• Journal of the Korea Institute of Building Construction
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• v.13 no.5
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• pp.491-497
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• 2013

The objective of the present study is to establish a straightforward mixture proportioning procedure for structural lightweight aggregate concrete (LWAC), and evaluate the selection range of the targeted dry density of concrete against the designed concrete compressive strength. In developing this procedure, mathematical models were formulated based on a nonlinear regression analysis over 347 data sets and two boundary conditions of the absolute volume and dry density of concrete. The proposed procedure demonstrated the appropriate water-to-cement ratio and dry density of concrete to achieve the designed strength decrease with the increase in volumetric ratio of coarse aggregates. This trend was more significant in all-LWAC than in sand-LWAC. Overall, the selection range of the dry density of LWAC exists within a certain range according to the designed strength, which can be obtained using the proposed procedure.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7219-7229
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• 2015

Background: Chromosomal aberrations identified in acute lymphoblastic leukemia (ALL) have an important role in disease diagnosis, prognosis and management. Information on karyotype and associated clinical parameters are essential to physicians for planning cancer control interventions in different geographical regions. Materials and Methods: In this study, we present the overall frequency and distribution patterns of chromosomal aberrations in both children and adult de novo B lineage ALL Indian patients using conventional cytogenetics, interphase FISH and multiplex RT-PCR. Results: Among the 215 subjects, cytogenetic results were achieved in 172 (80%) patients; normal karyotype represented 37.2% and abnormal 62.8% with a distribution as follows: 15.3% hypodiploidy; 10.3% hyperdiploidy; 15.8% t(9;22); 9.8% t(1;19); 3.7% t(12;21); 2.8% t(4;11); 2.8% complex karyotypes. Apart from these, we observed several novel, rare and common chromosomal rearrangements. Also, FISH studies using LSI extra-signal dual-color probes revealed additional structural or numerical changes. Conclusions: These results demonstrate cytogenetic heterogeneity of ALL and confirm that the incidence of chromosomal abnormalities varies considerably. To the best of our knowledge, this is one of the largest reported series of cytogenetic investigations in Indian B-lineage ALL cases. In addition, ongoing cytogenetic studies are warranted in larger groups of B-lineage ALL cases to identify newly acquired chromosomal abnormalities that may contribute to disease diagnosis and management.

• Journal of the Korean Institute of Rural Architecture
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• v.21 no.4
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• pp.17-24
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• 2019

It has been long time since the local small-and-medium cities had lost their vitality due to the progress of aging, economic decline in urban areas, the lack of new growth engines, and the declining population in korea. In addition, since the implementation of the local self-governing system, the creation of new urban areas and the transfer of the administrative institutions to the outskirts of a city have accelerated the decline of old downtown. Rather, local small-and-medium cities would have a problem to make urban regeneration impossible. Under the recognition of such problems, individual self-governing entities have come up with numerous policies and implemented various policies for the revitalization of local small-and-medium cities, but it is a condition that the effect of their efforts falls shorts of expectations, such as the space of the similar style, which has been widespread in developed countries, simple restoration, and a few structural changes. In this regard, the part to be realized anew is to enhance the attractiveness of small-and-medium cities. However, is not possible to raise the overall attractiveness in a short time in reality. To select local assets to be utilized in urban regeneration, it is judged that gathering opinions of local residents is more important than any other thing. Accordingly, this study intends to present positive outcome for the purpose of the revitalization of local small-and-medium cities by finding the factors which can remind us of the collective memory of Jinju city and selection the critical factors to determine a detailed project plan from the perspective of urban regeneration.

• Steel and Composite Structures
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• v.18 no.4
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• pp.985-1000
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• 2015

The method of cross-section analysis for different sections in a structural frame has been widely investigated since the 1960s for determination of sectional capacities of beam-columns. Many hand-calculated equations and design graphs were proposed for the specific shape and type of sections in pre-computer age decades ago. In design of many practical sections, these equations may be uneconomical and inapplicable for sections with irregular shapes, leading to the high construction cost or inadequate safety. This paper not only proposes a versatile numerical procedure for sectional analysis of beam-columns, but also suggests a method to account for residual stress and geometric imperfections separately and the approach is applied to design of high strength steels requiring axial force-moment interaction for advanced analysis or direct analysis. A cross-section analysis technique that provides interaction curves of arbitrary welded sections with consideration of the effects of residual stress by meshing the entire section into small triangular fibers is formulated. In this study, two doubly symmetric sections (box-section and H-section) fabricated by high-strength steel is utilized to validate the accuracy and efficiency of the proposed method against a hand-calculation procedure. The effects of residual stress are mostly not considered explicitly in previous works and they are considered in an explicit manner in this paper which further discusses the basis of the yield surface theory for design of structures made of high strength steels.

• Journal of Microbiology and Biotechnology
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• v.25 no.5
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• pp.579-588
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• 2015

Fungi of the genus Pestalotiopsis have drawn attention for their capability to produce an array of bioactive secondary metabolites that have potential for drug development. Here, we report the determination of a polyketide derivative compound, pestalotiollide B, in the culture of the saprophytic fungus Pestalotiopsis microspora NK17. Structural information acquired by analyses with a set of spectroscopic and chromatographic techniques suggests that pestalotiollide B has the same skeleton as the penicillide derivatives, dibenzodioxocinones, which are inhibitors of cholesterol ester transfer protein (CETP), and as purpactins A and C', inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). Strain NK17 can make a fairly high yield of pestalotiollide B (i.e., up to 7.22 mg/l) in a constitutive manner in liquid culture. Moreover, we found that a putative histone deacetylase gene, designated as hid1, played a role in the biosynthesis of pestalotiollide B. In the hid1 null mutant, the yield of pestalotiollide B increased approximately 2-fold to 15.90 mg/l. In contrast, deletion of gene hid1 led to a dramatic decrease of conidia production of the fungus. These results suggest that hid1 is a modulator, concerting secondary metabolism and development such as conidiation in P. microspora. Our work may help with the investigation into the biosynthesis of pestalotiollide B and the development for new CETP and ACAT inhibitors.

• Proceedings of the Materials Research Society of Korea Conference
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• 2009.11a
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• pp.6.2-6.2
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• 2009

Nanostructured materials arecurrently receiving much attention because of their unique structural andphysical properties. Research has been stimulated by the envisagedapplications for this new class of materials in electronics, optics, catalysisand magnetic storage since the properties derived from nanometer-scalematerials are not present in either isolated molecules or micrometer-scalesolids. This study presents the experimental results derived fromthe various functional materials processed in nano-scale using pulsed laserablation, since those materials exhibit new physical phenomena caused by thereduction dimensionality. This presentation consists of three mainparts to consider in pulsed laser ablation (PLA) technique; first nanocrystallinefilms, second, nanocolloidal particles in liquid, and third, nanocoating fororganic/inorganic hybridization. Firstly, nanocrystalline films weresynthesized by pulsed laser deposition at various Ar gas pressures withoutsubstrate heating and/or post annealing treatments. From the controlof processng parameters, nanocystalline films of complex oxides and non-oxidematerials have been successfully fabricated. The excellentcapability of pulsed laser ablation for reactive deposition and its ability totransfer the original stoichiometry of the bulk target to the deposited filmsmakes it suitable for the fabrication of various functionalmaterials. Then, pulsed laser ablation in liquid has attracted muchattention as a new technique to prepare nanocolloidal particles. Inthis work, we represent a novel synthetic approach to directly producehighly-dispersed fluorescent colloidal nanoparticles using the PLA from ceramicbulk target in liquid phase without any surfactant. Furthermore, novel methodbased on simultaneous motion tracking of several individual nanoparticles isproposed for the convenient determination of nanoparticle sizedistributions. Finally, we report that the GaAs nanocrystals issynthesized successfully on the surface of PMMA (polymethylmethacrylate)microspheres by modified PLD technique using a particle fluidizationunit. The characteristics of the laser deposited GaAs nanocrytalswere then investigated. It should be noted that this is the first successfultrial to apply the PLD process nanocrystals on spherical polymermatrices. The present process is found to be a promising method fororganic/inorganic hybridization.

• Journal of the Earthquake Engineering Society of Korea
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• v.14 no.3
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• pp.1-10
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• 2010

The target performance of a current seismic design code is to achieve collapse-prevention in order to minimize casualties. Existing structures are also being retrofitted to meet this target performance. This seismic performance seems to have been achieved in recent great overseas earthquakes, but the accompanying enormous economic loss is pointed out as a new problem. A new seismic design concept over the current target performance is required to reduce economic loss, in which a target performance is determined by the damage probability in order to control the damage levels of structures. In this study, the seismic behavior of bridges having different characteristics was investigated by nonlinear seismic analyses, and fragility curves with respect to a reference damage level were derived. Based on these results, the characteristics of target ductilities satisfying a target damage probability were investigated.

• International Journal of Highway Engineering
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• v.10 no.2
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• pp.81-89
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• 2008

Shear test procedure for concrete-dowel interaction was proposed along with determination of dowel support reaction factor or shear spring stiffness constant using the spreadsheet example. For this task, three AASHTO-type standard specimens were prepared to simulate behavior of the jointed concrete pavement. A side support system was adopted to minimize twisting of the test specimen which had been observed in a preliminary test. A typical elastic behavior of the dowel-concrete interaction was observed from several test loops of loading, unloading and reloading procedures. However load versus slab displacement represents to be nonlinear. Test results show that the dowel support reaction factor ranges from 550-880 GN/m3, which is 1.4-2.2 times greater than 407GN/m3 proposed by Yoder and Witczak. This is because less torsional distraction was occurred with the help of a side support system adopted in this experiment. The dowel support reaction factor or shear spring stiffness constant obtained from the procedures proposed in this paper may be used as a reference data for the structural analysis of jointed concrete pavement.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.95.2-96
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• 2003

In order to develop a new microbial fungicide for the control of vegetable diseases using endophytic bacteria, a total of 260 bacterial strains were isolated from fresh tissues of 5 plant species. After they were cultured in broth media, their antifungal activities were screened by in vivo bioassays against Botrytis cinerea(tomato gray mold), Pythium ultimum(cucumber damping-off), Phytopkhora infestans(tomato late blight), Colletotrichum orbiculare(cucumber anthracnose), and Blumeria graminis f. sp. hordei(barley powdery mildew). As the results of screening, 38 bacterial strains showed potent antifungal activities against at least one of 5 plant pathogens. A bacterial strain EB072 displayed potent disease control activities against 3 plant diseases. Among the bacterial strains with a potent antifungal activity against cucunlber anthracnose, three bacterial strains, EB054, EB151 and EB215, also displayed a potent in vitro antifungal activity against C. acutatum, a fungal agent causing pepper anthracnose. A bacterial strain EB215 obtained from roots of cucumber was identified as Burkholderia cepacia based on its physiological and biochemical characteristics and 165 rRNA gene sequence. An antifungal substance was isolated from the liquid cultures of B. cepacia EB215 strain by ethyl acetate partitioning, repeated silica gel column chromatography, and invitro bioassay, Its structural determination is in progress by various instrumental analyses.

• Journal of the Korean Ceramic Society
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• v.40 no.5
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• pp.481-487
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• 2003

A technique for determination of proportions of char, coal ana coke is needed in order to monitor pulverized coal injection performance in operating blast furnace. Quantitative X-ray powder diffraction analysis can be applied to the problem providing that structural information on carbonaceous materials, coal, char, coke and their mixture are known. Chars were prepared from a coal at different temperatures (1000∼1400$^{\circ}C$) and were characterised by X-Ray powder Diffraction (XRD). The XRD result gave crystallite size (height Lc and diameter, La), aromaticity, number of (002) plane in carbon, and d-spacing. As a result, with increasing heat treat temperature of char, Lc$_{(002)}$, La$_{(10)}$ and number of (002) plane in carbon were increased, and d-spacing and FWHM(Full With Half Maximum) were decreased. Result of prediction of amount of char from the mixtures (char, coke and ore) based on the Lc$_{(002)}$ information of two mixtures (coke and char) showed very close values expected.