTRP. Based on these results, we propose that the transthyretin-related proteins present in diverse organisms are not functionally related to transthyretin but actually function as hydroxyisourate hydrolases.

• Tuberculosis and Respiratory Diseases
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• 제56권1호
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• pp.97-102
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• 2004

저자들은 객혈을 주소로 내원한 환자에서 조영증강 전산화 단층촬영과 혈관 조영술을 통해서 좌하엽으로의 비정상적인 체순환을 진단하였으며 좌하엽 폐절제술로 치료를 성공적으로 시행한 경험이 있기에 이를 보고하는 바이다.

• 디지털융복합연구
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• 제19권11호
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• pp.615-623
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• 2021

본 연구는 루푸스 환자의 극복력에 영향을 미치는 요인을 파악하기 위해 수행되었다. 연구대상자(N=118)는 D시 소재의 E병원을 내원한 루푸스 환자를 대상으로 하였다. 수집된 자료는 기술통계, t-tset, ANOVA, pearson correlation, multiple regression으로 분석하였다. 연구결과, 극복력에 영향을 미치는 요인은 불확실성의 질병의 영향 영역, 피로, 불확실성의 자기관리 영역과 의사에 대한 신뢰영역 이었다. 본 연구를 토대로 루푸스 환자의 극복력을 향상시키기 위해서는 환자가 인지하는 불확실성을 줄이고 피로 조절을 위한 다각적인 접근이 필요하다. 또한 영향요인을 반영한 루푸스 환자의 극복력 증진을 위한 효과적인 간호중재 프로그램의 개발이 요구된다.

• 한국산업보건학회지
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• 제33권2호
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• pp.188-205
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• 2023

Objectives: Methanol poisoning accidents in smartphone parts manufacturing facilities were analyzed using a systemic accident analysis method, and the necessity and possibility of the application of this systemic method in the field of occupational health were reviewed. Methods: A STAMP model for accident analysis was created based on the previously published literature. CAST analysis was performed to find the causal factors of the components and between the components. Results: The STAMP model visually showed the abstract and complex system control structure. The CAST analysis results could include all the causal factors from the previously published literature, and presented them holistically. Additional causal factors that were not presented in the literature were found. Conclusions: The holistic accident analysis results in this study will be helpful to establish comprehensive measures to prevent methanol or other chemical poisoning accidents. Therefore, it will be necessary to use systemic accident analysis methods in the field of occupational health.