• KDI Journal of Economic Policy
• /
• 제42권3호
• /
• pp.1-32
• /
• 2020

This paper studies urban growth in Korean cities. First, I document that population growth patterns change over time and that the current population distribution supports random urban growth. I confirm two empirical laws-Zipf's law and Gibrat's law-both of which hold in the period of 1995-2015, but do not hold in the earlier period of 1975-1995. Second, I find a systematic employment growth pattern of Korean cities in spite of the random population growth. I examine market access effects on employment growth. Market access, a geographical advantage, has a significant influence on urban employment growth. The market access effect is higher in the Seoul metropolitan area than in the rest of the country. This effect is stronger on employment growth in the manufacturing industry compared to employment growth in the service industry. These results are robust with various checks (e.g., different definitions of urban areas). The results here suggest that policymakers should consider geographical characteristics when they make policy decisions with respect to regional development.

• 한국의학물리학회지:의학물리
• /
• 제23권2호
• /
• pp.81-90
• /
• 2012

방사선 치료에서 부정확한 환자 셋업이 표적에 전달되는 선량에 미치는 영향과 치료 마진과의 연관성을 몬테칼로 기법을 사용한 전산모사를 통하여 분석하였다. 실제 방사선 치료를 받은 직장암 환자에 대한 임상표적체적(CTV: Clinical Target Volume) 및 주요장기의 구조와 치료계획 시스템(Eclipse 8.9, USA)을 이용하여 수립된 세기조절 방사선치료계획에서의 선량분포에 대한 데이터를 전산모사에서 사용하였다. 전산모사 프로그램은 리눅스환경에서 오픈소스인 ROOT 라이브러리와 GCC를 기반으로 본 연구를 위하여 개발되었다. 환자셋업오차의 확률분포를 정규분포로 가정한 것에 따라 무작위로 생성된 크기만큼 셋업이 부정확한 경우를 모사하여 임상표적체적에서의 선량분포의 변화와 오차크기에 따른 마진크기를 3차원입체조형 방사선치료에 사용되는 마진공식과 비교분석 하였다. 셋업오차 생성에 사용된 정규분포의 표준편차 크기는 1 mm부터 10 mm까지 1 mm간격으로 두었으며 계통오차와 통계오차별로 2,000번 전산모사했다. 계통오차의 경우 전산모사에 사용된 표준편차가 커질수록 임상표적체적에 조사되는 최소선량 $D_{min}^{stat{\cdot}}$은 100.4%에서 72.50%로 감소하였고 평균선량 $\bar{D}_{syst{\cdot}}$도 100.45%에서 97.88%로 감소한 반면에 표준편차${\Delta}D_{sys}$는 0.02%에서 3.33%로 증가하였다. 통계오차의 경우 최소선량 $D_{min}^{rand{\cdot}}$은 100.45%에서 94.80%감소하였고 평균선량 $\bar{D}_{syst{\cdot}}$도 100.46%에서 97.87%로 감소하였으며 표준편차 ${\Delta}D_{rand}$는 0.01%에서 0.63%로 증가하였다. 그리고 마진공식으로부터 전산모사에 사용된 셋업오차에 해당되는 마진크기를 구하고 모집단비율(population ratio)을 정의하여 기존 마진공식의 목적이 세기조절방사선치료에 만족함을 확인했다. 개발된 전산모사 프로그램은 해당 환자의 치료계획 정보를 직접 사용하므로 직장암만 아니라 두경부암, 전립선암 등 여러 환부에 적용 가능하며 셋업오차 및 선량변화에 연관된 연구에도 사용할 수 있을 것으로 사료된다.

• 대한기계학회논문집A
• /
• 제29권11호
• /
• pp.1472-1479
• /
• 2005

Multiple surface crack distributed randomly along a weld toe influences strongly on the fatigue crack propagation life of welded joint. It is investigated by using statistical approaches based on series of systematic experiments. From the statistical results, initial crack numbers and its locations follow the normal distribution, and the probability of initial crack depths and lengths can be described well by tile Weibull distribution. These characteristics are used to calculate the fatigue crack propagation life, in which the mechanisms of mutual interaction and coalescence of the multiple cracks are considered as well as the Mk-factors obtained from a parametric study on the crack depths and lengths. The automatic calculation is achieved by the NESUSS, where the parameters such as the number, location and size of the cracks are all treated as random variables. The random variables are dealt through the Monte-Carlo simulation with sampling random numbers of 2,000. The simulation results show that the multiple cracks lead to much shorter crack propagation life compared with those in single crack situation. The sum of the simulation and tile fatigue crack initiation life derived by the notch strain approach agrees well with the experiments.

• Communications for Statistical Applications and Methods
• /
• 제8권1호
• /
• pp.73-85
• /
• 2001

The spatial population existing in a plane ares, such as an animal or aerial population, have certain relationships among regions which are located within a fixed distance from one selected region. We consider with the adaptive searching estimation in spatial sampling for a spatial population. The adaptive searching estimation depends on values of sample points during the survey and on the nature of the surfaces under investigation. In this paper we study the estimation by the adaptive searching in a spatial sampling for the purpose of estimating the area possessing a particular characteristic in a spatial population. From the viewpoint of adaptive searching, we empirically compare systematic sampling with stratified sampling in spatial sampling through the simulation data.

• Journal of Hospice and Palliative Care
• /
• 제24권3호
• /
• pp.144-153
• /
• 2021

Purpose: Advance care planning (ACP) is widely understood to improve end-of-life care. This systematic review and meta-analysis aimed to examine the effects of ACP interventions on decision conflict and psychological distress. Methods: A search of PubMed, CINAHL, CENTRAL, EMBASE, KISS, KoreaMed, and RISS was conducted in November 2020. The study included randomized controlled trials. Data were pooled using fixed- and random-effects models. Results: Fourteen studies were identified that cumulatively included 1,548 participants. ACP interventions were effective in alleviating decision conflict (d=-0.53; 95% CI: -0.83 to -0.23), depression (d=-1.22; 95% CI: -1.71 to -0.74) and anxiety (d=-0.76; 95% CI: -1.12 to -0.39). Conclusion: ACP interventions have significant positive effects on reducing decision conflict and psychological distress. A high level of bias was shown related to allocation concealment and blinding. The results of this study are expected to be useful for end-of-life care providers to improve the effectiveness of ACP interventions.

• 한국운동역학회지
• /
• 제32권2호
• /
• pp.56-68
• /
• 2022

Objective: The purpose of this systematic review and meta-analysis was to investigate potential effects of HRT (hormone replacement therapy) on motor functions in postmenopausal women. Method: In this meta-analysis, 19 studies that examined changes in motor functions between postmenopausal women with and without HRT intervention were qualified. We additionally conducted moderator variable analyses including: (1) motor function type, (2) hormone type, and (3) duration of HRT intervention. Results: The random effects model showed no significant overall effects (SMD = 0.199; SE = 0.115; 95% CI = -0.026~0.425; Z = 1.730; p = 0.084; I² = 93.258%). Additional three moderator variable analyses revealed no significant effect sizes indicating that specific HRT protocols did not improve different motor functions in postmenopausal women. Conclusion: These meta-analytic findings suggest that HRT had no positive effects on motor functions in postmenopausal women.

• 응용통계연구
• /
• 제17권1호
• /
• pp.105-117
• /
• 2004

본 논문에서는 선형추세를 갖는 모집단의 평균을 추정하기 위한 새로운 방법을 제시하였다. 이 방법은 변형계통추출에 의하여 표본을 뽑은 뒤 표본의 단순평균이 아니라 조정된 추정량을 사용하여 모평균을 추정하는 방법이다. 조정된 추정량을 정하는 데에 최소제곱법을 사용하였다. 제시된 방법은 선형 추세가 강할수록 효율적이라는 것이 밝혀졌으며, 무한초모집단 모형의 랜덤오차항의 분산인 $\sigma$$^2$이 매우 크지만 않다면 전통적인 방법들에 비해 상대적으로 효율적인 것으로 나타났다.

• Journal of Dental Anesthesia and Pain Medicine
• /
• 제21권5호
• /
• pp.397-411
• /
• 2021

This systematic review aimed to assess the effect of premedication on postoperative pain after root canal treatment in vital teeth. Five electronic databases were searched for randomized clinical trials, and two independent reviewers selected eligible studies, extracted data, and assessed the quality of studies using the Cochrane Risk of Bias tool. Meta-analysis was conducted using the random-effects model, and the pooled effect estimate of the standardized mean difference (SMD) between premedication and placebo was calculated. Subgroup analysis was conducted based on the class and route of the drug. Studies with a high risk of bias were excluded from the sensitivity analysis. Ten trials satisfied the inclusion criteria, of which eight were included in the meta-analysis. Premedication was more effective in reducing postoperative pain than placebo at 6 hours (SMD = -1.00; 95% confidence interval [CI] = -1.33 to -0.66), 12 hours (SMD = -0.80; 95% CI = -1.05 to -0.56), and 24 hours (SMD = -0.72; 95% CI = -1.02 to -0.43). The results of the sensitivity analysis confirmed the findings of the primary analysis. Based on these results, it can be concluded that premedication is effective in reducing postoperative pain in teeth with irreversible pulpitis. However, additional quality studies are required for further validation.

• 한국식생활문화학회지
• /
• 제35권6호
• /
• pp.553-568
• /
• 2020

This systematic review and meta-analysis aimed to determine whether food intake is effective in preventing diseases related to cognitive impairment. We searched English databases namely MEDLINE, PubMed and ScienceDirect from 2000 to May 2020, and Korean databases namely RISS, KISS, and DBPIA from 1990 to May 2020. We divided the data into 15 groups using the food group classification of the Korean Nutrition Society (KNS). The effect size (Cohen's d) was estimated using a random-effect model, and a 95% confidence interval was calculated for each study. We included 17 cross-sectional studies and 7 cohort studies which involved 45,115 participants. As a result of analyzing the subgroups in the Asian population of both sexes, it was observed that grain intake has a protective effect against cognitive impairment. For females, pulses and fish also have a protective role against cognitive impairment. In the case of seaweed, a negative relationship was found with a moderate protective effect against cognitive impairment (Cohen's d:-0.533, 95% CI: -0.939, -0.126; p=0.010) in Korean studies. Dairy products are associated with an increased risk of cognitive impairment in the American and European population but drinking alcohol is associated with a lower impairment risk. These results provide a basis for formulating the dietary guidelines for preventing dementia for each country.

• Journal of Ginseng Research
• /
• 제45권3호
• /
• pp.420-432
• /
• 2021

Background: Many ginsenosides have been shown to be efficacious for major depressive disorder (MDD), which is a highly recurrent disorder, through several preclinical studies. We aimed to review the literature assessing the antidepressant effects of ginsenosides on MDD animal models, to establish systematic scientific evidence in a rigorous manner. Methods: We performed a systematic review on the antidepressant effects of ginsenoside evaluated in in vivo studies. We searched for preclinical trials from inception to July 2019 in electronic databases such as Pubmed and Embase. In vivo studies examining the effect of a single ginsenoside on animal models of primary depression were included. Items of each study were evaluated by two independent reviewers. A meta-analysis was conducted to assess behavioral changes induced by ginsenoside Rg1, which was the most studied ginsenoside. Data were pooled using the random-effects models. Results: A total of 517 studies were identified, and 23 studies were included in the final analysis. They reported on many ginsenosides with different antidepressant effects and biological mechanisms of action. Of the 12 included articles assessing ginsenoside Rg1, pooled results of forced swimming test from 9 articles (mean difference (MD): 20.50, 95% CI: 16.13-24.87), and sucrose preference test from 11 articles (MD: 28.29, 95% CI: 22.90-33.69) showed significant differences compared with vehicle treatment. The risk of bias of each study was moderate, but there was significant heterogeneity across studies. Conclusion: These estimates suggest that ginsenosides, including ginsenoside Rg1, reduces symptoms of depression, modulates underlying mechanisms, and can be a promising antidepressant.