• Title/Summary/Keyword: system response

Search Result 13,106, Processing Time 0.043 seconds

Systemically administered neurotensin receptor agonist produces antinociception through activation of spinally projecting serotonergic neurons in the rostral ventromedial medulla

  • Li, Yaqun;Kang, Dong Ho;Kim, Woong Mo;Lee, Hyung Gon;Kim, Seung Hoon;You, Hyun Eung;Choi, Jeong Il;Yoon, Myung Ha
    • The Korean Journal of Pain
    • /
    • v.34 no.1
    • /
    • pp.58-65
    • /
    • 2021
  • Background: Supraspinal delivery of neurotensin (NTS), which may contribute to the effect of a systemically administered agonist, has been reported to be either pronociceptive or antinociceptive. Here, we evaluated the effects of systemically administered NTSR1 agonist in a rat model of neuropathic pain and elucidated the underlying supraspinal mechanism. Methods: Neuropathic pain was induced by L5 and L6 spinal nerve ligation in male Sprague-Dawley rats. The effects of intraperitoneally administered NTSR1 agonist PD 149163 was assessed using von Frey filaments. To examine the role of 5-HT neurotransmission, a serotonin (5-HT) receptor antagonist dihydroergocristine was pretreated intrathecally, and spinal microdialysis studies were performed to measure the change in extracellular level of 5-HT in response to PD 149163 administration. To investigate the supraspinal mechanism, NTSR1 antagonist 48692 was microinjected into the rostral ventromedial medulla (RVM) prior to systemic PD 149163. Additionally, the effect of intrathecal DHE on intra-RVM PD 149163 was assessed. Results: Intraperitoneally administered PD 149163 exhibited a dose-dependent attenuation of mechanical allodynia. This effect was partially reversed by intrathecal pretreatment with dihydroergocristine and was accompanied by an increased extracellular level of 5-HT in the spinal cord. The PD 149163-produced antinociception was also blocked by intra-RVM SB 48692. Direct injection of PD 149163 into the RVM mimicked the maximum effect of the same drug delivered intraperitoneally, which was reversed by intrathecal dihydroergocristine. Conclusions: These observations indicate that systemically administered NTSR1 agonist produces antinociception through the NTSR1 in the RVM, activating descending serotonergic projection to release 5-HT into the spinal dorsal horn.

Development of a DEVS Simulator for Electronic Warfare Effectiveness Analysis of SEAD Mission under Jamming Attacks (대공제압(SEAD) 임무에서의 전자전 효과도 분석을 위한 DEVS기반 시뮬레이터 개발)

  • Song, Hae Sang;Koo, Jung;Kim, Tag Gon;Choi, Young Hoon;Park, Kyung Tae;Shin, Dong Cho
    • Journal of the Korea Society for Simulation
    • /
    • v.29 no.4
    • /
    • pp.33-46
    • /
    • 2020
  • The purpose of Electronic warfare is to disturbe, neutralize, attack, and destroy the opponent's electronic warfare weapon system or equipment. Suppression of Enemy Air Defense (SEAD) mission is aimed at incapacitating, destroying, or temporarily deteriorating air defense networks such as enemy surface-to-air missiles (SAMs), which is a representative mission supported by electronic warfare. This paper develops a simulator for analyzing the effectiveness of SEAD missions under electronic warfare support using C++ language based on the DEVS (Discrete Event Systems Specification) model, the usefulness of which has been proved through case analysis with examples. The SEAD mission of the friendly forces is carried out in parallel with SSJ (Self Screening Jamming) electronic warfare under the support of SOJ (Stand Off Jamming) electronic warfare. The mission is assumed to be done after penetrating into the enemy area and firing HARM (High Speed Anti Radiation Missile). SAM response is assumed to comply mission under the degraded performance due to the electronic interference of the friendly SSJ and SOJ. The developed simulator allows various combinations of electronic warfare equipment specifications (parameters) and operational tactics (parameters or algorithms) to be input for the purpose of analysis of the effect of these combinations on the mission effectiveness.

Comparison of Blood Gas, Biochemical Factors, and Hormone Concentrations, and Muscle Stress Response Factors of Chickens in General Farms and Animal Welfare Farms (일반농장과 동물복지농장 닭의 혈액 내 gas, 생화학인자, 호르몬 농도 및 근육 내 스트레스 반응인자 비교)

  • Kim, Hee-Eun;Park, Jin-Ryong;Lee, Jeong-Eun;Kang, Da-Rae;Jang, Ae-Ra;Choe, Ho-Sung;Shim, Kwan-Seob
    • Korean Journal of Organic Agriculture
    • /
    • v.29 no.3
    • /
    • pp.415-427
    • /
    • 2021
  • It is generally recognized that high stocking density can increase the risk of immune dysfunction and reduction in productivity cause of elevated stress in broiler farm. The domestic livestock industry is implementing a certification system for animal welfare and livestock farms to reduce the problem of dense breeding. This study compared broiler from the general farm and animal welfare farm to confirm the effectiveness of animal welfare farms against stress. Gas concentrations in a farm of general and animal welfare farms were analyzed, blood (n=10) of the 28-day-old broiler was collected, the partial pressure of the gas in the blood was analyzed using whole blood, and biochemical factors and hormones were analyzed using the serum. Glycogen and L-lactate are analyzed using ELISA kit on finely pulverized muscles (n=10). CO2 and NH3 levels in the farm were significantly higher in general farm. Partial carbon dioxide tension (PCO2) in blood was significantly higher and partial oxygen tension (PO2) was significantly lower in the general farm. Creatinine (CREA), glucose (GLU), aspartateaminotransferase (AST), and creatinekinase (CK) in the blood were significantly higher in the general farm, and total protein (TP) and globulin (GLOB) were significantly higher in animal welfare farm. Blood corticosterone and norepinephrine were significantly higher in general farm and epinephrine was significantly higher in animal welfare farm. These results imply that animal welfare farm provides a stress-reduced breeding environment.

The Economic Effect of E-Commerce during COVID-19: A Case Study through "H" Shopping Mall's Garlic Sales (COVID-19에 따른 전자상거래의 경제적 효과에 관한 연구: 'H' 쇼핑몰의 마늘 사례를 중심으로)

  • Han, JinAh;Kim, JeongYeon
    • The Journal of Society for e-Business Studies
    • /
    • v.26 no.4
    • /
    • pp.81-93
    • /
    • 2021
  • Through processors, wholesale markets, intermediate sellers, and retailers, agricultural products have been distributed in a multi-level customary manner for a long time as they are easy to deteriorate and no not have a standardized system of size and quality. However, with the advancement of Internet networks and logistic services during the 2000s that facilitated the development of offline markets, and the rise of the non-contact purchase preference in direct response to COVID-19, previous offline consumers flowed into the online market to purchase agricultural goods. In other words, the volume of online agricultural transactions exploded since the pandemic. Against this social backdrop, this study focused on the difference in distribution costs as a result of converting from conventional offline distribution channels to online channels, and analyzed the reduced distribution costs through a case study of garlic sales on the online platform "H" shopping mall. The analysis found that considerable economic effects occurred, some of the effects being an approximate 39% decrease in distribution cost when comparing direct online transactions of the online shopping mall with other more traditional means, a reduced distribution cost rate of approximately 28%p, and increased profit for farmers.

A Study on Creation of Secure Storage Area and Access Control to Protect Data from Unspecified Threats (불특정 위협으로부터 데이터를 보호하기 위한 보안 저장 영역의 생성 및 접근 제어에 관한 연구)

  • Kim, Seungyong;Hwang, Incheol;Kim, Dongsik
    • Journal of the Society of Disaster Information
    • /
    • v.17 no.4
    • /
    • pp.897-903
    • /
    • 2021
  • Purpose: Recently, ransomware damage that encrypts victim's data through hacking and demands money in exchange for releasing it is increasing domestically and internationally. Accordingly, research and development on various response technologies and solutions are in progress. Method: A secure storage area and a general storage area were created in the same virtual environment, and the sample data was saved by registering the access process. In order to check whether the stored sample data is infringed, the ransomware sample was executed and the hash function of the sample data was checked to see if it was infringed. The access control performance checked whether the sample data was accessed through the same name and storage location as the registered access process. Result: As a result of the experiment, the sample data in the secure storage area maintained data integrity from ransomware and unauthorized processes. Conclusion: Through this study, the creation of a secure storage area and the whitelist-based access control method are evaluated as suitable as a method to protect important data, and it is possible to provide a more secure computing environment through future technology scalability and convergence with existing solutions.

An Analysis on Limited Warfare through the Falkland Islands Dispute (포클랜드제도 분쟁을 통한 제한전 분석)

  • Yang, Seong-sil;Lee, Hee-wan;Shin, Jin
    • Maritime Security
    • /
    • v.3 no.1
    • /
    • pp.211-235
    • /
    • 2021
  • As a result of the Falkland Islands War from April 2 to June 14, 1982, Britain overcame severe economic depression and reclaimed the glory of the former British Empire by winning the war. On the other hand, Argentina was greatly affected by the collapse of a military dictatorship and the birth of a democratic government. This study suggests strategies for responding to maritime disputes that may occur in Dokdo Island in the future by applying "DIME on PMESII" to the Falkland Islands dispute. In particular, the study analyzes how DIME (diplomacy, information, military, and economy) capabilities have an effect as a means of the total national power of a country that effectively controls the disputed territory. Based on the results of this study, the response strategies related to the Dokdo maritime dispute are as follows. First, effective control over the disputed territory should be effectively maintained and strengthened like in Britain. This strategy inspires patriotism, supports the government during warfare, secures a just cause for war, and gains international support. Second, 'DIME on PMESII' was effective in modern warfare by focusing our DIME capabilities on the weaknesses of the other country's PMESII system. That is, wars are not won simply by the conflict of armed forces but by a nation's overall national strength, such as diplomatic, information, and economic capabilities. Third, appropriate strategies for neighboring countries are needed to overcome the possibility of limited warfare in the sea through preparations for Dokdo maritime disputes in the future.

  • PDF

A Study on Non-Contact Vocal Instruction (비대면 가창 수업 방법 고찰)

  • Lim, Ji-Hyun;Min, Kyung-Won
    • Journal of Korea Entertainment Industry Association
    • /
    • v.15 no.1
    • /
    • pp.27-38
    • /
    • 2021
  • Non-Contact society has arrived due to social distinctions by COVID 19 pandemic. The arrival of the era of non-contact is having a profound impact on educational activities as well as on our social and economic lives. In response to the pandemic situation universities and all other educational institutions have implemented non-contact online classes. In particular arts physical educations and other practical classes are experiencing many difficulties due to the limited environment caused by social distancing from COVID 19 pandemic. Vocal classes are undergoing a transition mainly from 1:1 individual face-to-face lessons or group teaching methods to the non-contact era of online teaching or lesson methods. It is necessary to look at the direction of non-face-to-face practical classes in preparation for accelerated educational innovation. Edu-tech, which innovates technology in the wake of the age of non-contact after COVID 19 pandemic is expected to begin in earnest at school sites in Korea which have remained in the traditional way of education. The purpose of this study is to effectively non-contact vocal instructional methods by cogitating the current state of higher practical education and vocal classes in Korea. In addition, This study conducted two components of satisfied instructions such as 'Priorlearning of monitoring of recorded singing', and 'Immediate analyzing of various vocal contents and supplementary lessons of music theory' with a research on the peos and cons of non-face-to-face vocal class. Over a period of time, The effective non-contact of vocal instructional methods is in need to supplement non-face-to-face vocal class problems and further research and system construction with non-face-to-face vocal class's pros and cons to construct high-quality lecture contents is warranted.

Trend Forecasting and Analysis of Quantum Computer Technology (양자 컴퓨터 기술 트렌드 예측과 분석)

  • Cha, Eunju;Chang, Byeong-Yun
    • Journal of the Korea Society for Simulation
    • /
    • v.31 no.3
    • /
    • pp.35-44
    • /
    • 2022
  • In this study, we analyze and forecast quantum computer technology trends. Previous research has been mainly focused on application fields centered on technology for quantum computer technology trends analysis. Therefore, this paper analyzes important quantum computer technologies and performs future signal detection and prediction, for a more market driven technical analysis and prediction. As analyzing words used in news articles to identify rapidly changing market changes and public interest. This paper extends conference presentation of Cha & Chang (2022). The research is conducted by collecting domestic news articles from 2019 to 2021. First, we organize the main keywords through text mining. Next, we explore future quantum computer technologies through analysis of Term Frequency - Inverse Document Frequency(TF-IDF), Key Issue Map(KIM), and Key Emergence Map (KEM). Finally, the relationship between future technologies and supply and demand is identified through random forests, decision trees, and correlation analysis. As results of the study, the interest in artificial intelligence was the highest in frequency analysis, keyword diffusion and visibility analysis. In terms of cyber-security, the rate of mention in news articles is getting overwhelmingly higher than that of other technologies. Quantum communication, resistant cryptography, and augmented reality also showed a high rate of increase in interest. These results show that the expectation is high for applying trend technology in the market. The results of this study can be applied to identifying areas of interest in the quantum computer market and establishing a response system related to technology investment.

Quantitative analysis of drought propagation probabilities combining Bayesian networks and copula function (베이지안 네트워크와 코플라 함수의 결합을 통한 가뭄전이 발생확률의 정량적 분석)

  • Shin, Ji Yae;Ryu, Jae Hee;Kwon, Hyun-Han;Kim, Tae-Woong
    • Journal of Korea Water Resources Association
    • /
    • v.54 no.7
    • /
    • pp.523-534
    • /
    • 2021
  • Meteorological drought originates from a precipitation deficiency and propagates to agricultural and hydrological droughts through the hydrological cycle. Comparing with the meteorological drought, agricultural and hydrological droughts have more direct impacts on human society. Thus, understanding how meteorological drought evolves to agricultural and hydrological droughts is necessary for efficient drought preparedness and response. In this study, meteorological and hydrological droughts were defined based on the observed precipitation and the synthesized streamflow by the land surface model. The Bayesian network model was applied for probabilistic analysis of the propagation relationship between meteorological and hydrological droughts. The copula function was used to estimate the joint probability in the Bayesian network. The results indicated that the propagation probabilities from the moderate and extreme meteorological droughts were ranged from 0.41 to 0.63 and from 0.83 to 0.98, respectively. In addition, the propagation probabilities were highest in autumn (0.71 ~ 0.89) and lowest in winter (0.41 ~ 0.62). The propagation probability increases as the meteorological drought evolved from summer to autumn, and the severe hydrological drought could be prevented by appropriate mitigation during that time.

Effect of Activity Constraint due to Disability on Daily Life Satisfaction among the Disabled : Focusing on the Mediating Effect of Subjective Health Status (장애인의 장애로 인한 활동제약이 일상생활 만족도에 미치는 영향 : 주관적 건강상태의 매개효과를 중심으로)

  • Kim, Min-Soo;Ko, Min-Seok
    • Journal of Korea Entertainment Industry Association
    • /
    • v.15 no.7
    • /
    • pp.169-180
    • /
    • 2021
  • The purpose of this study was to examine the effects of the activity constraints due to disability on subjective health status and daily life satisfaction among disabled, and mediating effects of subjective health status on the relationship between activity constraints due to disability and daily life satisfaction. For this purpose, the response data of 3,809 people who participated in the 5th year of the 2nd Wave of the Panel Survey of Employment for the Disabled (PSED) were used and analyzed. As a result, all sub-factors except for the degree of difficulties in hearing even when using hearing aids among activity constraints due to disability has a statistically significant negative effect on subjective health status, and all sub-factors has a significant negative effect on daily life satisfaction. And, subjective health status has a significant partial mediating effect on the relationship between all sub-factors except for the degree of difficulties in hearing even when using hearing aids among activity constraints due to disability and daily life satisfaction. Therefore, the level of activity constraint for the disabled should be reduced by providing systematic and differentiated customized rehabilitation programs that take into account the disability characteristics of the disabled, thereby improving the health level and social independence ability of the disabled. Furthermore, in order to improve the daily life satisfaction of the disabled, it is necessary to provide policy support such as the establishment of a community-based integrated support system for the disabled by linked rehabilitation program and health promotion program.