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http://dx.doi.org/10.17245/jdapm.2021.21.5.397

Effect of premedication on postoperative pain after root canal therapy in patients with irreversible pulpitis: a systematic review and meta-analysis  

Kumar, Gaurav (Post Graduate Institute of Dental Sciences Rohtak)
Sangwan, Pankaj (Post Graduate Institute of Dental Sciences Rohtak)
Tewari, Sanjay (Post Graduate Institute of Dental Sciences Rohtak)
Publication Information
Journal of Dental Anesthesia and Pain Medicine / v.21, no.5, 2021 , pp. 397-411 More about this Journal
Abstract
This systematic review aimed to assess the effect of premedication on postoperative pain after root canal treatment in vital teeth. Five electronic databases were searched for randomized clinical trials, and two independent reviewers selected eligible studies, extracted data, and assessed the quality of studies using the Cochrane Risk of Bias tool. Meta-analysis was conducted using the random-effects model, and the pooled effect estimate of the standardized mean difference (SMD) between premedication and placebo was calculated. Subgroup analysis was conducted based on the class and route of the drug. Studies with a high risk of bias were excluded from the sensitivity analysis. Ten trials satisfied the inclusion criteria, of which eight were included in the meta-analysis. Premedication was more effective in reducing postoperative pain than placebo at 6 hours (SMD = -1.00; 95% confidence interval [CI] = -1.33 to -0.66), 12 hours (SMD = -0.80; 95% CI = -1.05 to -0.56), and 24 hours (SMD = -0.72; 95% CI = -1.02 to -0.43). The results of the sensitivity analysis confirmed the findings of the primary analysis. Based on these results, it can be concluded that premedication is effective in reducing postoperative pain in teeth with irreversible pulpitis. However, additional quality studies are required for further validation.
Keywords
Meta-Analysis; Postoperative Pain; Premedication; Root Canal Therapy; Systematic Review;
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