• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.267-275
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• 2023

Cardiotoxicity, particularly drug-induced Torsades de Pointes (TdP), is a concern in drug safety assessment. The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (human iPSC-CMs) has become an attractive human-based platform for predicting cardiotoxicity. Moreover, electrophysiological assessment of multiple cardiac ion channel blocks is emerging as an important parameter to recapitulate proarrhythmic cardiotoxicity. Therefore, we aimed to establish a novel in vitro multiple cardiac ion channel screening-based method using human iPSC-CMs to predict the drug-induced arrhythmogenic risk. To explain the cellular mechanisms underlying the cardiotoxicity of three representative TdP high- (sotalol), intermediate- (chlorpromazine), and low-risk (mexiletine) drugs, and their effects on the cardiac action potential (AP) waveform and voltage-gated ion channels were explored using human iPSC-CMs. In a proof-of-principle experiment, we investigated the effects of cardioactive channel inhibitors on the electrophysiological profile of human iPSC-CMs before evaluating the cardiotoxicity of these drugs. In human iPSC-CMs, sotalol prolonged the AP duration and reduced the total amplitude (TA) via selective inhibition of I_Kr and I_Na currents, which are associated with an increased risk of ventricular tachycardia TdP. In contrast, chlorpromazine did not affect the TA; however, it slightly increased AP duration via balanced inhibition of I_Kr and I_Ca currents. Moreover, mexiletine did not affect the TA, yet slightly reduced the AP duration via dominant inhibition of I_Ca currents, which are associated with a decreased risk of ventricular tachycardia TdP. Based on these results, we suggest that human iPSC-CMs can be extended to other preclinical protocols and can supplement drug safety assessments.

• Journal of the Korea Society for Simulation
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• v.18 no.4
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• pp.39-47
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• 2009

Recently, the threat of DDoS attacks is increasing and many companies are planned to deploy the DDoS defense solutions in their networks. The DDoS attack usually transmits heavy traffic data to networks or servers and they cannot handle the normal service requests because of running out of resources. Since it is very hard to prevent the DDoS attack beforehand, the strategic plan is very important. In this work, we have conducted modeling and simulation of the DDoS attack by changing the number of servers and estimated the duration that services are available. In this work, the modeling and simulation is conducted using OPNET Modeler. The simulation result can be used as a parameter of trade-off analysis of DDoS defense cost and the service's value. In addition, we have presented a way of estimating the cost effectiveness in deployment of the DDoS defense system.

• Journal of the Korea Society for Simulation
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• v.19 no.2
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• pp.73-80
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• 2010

A wireless sensor network which is deployed in hostile environment can be easily compromised by attackers. The selective forwarding attack can jam the packet or drop a sensitive packet such as the movement of the enemy on data flow path through the compromised node. Xiao, Yu and Gao proposed the checkpoint-based multi-hop acknowledgement scheme(CHEMAS). In CHEMAS, each path node enable to be the checkpoint node according to the pre-defined probability and then can detect the area where the selective forwarding attacks is generated through the checkpoint nodes. In this scheme, the number of hops is very important because this parameter may trade off between energy conservation and detection capacity. In this paper, we used the fuzzy rule system to determine adaptive threshold value which is the number of hops for the ACK packets. In every period, the base station determines threshold value while using fuzzy logic. The energy level, the number of compromised node, and the distance to each node from base station are used to determine threshold value in fuzzy logic.

• Nuclear Engineering and Technology
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• v.26 no.3
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• pp.401-410
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• 1994

Validation study of two radionuclide migration models for single fracture developed in geologic medium the hydrodynamic dispersion diffusion model(HDDM) and the channeling dispersion diffusion model(CDDM), was studied by migration experiment of tracers through an artificial granite fracture on the labolatory scale. The tracers used were Uranine and Sodium lignosulfonate know as nonsorbing material. The flow rate ranged 0.4 to 1.5 cc/min. Related parameters for the models were estimated by optimization technique. Theoretical breakthrough curves with experimental data were compared. In the experiment, it was deduced that the surface sorption for both tracers did not play an important role while the diffusion of Uranine into the rock matrix turned out to be an important mass transfer mechanism. The parameter characterizing the rock matrix diffusion of each model agreed well The simulated result showed that the amount of flow rate could not tell the CDDM from the HDDM quantitatively. On the other hand, the variation of fracture length gave influence on the two models in a different degree. The dispersivity of breakthrough curve of the CDDM was more amplified than that of the CDDM when the fracture length was increased. A good agreement between the models and experimental data gave a confirmation that both models were very useful in predicting the migration system through a single fracture.

• Nuclear Engineering and Technology
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• v.25 no.1
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• pp.91-101
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• 1993

To predict accurately the thermal hydraulic behavior of light water reactors during normal or abnormal operation, the accurate estimation of the void distribution is required. Up to date, many techniques for predicting void fraction of two-phase flow systems have been suggested. Among these techniques, the drift-flux model is widely used because of its exact calculation ability and simplicity. However, to get more accurate prediction of void fraction using drift-flux model, slip and flow regime effects must be considered more properly In the drift-flux method, these two effects are accounted for by two drift-flux parameters ; $C_{o}$ and (equation omitted). At earlier stage, $C_{o}$ is measured in a circular tube. In this study, $C_{o}$ is experimentally determined by measuring local void fraction and vapor velocity distribution in a rectangular subchannel having 4 heating rods which simulates nuclear subchannels. The measurements are peformed with two-electrical conductivity probes which are known to be adequate for measuring local parameters. The experiments are performed at low flow rate and the system pressure less than 3 atmo spheric pressure. In this experiment, (equation omitted), is not measured, but quoted from well-known empirical correlation to formulate $C_{o}$. Finally, $C_{o}$ is expressed as a function of channel averaged void fraction. fraction.

• Korean Journal of Optics and Photonics
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• v.34 no.3
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• pp.99-105
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• 2023

The performance of astronomical telescopes can be negatively affected by atmospheric turbulence. To address this issue, techniques for atmospheric turbulence correction have been developed, requiring the simulation of atmospheric turbulence in the laboratory. The most practical way to simulate atmospheric turbulence is to use a phase plate. When measuring a phase plate that simulates strong turbulence, a Shack-Hartmann wave-front sensor is commonly used. However, the laser power decreases as it passes through the phase plate, potentially leading to a weak laser signal at the sensor. This paper investigates the need to control the laser power when measuring a phase plate that simulates strong atmospheric turbulence, and examines the effects of the laser power on the measured wavefront. For phase plates with relatively high Fried parameter r₀, the laser power causes a variation of over 10% in r₀. For phase plates with relatively low r₀, the laser power causes a variation of less than 5%, which means that the influence of the laser power is negligible for phase plates that simulate strong atmospheric turbulence. Based on the system described in this paper, a phase plate simulating strong atmospheric turbulence can be measured at a laser power of 5 mW or higher. Therefore, controlling the laser's output power is necessary when measuring a phase plate for simulating atmospheric turbulence, especially for phase plates with low r₀ values.

• The Journal of the Acoustical Society of Korea
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• v.41 no.2
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• pp.184-191
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• 2022

Underwater acoustic wave in shallow water is propagated through multipath that has a large delay spread causing Inter-Symbol Interference (ISI) and these characteristics deteriorate the performance in the communication system. In order to analyze the communication performance and investigate the correlation with multipath delay spread in a reverberant environment, an underwater acoustic communication experiment using Binary Phase-Shift Keying (BPSK) signals with symbol rates from 100 sym/s to 8000 sym/s was conducted in a 5 × 5 × 5 m³ water tank. The acoustic channels in a well-controlled tank environment had the characteristics of dense multipath delay spread due to multiple reflections from the interfaces and walls within the tank and showed the maximum excess delay of 40 ms or less, and the Root Mean Squared (RMS) delay spread of 8 ms or less. In this paper, the performances of Bit Error Rate (BER) and output Signal-to-Noise Ratio (SNR) were analyzed using four types of communication demodulation techniques. And the parameter, Symbol interval to Delay spread Ratio in reverberant environment (SDR_rev), which is the ratio of symbol interval to RMS delay spread in the reverberant environment is defined. Finally, the SDR_rev was compared to the BER and the output SNR. The results present the reference symbol rate in which high communication performance can be guaranteed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.5B
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• pp.437-444
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• 2010

Soil moisture has been recognized as the essential parameter when understanding the complicated relationship between land surface and atmosphere in water and energy recycling system. It has been generally known that it is related with the temperature, wind, evaporation dependent on soil properties, transpiration due to vegetations and other constituents. There is, however, little research concerned about the relationship between soil moisture and these constitutes, thus it is needed to investigate it in detail. We estimated the soil moisture and then compared with field data using the hydrometerological data such as atmospheric temperature, specific humidity, and wind obtained from the Flux tower in Selmacheon, Korea. In the winter season, subterranean temperature showed highly positive correlation with soil moisture while it was negatively correlated from the spring to the fall. Estimation of seasonal soil moisture was compared with field measurements with the correlation of determination, R=0.82, 0.81, 0.82, and 0.96 for spring, summer, fall, and winter, respectively. Comprehensive relationship from this study can supply useful information about the downscaling of soil moisture with relatively large spatial resolutions, and will help to deepen the understanding of the water and energy recycling on the earth's surface.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.1D
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• pp.33-40
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• 2009

The critical lag of crosswalk pedestrians is an important parameter in analyzing traffic operation at unsignalized crosswalks, however there is few research in this field in Korea. The purpose of this study is to develop a model to estimate the critical lag. Among the elements which influence the critical lag, the age of pedestrians and the length of crosswalks, which have fuzzy characteristics, and the each lag which is rejected or accepted are collected on crosswalks of which lengths range from 3.5 m to 10.5 m. The values of the critical lag range from 2.56 sec. to 5.56 sec. The age and the length are divided to the 3 fuzzy variables each, and the critical lag of each case is estimated according to Raff's technique, so a total of 9 fuzzy rules are established. Based on the rules, an ANFIS (Adaptive Neuro-Fuzzy Inference System) model to estimate the critical lag is built. The predictability of the model is evaluated comparing the observed with the estimated critical lags by the model. Statistics of $R^2$, MAE, MSE are 0.96, 0.097, 0.015 respectively. Therefore, the model is evaluated to explain the result well. During this study, it is found that the critical lag increases rapidly over the pedestrian's age of 40 years.

• Journal of Internet Computing and Services
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• v.24 no.5
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• pp.17-27
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• 2023

Today, as AI (Artificial Intelligence) technology develops and its practicality increases, it is widely used in various application fields in real life. At this time, the AI model is basically learned based on various statistical properties of the learning data and then distributed to the system, but unexpected changes in the data in a rapidly changing data situation cause a decrease in the model's performance. In particular, as it becomes important to find drift signals of deployed models in order to respond to new and unknown attacks that are constantly created in the security field, the need for lifecycle management of the entire model is gradually emerging. In general, it can be detected through performance changes in the model's accuracy and error rate (loss), but there are limitations in the usage environment in that an actual label for the model prediction result is required, and the detection of the point where the actual drift occurs is uncertain. there is. This is because the model's error rate is greatly influenced by various external environmental factors, model selection and parameter settings, and new input data, so it is necessary to precisely determine when actual drift in the data occurs based only on the corresponding value. There are limits to this. Therefore, this paper proposes a method to detect when actual drift occurs through an Anomaly analysis technique based on XAI (eXplainable Artificial Intelligence). As a result of testing a classification model that detects DGA (Domain Generation Algorithm), anomaly scores were extracted through the SHAP(Shapley Additive exPlanations) Value of the data after distribution, and as a result, it was confirmed that efficient drift point detection was possible.