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http://dx.doi.org/10.7314/APJCP.2012.13.9.4413

Prognostic Significance of GSTP1, XRCC1 and XRCC3 Polymorphisms in Non-small Cell Lung Cancer Patients  

Ke, Hong-Gang (Department of Cardiovascular Surgery, the First Affiliated Hospital of Soochow University)
Li, Jun (Department of Respiratory Medicine, the Affiliated Hospital of Nantong University)
Shen, Yi (Department of Statistical Research, Nantong University)
You, Qing-Sheng (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University)
Yan, Yu (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University)
Dong, Han-Xuan (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University)
Liu, Jun-Hua (Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Nantong University)
Shen, Zhen-Ya (Department of Cardiovascular Surgery, the First Affiliated Hospital of Soochow University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.9, 2012 , pp. 4413-4416 More about this Journal
Abstract
Aim: Individual differences in chemosensitivity and clinical outcome in non-small cell lung cancer (NSCLC) patients treatment with platinum-based chemotherapy may be due to genetic factors. Our study aimed to investigate the prognostic role of GSTP1, XRCC1 and XRCC3 in NSCLC patients treated with chemotherapy. Methods: A total of 460 cases were consecutively selected from The Affiliated Hospital of Nantong University between Jan. 2003 to Nov. 2006, and all were followed-up until Nov. 2011. Genotyping of GSTP1 Ile105Val, XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met was conducted by duplex polymerase-chain-reaction with confronting-two-pair primer methods. Results: Patients with GSTP Val/Val exhibited a shorter survival time, and had a 1.89 fold greater risk of death than did those with the IIe/IIe genotype. For XRCC1 Arg194Trp, the variant genotype Trp/Trp was significantly associated with a decreased risk of death from NSCLC when compared with the Arg/Arg. Individuals carrying XRCC1 399Gln/Gln genotype had a longer survival time, with a lowered risk of death from NSCLC. Conclusion: This study indicated that GSTP1 Ile105Val, XRCC1 Arg194Trp and XRCC1Arg399Gln genes have a role in modifying the effect of platinum-based chemotherapy for NSCLC patients in a Chinese population. Our findings provide information for therapeutic decisions for individualized therapy in NSCLC cases.
Keywords
GST-pi; XRCC1; XRCC3; non-small cell lung cancer; prognosis; chemotherapy;
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