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Effects of Hormone Replacement Therapy on Motor Functions in Postmenopausal Women: A Systematic Reviews and Meta-Analysis

호르몬 대체 요법 제공이 폐경기 이후 여성들의 운동기능에 미치는 영향: 체계적 문헌고찰 및 메타분석 연구

  • Lee, Hanall (Department of Human Movement Science, Incheon National University) ;
  • Park, Young-Min (Division of Health and Kinesiology, Incheon National University) ;
  • Kang, Nyeonju (Department of Human Movement Science, Incheon National University)
  • Received : 2022.06.02
  • Accepted : 2022.06.27
  • Published : 2022.06.30

Abstract

Objective: The purpose of this systematic review and meta-analysis was to investigate potential effects of HRT (hormone replacement therapy) on motor functions in postmenopausal women. Method: In this meta-analysis, 19 studies that examined changes in motor functions between postmenopausal women with and without HRT intervention were qualified. We additionally conducted moderator variable analyses including: (1) motor function type, (2) hormone type, and (3) duration of HRT intervention. Results: The random effects model showed no significant overall effects (SMD = 0.199; SE = 0.115; 95% CI = -0.026~0.425; Z = 1.730; p = 0.084; I2 = 93.258%). Additional three moderator variable analyses revealed no significant effect sizes indicating that specific HRT protocols did not improve different motor functions in postmenopausal women. Conclusion: These meta-analytic findings suggest that HRT had no positive effects on motor functions in postmenopausal women.

Keywords

References

  1. Armstrong, A. L., Oborne, J., Coupland, C. A., Macpherson, M. B., Bassey, E. J. & Wallace, W. A. (1996). Effects of hormone replacement therapy on muscle performance and balance in post-menopausal women. Clinical Science (London, England: 1979), 91(6), 685-690. doi:10.1042/cs0910685
  2. Bayer, U. & Erdmann, G. (2008). The influence of sex hormones on functional cerebral asymmetries in postmenopausal women. Brain and Cognition, 67(2), 140-149. doi:10.1016/j.bandc.2007.12.003
  3. Bayer, U. & Hausmann, M. (2010). Hormone therapy in postmenopausal women affects hemispheric asymmetries in fine motor coordination. Hormones and Behaviors, 58(3), 450-456. doi:10.1016/j.yhbeh.2010.05.008
  4. Boardman, H. M., Hartley, L., Eisinga, A., Main, C., Roque, I., Figuls, M., Bonfill Cosp, X. ... & Knight, B. (2015). Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Systematic Reviews, (3), Cd002229. doi:10.1002/14651858.CD002229.pub4
  5. Bohannon, R. W. (2008). Hand-grip dynamometry predicts future outcomes in aging adults. Journal of Geriatric Physical Therapy, 31(1), 3-10. doi:10.1519/00139143-200831010-00002
  6. Bondarev, D., Laakkonen, E. K., Finni, T., Kokko, K., Kujala, U. M., Aukee, P. ... & Sipila, S. (2018). Physical performance in relation to menopause status and physical activity. Menopause, 25(12), 1432-1441. doi:10.1097/gme.0000000000001137
  7. Borenstein, M. (2009). Introduction to meta-analysis. Chichester, U.K.: John Wiley & Sons.
  8. Borenstein, M., Higgins, J. P., Hedges, L. V. & Rothstein, H. R. (2017). Basics of meta-analysis: I(2) is not an absolute measure of heterogeneity. Research Synthesis Methods, 8(1), 5-18. doi:10.1002/jrsm.1230
  9. Brown, M. (2008). Skeletal muscle and bone: effect of sex steroids and aging. Advances in Physiology Education, 32(2), 120-126. doi:10.1152/advan.90111.2008
  10. Carville, S. F., Rutherford, O. M. & Newham, D. J. (2006). Power output, isometric strength and steadiness in the leg muscles of pre- and postmenopausal women; the effects of hormone replacement therapy. European Journal of Applied Physiology, 96(3), 292-298. doi:10.1007/s00421-005-0078-4
  11. Chidi-Ogbolu, N. & Baar, K. (2018). Effect of Estrogen on Musculoskeletal Performance and Injury Risk. Frontiers in Physiology, 9, 1834. doi:10.3389/fphys.2018.01834
  12. Ciana, P., Raviscioni, M., Mussi, P., Vegeto, E., Que, I., Parker, M. G. ... & Maggi, A. (2003). In vivo imaging of transcriptionally active estrogen receptors. Nature Medline, 9(1), 82-86. doi:10.1038/nm809
  13. Colcombe, S. J., Kramer, A. F., Erickson, K. I. & Scalf, P. (2005). The implications of cortical recruitment and brain morphology for individual differences in inhibitory function in aging humans. Psychology and Aging, 20(3), 363-375. doi:10.1037/0882-7974.20.3.363
  14. Cooper, R., Mishra, G., Clennell, S., Guralnik, J. & Kuh, D. (2008). Menopausal status and physical performance in midlife: findings from a British birth cohort study. Menopause, 15(6), 1079-1085. doi:10.1097/gme.0b013e31816f63a3
  15. Egger, M., Smith, G. D., Schneider, M. & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical Research ed.), 315(7109), 629-634. https://doi.org/10.1136/bmj.315.7109.629
  16. Figueroa, A., Going, S. B., Milliken, L. A., Blew, R. M., Sharp, S., Teixeira, P. J. & Lohman, T. G. (2003). Effects of exercise training and hormone replacement therapy on lean and fat mass in postmenopausal women. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 58(3), 266-270. doi:10.1093/gerona/58.3.m266
  17. Greeves, J. P., Cable, N. T., Luckas, M. J., Reilly, T. & Biljan, M. M. (1997). Effects of acute changes in oestrogen on muscle function of the first dorsal interosseus muscle in humans. The Journal of Physiology, 500, 265-270. doi:10.1113/jphysiol.1997.sp022016
  18. Greising, S. M., Baltgalvis, K. A., Lowe, D. A. & Warren, G. L. (2009). Hormone therapy and skeletal muscle strength: a meta-analysis. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 64(10), 1071-1081. doi:10.1093/gerona/glp082
  19. Higgins, J. P. & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Statistics in Medicine, 21(11), 1539-1558. doi:10.1002/sim.1186
  20. Iannuzzi-Sucich, M., Prestwood, K. M. & Kenny, A. M. (2002). Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 57(12), M772-777. doi:10.1093/gerona/57.12.m772
  21. Ibeneme, S. C., Ekanem, C., Ezuma, A., Iloanusi, N., Lasebikan, N. N., Lasebikan, O. A. & Oboh, O. E. (2018). Walking balance is mediated by muscle strength and bone mineral density in postmenopausal women: an observational study. BMC Musculoskeletal Disorders, 19(1), 84. doi:10.1186/s12891-018-2000-3
  22. Javed, A. A., Mayhew, A. J., Shea, A. K. & Raina, P. (2019). Association Between Hormone Therapy and Muscle Mass in Postmenopausal Women: A Systematic Review and Meta-analysis. JAMA Network Open, 2(8), e1910154. doi:10.1001/jamanetworkopen.2019.10154
  23. Johnson, A., Roberts, L. & Elkins, G. (2019). Complementary and Alternative Medicine for Menopause. Journal of Evidence-Based Integrative Medicine, 24, 2515690x19829380. doi:10.1177/2515690x19829380
  24. Kok, L., Kreijkamp-Kaspers, S., Grobbee, D. E., Lampe, J. W. & van der Schouw, Y. T. (2005). Soy isoflavones, body composition, and physical performance. Maturitas, 52(2), 102-110. doi:10.1016/j.maturitas.2005.01.003
  25. Laakkonen, E. K., Soliymani, R., Karvinen, S., Kaprio, J., Kujala, U. M., Baumann, M. ... & Lalowski, M. (2017). Estrogenic regulation of skeletal muscle proteome: a study of premenopausal women and postmenopausal MZ cotwins discordant for hormonal therapy. Aging Cell, 16(6), 1276-1287. doi:10.1111/acel.12661
  26. Langer, R. D., Hodis, H. N., Lobo, R. A. & Allison, M. A. (2021). Hormone replacement therapy - where are we now? Climacteric: the Journal of the International Menopause Society, 24(1), 3-10. doi:10.1080/13697137.2020.1851183
  27. Lindmark, B., Lagerstrom, C., Naessen, T., Larsen, H. C. & Persson, I. (1999). Performance in functional balance tests during menopausal hormone replacement: a double-blind placebo-controlled study. Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy, 4(1), 43-54. doi:10.1002/pri.1999.4.1.43
  28. Maher, C. G., Sherrington, C., Herbert, R. D., Moseley, A. M. & Elkins, M. (2003). Reliability of the PEDro scale for rating quality of randomized controlled trials. Physical Therapy, 83(8), 713-721. https://doi.org/10.1093/ptj/83.8.713
  29. Maltais, M. L., Desroches, J. & Dionne, I. J. (2009). Changes in muscle mass and strength after menopause. Journal of Musculoskeletal and Neuronal Interactions, 9(4), 186-197.
  30. Manson, J. E., Aragaki, A. K., Rossouw, J. E., Anderson, G. L., Prentice, R. L., LaCroix, A. Z. ... & Wactawski-Wende, J. (2017). Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women's Health Initiative Randomized Trials. JAMA, 318(10), 927-938. doi:10.1001/jama.2017.11217
  31. Manson, J. E., Chlebowski, R. T., Stefanick, M. L., Aragaki, A. K., Rossouw, J. E., Prentice, R. L. ... & Wallace, R. B. (2013). Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA, 310(13), 1353-1368. doi:10.1001/jama.2013.278040
  32. Marjoribanks, J., Farquhar, C. M., Roberts, H. & Lethaby, A. (2018). Cochrane corner: long-term hormone therapy for perimenopausal and postmenopausal women. Heart (British Cardiac Society), 104(2), 93-95. doi:10.1136/heartjnl-2017-311583
  33. Meeuwsen, I. B., Samson, M. M., Duursma, S. A. & Verhaar, H. J. (2002). Muscle strength and tibolone: a randomised, double-blind, placebo-controlled trial. BJOG: An International Journal of Obstetrics and Gynaecology, 109(1), 77-84. doi:10.1111/j.1471-0528.2002.01213.x
  34. Michael, Y. L., Gold, R., Manson, J. E., Keast, E. M., Cochrane, B. B., Woods, N. F. ... & Wallace, R. B. (2010). Hormone therapy and physical function change among older women in the Women's Health Initiative: a randomized controlled trial. Menopause, 17(2), 295-302. doi:10.1097/gme.0b013e3181ba56c7
  35. Moher, D., Liberati, A., Tetzlaff, J. & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. PLoS Medicine, 3(3), e123-130.
  36. Morabia, A. & Costanza, M. C. (1998). International variability in ages at menarche, first livebirth, and menopause. World Health Organization Collaborative Study of Neoplasia and Steroid Contraceptives. American Journal of Epidemiology, 148(12), 1195-1205. doi:10.1093/oxfordjournals. aje.a009609
  37. Murphy, L. J. & Ghahary, A. (1990). Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation. Endocrine Reviews, 11(3), 443-453. doi:10.1210/edrv11-3-443
  38. Naessen, T., Lindmark, B., Lagerstrom, C., Larsen, H. C. & Persson, I. (2007). Early postmenopausal hormone therapy improves postural balance. Menopause, 14(1), 14-19. doi:10.1097/01.gme.0000248707.53075.7f
  39. Naessen, T., Lindmark, B., Larsen, H. C., van Os, S. & Larsson, M. (2009). Tibolone low dose (1.25 mg/d) therapy and postural balance in elderly women. Maturitas, 62(1), 72-75. doi:10.1016/j.maturitas.2008.11.004
  40. Onambele-Pearson, G. L., Tomlinson, D. J., Morse, C. I. & Degens, H. (2021). A prolonged hiatus in postmenopausal HRT, does not nullify the therapy's positive impact on ageing related sarcopenia. PLoS One, 16(5), e0250813. doi:10.1371/journal.pone.0250813
  41. Perry, S. D., Bombardier, E., Radtke, A. & Tiidus, P. M. (2005). Hormone replacement and strength training positively influence balance during gait in post-menopausal females: a pilot study. Journal of Sports Science and Medicine, 4(4), 372-381.
  42. Phillips, S. K., Rook, K. M., Siddle, N. C., Bruce, S. A. & Woledge, R. C. (1993). Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy. Clinical Science (London, England: 1979), 84(1), 95-98. doi:10.1042/cs0840095
  43. Ribom, E. L., Piehl-Aulin, K., Ljunghall, S., Ljunggren, O. & Naessen, T. (2002). Six months of hormone replacement therapy does not influence muscle strength in postmenopausal women. Maturitas, 42(3), 225-231. doi:10.1016/s0378-5122(02)00079-8
  44. Rodrigues Barral, A. B., Nahas, E. A., Nahas-Neto, J., Cangussu, L. M. & Buttros Dde, A. (2012). Effect of hormone therapy on postural balance in postmenopausal women. Menopause, 19(7), 768-775. doi:10.1097/gme.0b013e318240fc36
  45. Ronkainen, P. H., Kovanen, V., Alen, M., Pollanen, E., Palonen, E. M., Ankarberg-Lindgren, C. ... & Sipila, S. (2009). Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: a study with monozygotic twin pairs. Journal of Applied Physiology (Bethesda, Md: 1985), 107(1), 25-33. doi:10.1152/japplphysiol.91518.2008
  46. Roubenoff, R. & Hughes, V. A. (2000). Sarcopenia: current concepts. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 55(12), M716-724. doi:10.1093/gerona/55.12.m716
  47. Salpeter, S. R., Walsh, J. M., Greyber, E., Ormiston, T. M. & Salpeter, E. E. (2004). Mortality associated with hormone replacement therapy in younger and older women: a meta-analysis. Journal of General Internal Medicine, 19(7), 791-804. doi:10.1111/j.1525-1497.2004.30281.x
  48. Schierbeck, L. L., Rejnmark, L., Tofteng, C. L., Stilgren, L., Eiken, P., Mosekilde, L. ... & Jensen, J. E. (2012). Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ, 345, e6409. doi:10.1136/bmj.e6409
  49. Sipila, S., Taaffe, D. R., Cheng, S., Puolakka, J., Toivanen, J. & Suominen, H. (2001). Effects of hormone replacement therapy and highimpact physical exercise on skeletal muscle in post-menopausal women: a randomized placebo-controlled study. Clinical Science (London, England: 1979), 101(2), 147-157. https://doi.org/10.1042/CS20000271
  50. Taaffe, D. R., Sipila, S., Cheng, S., Puolakka, J., Toivanen, J. & Suominen, H. (2005). The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention. Clinical Physiology and Functional Imaging, 25(5), 297-304. doi:10.1111/j.1475-097X.2005.00628.x
  51. Tella, S. H. & Gallagher, J. C. (2014). Prevention and treatment of postmenopausal osteoporosis. The Journal of Steroid Biochemistry and Molecular Biology, 142, 155-170. doi:10.1016/j.jsbmb.2013.09.008
  52. Tieland, M., Trouwborst, I. & Clark, B. C. (2018). Skeletal muscle performance and ageing. Journal of Cachexia, Sarcopenia and Muscle, 9(1), 3-19. doi:10.1002/jcsm.12238
  53. Tiidus, P. M. (2017). Estrogen and Menopause: Muscle Damage, Repair and Function in Females. In A. C. Hackney (Ed.), Sex Hormones, Exercise and Women: Scientific and Clinical Aspects (pp. 71-85). Cham: Springer International Publishing.
  54. Uusi-Rasi, K., Beck, T. J., Sievanen, H., Heinonen, A. & Vuori, I. (2003). Associations of hormone replacement therapy with bone structure and physical performance among postmenopausal women. Bone, 32(6), 704-710. doi:10.1016/s8756-3282(03)00098-x
  55. Ward, N. S. (2006). Compensatory mechanisms in the aging motor system. Ageing Research Reviews, 5(3), 239-254. doi:10.1016/j.arr.2006.04.003
  56. Xu, Y., Deng, K. L., Xing, T. F., Mei, Y. Q. & Xiao, S. M. (2020). Effect of hormone therapy on muscle strength in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Menopause, 27(7), 827-835. doi:10.1097/gme.0000000000001538
  57. Yoon, H. J., Kim, R. K., Kang, N. & Park, Y. M. (2021). Exercise Training with Hormone Replacement Therapy Has No Synergistic Effect on the Improvement of Lean and Fat Mass in Postmenopausal Women: A Meta-analysis of Randomized Controlled Trials. International Journal of Human Movement Science, 15(2), 71-85. https://doi.org/10.23949/ijhms.2021.08.15.2.6