• Title/Summary/Keyword: study model

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Predicting fetal toxicity of drugs through attention algorithm (Attention 알고리즘 기반 약물의 태아 독성 예측 연구)

  • Jeong, Myeong-hyeon;Yoo, Sun-yong
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2022.05a
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    • pp.273-275
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    • 2022
  • The use of drugs by pregnant women poses a potential risk to the fetus. Therefore, it is essential to classify drugs that pregnant women should prohibit. However, the fetal toxicity of most drugs has not been identified. This takes a lot of time and cost. In silico approaches, such as virtual screening, can identify compounds that may present a high risk to the fetus for a wide range of compounds at the low cost and time. We collected class information of each drug from the hazard classification lists for prescribing drugs in pregnancy by the government of Korea and Australia. Using the structural and chemical features of each drug, various machine learning models were constructed to predict fetal toxicity of drugs. For all models, the quantitative performance evaluation was performed. Based on the attention algorithm, important molecular substructures of compounds were identified in the process of predicting the fetal toxicity of the drug by the proposed model. From the results, we confirmed that drugs with a high risk of fetal toxicity can be predicted for a wide range of compounds by machine learning. This study can be used as a pre-screening tool for fetal toxicity predictions, as it provides key molecular substructures associated with the fetal toxicity of compounds.

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The Effect of Family Resilience on Willingness for Self-sufficiency in Self-sufficiency Program Participants: Focusing on the Mediating Effect of Mental Health (자활사업참여자의 가족탄력성이 자활의지에 미치는 영향: 정신건강의 매개효과를 중심으로)

  • Kim, Jung-Hee
    • The Journal of the Korea Contents Association
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    • v.22 no.8
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    • pp.607-618
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    • 2022
  • The purpose of this study was to identify the effect of family resilience on willingness for self-sufficiency in self-sufficiency program participants and to verify the mediating effect of mental health in the relationship. The survey subjects were 283 participants from a local self-support center in Gangwon-do. As for the analysis method, descriptive statistics and difference verification were performed. Also, hierarchical regression analysis and mediating effect method were performed to verify the research model. First, as a result of the difference test, the level of self-support was higher when there was a caring family. The level of family resilience was higher in those who were in their 40s and 50s than in their 30s or less, married than unmarried, had normal or excellent health conditions than deplorable health conditions, and had a caring family. Mental health quality was higher in very healthy people rather than in people who had poor health. Also, people with no dept had a higher mental health quality. Second, as a result of analyzing the relationship of influence on self-support, the higher the age, the more caring families, the higher the level of family resilience and mental health, the higher the self-sufficiency. Third, as a result of the mediating effect analysis, mental health had a partial mediating effect between family resilience and willingness for self-sufficiency. Therefore, we discussed the implications for improving family resilience and mental health as a factor in improving the level of self-sufficiency in self-sufficiency program participants.

The Effect of Youth Mentoring Program on Developmental Outcomes of At-risk Adolescents (고위험 청소년을 위한 멘토링 프로그램의 효과분석: 프로그램 과정산물의 매개효과를 중심으로)

  • Park, Hyun-Sun
    • Korean Journal of Social Welfare Studies
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    • v.41 no.1
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    • pp.175-201
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    • 2010
  • The purpose of this study was to examine the mechanism through which youth school-based mentoring program impacts mentees' psychological and school-related outcomes such as self-esteem, self-efficacy, and attitudes toward school. The hypothetical model was assumed that mentors could improve their mentees' developmental outcomes through positive relationships with mentors as good role models and enhancement of help-seeking orientation. To investigate the mediating effect of process-related outcomes, structural equation modeling was used. The 97 adolescents were recruited through referral and random selection from middle schools in Seoul. The result showed that the effects of program participation were mediated by proximal changes in connectedness to role models and development of help-seeking orientation that, in turn, led to facilitate more positive attitudes toward school and academic activity, and improve psychological outcomes. Practice and policy implications as well as further research topics were discussed to aid the search for highly effective mentoring programs.

Circularity of the Program Development Activities: Empirical Investigation in the Social Service Agencies in Korea (사회복지기관에서 프로그램 개발의 순환적인 활동에 대한 실증적 연구: 수용, 개발, 전파를 중심으로)

  • Seo, In Hae;Kong, Gye Soon
    • Korean Journal of Social Welfare Studies
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    • v.41 no.3
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    • pp.443-475
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    • 2010
  • Despite the rapidly increased concern on the circularity of the program development activities in the social service agencies, there are only a few studies about the phenomena. This study is to describe the characteristics of program development in the process of adopting, developing, and disseminating the social programs and to figure out the factors influencing differences in the 3 activities in social service agencies. The researchers constructed an explanative model including each 12-13 independent variables with 3 consecutive dependent variables on the basis of reviewing the related literatures. A multiple regression analysis was applied to predict the features of the program development using 195 questionaries responded from social workers in community service centers. As the result of the descriptive analysis, the two noticeable features are found; (1) the agencies have very actively adopted outside programs, developed appropriate programs for the agency, and disseminated the programs into other agencies in the community. (2) there are some positive aspects of the factors in related to the process of the program development. The results of the regression analysis show that the three dependent variables of the adoption, development, and dissemination are very closely interconnected with each others, showing the evidence of the circularity in the agencies. In addition, the 5 independent variables at the value of p .01 are statistically related with the circularity of the three dependent activities. The implication of major findings were discussed in academic and practical perspectives in Korea, including future research works in the area.

The Holocene tidal sedimentary changes in Mosan Bay Estuary, Korea (홀로세 충남 모산만 하구역내 간석지의 퇴적과정)

  • Shin, Young Ho
    • Journal of The Geomorphological Association of Korea
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    • v.18 no.3
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    • pp.37-51
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    • 2011
  • Geomorphic changes and sedimentary changes are investigated by sediment analysis from estuarine tidal flat, Mosan Bay Estuary, which is a tide-dominated and rias estuary. Sediments separatedly deposited during the early Holocene and the late Holocene. There are unconformities between the early Holocene sediment unit and the late Holocene sediment unit. Developments of these unconformities were related with fluctuated sea level change during the mid Holocene. Three deposit zones are spatially classified, which are named "intermittent tide channel deposit zone"(A1, B1, D3), "flood-dominated deposit zone"(A3, B3, C1, C3), and "fluvial sediment deposit zone"(A2, B2). This classification is explained by three main effects; laterally restricted migration of a tidal channel, diffract flood effect and settling lag effect, and fluvial induced reworking. These effects are deserved as main factors which have formed estuarine geomorphology in tidedominated and rias estuary. This study suggests research directions in reconstructing estuarine geomorphic and sedimentary change in west coast of Korea. Furthermore, it gives useful data for making a "land-ocean interaction" model for west coast of Korea.

Factors Related to Depression of Children and Adolescents in South Korea: A Meta-Analysis (메타분석을 통한 국내 아동·청소년의 우울 관련 변인 탐색)

  • Sunmee Kim ;Hayoung Ko ;Soohyun Park ;Eunjoo Yang
    • Korean Journal of Culture and Social Issue
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    • v.18 no.4
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    • pp.533-555
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    • 2012
  • This study investigated the relationship of self-esteem, academic stress, social support, and parenting attitudes with depression of Korean children and adolescents using a meta-analysis. A total of 86 studies, both published and unpublished manuscripts, were included. The results showed that depression of children and adolescents were positively associated with self-esteem, social support, and functional parenting attitudes, and negatively related to academic stress. The largest effect size was found in the relationship with self-esteem, followed by the relationships with academic stress, social support, and functional parenting attitudes, all in the range between moderate and large effect size. As the analysis indicated the heterogeneity of the results, subsequent analyses were performed to test the moderating effects of instrument and age. The significant moderators were the types of instruments used to measure self-esteem, academic stress, parenting attitudes, and depression. Age was also a significant moderator.

항만하역업 안전관리 개선방안에 관한 연구

  • 심민섭;이정민;김율성
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2022.06a
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    • pp.389-390
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    • 2022
  • Recently, Recently, the increase in international trade volume and the explosive increase in cargo volume due to the non-face-to-face society are leading to an increase in risk exposure and safety accidents in the port industry. In addition, as the Serious Disaster Punishment Act came into effect on January 27, 2021, various guidelines and laws to protect safety and life in port terminals are being enacted. However, despite these efforts, medium-to-large safety accidents in the port terminal industry continue to occur. According to the Korea Occupational Safety and Health Agency, from 2016 to 2019, the number of casualties in the port handling industry increased by 4.2%. For effective follow-up management of port accidents or the preparation of related safety laws/systems, a risk analysis in consideration of the cause and damage of the accident must be conducted first, so that realistic accident reduction and prevention measures can be established. Therefore, in this study, major risk factors and preventive measures were derived by conducting risk assessment based on 1,039 cases of port terminal accidents collected by the Korea Occupational Safety and Health Agency for 5 years from 2016 to 2022. After that, the priorities for preventive measures were determined through IPA analysis, Borich needs analysis, and The Locus For Focus analysis.

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Analysis of Differences between On-line Customer Review Categories: Channel, Product Attributes, and Price Dimensions (온라인 고객 리뷰의 분류 항목별 차이 분석: 채널, 제품속성, 가격을 중심으로)

  • Yang, So-Young;Kim, Hyung-Su;Kim, Young-Gul
    • Asia Marketing Journal
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    • v.10 no.2
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    • pp.125-151
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    • 2008
  • Both companies and consumers are highly interested in on-line customer reviews which enable consumers to share their experience and knowledge about products. In this study, after classifying real reviews into context units and deriving categories, we analyzed differences between categories based on channel(manufacturers' homepage/ shopping mall), product attribute(search/experience) and price(high/low). The method to derive categories is based on roughly adopting constructs of ACSI model and elaborate and repetitive classification of real reviews. We set up the classification category with 3 levels. Level 1 consists of product and service, level 2 consists of function, design, price, purchase motive, suggestion/user-tip and recommendation/repurchase in product and AS/up-grade and delivery/others in service and level 3 is composed of details of level 2 of category. We could find remarkable differences between channels in all 8 items of level 2 of category. As the number of context units in homepage is more than in shopping mall, we found reviews in homepage is more concrete. Moreover, overall satisfaction in review was higher at homepage's. Also, in product attribute dimension, we found different patterns of reviews in design, purchase motive, suggestion/user-tip, recommendation/repurchase, AS/up-grade and delivery/others and no difference in overall customer's satisfaction. In price dimension, we found differences between high and low price in design, price and AS/up-grade and no difference in overall customer's satisfaction.

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Case Study on Marketing Strategy of E-mart to Be No. 1 Discount Store in Korea (대한민국 1등 할인점을 추구하는 이마트의 마케팅전략에 관한 사례분석)

  • Yoo, Changjo;Ahn, Kwangho;Hwang, Eui Rok
    • Asia Marketing Journal
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    • v.6 no.3
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    • pp.143-156
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    • 2004
  • This case intorduced E-mart's business philosophy and vision, analyzed E-mart's outline of marketing strategy, and discussed its performance and future task. E-mart took the role of market pioneer by developing discount store market in Korea. It's mission was to provide substantial benefits to the customers by selling quality products at the lowest price in the market. For this purpose, E-mart has conducted a slogan of 'everyday low price discount store-E-mart'. Objective of E-mart's brand strategy was to be No. 1 discount store in Korea or to be a representative brand in the discount store market. To achieve this objective, E-mart has conducted various efforts such as construction of national network, realization of the lowest price, formation of the most reliable discount store image, establishment of competitive edge and so on. E-mart settled a new model for discount store in Korea and took the lead in expanding market potential. With these efforts, E-mart has maintained secure position as a leading company in the discount store market.

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Latent Profile Analysis of PTSD symptoms and PTG among Adults in South Korea: the Differences in Binge Eating, Non-Suicidal Self-Injury, and Problem Drinking Behaviors (잠재프로파일분석(LPA)을 활용한 PTSD 증상과 외상 후 성장 수준의 양상: 폭식, 비자살적 자해, 문제성 음주행동에서의 차이)

  • DeokHee Lee;DongHun Lee;HayoungJung
    • Korean Journal of Culture and Social Issue
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    • v.25 no.4
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    • pp.325-351
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    • 2019
  • The present study examined patterns of co-occurrence between DSM-5 posttraumatic stress disorder(PTSD) symptoms and posttraumatic growth(PTG) among Korean populations(n= 860). Latent profile analysis was used to identify subclasses and suggested that the 3-class model fit best: (1) Low PTSD/Mild PTG group (2) Low PTSD/High PTG group; (3) High PTSD/High PTG group. Class membership was predicted by demographic variables, social isolation, and frequency of traumatic experiences. Classes also differed with respect to self-destructive behaviors(binge eating, non-suicidal self-injury, and problem drinking). These findings contribute to future research about the coexisting patterns of PTSD and PTG, and to identify high-risk individuals who suffer from trauma-related problems in clinical practice.