• Korean Journal of Radiology
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• 제24권3호
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• pp.247-258
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• 2023

Objective: To localize the neuroanatomical substrate of rapid eye movement sleep behavior disorder (RBD) and to investigate the neuroanatomical locational relationship between RBD and α-synucleinopathy neurodegenerative diseases. Materials and Methods: Using a systematic PubMed search, we identified 19 patients with lesions in different brain regions that caused RBD. First, lesion network mapping was applied to confirm whether the lesion locations causing RBD corresponded to a common brain network. Second, the literature-based RBD lesion network map was validated using neuroimaging findings and locations of brain pathologies at post-mortem in patients with idiopathic RBD (iRBD) who were identified by independent systematic literature search using PubMed. Finally, we assessed the locational relationship between the sites of pathological alterations at the preclinical stage in α-synucleinopathy neurodegenerative diseases and the brain network for RBD. Results: The lesion network mapping showed lesions causing RBD to be localized to a common brain network defined by connectivity to the pons (including the locus coeruleus, dorsal raphe nucleus, central superior nucleus, and ventrolateral periaqueductal gray), regardless of the lesion location. The positive regions in the pons were replicated by the neuroimaging findings in an independent group of patients with iRBD and it coincided with the reported pathological alterations at post-mortem in patients with iRBD. Furthermore, all brain pathological sites at preclinical stages (Braak stages 1-2) in Parkinson's disease (PD) and at brainstem Lewy body disease in dementia with Lewy bodies (DLB) were involved in the brain network identified for RBD. Conclusion: The brain network defined by connectivity to positive pons regions might be the regulatory network loop inducing RBD in humans. In addition, our results suggested that the underlying cause of high phenoconversion rate from iRBD to neurodegenerative α-synucleinopathy might be pathological changes in the preclinical stage of α-synucleinopathy located at the regulatory network loop of RBD.

• Journal of Information Technology Applications and Management
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• 제12권4호
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• pp.133-155
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• 2005

This Paper makes an attempt to suggest a process of automatically generating application software based on the Entity-Relationship model 1. The designer develops an E-R model of an real-world system. 2. The designer inputs the entity and relationship types, and attributes shown in the E-R model, and also the basic operations of the application system to the software generator. 3. The application generator produces database schema and link information between application programs, and then automatically generates a stereo-type application system. In order for the automated application generator to build the application system in a systematic way, four basic program generation rules have been suggested. A set of computer programs have been developed in order to show the applicability of the automated software generation process suggested in this paper. By following each rule with the generator, the designer can build an application in an efficient manner compared with traditional (manual programming) approaches. It has been demonstrated from the case study that the idea of applying an automated generator in systems development based upon the E-R model is feasible.

• International Journal of Quality Innovation
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• 제7권3호
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• pp.24-45
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• 2006

In recent years, the labor consciousness is gradually valued. During the process of pursuing sustainable operation, the enterprises treat occupational hazard risk as the waste of cost. The purpose of OHSAS 18000 occupational security and health management system is to systematically establish the business managerial measures in terms of occupational security and calamity prevention. This research proceeded with questionnaire analysis with respect to the relationship between the OHSAS 18000 system implementation and competitiveness in Taiwan's industries. The research result revealed that there was significant relationship between Taiwan firms' execution of OHSAS 18000 system and industry competitiveness. Thus, the enterprises can decide the proper managerial plans according to the result of their own risk evaluation to prevent the happening of accidents and reduce the operational cost. They can thus completely control business occupational hazard risk through "systematic" management.

• Bulletin of the Korean Chemical Society
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• 제32권6호
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• pp.1945-1950
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• 2011

The pyridinolysis of methyl phenyl phosphinic chloride is investigated kinetically in acetonitrile at -20.0 $^{\circ}C$. The Hammett and Br${\o}$nsted plots for substituent X variations in the nucleophiles are biphasic concave downwards with a break point at X = H, and unusual positive ${\rho}_X$ (= 2.94) and negative ${\beta}_X$ (= -0.48) values are obtained for the strongly basic nucleophiles. A stepwise mechanism with a rate-limiting step change from bond breaking for the weakly basic pyridines to bond formation for the strongly basic pyridines is proposed on the basis of biphasic concave downward Hammett and Br${\o}$nsted plots. Unusual positive ${\rho}_X$ and negative ${\beta}_X$ values are rationalized by the isokinetic relationship. The pyridinolyses and anilinolyses of four $R_1R_2$P(=O)Cl-type substrates, dimethyl, diethyl, methyl phenyl, and diphenyl phosphinic chlorides in acetonitrile are compared to obtain systematic information on phosphoryl transfer reaction mechanism. The combination of the two ligands, Me and Ph, shows unexpected kinetic results for both the anilinolysis and pyridinolysis: greatest magnitude of $k_H/k_D$ (= 2.10) involving deuterated anilines $[XC_6H_4NH_2(D_2)]$ for the anilinolysis, and exceptionally fast rate and biphasic concave downward free energy correlation for the pyridinolysis.

• 한국치위생학회지
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• 제16권3호
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• pp.363-371
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• 2016

Objectives: The purpose of the study was to investigate the relationship between oral health perception and oral health-related quality of life-14(OHIP-14) in a geriatric hospital. Methods: A self-reported questionnaire was completed by 230 elderly people in a long-term care institution. The questionnaire was consisted of items on general characteristics, oral health perception and OHIP-14. Except incomplete answers, 226 data were analyzed statistically with one-way ANOVA, t-test, Pearson's correlation coefficient and post hoc Tukey test and ANOVA when significance was set at 0.05. Results: The OHIP-14 showed a negative linear relationship(p<0.01) of r=-0.272 with the oral health perception. Among the subgroups of the OHIP-14, quantitative linear relationship(p<0.01) was shown in functional limitation(r=0.822), physical pain(r=0.825), psychological discomfort(r=0.568), physical disability(r=0.895), psychological disability(r=0.652), social disability(r=0.804) and handicap(r=0.818). Conclusions: In order to improve the oral health perception and OHIP-14 in a geriatric hospital, it is necessary to develop continuously a variety of oral health education and systematic oral health promotion program.

• 토지주택연구
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• 제9권4호
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• pp.10-18
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• 2018

As the volatility increasement of the number of tourist, there was been controversy over supply-demand imbalance in hotel market. The purpose of this study is to analysis on determinants of hotel occupancy rate in Jeju Island. The quantitative method is based on cointegrating regression, using an empirical dataset with hotel from 2000 to 2017. The primary results of research is briefly summarized as follows; First, there are high relationship between total hotel occupancy rate and hotel occupancy of foreign tourist. The volatility of hotel occupancy is caused by foreigner user than local tourists though local tourist high propotion of hotel occupancy in Jeju Island. Second, hotel occupancy of local tourist has not relationship with demand and supply variables. Because some hotel users are not local tourists but local resident, and effects to other variables of hotel consumer trend, accommodation such as Guest house, Airbnb. Third, there are high relationship between foreign hotel occupancy rate and demand-supply variables. These research imply that total management of supply-demand is very important to seek stability of hotel occupancy rate in Jeju Island. Also it can provide a useful solution regarding mismatch problem between supply-demand as well as development the systematic forecasting model for hotel market participants.

• Journal of Information Technology Applications and Management
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• 제17권3호
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• pp.1-24
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• 2010

Most of enterprises depend on a data modeler during developing their management information systems. In formulating business requirements for information systems, they widely and naturally use the interview method between a data modeler and a field worker. But, the discrepancy between both parties would certainly cause information loss and distortion that lead to let the systems not faithful to real business works. To improve or avoid modeler-dependant data modeling process, many automated data design CASE tools have been introduced. However, since most of traditional CASE tools just support drawing works for conceptual data design, a data modeler could not generate an ERD faithful to real business works and a user could not use them without any knowledge on database. Although some CASE tools supported conceptual data design, they still required too much preliminary database knowledge for a user. Against these traditional CASE tools, we proposed a Requirement-Oriented Entity Relationship Model for automated data design tool, called ROERM. Based on Non-Stop Methodology, ROERM adopts inner systematic modules for complete and sound ERD that is faithful to real field works, where modules are composed of interaction modules with a user, rules of schema operations and sentence translations. In addition to structure design of ROERM, we also devise detailed algorithms and perform an experiment for a case study.

• 식물분류학회지
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• 제37권1호
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• pp.61-78
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• 2007

까치수염속 Spicatae절에 포함되는 3종 14집단 34개체의 형태형질을 검토하였고, 이를 토대로 수리 분류학적 연구를 수행하였으며, 본 절의 각 종에 대한 중요형질 및 변이의 한계를 파악하고 종집단간의 유연관계를 고찰하였다. 정량형질보다는 정성형질인 서식지와 엽선 그리고 잎, 탁엽, 줄기 및 포에 존재하는 털의 유무, 줄기의 가지 여부, 화축과 소화경에 존재하는 털의 종류 및 화서의 형태 등이 종 동정에 유용한 식별형질로 밝혀졌다. 또한, 정성형질의 검토에 의하여 큰까치수염과 까치수염이 진퍼리까치수염에 비해 유연관계가 더 밀접한 것으로 밝혀졌고, 이를 근거로 종 검색표를 제시하였다.

• 정보처리학회논문지D
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• 제13D권4호
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• pp.619-624
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• 2006

현재 국내 게임시장은 급속도로 발전하고 있으나 게임제작 프로세스는 체계화 되지 못하고 있다. 또한 게임기획자와 게임개발자 간의 의사 소통의 문제점은 게임의 실패를 초래 하고 있다. 본 연구는 게임기획자와 게임개발자 간의 원활한 의사소통을 위하여 게임기획을 위한 산출물에서 게임의 특성을 표현하는 요소를 추출하여 클래스화 하고, 추출된 요소간의 관계를 나타내기 위하여 클래스의 연관관계를 제시한다. 사례 연구를 통해 추출된 클래스와 클래스간의 연관관계를 파악하여 체계적인 게임기획을 지원한다.

• International Journal of Advanced Culture Technology
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• 제7권4호
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• pp.172-186
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• 2019

As ICT technology develops rapidly and social and consumer interactions require more knowledge of the technology, the interest for baby boomers' ICT technology acceptance is increasing as they age. However, previous studies have limitations as they lack a systematic and in-depth understanding of this phenomenon in which the emerging elderly population embraces emerging technology. To overcome this limitation, this study carried out a phenomenological study on baby boomers' ICT technology acceptance. In addition, since existing studies have just simply listed variables or proved the relationship between a few variables, this study aimed to find the relationship between variables by analyzing the data obtained through semi-structured interviews. Through this procedure, it was aimed to construct conceptual model which illustrates the relationships between variables so that understanding the phenomenon of baby boomers' acceptance of ICT technology with a holistic view could be possible. The ten variables suggested by Lee & Coughlin (2015) that cover multiple sides of baby boomers' technology acceptance were used. As a result, we found that there is a sequential relationship between these variables and different agents can be related to each variable in sequence. Also, from an ecological perspective, we analyzed baby boomers and their surroundings to find agents involved in this phenomenon.