• Journal of Korean Medical Science
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• 제33권43호
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• pp.277.1-277.10
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• 2018

Background: To examine survival rates and renal function after partial nephrectomy (PN) and radical nephrectomy (RN) in patients with chronic kidney disease (CKD). Methods: We studied 4,332 patients who underwent PN or RN for pathological T1a-T2N0M0 renal cell carcinoma from 1988 to 2014. Patients were divided into two subgroups of CKD stage I-II and stage III. Kidney function, and survival outcomes were compared between groups. Results: We included 1,756 patients with CKD I-II and 276 patients with CKD III in the final pair-matched analysis. Kidney function was significantly better preserved in the PN than in the RN group among all patients. However, the beneficial effect of PN on kidney function gradually disappeared over time in CKD III patients. The 5-year overall survival (OS) rates after PN and RN differed in patients with CKD I-II disease (99.4% vs. 96.5%, respectively, P = 0.015). The 5-year OS rates after surgery were not affected by mode of nephrectomy in CKD III patients (97.8% vs. 93.5%, P = 0.103). The 5-year cancer-specific survival rates did not differ between treatment groups in all CKD stage. Cox hazard analysis showed that the operative method was a significant factor for OS in CKD I-II patients (hazard ratio [HR], 0.320; confidence interval [CI], 0.122-0.840; P = 0.021). However, PN was not beneficial in terms of OS in CKD III patients (HR, 0.395; CI, 0.086-1.172; P = 0.117). Conclusion: PN is associated with a higher OS rate and better kidney function in patients with preoperative CKD stage I and II, but not in those with CKD stage III.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4413-4416
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• 2012

Aim: Individual differences in chemosensitivity and clinical outcome in non-small cell lung cancer (NSCLC) patients treatment with platinum-based chemotherapy may be due to genetic factors. Our study aimed to investigate the prognostic role of GSTP1, XRCC1 and XRCC3 in NSCLC patients treated with chemotherapy. Methods: A total of 460 cases were consecutively selected from The Affiliated Hospital of Nantong University between Jan. 2003 to Nov. 2006, and all were followed-up until Nov. 2011. Genotyping of GSTP1 Ile105Val, XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met was conducted by duplex polymerase-chain-reaction with confronting-two-pair primer methods. Results: Patients with GSTP Val/Val exhibited a shorter survival time, and had a 1.89 fold greater risk of death than did those with the IIe/IIe genotype. For XRCC1 Arg194Trp, the variant genotype Trp/Trp was significantly associated with a decreased risk of death from NSCLC when compared with the Arg/Arg. Individuals carrying XRCC1 399Gln/Gln genotype had a longer survival time, with a lowered risk of death from NSCLC. Conclusion: This study indicated that GSTP1 Ile105Val, XRCC1 Arg194Trp and XRCC1Arg399Gln genes have a role in modifying the effect of platinum-based chemotherapy for NSCLC patients in a Chinese population. Our findings provide information for therapeutic decisions for individualized therapy in NSCLC cases.

• 수산경영론집
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• 제35권1호
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• pp.23-56
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• 2004

The offshore trawl fishery is seeking its survival way to overcome current management conditions in red, resulted from the bilateral agreement with China and Japan. However, this movement magnifies conflicts between fisheries on the contrary and it is thought to be impossible to get over current situations. For all that, this study is aimed at investigating how this current situations have occurred. The management freedom as response to the change in fishing conditions of a certain fishery, in case of Korea, is affected by institutional regulations. The example of this is controls on fishing gears, fishing vessels, and fishing grounds. The most exposure of this control is a segmentation of institutional fisheries. The initial segmentation of the offshore trawl fishery in Korea was occurred in the period of Japan's colonization when the degree of use of fishing grounds was limited geographically. At that time, fisheries were divided by fishing areas, but it did not divide the fishery itself. The large - sized fishing vessels were developed politically to be more competative to Japanese fishing vessels since 1950s. During this time, the trawl fishery was merged into current Eastern trawl fishery and South - Western trawl fishery. It was also inevitable to divide into the pair trawl and single trawl fishery as a result of the physical mergency between Western trawl and Southern trawl fishery. In order to develop the trawl fishery, new licenses were issued on the shrimp trawl fishery, through which it was expected to boost the trawl fishery. As opposed, the shrimp trawl fishery was changed into the mid - sized trawl fishery, targeting on the eastern fishing areas and the large - sized trawl fishery was developed since the late of 1970s with the development of filefish processing industry. The large trawl fishery that led in development of offshore trawl fishery since the late of 1950s was started to divide into a pair trawl and single trawl according to the fishing method and capital power. It finally became an institutionally independent fishery in 1980s, respectively. Looking into these historical process, the segmentation of the trawl fishery is thought as a result of the lack of long - term perspective and as a production of trial and error resulted by unprepared policy. As a result, these segmentation of fisheries roles as critical obstacles in harmonization of fisheries and in overcoming of current situations. Therefore, the review of this institutional segmentation of the offshore trawl fishery should be taken for an optimal redistribution of fishing grounds suits with business and fishing technology. For this, the fishery must be divided into large capitalized fishery and small - mid fishery with consideration of capital, fishing method, and the condition of use of fishing grounds. In addition to this, by limiting outline of fishing ground that the large fishery can harvest, it must allow for the small - mid fishery to catch with its own boundary. Furthermore, by launching buyback programs on the trawl, eastern trawl, pair trawl, it can provide broader fishing grounds where the fishery can harvest with management freedom.

• Journal of Microbiology and Biotechnology
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• 제15권6호
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• pp.1170-1177
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• 2005

Terminal-restriction fragment length polymorphism (T-RFLP) analysis was used to monitor inoculated oil-degrading microorganisms during bioremedial treatability tests. A pair of universal primers, fluorescently labeled 521F and 1392R, was employed to amplify small subunit rDNA in order to simultaneously detect two bacterial strains, Corynebacterium sp. IC10 and Sphingomonas sp. KH3-2, and a yeast strain, Yarrowia lipolytica 180. Digestion of the 5'-end fluorescence/labeled PCR products with HhaI produced specific terminal-restriction fragments (T-RFs) of 185 and 442 bases, corresponding to Corynebacterium sp. IC10 and Y. lipolytica 180, respectively. The enzyme NruI produced a specific T-RF of 338 bases for Sphingomonas sp. KH3-2. The detection limit for oildegrading microorganisms that were inoculated into natural environments was determined to be $0.01\%$ of the total microbial count, regardless of the background environment. When three oil-degrading microorganisms were released into oil-contaminated sand microenvironments, strains IC10 and 180 survived for 35 days after inoculation, whereas strain KH3-2 was detected at 8 days, but not at 35 days. This result implies that T-RFLP could be a useful tool for monitoring the survival and relative abundance of specific microbial strains inoculated into contaminated environments.

• Journal of Microbiology and Biotechnology
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• 제14권3호
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• pp.593-598
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• 2004

The arsenical resistance (ars) operon was cloned from a 67-kilobase pair (kb) plasmid, which was previously shown to be responsible for arsenic salts resistance in K. oxytoca D12. When plasmid pAE48, carrying the ars operon, was transformed into E. coli, transformed cells displayed enhanced survival in the presence of 4 mM arsenite, 50 mM arsenate, or 0.4 mM antimonite. The nucleotide sequence of the 5.6-kb fragment encoding arsenical resistance revealed five open reading frames (ORFs), which were predicted to encode polypeptides of 12.8 (arsR), 13.4 (arsD), 62.6 (arsA), 45 (arsB), and 16.7 (arse) kilodaltons (kDa). Each ORF was preceded by a ribosome binding site. A putative promoter-like sequence was identified upstream of arsR, and a possible termination site was found downstream of arsC. When the deduced amino acid sequences of the K. oxytoca Dl2 Ars proteins were compared with the amino acid sequences of the E. coli R773 Ars proteins, a significant amino acid similarity was observed (87.9％ for ArsR, 89.2％ for ArsD, 83.2％ for ArsA, 92.6％ for ArsB, and 91.3％ for ArsC), suggesting an evolutionary relationship of the ars genes of E. coli plasmid R773 and K. oxytoca Dl2.

• Molecules and Cells
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• 제40권5호
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• pp.331-338
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• 2017

Regulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a Drosophila adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor Gr2a is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner.

• 한국사회복지학
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• 제63권2호
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• pp.179-205
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• 2011

암환자에게 부부적응은 심리적인 안녕 뿐만 아니라 치료경과 및 생존율에 영향을 미치는 것으로 보고되고 있어 이들의 부부적응을 도모하기 위한 사회복지 노력과 관심이 절실히 필요하다 하겠다. 이에 본 연구는 암환자와 배우자의 커플자료를 수집하여 이들의 부부적응에 대해 조사하였으며, 기초자료가 미비한 실정에서 부부관계의 지표로 부부적응에의 필수고려 요인으로 지목되고 있는 부부의사소통의 영향을 조사하였다. 또한 암환자와 배우자의 상호의존성을 고려하여 부부의사소통이 부부적응에 미치는 영향을 자기 자신에게 미치는 영향(자기효과), 상대방에게 미치는 영향(상대방효과)을 고찰하였다. 이를 통해 부부적응에 긍정적 부부의사소통의 중요성을 제시하였으며, 부정적 의사소통 유형인 요구-철회의사소통에서 환자의 배우자에 대한 상대방효과가 유의한 것으로 나타나 환자에 대한 의사소통 교육에의 필요성을 제시하였다. 이러한 연구결과를 바탕으로 실천적 함의 및 후속연구에 대한 제언을 제시하였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제15권2호
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• pp.115-122
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• 2004

섭생, 수면, 활동과 같이 생존에 필수 요소 뿐 아니라 인간은 사회적 동물로서 타인과의 애착관계 역시 몹시 중요하다. 사회적 애착(social attachment)은 인간에게 중요하기도 하지만 연구하기가 힘든 분야 중 하나이다. 이 분야의 선도적 연구자인 Harry Harlow는 부모-자녀, 친구, 부부관계의 세 가지의 다른 애착 행동체계가 존재한다고 보았다. 이러한 행동 패턴에는 여러 가지 감각 기관, 복잡한 운동반응, 그리고 기억, 사회적 인지, 동기 등의 인지과정이 포함된다. 또한 John Bowlby는 부모-자녀간의 초기 애착관계의 중요성을 정신과 영역에서 강조하였다. 사회적 애착에 관련된 신경학적 구조, 기능에 대한 연구는 주로 포유류가 아닌 동물들에 대한 연구가 주를 이루나, 최근에는 원숭이에 대한 약리학적 연구와 인간의 뇌영상 연구 결과들이 이 분야에 대한 새로운 개념을 첨가하고 있다. 본 고에서는 애착에 대한 신경생물학적 이론에 대해 자세히 기술하고자 하며, 크게 1) 유아-부모 애착, 부모-유아 애착에 대한 신경생물학적 연구 분야, 2) 애착에 대한 동물 실험 연구, 3) 애착관계의 심각한 단절이 발생하는 maltreatment/deprivation 상태에서 인간에게 어떠한 행동적, 신경생물학적 변화가 초래되는지에 대한 세 분야로 나누어 기술하고자 한다. 아직 이러한 연구 결과들이 임상적 측면과 직접적 관련을 짓기는 한계가 있으나, 향후 사회적 애착관계의 문제가 심각한 정신병리를 연구하고 치료하는 분야에도 응용될 것으로 기대한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1719-1723
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• 2014

Background: The current study was aimed to elucidate the association of thymidylate synthase (TYMS) 5'-UTR 28bp tandem repeat and cytosolic serine hydroxymethyltransferase (cSHMT) C1420T polymorphisms with acute leukemia in South Indian subjects. A total of 812 subjects [523 healthy controls, 148 acute lymphoblastic leukemia (ALL) cases and 141 acute myeloid leukemia (AML) cases] were screened for TYMS 5'-UTR 28bp tandem repeat and cSHMT C1420T using PCR-AFLP and PCR-with confronting two-pair primers (CTPP) approaches. TYMS 5'-UTR 2R allele frequencies of controls, ALL and AML cases were 35.3%, 28.0% and 30.1% respectively. This polymorphism conferred protection against ALL (OR: 0.71, 95%CI: 0.53-0.96) while showing no statistically significant association with AML (OR: 0.79, 95%CI: 0.58, 1.07). The cSHMT variant allele (T-) frequencies of ALL and AML cases (6.42% and 5.68% respectively) were significantly lower compared to controls (58.3%). This polymorphism conferred protection against ALL (OR: 0.049, 95%CI: 0.029-0.081) and AML (OR: 0.043, 95%CI: 0.025-0.074). The TYMS 5'-UTR 2R2R genotype was associated with a lower total leukocyte count, smaller percentage of blasts, and more adequate platelet count compared to 2R3R and 3R3R genotypes in ALL cases. No such genotype-dependent differences were observed in AML cases. ALL cases carrying the cSHMT C1420T polymorphism showed higher disease free survival compared to those with the wild genotype. To conclude, the TYMS 5'-UTR 28bp tandem repeat reduces risk for ALL while cSHMT C1420T reduces risk for both ALL and AML. Both also influence disease progression in ALL.

• Radiation Oncology Journal
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• 제16권3호
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• pp.251-258
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• 1998

목적 : 수술과 방사선치료를 받은 이하선 악성종양에서 국소 종양 제어율에 영향을 주는 요인을 알기 위하여 본 연구를 수행하였다. 대상 및 방법 : 1986년부터 1995년까지 전남대학교병원에서 이하선 악성 종양으로 수술과 방사선 치료를 함께 받은 26명을 대상으로 하였다. 대상 환자의 연령 분포는 14세부터 72세까지였고 중앙간은 55세였다. 조직학적 유형별 분포는 10명이 점액표피양암종, 7명이 편평상피세포암, 4명이 포상세포암, 4명이 선양성낭종암, 1명이 선암이었다. 수술은 15명이 이하선 전절제술, 7명이 표재성 절제술, 4명이 아전절제술을 받았다. 안면신경이 절제된 경우는 5명 있었다. 수술 후 병리학적으로 잔존 병변이 있었던 경우가 4명, 절제연 양성이 4명이었다. 방사선치료는 선형가속기의 광자선과 전자선속을 사용하였다. 26명 중 11명은 광자선만으로 치료하였고 전자선이 병용된 경우는 15명이었으며 전자선량은 900 cGy부터 3800 cGy (중앙값: 1760 cGy)까지였다. 이하선종양 부위에 조사된 총방사선량은 5000 cGy부터 7560 cGy (중앙값 : 6020 cGy)까지였다. 대상 환자들의 최소추적기간은 2년이었다. 국소종양제어율의 산출은 Kaplan-Meier법을 이용하였고 단변량분석에는 generalized Wilcoxon test, 다변량분석에는 Cox 모델을 이용하였다. 결과 : 방사선 치료 후 국소종양의 재발은 25명 중 5명 (19$\%$)에서 관찰되었으며 국소종양제어율은 5년에 77$\%$였다. 환자의 5년 생존율은 70$\%$였다. 성별, 연령 (>60세), 종양크기 (>4 cm), 수술소견상 경부림프절 침범과 신경 침범, 절제연 침범 여부 및 총방사선량 (>60 Gy)의 요인이 국소 종양 제어율에 미치는 영향을 단변량 분석한 결과 종양 크기 (p=0.002), 절제연 침범 여부(p=0.011)에 따라 국소종양제어율에 있어서 통계학적으로 의의가 있는 차이를 보였다. 같은 요인들에 대한 다변량 분석에서는 종양 크기 (p=0.022)만이 국소 종양 제어율에 관련이 있는 것으로 나타났다. 결론 : 국소종양 제어율에 영향을 주는 여러가지 예후 인자들의 다변량 분석에서 종양 크기만이 의의가 있었으나 앞으로 더욱 많은 환자를 대상으로 연구가 요구된다.