• Journal of Dental Anesthesia and Pain Medicine
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• 제20권3호
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• pp.129-135
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• 2020

Background: Postoperative fluid retention is a factor that causes delay in recovery and unexpected adverse events. It is important to prevent intraoperative fluid retention, which is putatively caused by intraoperative release of stress hormones, such as ADH (anti-diuretic hormone) or others. We hypothesized that intraoperative analgesia may prevent pathological fluid retention. We retrospectively explored the relationship between analgesics and in-out balance in surgical patients from anesthesia records. Methods: Anesthetic records of 80 patients who had undergone orthognathic surgery were checked in this study. Patients were anesthetized with either TIVA (propofol and remifentanil) or inhalational anesthesia (sevoflurane and remifentanil). During surgery, acetated Ringer's solution was infused for maintenance at a rate of 3-5 ml/kg/h at the discretion of the anesthetist. The perioperative parameters, including the amount of crystalloid and colloid infused, and the amount of urine and bleeding were checked. Furthermore, we checked the amount and administration rate of remifentanil during the surgical procedure. The correlation coefficient between the remifentanil dose and the in-out balance or the urinary output was analyzed using the Pearson correlation coefficient. The contributing factor to fluid retention, including urinary output, was statistically examined by means of multivariate logistic regression analysis. Results: A significant positive correlation was found between remifentanil dose and urinary output. Urinary output less than 0.04 ml/kg/min was suggested to cause positive fluid balance. Although in-out balance approaches zero balance with increase in remifentanil administration rate, no contributing factor for near-zero fluid balance was statistically picked up. The remifentanil administration rate was statistically picked up as the significant factor for higher urinary output (> 0.04 ml/kg/min) (OR, 2,644; 95% CI, 3.2-2.2 × 10⁶) among perioperative parameters. Conclusions: In conclusion, remifentanil contributes in maintaining the urinary output during general anesthesia. Although further prospective study is needed to confirm this hypothesis, it was suggested that fluid retention could be avoided through suppressing intraoperative stress response by means of appropriate maintenance of remifentanil infusion rate.

• 한국자원식물학회지
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• 제23권2호
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• pp.165-171
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• 2010

산화적 스트레스로부터 참다래 과실 추출물의 신경세포 보호효과에 미치는 영향을 알아보기 위하여 신경세포주인 PC12 세포를 이용하여 참다래 과실추출물의 전처리가 산화적 손상으로부터 유발되는 신경세포사멸을 억제할 수 있는지 조사하였다. t-BHP에 의해 유도된 신경세포손상으로부터 세포사멸을 억제하여 세포생존도를 증가시켰으며 세포사멸로부터 형성되는 핵의 농축현상과 단편화가 현저히 감소함을 확인 할 수 있었다. 그리고 Bcl-2 단백의 발현 증가, Bax 단백의 발현 감소, caspase-3의 활성, PARP 분해 단백(85KDa)감소, ERK, p38 활성을 감소시켰다. 따라서 참다래 과실의 추출물은 신경세포증식효과를 통해 신경세포손상으로부터 유발되는 다양한 퇴행성 뇌질환의 예방에 도움이 될 것으로 나타났다.

• 한국구조물진단유지관리공학회 논문집
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• 제24권6호
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• pp.67-76
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• 2020

본 논문은 철계-형상기억합금(Fe-SMA) 바를 이용하여 제작된 콘크리트 보의 휨 거동 평가를 위한 실험적 연구이다. 실험을 위해 200mm×300mm × 2,200mm의 콘크리트 보를 제작하였으며 인장재로 4% 사전변형된 Fe-SMA 바를 사용하였다. 실험 변수로 인장재 종류(SD400, Fe-SMA), 철근 비(0.2, 0.39, 0.59, 0.78), Fe-SMA 활성화(활성화, 비활성화) 그리고 Fe-SMA bar 연결방법(미연결, 용접, 커플러)를 고려하였다. Fe-SMA 바를 활성화하기 위해 전기저항 가열 방법을 이용하여 5A/㎟의 전류를 실험체가 160℃에 도달할 때 까지 공급하였다. 캠버효과에 의한 실험체의 상향 변위가 안정되면 2,000kN 용량의 엑츄레이터를 이용하여 3점 휨 재하 실험을 실시하였다. 실험결과 Fe-SMA 바를 활성화 함에 따라 캠버효과에 의해 상향 변위가 발생하는 것으로 나타났다. Fe-SMA 바를 활성화한 실험체는 활성화하지 않은 실험체에 비해 더 높은 하중에서 초기균열이 발생하였다. 그러나 일반적인 프리스트레스 콘크리트와 동일하게 Fe-SMA 활성화에 따른 프리스트레스 도입이 보의 극한 상태에 미치는 영향은 미미한 것으로 나타났다.

• 한국재난정보학회 논문집
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• 제19권4호
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• pp.788-805
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• 2023

연구목적: 본 연구는 우기의 상습 침수로 인해 지속적으로 재난 스트레스를 경험한 방글라데시 남부 거주민들을 대상으로 (사)한국 해비타트의 재난위기경감 개입이 수혜자들의 정신건강 및 삶의 만족도에 어떠한 영향을 미치는지 검증하고자 하였다. 연구방법: 이를 위해 개입대상지역에 거주하는 138명의 성인 남녀를 대상으로 2020년 8월 사전조사 및 2021년 11월 사후조사를 수행하였다. 중재적 개입은 개별 점진주택 제공, 공용인프라시설 개보수, 재난대응훈련을 통한 역량개발로 구성되었다. 자료분석방법으로는 사전-사후의 변화에 대한 대응표본 t-test와 처치집단 간의 차이를 밝히기 위한 일원분산분석을 사용하였다. 연구결과:분석결과, 개입 후 거주민의 우울, 불안, 신체화 및 삶의 질 모두에서 유의한 향상이 나타났으며, 개입 처치에 따른 정신건강 수준에서도 유의한 차이를 보였다. 구체적으로 재난대응훈련과 대비하여 개별 점진주택 제공과 공용인프라시설 개보수에서 상대적으로 높은 효과가 확인되었다. 결론:이러한 결과는 (사)한국 해비타트의 재난위기경감 개입이 재난 피해자의 정신건강 회복에 미치는 긍정적 역할을 입증하였으며, 이를 바탕으로 재난취약 개도국 대상의 위험 지역에서 적용할 수 있는 실제적 개입방식을 제안하였다.

• 대한약침학회지
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• 제17권2호
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• pp.7-17
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• 2014

Objectives: Condurango is widely used in various systems of complementary and alternative medicines (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats, in vivo to validate its use as traditional medicine. Methods: Fifteen male and 15 female Sprague-Dawley (SD) rats were treated with 0.28 mg/kg of Sweet Bee Venom (SBV) (high-dosage group) and the same numbers of male and female SD rats were treated with 0.2 mL/kg of normal saline (control group) for 13 weeks. We selected five male and five female SD rats from the high-dosage group and the same numbers of male and female SD rats from the control group, and we observed these rats for four weeks. We conducted body-weight measurements, ophthalmic examinations, urinalyses and hematology, biochemistry, histology tests. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate reactive oxygen species (ROS), which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer cell-death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusion: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2005년도 제24회 춘계학술대회논문집
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• pp.225-230
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• 2005

리쿠퍼레이터 사이클을 적용하는 경우 단순사이클에 비하여 이론적으로 상당한 효율 증가를 가져올 수 있는 것으로 알려져 있으나 기기 내부의 압력손실, 열응력, 지나친 무게 증가 불리한 요소도 많이 있다. 그러므로 리쿠퍼레이터를 발전용 가스터빈에 적용하고자 하는 경우 리쿠퍼레이터가 가지는 여러 장단점을 고려하여 전체 수명 기간 중 경제적 타당성 측면에서 신중히 검토되어 져야 할 것으로 판단된다. 아직까지 산업 분야에서는 $20\sim300kW$급까지의 마이크로 터빈에서만 리쿠퍼레이터가 적용되고 있으며 그 이상 급의 가스터빈의 경우 지난 $40\sim60년대$ 해군에 잠시 시도된 외에 발전용으로는 거의 적용된 바가 없다. 본 논문에서는 이러한 발전용 리쿠퍼레이터 사이클의 적용성을 압력 손실, 부분부하 제어 등의 측면에서 검토하였다.

• Molecular & Cellular Toxicology
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• 제3권4호
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• pp.273-281
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• 2007

Ceramide is involved in cell death as a lipid mediator of stress responses. In this study, we developed an improved method of ceramide quantification based on added synthetic ceramide and thin layer chromatography (TLC) separation, and applied to biological samples. Lipids were extracted from samples spiked with N-oleoyl-D-erythro-sphingosine ($C_{17}$ ceramide) as an internal standard. Ceramide was resolved by TLC, complexed with fatty-acidfree bovine serum albumin (BSA), and deacylated by ceramidase (CDase). The released sphingosine was derivatized with o-phthalaldehyde (OPA) and measured by high performance liquid chromatography (HPLC). The limit of detection for ceramide was about 1-2 pmol and the lower limit of quantification was 5 pmol. Ceramide recovery was approximately 86-93%. Ceramide concentrations were determined in biological samples including cultured cells, mouse tissues, and mouse and human plasma. TLC separation of ceramide provides HPLC chromatogram with a clean background without any interfering peaks and the enhanced solubility of ceramide by BSAceramide complex leads to the increased deacylation of ceramide. The use of an internal standard for the determination of ceramide concentration in these samples provides an accurate and reproducible analytical method, and this method can be applicable to diverse biological samples.

• 한국가구학회지
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• 제26권1호
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• pp.77-91
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• 2015

The appeal of sauna is caused by the fact that through that, one can feel Korea's unique temperament and culture; however, because of its being a public facility and flooding of businesses due to excessive supplies of various additional features such as washing, playing, eating, sleeping and health care functions, issues of social resources and environment come to the fore, so it has reached a situation of red ocean that it is difficult to enter the market anymore. Taking these into account, this study focused on developing a thermal technology and design of the housing of an environment-friendly mobile home sauna, making the most use of the sauna's fundamental purpose and settling it as a tourist product, analyzing the marketing research on the existing sauna and considering the recent housing trends and lifestyles for a new concept sauna. Thus, regarding its characteristics and utilization, it was designed smaller than $10m^2$ (3 pyeong) so that it would be easy to install in any space and convenient to move. It can be installed in separate buildings and rest spaces such as country houses, resorts, pensions, camping grounds as well as outdoor houses, custom produced for a measure of pyeong that customers want so as to match up with the Enforcement Ordinance of the Agricultural Land Act in a concept of the farmer's hut and kitchen, bathroom and bathroom can be installed inside according to an option. In addition, regarding its efficacy, in order to give environment-friendly healing effects, materials such as Hinoki Cypress, red clay and hardwood charcoal were used, a fixed indoor temperature of $70{\sim}100^{\circ}C$ was maintained by heating methods such as electromagnetic wave free, energy saving and low-power boiler, and it was made to have excellent effects on fatigue recovery, relieving stress, skin care and diet through far-infrared emission.

• 동의신경정신과학회지
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• 제12권2호
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• pp.27-35
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• 2001

Objective : Doctors who treat women in childbed have to pay attention to postpartum blues and depression which women in childbed can suffer from, as well as recovery of physical function. Methods : Subjects were 107 females who admitted in Woosuk Hospital of Oriental Medicine from September, 2000 to October, 2001 and made out the question paper within 10 days after delivery. The paper included EPDS(Edinburgh Postnatal Depression Scale) and many items known to be the factors related to postpartum blues and depression. Results : The rate of postpartum depression assessed by EPDS was 16.8%. As the result of analysis, there were significant statistic corelations between each group assessed by EPDS and age parity relation with husband yes or no living with parents-in-law. But there were no significant corelations between each group assessed by EPDS and education religion yes or no occupation delivery method sex of infant marriage type yes or no rearing the infant. Conclusions : We recognized that insufficiency- of delivery experience and stress due to bad adaptation after delivery are possible to be risk factors of postpartum blues and depression. More research should be taken on the corelation between postpartum depression and yes or no living with parents-in-law, because this result is opposite to the trouble between mother-in-law and daughter-in-law. In addition, more research is needed on corelation between physical condition, oriental-diagnosis of women in childbed and postpartum depression.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1507-1510
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• 2005

This study was carried out as a part of the research on the development of a maskless and electroless process for fabricating metal micro/nanostructures by using a nanoindenter and an electroless deposition technique. $2-\mu{m}-deep$ indentation tests on Ni and Cu samples were performed. The elastic recovery of the Ni and Cu was 9.30% and 9.53% of the maximum penetration depth, respectively. The hardness and the elastic modulus were 1.56 GPa and 120 GPa for Ni and 1.49 GPa and 100 GPa for Cu. The effect of single-point diamond machining conditions such as the Berkovich tip orientation (0, 45, and $90^{\circ}$) and the normal load (0.1, 0.3, 0.5, 1, 3, and 5 mN), on both the deformation behavior and the morphology of cutting traces (such as width and depth) was investigated by constant-load scratch tests. The tip orientation had a significant influence on the coefficient of friction, which varied from 0.52-0.66 for Ni and from 0.46-0.61 for Cu. The crisscross-pattern sample showed that the tip orientation strongly affects the surface quality of the machined area during scratching. A selective deposition of Cu at the pit-like defect on a p-type Si(111) surface was also investigated. Preferential deposition of the Cu occurred at the surface defect sites of silicon wafers, indicating that those defect sites act as active sites for the deposition reaction. The shape of the Cu-deposited area was almost the same as that of the residual stress field.