• Proceedings of the Korea Crystallographic Association Conference
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• 2002.11a
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• pp.24-24
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• 2002

HtrA (high temperature requirement A), a periplasmic heat shock protein, is known to have molecular chaperone function at low temperatures and proteolytic activity at elevated temperatures. To investigate the mechanism of functional switch to pretense, we have determined the crystal structure of the N-terminal protease domain (PD) of HtrA from Thermotoga maritima. HtrA PD shares the same fold with chymotrypsin-like serine professes. However, crystal structure suggests that HtrA PD is not an active pretense at current state since its active site is not formed properly and blocked by an additional helical lid. On the surface of the lid, HtrA PD has hydrophobic patches that could be potential substrate binding sites for molecular chaperone activity. Present structure suggests that the activation of the proteolytic function of HtrA PD at elevated temperatures might occur by the conformational change.

• Journal of the Korea Computer Industry Society
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• v.3 no.1
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• pp.95-104
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• 2002

This paper presents some studies on the Internet TCP/IP(Transmission Control Protocol-Internet Protocol) traffic over ATM(Asynchronous Transfer Mode) UBR(Unspecified Bit Rate) and ABR(Available Bit Rate) classes of service. Fuzzy logic prediction has been used to improve the efficiency and fairness of traffic throughput. For TCP/IP over UBR, a novel fuzzy logic based cell dropping scheme is presented. This is referred to as fuzzy logic selective cell drop (FSCD). A key feature of the scheme is its ability to accept or drop a new incoming packet dynamically based on the predicted future buffer condition in the switch. This is achieved by using fuzzy logic prediction for the production of a drop factor. Packet dropping decision is then based on this drop factor and a predefined threshold value. Simulation results show that the proposed scheme significantly improves TCP/IP efficiency and fairness. To study TCP/IP over ABR, we applied the fuzzy logic ABR service buffer management scheme from our previous work to both approximate and exact fair rate computation ER(Explicit cell Rate) switch algorithms. We then compared the performance of the fuzzy logic control with conventional schemes. Simulation results show that on zero TCP packet loss, the fuzzy logic control scheme achieves maximum efficiency and perfect fairness with a smaller buffer size. When mixed with VBR traffic, the fuzzy logic control scheme achieves higher efficiency with lower cell loss.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.7B
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• pp.901-906
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• 2001

본 논문에서는 이득-투명 SOA 스위치를 이용한 새로운 구조의 광 셀 역압축기를 제안하였다. 제안된 구조는 하드웨어 및 제어의 단순화와 이득-투명 SOA를 이용함으로써 처리용량을 극대화하기 위한 요구조건을 만족시킨다. 제안된 구조의 동작을 실험으로 보이기 위해 4-비트의 소규모 광 압축셀을 역압축시키는 실험을 수행하였으며, 제안구조의 동작원리와 일치하는 결과를 얻을 수 있었다. 이는 시간분할 방식을 포함하는 광 ATM 교환기와 광 패킷망 등에 주요 요소로서 적용될 수 있다.

• Proceedings of the Korean Information Science Society Conference
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• 2001.10c
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• pp.412-414
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• 2001

본 논문은 초고속통신망에서 멀티캐스트 스위칭에서 발생될 수 있는 오버플로우 문제와 블로킹 문제를 보다 효율적으로 해결하고, 공정하게 입력포트에 접근함으로 작은 fanout에 대한 불공정성을 해결하기 위한 멀티캐스트 스위치를 제안하고자 한다. 제안된 스위치는 셀 분할(cell pre-splitting)과 공유된 버퍼, Group Spliiting, 그리고 그룹분할망으로 구성되어지며, 큰 fanout에 대한 작은 fanout을 가진 입력포트에 도착한 패킷의 불공정한 대우를 해결하여 시스템 전체 지연 시간을 줄여 산출량을 극대화할 수 있다.

• Proceedings of the Korean Information Science Society Conference
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• 2001.04a
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• pp.232-234
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• 2001

본 논문은 초고속통신망에서 멀티캐스트 교환에서 발생될 수 있는 오버플로우 문제와 블로킹 문제를 보다 효율적으로 해결함으로써 높은 산출량과 낮은 셀 손실을 가지는 복사망(copy network)에 관하여 언급한다. 제안된 복사망은 셀 분할(cell splitting)과 공유된 버퍼, 그리고 그룹분할 스위치로 구성되어지며, 기존의 반얀 계열의 네트워크 보다 높은 산출량과 낮은 셀 손실률로 인한 성능 향상을 얻을 수 있다.

• IMMUNE NETWORK
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• v.3 no.1
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• pp.53-60
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• 2003

Background: The role of macrophages in tumor angiogenesis is known to be the production of angiogenic cytokines and growth factors including TNF-${\alpha}$. Recently, macrophage also can produce the INF-${\gamma}$ that is being studied to be involved in angiogenic inhibition. Thus, the importance of macrophages in tumor angiogenesis is might being an angiogenic switch. Thus, the hypothesis tested here is that TNF-${\alpha}$ can modulate the INF-${\gamma}$ production in the macrophages from tumor environment as a part of tumor angiogenic switch. Methods: Macrophages in tumor environment were obtained from the peritoneal cavity of C57BL/6 mice injected with B16F10 melanoma cell line for 6 or 11 days. $Mac1^+$-macrophages were purified using magnetic bead ($MACs^{TM}$; Milteny Biotech, Germany) and cultured with various concentrations of TNF-${\alpha}$ for various time points at $37^{\circ}C$. The supernatants were analyzed for IFN-${\gamma}$ or VEGF by ELISA kit (Endogen, Woburn, MA). Results: Residential macrophages from the peritoneal cavity did not respond to LPS or TNF-${\alpha}$ to produce INF-${\gamma}$. However, the cells from tumor environment produced IFN-${\gamma}$ as well as VEGF and upregulated by the addition of LPS or TNF-${\alpha}$. RT-PCR analysis revealed the external TNF-${\alpha}$-induced IFN-${\gamma}$ gene expression in the macrophages from tumor environment. Conclusion: The overall data suggest that the macrophages in tumor environment might have an important role not only in angiogenic signal but also in anti-angiogenic signal by producing related cytokines. And TNF-${\alpha}$ might be a key cytokine in tumor angiogenic switch.

• Food Science and Biotechnology
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• v.17 no.3
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• pp.598-602
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• 2008

Concentrated catfish Silurus asotus bile (SAB) containing high amounts of ursodeoxycholic acid (UDCA) and taurocholic acid may have immunosuppressive properties. To investigate the putative immunosuppressive properties of SAB, the anti-proliferation and suppression of early T cell activation markers, and the inhibition of cytokines induced by T cells in response to anti-CD3 mAb activation in mouse splenocytes were examined. The suppression of these activation repertoires are the main properties of calcineurin inhibitors. It was found that SAB effectively suppressed the activation of T cells, and cytokines from T cell activation, at levels similar to cyclosporine A, a calcineurin inhibitor. Although the mechanism in which suppression occurs is not clear, we speculate that SAB from Silurus asotus, which has been known to switch their intake habits to zoophagy during an early adult stage, may explain the suppressive effect of SAB as a result of high amounts of functional UDCA in bile. Our results suggest that the treatment or intake of SAB, either in therapy or as a food supplement, may act as an adjuvant therapy for the prevention of transplant rejection, although further investigation is required before this treatment can be applied clinically.

• Journal of Electrical Engineering and Technology
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• v.12 no.5
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• pp.1891-1901
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• 2017

In this paper, optimal control of the fuel cell and design of a high-efficiency power converter is implemented to build a high-priced fuel cell system with minimum capacity. Conventional power converter devices use a non-isolated boost converter for high efficiency while the battery is charged, and reduce its conduction loss by using MOSFETs instead of diodes. However, the efficiency of the boost converter decreases, since overshoot occurs because there is a moment when the body diode of the MOSFET is conducted during the dead time and huge loss occurs when the dead time for the maximum-power-flowing state is used in the low-power-flowing state. The method proposed in this paper is to adjust the dead time of boost and rectifier switches by predicting the power flow to meet the maximum efficiency in every load condition. After analyzing parasite components, the stability and efficiency of the high-efficiency boost converter is improved by predictive compensation of the delay component of each part, and it is proven by simulation and experience. The variation in switching delay times of each switch of the full-bridge converter is compensated by falling time compensation, a control method of PWM, and it is also proven by simulation and experience.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.27 no.7
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• pp.67-75
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• 2013

In this paper, parallel input/serial output dual converter is designed appropriately for fuel cell hybrid power system. In case of proposed converter, zero voltage switching condition is designed without additional resonance device using leakage inductance of transformer and output capacitance of switch, and zero voltage switching method is used. Also, the system method is for increasing power by connecting half-bridge in parallel and increasing output voltage by connecting secondary output of transformer in serial. Through this method we can increase power and decrease volume of system. So in this paper, dual converter is designed. 1.5kW fuel cell hybrid power system was implemented, and system operation and stability was verified through experiment.

• BMB Reports
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• v.51 no.5
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• pp.219-224
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• 2018

Necroptosis is an emerging form of programmed cell death occurring via active and well-regulated necrosis, distinct from apoptosis morphologically, and biochemically. Necroptosis is mainly unmasked when apoptosis is compromised in response to tumor necrosis factor alpha. Unlike apoptotic cells, which are cleared by macrophages or neighboring cells, necrotic cells release danger signals, triggering inflammation, and exacerbating tissue damage. Evidence increasingly suggests that programmed necrosis is not only associated with pathophysiology of disease, but also induces innate immune response to viral infection. Therefore, necroptotic cell death plays both physiological and pathological roles. Physiologically, necroptosis induce an innate immune response as well as premature assembly of viral particles in cells infected with virus that abrogates host apoptotic machinery. On the other hand, necroptosis per se is detrimental, causing various diseases such as sepsis, neurodegenerative diseases and ischemic reperfusion injury. This review discusses the signaling pathways leading to necroptosis, associated necroptotic proteins with target-specific inhibitors and diseases involved. Several studies currently focus on protective approaches to inhibiting necroptotic cell death. In cancer biology, however, anticancer drug resistance severely hampers the efficacy of chemotherapy based on apoptosis. Pharmacological switch of cell death finds therapeutic application in drug- resistant cancers. Therefore, the possible clinical role of necroptosis in cancer control will be discussed in brief.