• 센서학회지
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• 제5권3호
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• pp.17-24
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• 1996

이 논문은 압력센서의 압저항 소자 값에 영향을 미치는 실리론 박막의 잔류응력과 4개 저항의 특성 차에 의해 발생하는 오프셋과 온도 드리프트 특성을 보상하기 위하여 2중 브리지구조의 압력센서에 대하여 연구한 것이다. 압력 변화에 무관한 브리지회로의 각 저항 소자를 압력 변화를 감지하는 브리지회로의 각 저항 소자 가까이 배치하여 각 브리지회로의 출력을 감산하므로 오프셋과 온도 드리프트를 소자내부에서 제거하는 것이다. 이 방법에 의해 오프셋과 온도 드리프트 성분의 약 95%가 제거되었다. 제작된 압력센서의 감도는 $0.9\;kgfcm^{-2}$ full-range에 대해서 $11.7\;mV/Vkg/cm^{-2}$ 이었다.

• The Korean Journal of Physiology and Pharmacology
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• 제13권2호
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• pp.131-138
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• 2009

The binding of interleukin-6 (IL-6) cytokine family ligands to the gp130 receptor complex activates the Janus kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signal transduction pathway, where STA T3 plays an important role in cell survival and tumorigenesis. Constitutive activation of STAT3 has been frequently observed in many cancer tissues, and thus, blocking of the gp130 signaling pathway, at the JAK level, might be a useful therapeutic approach for the suppression of STAT3 activity, as anticancer therapy. AG490 is a tyrphostin tyrosine kinase inhibitor that has been extensively used for inhibiting JAK2 in vitro and in vivo. In this study, we demonstrate a novel mechanism associated with AG490 that inhibits the JAK/STAT3 pathway. AG490 induced downregulation of gp130, a common receptor for the IL-6 cytokine family compounds, but not JAK2 or STAT3, within three hours of exposure. The downregulation of gp130 was not caused by enhanced degradation of gp130 or by inhibition of mRNA transcription. It most likely occurred by translation inhibition of gp130 in association with phosphorylation of the eukaryotic initiation factor-2 a. The inhibition of protein synthesis of gp130 by AG490 led to immediate loss of mature gp130 in cell membranes, due to its short half-life, thereby resulting in reduction in the STAT3 response to IL-6. Taken together, these results suggest that AG490 blocks the STAT3 activation pathway via a novel pathway.

• 한국항해항만학회지
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• 제26권3호
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• pp.317-322
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• 2002

본 논문은 마그네트 천장크레인 거더에 대한 경량화를 위한 구조최적설계를 수행하였다. 최적화는 ANSYS 소프트웨어를 사용하여 거더의 중량에 대하여 수행되어졌으며, 특히 거더의 상판, 하판, 옆판 그리고 보강판의 두께인 치수에 초점을 맞추었다. 마그네트 크레인의 중량은 처짐, 응력, 고유진동수와 좌굴강도의 제한을 만족하며 약 15%까지 감량되었으며 또한, 구조적인 안전성이 거더의 판넬구조물의 좌굴해석에 의해 입증되었다. 구조최적화로 중량감소에 대해 예로부터 경험적으로 설계된 구조물을 설계하는 것에 매우 유용할 것으로 생각된다. 또한, 본 논문에서는 설계변수들이 목적함수와 상태변수에 미치는 민감도를 평가하였다.

• 한국건축시공학회지
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• 제9권3호
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• pp.95-101
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• 2009

Constructing large-scale mat foundation mass concrete is increasing for the stability of building structure, because a lot of high rise building are being built in order to make full use of limited space. However, It is of increasing concerns that because limited placing equipments, available job-site and systems for mass concete placement in construction field do not allow to place great quantity of concrete at the same time in large scale mat foundation, consistency between placement lift can not be secured. And also, it is likely to crack due to stress caused by the difference of hydration heat generation time. To find out the solution against above problems, this study is to reconfirm the performance of normal concrete designed by mix proportion and super retarding concrete. The Fundamental test shows what happens if low heat proportioning and control method of setting time are applied at the job-site of newly constructed high rise building. The test result show that slump flow of concrete has been somewhat increased as the target retarding time gets longer, while the air content has been slightly decreased but this is no great difference from normal concrete. The setting time shows to be retarded as target retarding time gets longer, the range of retarding time increases. It is necessary to increase the amount of mix of super retarding agent in the proportion ration by setting curing temperature high since outdoor curing is about 6 hours faster than standard curing, which means the temperature of the concrete will be higher than the temperature of the surrounding environment, due to its high hydration heat when applying in a construction site. The compressive strength of super retarding concrete appears to be lower than normal concrete due to the retarding action in the early stage. However, as the time goes by, the compressive strength gets higher, and by the 28th day the strength becomes the same or higher than normal concrete.

• 한국재료학회지
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• 제27권12호
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• pp.652-657
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• 2017

The use of continuous welded rail is increasing because of its many advantages, including vibration reduction, enhanced driving stability, and maintenance cost savings. In this work, two different types of continuous welded rails were examined to determine the influence of repeated wheel-rail contact on the crystal structure, microstructure and mechanical properties of the rails. The crystal structure was determined by x-ray diffraction, and the microstructure was examined using optical microscopy and scanning electron microscopy. Tensile and microhardness tests were conducted to examine the mechanical behaviors of prepared specimens taken from different positions in the cross section of both newly manufactured rail and worn rail. Analysis revealed that both the new and worn rail had a mixed microstructure consisting of ferrite and pearlite. The specimens from the top position of each rail exhibited decreased lamella spacing of the pearlite and increased yield strength, ultimate tensile strength and hardness, as compared with those from other positions of the rail. It is thought that the enhanced mechanical property on the top position of the worn rail might be explained by a mixed effect resulting from a directional microstructure, the decreased lamella spacing of pearlite, and work hardening by the repeated wheel-rail contact stress.

• 생약학회지
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• 제41권3호
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• pp.166-173
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• 2010

Oxidative stress to proteins, lipids, or DNA is higher in human autopsy tissue and in rodent models of a number of neurodegenerative conditions, including Alzheimer's and Parkinson's disease. On the basis of this information, we established a screening system using N18-RE-105 cells to identify therapeutic agents that can protect cells from glutamate toxicity. During the course of our screening program, we recently isolated the active compound 9-hydroxy-$\alpha$-tocopherone ($\alpha$-TP), which prevents glutamate-induced cell death, from Viola mandshurica. The chemical structure of $\alpha$-TP was identified using spectroscopic methods and by comparison with literature values. Antioxidant activity and protective effects of $\alpha$-TP were evaluated by DPPH radical-scavenging assay, morphological assay, MTT reduction assay, and lactate dehydrogenase (LDH) release assay. These results suggest that $\alpha$-TP could be a new potential chemotherapeutic agent against neuronal diseases.

• 한국재료학회지
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• 제21권11호
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• pp.596-603
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• 2011

The very high temperature gas reactor (VHTR) is one of the next generation nuclear reactors for its safety, long-term stability, and proliferation-resistance. The high operating temperature of over 800$^{\circ}C$ enables various applications with high energy efficiency. Heat is transferred from the primary helium loop to the secondary helium loop through the intermediate heat exchanger (IHX). The IHX material requires creep resistance, oxidation resistance, and corrosion resistance in a helium environment at high operating temperatures. A Ni-based superalloy such as Alloy 617 is considered as a primary candidate material for the intermediate heat exchanger. In this study, the microstructures of Alloy 617 crept in pure helium and air environments at 950$^{\circ}C$ were observed. The rupture time in helium was shorter than that in air under small applied stresses. As the exposure time increased, the thickness of outer oxide layer of the specimens clearly increased but delaminated after a long creep time. The depth of the carbide-depleted zone was rather high in the specimens under high applied stress. The reason was elucidated by the comparison between the ruptured region and grip region of the samples. It is considered that decarburization caused by minor gas impurities in a helium environment caused the reduction in creep rupture time.

• Structural Engineering and Mechanics
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• 제76권3호
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• pp.311-324
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• 2020

Until now, a comparative study on fully and partially-connected steel shear walls leading to enhancing strength and stiffness reduction of partially-connected steel plate shear wall structures has not been reported. In this paper a number of 4-story and 8-story steel plate shear walls, are considered with three different connection details of infill plate to surrounding frame. The specimens are modeled using nonlinear finite element method verified excellently with the experimental results and analyzed under monotonic loading. A comparison between initial stiffness and shear strength of models as well as percentage of shear force by model boundary frame and infill plate are performed. Moreover, a comparison between energy dissipation, ductility factor and distribution of Von-Mises stresses of models are presented. According to the results, the initial stiffness, shear resistance, energy dissipation and ductility of the models with beam-only connected infill plates (SSW-BO) is found to be about 53%, 12%, 15% and 48% on average smaller than those of models with fully-connected infill plates (SPSW), respectively. However, performance characteristics of semi-supported steel shear walls (SSSW) containing secondary columns by simultaneously decreasing boundary frame strength and increasing thickness of infill plates are comparable to those of SPSWs. Results show that by using secondary columns as well as increasing thickness of infill plates, the stress demands on boundary frame decreases substantially by as much as 35%. A significant increase in infill plate share on shear capacity by as much as 95% and 72% progress for the 4-story SSW-BO and 8-story SSSW8, respectively, as compared with non-strengthened counterparts. A similar trend is achieved by strengthening secondary columns of 4-story SSSW leading to an increase of 50% in shear force contribution of infill plate.

• Computers and Concrete
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• 제21권6호
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• pp.623-635
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• 2018

In order to research the influence of different recycled aggregate contents on the mechanical properties of pervious concrete, the experimental study and numerical simulation analysis of the mechanical properties of pervious concrete with five kinds of recycled aggregates contents (0%, 25%, 50%, 75% and 100%) are carried out in this paper. The experimental test were first performed on concrete specimens of different sizes in order to determine the influence of recycled aggregate on the compressive strength and splitting tensile strength, direct tension strength and bending strength. Then, the development of the internal cracks of pervious concrete under different working conditions is studied more intuitively by $PFC^{3D}$. The experimental results show that the concrete compressive strength, tensile strength and bending strength decrease with the increase of the recycled aggregate contents. This trend of reduction is not only related to the brittleness of recycled aggregate concrete, but also to the weak viscosity of recycled aggregate and cement paste. It is found that the fracture surface of pervious concrete with recycled aggregate is smoother than that of natural aggregate pervious concrete by $PFC^{3D}$, which means that the bridging effect is weakened in the stress transfer between the left and right sides of the crack. Through the analysis of the development of the internal cracks, the recycled aggregate concrete generated more cracks than the natural aggregate concrete, which means that the recycled aggregate concrete is easier to form a coalescence fracture surface and eventually break.

• 대한토목학회논문집
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• 제41권5호
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• pp.523-531
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• 2021

일반적으로 기초는 여러 개의 단일말뚝이 상부 구조체에 의해 연결된 상태로 군말뚝을 의미한다. 하지만, 군말뚝에 상부 하중 재하 시 지반에 작용하는 응력 범위는 단일말뚝에 비해 더 넓은 폭과 깊이로 확장되고, 중복되기 때문에 전체적인 지지력은 감소할 수 있다. 이러한 지지력 감소비를 군말뚝 효율이라 하나 일반적인 말뚝과 지반의 접촉 조건에 따른 영향을 분석한 연구는 부족한 실정이다. 따라서 본 연구에서는 지반 구성 및 군말뚝의 배치, 간격, 지반과 말뚝간의 접촉 특성을 해석 변수로 설정하고, 군말뚝 효율 및 군말뚝을 구성하는 개별말뚝의 거동을 분석하였다. 해석 결과, 지반 종류에 따라 마찰계수 증가 시 군말뚝 효율은 수렴 또는 감소하는 경향을 보였으며, 이를 통해 최적 군말뚝 효율을 분석하였다. 또한, 개별말뚝 분석을 통한 하중 감소비 파악 결과, 군말뚝 내부에 위치한 말뚝의 경우 하중을 상대적으로 적게 받았으며, 이는 내부 지반에 대한 영향인 것으로 판단된다.