• Economic and Environmental Geology
• /
• v.38 no.4 s.173
• /
• pp.421-434
• /
• 2005

Abstract Based onthe characteristics of Carlin-type gold deposit in Nevada district, a potential in Korea is evaluated to the Yemi area where is structurally controlled by folds and trust fault. The fault of high angles are combined with a more permeable rocks such as the Yemi breccia and laminated silty limestone. The pattern of enrichment factors for Tl, Sb, As, Ag, Pb, Zn, Cu, Mo and W of limestones in the southern area are geochemically similar with those reported from the Carlin-type Bold deposit. Moreover, the oxygen and carbon isotopes show a hydrothermal alteration is widely developed in this area. According to the result of geophysical interpretation, stable isotope, alteration mineralogy, geochemical study, and geological structure, this mineralized zone may be extended to the M direction, so a detailed systematic exploration is required to identify this alteration zone.

• Tunnel and Underground Space
• /
• v.20 no.6
• /
• pp.446-454
• /
• 2010

CAES-G/T (Compressed Air Energy Storage - Gas Turbine) power generation is a likely option for the buffer facility stabilizing the fluctuation of the renewable powers, such as wind and solar powers. Considering the geological conditions, the underground CAES facility is most probable if the CAES-G/T generation is planed in Korea. In this kind of facility, a concrete plug is installed to seal the compressed air in the container, so that the selection of the shape and dimension of concrete plug could be a critical design factor. The stability evaluation of two types of plug was carried out by investigating the distribution of the factor of safety in the plugs and the distribution of contact pressure over the contact surface. The analysis result shows that the taper-shaped plug is more structurally stable than the wedge-shaped plug for the given geological condition. Possible separation of the rock-concrete interface around the spring line of the wedge-shaped plug is anticipated, which means the possible leakage of compressed air through the side wall and also means the poor mobilization of frictional resistance on that area.

• Wind and Structures
• /
• v.27 no.5
• /
• pp.347-356
• /
• 2018

In this paper, stress distribution for a structurally stable greenhouse is considered in the present paper with subsequent investigation into the detailed stress distribution contour with the variation of self-weight and wind pressure level designation method under wind velocity of less than 30 m/sec. For reliable analysis, wind pressure coefficients of a single greenhouse unit were modeled and compared with experiment with correlation coefficient greater than 0.99. Wind load level was designated twofold: direct mapping of fluid dynamic analysis and conversion of modeled results into wind pressure coefficients ($C_P$). Finally, design criteria of EN1991-1-4 and NEN3859 were applied in terms of their wind pressure coefficients for comparison. $C_P$ of CFD result was low in the most of the modeled area but was high only in the first roof wind facing and the last lee facing areas. Besides, structural analysis results were similar in terms of stress distribution as per EN and direct mapping while NEN revealed higher level of stress for the last roof area. The maximum stress levels are arranged in decreasing order of mapping, EN, and NEN, generating 8% error observed between the EN and mapping results under 30 m/sec of wind velocity. On the other hand, effect of dead weight on the stress distribution was investigated via variation of high stress position with wind velocity, confirming shift of such position from the center to the forward head wind direction. The sensitivity of stress for wind velocity was less than 0.8% and negligible at wind velocity greater than 20 m/sec, thus eliminating self-weight effect.

• Journal of Radiation Industry
• /
• v.5 no.3
• /
• pp.221-225
• /
• 2011

To detect superoxide anion ($O_2{\cdot}^-$) or singlet oxygen ($^1O_2$) in biological systems during gamma irradiation, specific chemical probes, 4,5-dihydroxy-1,3-benzene disulfonic acid (Tiron) or 2,2,6,6-tetramethyl-piperidine (TEMP), were evaluated. Tiron or TEMP spin adducts was structurally stable in aqueous solution during gamma irradiation up to 500 or 1,000 Gy, respectively. The signal of Tiron semiquinone radical, a spin adduct of Tiron upon reaction with $O_2{\cdot}^-$, was slightly increased by gamma irradiation. This trend was dose-dependently manifested in $O_2$-saturated aqueous solution using nitro blue tetrazolium (NBT), a common probe for both hydrated electron ($e{^-}_{aq}$) and $O_2{\cdot}^-$. In contrast, a spin adduct of TEMP, was never inducible by gamma irradiation, while its signal was substantially enhanced by photosensitization of riboflavin. These results suggest that Tiron and NBT or TEMP could be utilized to detect $O_2{\cdot}^-$ or $^1O_2$ in biological systems during gamma irradiation, although $O_2{\cdot}^-$ or $^1O_2$ are not the main reactive oxygen species produced by water radiolysis.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2011.04a
• /
• pp.291-295
• /
• 2011

Thermo-structural analysis was performed for a radiation-cooled nozzle extension of thrust chamber. A Niobium alloy that is known to be a high-performance refractory alloy was used. Since area ratio of the nozzle extension is larger than that of nozzle divergence part, its size also becomes larger. For this reason, it is important to minimize the thickness of nozzle extension to reduce its weight. For the purpose of weight minimization, the thickness of nozzle extension was varied from 1.0 mm to 0.4 mm and structural stability was evaluated for each case. Analysis results showed that nozzle extension with thickness of 0.4 mm is structurally stable for the operation condition. The effect of combustion-included vibration will be additionally considered in the future.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.3
• /
• pp.470-475
• /
• 2019

This paper deals with a 30kW grid-connected PCS (Power Conversion System) for an Oscillating Water Column (OWC) wave-power generation system. Wave power generation in marine energy is suitable for Korea with the characteristics of a peninsula with three sides facing the sea. In the case of coastal disasters, wave generators can act as a breakwater to reduce damage, and can be integrated with other marine power generation systems to increase efficiency. Wave power generation systems are classified into various types, such as oscillating bodies, OWC, and overtopping according to the operation principle, and they can also be classified into two types according to the installation method: a fixed structure and floating structure. This paper proposes a 30kW grid-connected PCS topology and model for OWC wave power generation that is structurally stable with a turbine and generator that are relatively easy to maintain, and then provide a control method required for grid connection, including DC link voltage control. Simulation verification was performed to verify the proposed PCS.

• KIPS Transactions on Software and Data Engineering
• /
• v.8 no.7
• /
• pp.289-302
• /
• 2019

Structural change of time series means that the distribution of observations is relatively stable in the period of constituting the entire time series data, but shows a sudden change of the distribution characteristic at a specific time point. Within a non-stationary long-term time series, it is important to determine in a timely manner whether the change in short-term trends is transient or structurally changed. This is because it is necessary to always detect the change of the time series trend and to take appropriate measures to cope with the change. In this paper, we propose a method for decision makers to easily grasp the structural changes of time series by visualizing the test results based on the unit root test. Particularly, it is possible to grasp the short-term structural changes even in the long-term time series through the method of dividing the time series and testing it.

• Journal of the Architectural Institute of Korea Planning & Design
• /
• v.34 no.10
• /
• pp.33-44
• /
• 2018

The purpose of this research is to identify the characteristics of the positive and negative expressions about residential common life between the elderly and the young and present the direction on Homeshare. In-depth interviews were conducted from Feb. to May 2016 to identify the experiences of residential common life with 10 elderly and 11 young. The result is as follows. First, Homeshare dwelling was classified into five themes of human being, residential environment, life, management and emotion. Homeshare unlike ordinary dwelling centered on blood relatives, is characteristic to involve the management that connects between the elderly and young. Second, both the elderly and young were analyzed to be positive about the residential common life. It was shown that the elderly are most positive about human being, whereas young are positive about management and residential environment. The elderly is positive to mutual exchange with the young and young's independent life but the young is positive to factors that support comfortable personal life. Third, negative expression was shown a generation gap between the elderly and the young. The elderly recognized to be negative that young people has lived freely without consideration for the elderly. In order to solve these factors, it is necessary to make improvements through arranging rules for living. Fourth, three themes, human being, residential environment and life, analyzed to be the most important factors to sustain residential common life of Homeshare. The link between management and 3 themes leads to an expansion of positive emotion, which is structurally stable and is expected to increase the sustainability of the residential common life on Homeshare.

• Genomics & Informatics
• /
• v.21 no.3
• /
• pp.30.1-30.13
• /
• 2023

Ephs belong to the largest family of receptor tyrosine kinase and are highly conserved both sequentially and structurally. The structural organization of Eph is similar to other receptor tyrosine kinases; constituting the extracellular ligand binding domain, a fibronectin domain followed by intracellular juxtamembrane kinase, and SAM domain. Eph binds to respective ephrin ligand, through the ligand binding domain and forms a tetrameric complex to activate the kinase domain. Eph-ephrin regulates many downstream pathways that lead to physiological events such as cell migration, proliferation, and growth. Therefore, considering the importance of Eph-ephrin class of protein in tumorigenesis, 7,620 clinically reported missense mutations belonging to the class of variables of unknown significance were retrieved from cBioPortal and evaluated for pathogenicity. Thirty-two mutations predicted to be pathogenic using SIFT, Polyphen-2, PROVEAN, SNPs&GO, PMut, iSTABLE, and PremPS in-silico tools were found located either in critical functional regions or encompassing interactions at the binding interface of Eph-ephrin. However, seven were reported in nonsmall cell lung cancer (NSCLC). Considering the relevance of receptor tyrosine kinases and Eph in NSCLC, these seven mutations were assessed for change in the folding pattern using molecular dynamic simulation. Structural alterations, stability, flexibility, compactness, and solvent-exposed area was observed in EphA3 Trp790Cys, EphA7 Leu749Phe, EphB1 Gly685Cys, EphB4 Val748Ala, and Ephrin A2 Trp112Cys. Hence, it can be concluded that the evaluated mutations have potential to alter the folding pattern and thus can be further validated by in-vitro, structural and in-vivo studies for clinical management.

• Analytical Science and Technology
• /
• v.37 no.2
• /
• pp.98-113
• /
• 2024

The current investigation entails the characterization of five degradation products (DPs) formed under different stress conditions of loteprednol using liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, this study developed a stable high-performance liquid chromatography (HPLC) method for evaluating loteprednol along with impurities. The method conditions were meticulously fine-tuned which involved the exploration of the appropriate solvent, pH, flow of the mobile phase, columns, and wavelength. The method conditions were carefully chosen to successfully resolve the impurities of loteprednol and were employed in subsequent validation procedures. The stability profile of loteprednol was exposed to stress degradation experiments conducted under five conditions, and DPs were structurally characterized by employing LC-MS/MS. The chromatographic resolution of loteprednol and its impurities along with DPs was effectively achieved using a Phenomenex Luna 250 mm C18 column using 0.1 % phosphoric acid, methanol, and acetonitrile in 45:25:30 (v/v) pumped isocratically at 0.8 mL/min with 243 nm wavelength. The method produces an accurate fit calibration curve in 50-300 ㎍/mL for loteprednol and LOQ (0.05 ㎍/mL) - 0.30 ㎍/mL for its impurities with acceptable precision, accuracy, and recovery. The stress-induced degradation study revealed the degradation of loteprednol under basic, acidic, and photolytic conditions, resulting in the formation of seven distinct DPs. The efficacy of this method was validated through LC-MS/MS, which allowed for the verification of the chemical structures of the newly generated DPs of loteprednol. This method was appropriate for assessing the impurities of loteprednol and can also be appropriate for structural and quantitative assessment of its degradation products.