• Smart Structures and Systems
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• v.14 no.5
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• pp.981-1004
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• 2014

Structural control is a very broad field combining the areas of automatic control and structural engineering, with applications ranging from aerospace and mechanical engineering to building and civil infrastructure systems. In this paper, the focus is placed on civil engineering applications only. The goal is to address the issues concurring to form the scientific paradigm. As a resut, possible future directions of research into this field are identified.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1994.10a
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• pp.17-24
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• 1994

The pre- and post-processor for finite element structural analysis considering the user-friendly device are developed by using GUI. These can be used on WINDOWS' environment which is realized the multi-tasking and the concurrency by object-oriented paradigm. They are designed to control integratedly the pre-processing, execution and the post-processing of the finite element structural analysis program on multiple windows. These object-oriented modeling approach can be used for complex integrated engineering systems.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1994.04a
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• pp.25-32
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• 1994

The pre-processor for finite to element structural analysis considering the user-friendly device is developed by using GUI. This can be used on WINDOWS' environment which is realized the multi-tasking and the concurrency by object-oriented paradigm. Data input can be done easily through menu, dialog box, automatic stepwise input and concurrent representation with the structural geometry on multiple windows. It in designed to control integratedly the pre-processing, execution and the post-processing of the finite element structural analysis program on multiple windows, and input data can be seen with result outputs at the same time. In addition, the object-oriented programming environment makes convenient revision and addition of the program components for expanding the scope of analysis and making better user environment.

• Smart Structures and Systems
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• v.25 no.1
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• pp.105-109
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• 2020

The authors address the problem of ameliorating or updating existing educational buildings. This building typology is quite sensitive to social and media pressure, mainly when accidents have occurred nearby. When a building is classified as unsatisfactory, the current code requirements oblige one to re-design the building with significant penalty factors in the resistance values. Often the only solution is to destroy the existing facility and to build a new one. When attempting to preserve the existing building, higher levels of safety are demanded by the society and this can only be achieved by innovative system architectures. The authors propose and discuss a prototype that can be easily adopted to retrofit small educational buildings as the ones common in small municipalities. The higher performance is pursued by a special design of the control scheme, with new control devices and special control laws.

• Molecules and Cells
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• v.20 no.2
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• pp.167-172
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• 2005

Ceruloplasmin (Cp) is a copper protein with important functions in iron homeostasis and in inflammation. Cp mRNA expression is induced by interferon (IFN)-${\gamma}$ in U937 monocytic cells, but synthesis of Cp protein is halted after about 12 h by transcript-specific translational silencing. The silencing mechanism requires binding of a 4-component cytosolic inhibitor complex, IFN-gamma-activated inhibitor of translation (GAIT), to a defined structural element (GAIT element) in the Cp 3'-UTR. Translational silencing of Cp mRNA requires the essential proteins of mRNA circularization, suggesting that the translational inhibition requires end-to-end mRNA closure. These studies describe a new mechanism of translational control, and may shed light on the role that macrophage-derived Cp plays at the intersection of iron homeostasis and inflammation.

• Molecules and Cells
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• v.41 no.11
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• pp.933-942
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• 2018

Traditionally, small-molecule or antibody-based therapies against human diseases have been designed to inhibit the enzymatic activity or compete for the ligand binding sites of pathological target proteins. Despite its demonstrated effectiveness, such as in cancer treatment, this approach is often limited by recurring drug resistance. More importantly, not all molecular targets are enzymes or receptors with druggable 'hot spots' that can be directly occupied by active site-directed inhibitors. Recently, a promising new paradigm has been created, in which small-molecule chemicals harness the naturally occurring protein quality control machinery of the ubiquitin-proteasome system to specifically eradicate disease-causing proteins in cells. Such 'chemically induced protein degradation' may provide unprecedented opportunities for targeting proteins that are inherently undruggable, such as structural scaffolds and other non-enzymatic molecules, for therapeutic purposes. This review focuses on surveying recent progress in developing E3-guided proteolysis-targeting chimeras (PROTACs) and small-molecule chemical modulators of deubiquitinating enzymes upstream of or on the proteasome.

• Korean Institute of Interior Design Journal
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• v.20 no.1
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• pp.33-42
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• 2011

This study, by applying the experiential and psychological thought category of "impression" as the space design strategy for drawing out "sensitivity," aims to break down the psychological mechanism forming the image held by the subject, and based on such segmentation, seek and strategize an effective design methodology. The subject's memory, pure sensation, and movement sensation are set as the preceding determinants comprising the psychological mechanism of space impression. The control determinants for achieving activation of psychological effect are reinterpreted as the relations of memory-cognition, sensation-perception, and movement-sensation and categorized into a cognitive strategy based on association, metaphor and remembrance; a direct sensation strategy based on formation, superposition and transposition of sensation; and a sensation strategy of process-formation based on expectation organization and reversal, contraction and relaxation. Each strategy is achieved through the formal, material and structural control of architecture. As a restructuring of the design methodology that has been experientially applied, the strategy categorization is important in that, by presenting the usefulness and effect by strategy according to space experience, it makes concrete the basic data that are useful for designing experience of sensitivity.

• Investigative Magnetic Resonance Imaging
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• v.14 no.2
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• pp.115-120
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• 2010

Purpose : To separate and evaluate the low frequency spontaneous fluctuation BOLD signals from the functional magnetic resonance imaging data using sensorimotor active task. Materials and Methods : Twenty female archery players and twenty three control subjects were included in this study. Finger-tapping task consisted of three cycles of right finger tapping, with a subsequent 30 second rest. Blood oxygenation level-dependent (BOLD) data were collected using $T2^*$-weighted echo planar imaging at a 3.0 T scanner. A 3-D FSPGR T1-weighted images were used for structural reference. Image processing and statistical analyses were performed using SPM5 for active finger-tapping task and GIFT program was used for statistical analyses of low frequency spontaneous fluctuation BOLD signal. Results : Both groups showed the activation in the left primary motor cortex and supplemental motor area and in the right cerebellum for right finger-tapping task. ICA analysis using GIFT revealed independent components corresponding to contralateral and ipsilateral sensorimotor network and cognitive-related neural network. Conclusion : The current study demonstrated that the low frequency spontaneous fluctuation BOLD signals can be separated from the fMRI data using finger tapping paradigm. Also, it was found that these independent components correspond to spontaneous and coherent neural activity in the primary sensorimotor network and in the motor-cognitive network.

• The Journal of Information Systems
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• v.29 no.2
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• pp.197-220
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• 2020

Purpose Cloud computing that provides a new paradigm for a firm's use of information technology is getting a lot of attentions by practitioners. However, the empirical investigation on members of organizations using cloud computing are insufficient. Therefore, this study aims to examine the capabilities and perceptions of organizational members that should be considered important for successful cloud computing implementation. Design/methodology/approach This study proposed factors related to the capabilities and perceptions of members of the organization, and examined the relationship between these factors and successful cloud computing implementation and performance. In addition, this study tested the moderating effect of leadership and continuous supports through empirical analysis. The proposed hypotheses were verified through structural equation modeling using SmartPLS3.0 with the collected data. Findings The results showed that four factors except 'member behavior control' had a positive effect on successful cloud computing implementation, which had a positive effect on performance. In addition, leadership and organizational continuous support have been shown to strengthen the relationship among factors.

• Journal of Digital Convergence
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• v.17 no.1
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• pp.347-356
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• 2019

Recently, the liberalization of industrial control systems has been accompanied by a major change in the structural paradigm of information systems in the public and public sectors, and potential cyber security problems in the future major infrastructure control systems that cannot respond to the level of security of existing information systems. To cope with this, a cyber security evaluation tool that can evaluate security vulnerability in three dimensions against various infrastructure control system environment is needed. However, a cyber security evaluation in the domestic environments does not have the concept of the current security status and satisfy settings of the infrastructure. Also, the most of items in that environments have had short-term inspection themselves which makes a limitation by a technical area. In order to overcome this problems, many researches are needed to apply CSET (Cyber Security Evaluation Tool) which is the US cyber security evaluation tool to the control environment of various domestic infrastructure. In this paper, first, we analyze methods to apply to the major domain through the analysis of various case studies on existing security assessement tools. Finally, we discuss future directions.