• Journal of Dental Anesthesia and Pain Medicine
• /
• v.20 no.3
• /
• pp.129-135
• /
• 2020

Background: Postoperative fluid retention is a factor that causes delay in recovery and unexpected adverse events. It is important to prevent intraoperative fluid retention, which is putatively caused by intraoperative release of stress hormones, such as ADH (anti-diuretic hormone) or others. We hypothesized that intraoperative analgesia may prevent pathological fluid retention. We retrospectively explored the relationship between analgesics and in-out balance in surgical patients from anesthesia records. Methods: Anesthetic records of 80 patients who had undergone orthognathic surgery were checked in this study. Patients were anesthetized with either TIVA (propofol and remifentanil) or inhalational anesthesia (sevoflurane and remifentanil). During surgery, acetated Ringer's solution was infused for maintenance at a rate of 3-5 ml/kg/h at the discretion of the anesthetist. The perioperative parameters, including the amount of crystalloid and colloid infused, and the amount of urine and bleeding were checked. Furthermore, we checked the amount and administration rate of remifentanil during the surgical procedure. The correlation coefficient between the remifentanil dose and the in-out balance or the urinary output was analyzed using the Pearson correlation coefficient. The contributing factor to fluid retention, including urinary output, was statistically examined by means of multivariate logistic regression analysis. Results: A significant positive correlation was found between remifentanil dose and urinary output. Urinary output less than 0.04 ml/kg/min was suggested to cause positive fluid balance. Although in-out balance approaches zero balance with increase in remifentanil administration rate, no contributing factor for near-zero fluid balance was statistically picked up. The remifentanil administration rate was statistically picked up as the significant factor for higher urinary output (> 0.04 ml/kg/min) (OR, 2,644; 95% CI, 3.2-2.2 × 10⁶) among perioperative parameters. Conclusions: In conclusion, remifentanil contributes in maintaining the urinary output during general anesthesia. Although further prospective study is needed to confirm this hypothesis, it was suggested that fluid retention could be avoided through suppressing intraoperative stress response by means of appropriate maintenance of remifentanil infusion rate.

• Korean Journal of Plant Resources
• /
• v.23 no.2
• /
• pp.165-171
• /
• 2010

Oxidative stress induced by reactive oxygen intermediates has been implicated in a variety of human diseases including neurodegenerative disorders, cancer, cardiovascular and respiratory diseases, and mode of action of environmental toxicants. Tert-butylhydroperoxide (t-BHP) is an organic lipid hydroperoxide analogue, which is commonly used as a pro-oxidant for evaluating mechanisms involving oxidative stress in cells and tissues. In this study, the underlying mechanisms involved in the protective effects of Hwabuk 94 kiwifruit (Actinidia deliciosa cv. 'Hwabuk 94'), which is cultivated in Jeju, on the t-BHP-induced cytotoxicity in PC12 cell. The pretreatment of rat pheochromocytoma cell line PC12 with Hwabuk 94 extract ($1-100\;{\mu}g/ml$) resulted in a significant recovery from t-BHP-induced cell death and increased Bcl-2 and procaspase-3 expression, whereas the expression of Bax and cleaved PARP were decreased in a dose-dependent manner compared to the control. Furthermore, Hwabuk 94 inhibited the t-BHP-induced p38 MAP kinase and extracellular signal-regulated kinase 1/2, but not c-Jun N-terminal kinase activations. Finally, these findings suggest that Hwabuk 94 kiwifruit might attenuate t-BHP-induced PC12 cell cytotoxicity, at least in part, through the inhibition of signaling pathways mediated by the ERK1/2 and p38 MAP kinase.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.24 no.6
• /
• pp.67-76
• /
• 2020

This paper reports an experimental study to evaluate the flexural behavior of concrete beams reinforced using Fe based shape memory alloy (Fe-SMA) bars. For the experiment, a concrete beam of 200mm×300mm×2,200mm was produced, and a 4% pre-strained Fe-SMA bar was used as a tensile reinforcement. As experimental variables, type of tensile reinforcement (SD400, Fe-SMA), reinforcement ratio (0.2, 0.39, 0.59, 0.78), activation of Fe-SMA (activation, non-activation), and joint method of Fe-SMA bar (Continuous, welding, coupler) were considered. The electric resistance heating method was used to activate the Fe-SMA bar, and a current of 5A/㎟ was supplied until the specimen reached 160℃. After the upward displacement of the specimen due to the camber effect was stabilized, a three-point flexural loading experiment was performed using an actuator of 2,000 kN capacity. As a result of the experiment, it was found that the upward displacement occurred due to the camber effect as the Fe-SMA bar was activated. The specimen that activated the Fe-SMA bar had an initial crack at a higher load than the specimen that did not activate it. However, as with general prestressed concrete, the effect of the prestress by Fe-SMA activation on the ultimate state of the beam was insignificant.

• Journal of the Society of Disaster Information
• /
• v.19 no.4
• /
• pp.788-805
• /
• 2023

Purpose: This study aimed to verify the impact of Habitat for Humanity Korea's disaster risk reduction intervention on the mental health and satisfaction with life among residents of southern Bangladesh who had constantly suffered from disaster stress due to perennial flooding. Method: The target group was 138 residents who were pre-surveyed in August 2020 and post-surveyed in November 2021. The interventions consisted of individual incremental housing, public facilities for evacuation, and disaster response training for capacity development. The data were analysed using paired sample t-tests for pre-post changes and one-way analysis of variance to identify differences between treatment groups. Result: The results showed significant improvements in residents' depression, anxiety, somatisation and satisfaction with life after the intervention, with significant differences in mental health levels between the intervention treatments. Specifically, relatively higher disaster mitigation effects were found for individual infrastructure improvements and employment facilities compared to disaster response drills. Conclusion: These results demonstrate the positive role of Habitat for Humanity Korea's disaster risk reduction interventions on the mental health recovery of disaster victims and suggest practical approaches that can be applied in disaster risk areas.

• Journal of Pharmacopuncture
• /
• v.17 no.2
• /
• pp.7-17
• /
• 2014

Objectives: Condurango is widely used in various systems of complementary and alternative medicines (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats, in vivo to validate its use as traditional medicine. Methods: Fifteen male and 15 female Sprague-Dawley (SD) rats were treated with 0.28 mg/kg of Sweet Bee Venom (SBV) (high-dosage group) and the same numbers of male and female SD rats were treated with 0.2 mL/kg of normal saline (control group) for 13 weeks. We selected five male and five female SD rats from the high-dosage group and the same numbers of male and female SD rats from the control group, and we observed these rats for four weeks. We conducted body-weight measurements, ophthalmic examinations, urinalyses and hematology, biochemistry, histology tests. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate reactive oxygen species (ROS), which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer cell-death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusion: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• v.y2005m4
• /
• pp.225-230
• /
• 2005

It is theoretically known that recuperator can bring a significant increase in thermal efficiency of the gas turbine unit, but it also has disadvantages such as pressure loss in the flow channel, thermal stress and increase in weight. Therefore it is necessary to consider all pros and cons of this equipment in view of economic aspects throughout its life cycle. Recuperator has been applied mostly in the power ranges of $20\sim300kW$ class industrial units but hasn't been used as a larger power generation unit except for naval applications in mid twentieth century. Present paper considered the applicability of a recuperator cycle in term of pressure loss, part load aspects for power generation purpose.

• Molecular & Cellular Toxicology
• /
• v.3 no.4
• /
• pp.273-281
• /
• 2007

Ceramide is involved in cell death as a lipid mediator of stress responses. In this study, we developed an improved method of ceramide quantification based on added synthetic ceramide and thin layer chromatography (TLC) separation, and applied to biological samples. Lipids were extracted from samples spiked with N-oleoyl-D-erythro-sphingosine ($C_{17}$ ceramide) as an internal standard. Ceramide was resolved by TLC, complexed with fatty-acidfree bovine serum albumin (BSA), and deacylated by ceramidase (CDase). The released sphingosine was derivatized with o-phthalaldehyde (OPA) and measured by high performance liquid chromatography (HPLC). The limit of detection for ceramide was about 1-2 pmol and the lower limit of quantification was 5 pmol. Ceramide recovery was approximately 86-93%. Ceramide concentrations were determined in biological samples including cultured cells, mouse tissues, and mouse and human plasma. TLC separation of ceramide provides HPLC chromatogram with a clean background without any interfering peaks and the enhanced solubility of ceramide by BSAceramide complex leads to the increased deacylation of ceramide. The use of an internal standard for the determination of ceramide concentration in these samples provides an accurate and reproducible analytical method, and this method can be applicable to diverse biological samples.

• Journal of the Korea Furniture Society
• /
• v.26 no.1
• /
• pp.77-91
• /
• 2015

The appeal of sauna is caused by the fact that through that, one can feel Korea's unique temperament and culture; however, because of its being a public facility and flooding of businesses due to excessive supplies of various additional features such as washing, playing, eating, sleeping and health care functions, issues of social resources and environment come to the fore, so it has reached a situation of red ocean that it is difficult to enter the market anymore. Taking these into account, this study focused on developing a thermal technology and design of the housing of an environment-friendly mobile home sauna, making the most use of the sauna's fundamental purpose and settling it as a tourist product, analyzing the marketing research on the existing sauna and considering the recent housing trends and lifestyles for a new concept sauna. Thus, regarding its characteristics and utilization, it was designed smaller than $10m^2$ (3 pyeong) so that it would be easy to install in any space and convenient to move. It can be installed in separate buildings and rest spaces such as country houses, resorts, pensions, camping grounds as well as outdoor houses, custom produced for a measure of pyeong that customers want so as to match up with the Enforcement Ordinance of the Agricultural Land Act in a concept of the farmer's hut and kitchen, bathroom and bathroom can be installed inside according to an option. In addition, regarding its efficacy, in order to give environment-friendly healing effects, materials such as Hinoki Cypress, red clay and hardwood charcoal were used, a fixed indoor temperature of $70{\sim}100^{\circ}C$ was maintained by heating methods such as electromagnetic wave free, energy saving and low-power boiler, and it was made to have excellent effects on fatigue recovery, relieving stress, skin care and diet through far-infrared emission.

• Journal of Oriental Neuropsychiatry
• /
• v.12 no.2
• /
• pp.27-35
• /
• 2001

Objective : Doctors who treat women in childbed have to pay attention to postpartum blues and depression which women in childbed can suffer from, as well as recovery of physical function. Methods : Subjects were 107 females who admitted in Woosuk Hospital of Oriental Medicine from September, 2000 to October, 2001 and made out the question paper within 10 days after delivery. The paper included EPDS(Edinburgh Postnatal Depression Scale) and many items known to be the factors related to postpartum blues and depression. Results : The rate of postpartum depression assessed by EPDS was 16.8%. As the result of analysis, there were significant statistic corelations between each group assessed by EPDS and age parity relation with husband yes or no living with parents-in-law. But there were no significant corelations between each group assessed by EPDS and education religion yes or no occupation delivery method sex of infant marriage type yes or no rearing the infant. Conclusions : We recognized that insufficiency- of delivery experience and stress due to bad adaptation after delivery are possible to be risk factors of postpartum blues and depression. More research should be taken on the corelation between postpartum depression and yes or no living with parents-in-law, because this result is opposite to the trouble between mother-in-law and daughter-in-law. In addition, more research is needed on corelation between physical condition, oriental-diagnosis of women in childbed and postpartum depression.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2005.06a
• /
• pp.1507-1510
• /
• 2005

This study was carried out as a part of the research on the development of a maskless and electroless process for fabricating metal micro/nanostructures by using a nanoindenter and an electroless deposition technique. $2-\mu{m}-deep$ indentation tests on Ni and Cu samples were performed. The elastic recovery of the Ni and Cu was 9.30% and 9.53% of the maximum penetration depth, respectively. The hardness and the elastic modulus were 1.56 GPa and 120 GPa for Ni and 1.49 GPa and 100 GPa for Cu. The effect of single-point diamond machining conditions such as the Berkovich tip orientation (0, 45, and $90^{\circ}$) and the normal load (0.1, 0.3, 0.5, 1, 3, and 5 mN), on both the deformation behavior and the morphology of cutting traces (such as width and depth) was investigated by constant-load scratch tests. The tip orientation had a significant influence on the coefficient of friction, which varied from 0.52-0.66 for Ni and from 0.46-0.61 for Cu. The crisscross-pattern sample showed that the tip orientation strongly affects the surface quality of the machined area during scratching. A selective deposition of Cu at the pit-like defect on a p-type Si(111) surface was also investigated. Preferential deposition of the Cu occurred at the surface defect sites of silicon wafers, indicating that those defect sites act as active sites for the deposition reaction. The shape of the Cu-deposited area was almost the same as that of the residual stress field.