• Korean Journal of Psychosomatic Medicine
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• v.28 no.2
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• pp.155-160
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• 2020

Objectives : This study investigate to identify the stability of temperament and personality characteristics of patients including Posttraumatic Stress Disorder (PTSD) patients. Methods : The number of subjects was 102, of which 33 were PTSD patients and 69 were non-PTSD patients. To demonstrate the change in individual temperament and personality characteristics, Temperament and Character Inventory (TCI) were administered repeatedly on the subjects. Repeated measures ANOVA and simple main effects analysis were conducted. Results : When analysed by dividing the subjects into PTSD groups and non-PTSD groups, the differences between the primary and secondary tests did not appear in the non-PTSD groups, but the differences between the primary and secondary tests were significant in Harm Avoidance (HA), Reward Dependence (RD), Self-Directedness (SD), Cooperativeness (C). In addition, it was noted that the time and group interaction effects of HA, RD, SD and C were significant, and that the main effects of time of HA, RD, SD and C were significant. Conclusions : This study is meaningful in that in the course of experience and recovery of traumatic events, we have clinically confirmed that changes in the temperament, known as stable variables, are possible.

• Analytical Science and Technology
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• v.37 no.2
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• pp.98-113
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• 2024

The current investigation entails the characterization of five degradation products (DPs) formed under different stress conditions of loteprednol using liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, this study developed a stable high-performance liquid chromatography (HPLC) method for evaluating loteprednol along with impurities. The method conditions were meticulously fine-tuned which involved the exploration of the appropriate solvent, pH, flow of the mobile phase, columns, and wavelength. The method conditions were carefully chosen to successfully resolve the impurities of loteprednol and were employed in subsequent validation procedures. The stability profile of loteprednol was exposed to stress degradation experiments conducted under five conditions, and DPs were structurally characterized by employing LC-MS/MS. The chromatographic resolution of loteprednol and its impurities along with DPs was effectively achieved using a Phenomenex Luna 250 mm C18 column using 0.1 % phosphoric acid, methanol, and acetonitrile in 45:25:30 (v/v) pumped isocratically at 0.8 mL/min with 243 nm wavelength. The method produces an accurate fit calibration curve in 50-300 ㎍/mL for loteprednol and LOQ (0.05 ㎍/mL) - 0.30 ㎍/mL for its impurities with acceptable precision, accuracy, and recovery. The stress-induced degradation study revealed the degradation of loteprednol under basic, acidic, and photolytic conditions, resulting in the formation of seven distinct DPs. The efficacy of this method was validated through LC-MS/MS, which allowed for the verification of the chemical structures of the newly generated DPs of loteprednol. This method was appropriate for assessing the impurities of loteprednol and can also be appropriate for structural and quantitative assessment of its degradation products.

• Journal of Oriental Neuropsychiatry
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• v.26 no.1
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• pp.63-78
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• 2015

Objectives: Pinelliae Rhizoma has traditionally been used as an anti-depressant in oriental medicine. This study is to investigate the effect of Pinelliae Rhizoma extract (PRe) on psychological stress in genome wild expression of mice. Methods: After giving physical stress to mice, PRe was orally administered with 100 mg/kg/day for five days. After extracting whole brain tissue from the mice, their genome changes were observed by micorarray analysis method. The genome changes were analyzed by IMAGENE 4.0, TREEVIEW, FatiGo algorithems, BOND database, cytoscape program, etc. Results: 1. PRe administered group were remained at normal level; 60% of increase was shown in expressed genes by physical stress, and 65% of decrease was shown in expressed genes by psychological stress. 2. Genes with increased expression in control group that remained at a normal state in PRe administered group were involved with the gene of a cellular metabolic process on biological process, protein binding on molecular function, and cell part on cell composition. The pathway was found to be cytokin-cytokin receptor interaction. 3. Genes with decreased expression in control group that remained at a normal state in PRe administered group were involved with the gene of a cellular metabolic process on biologiacl detail and coupled ATPaes activity on molecular function. This gene related path was Ubiquintin mediated proteolysis etc. 4. Core node genes analyzed by protein interaction network were Vinculin, Cell sdivision cycle 42 homolog (S. cerevisiae) etc. They played an important role in maintaining cytoskeleton and controlling cell cycle. Conclusions: Several genes were up-regulated and down-regulated in response to psychological stress. The expression of most of the genes that were altered in response to psychological stress was restored to normal levels in PRe treated mice. When the interaction network information was analyzed, the recovery of the core node genes in PRe treated mice indicates that this final set of genes may be the effective target of PRe.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.4
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• pp.167-177
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• 2018

This study was conducted to investigate the effects of post-traumatic stress on the quality of life and effects of resilience in industrial accident patients. Participants in this study were 158 patients in an industrial hospital and general hospital in two metropolitan urban areas. Data were collected from July 1 to September 30, 2017 using self-report questionnaires and analyzed by descriptive statistics, Pearson's correlation coefficient, hierarchical regression, and Sobel's test using SPSS 21.0. There were significant negative correlations post-traumatic stress, quality of life, effects of resilience and were significant positive correlations quality of life, effects of resilience. The effects of resilience showed partial mediating effects, but not moderating effects on post-traumatic stress and quality of life. Post-traumatic stress and resilience explained 45% of the effects of industrial accidents on quality of life, post-traumatic stress explained 23% of the effects on quality of life, and the mediating effect of resilience was 22%. Based on the results of this study, it is necessary to develop interventions that improve quality of life by reducing post-traumatic stress and increasing resilience among workers who experience industrial accidents.

• Journal of Korean Academy of Nursing
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• v.30 no.1
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• pp.7-17
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• 2000

The purpose of this study is to affect health improvement of adolescent, to understand behavioral causes follow adolescent's drug abuse, to understand recovery and rehabilitaton process of adolescent drug abuser. The data are collected through open questionnaire and interview of 25 adolescents from the experienced drug abuse 16 students(male 8, female 8) in two vocational high schools and admissing adolescents 9 person in Alcohol-Drug Addiction Care Centre in Seoul from June 28th to August 31st, 1994. The collected data are arranged and explained through categorizing method stated contents about motives, causes, experiences and effected behaviors for using the drugs of drug abuser adolescents. DRUG USING MOTIVATION They are almost first son and daughter in their family. In their conversation person, male converses to their mother well, but female does not converse to their parents include family. Both groups respond positively to companionship and attitude to other, but negatively to self-confidence and actualizing attitude. They hope always peace of family and want to do their best for their life. In school group, hard and difficult things are school life and family problems, also using the drugs for resolving the them. About drug using behaviors, male responds to bad habbit and shamfull, but female is unconcerned with drug using attitude. The first background of drug using, male gets to use because of curiosity and to be induced from friends or seniors, but female gets to use for feminine beauty(thin body) and escape from reality. Used the drugs, male uses frequently Bond, Butane-Gas among inhalation materials and also marijuana, but female uses various diuretics. The times of drug using, both groups repond to use during the chaging of emotion or filling with stress. The place of drug using, both groups take drugs in vacant houses or in the mountain. The frequency of drug using, they use almost once in a day and they use mostly alone or drug user in friends. Experienced mental changing after drug using, which is fantasy, ecstasy, anxiety and suicidal feeling, and experienced physical changing after drug using, which is elevating sense, headach, abdominal pain, dyspnea and chaging of skin colour and reddish. They coincide with inconvenience feeling due to drug using. RECOVERY AND REHABILITATION PROCESS OF DRUG USING ADOLESCENTS The reason for reforming drug using behavior and attitude, both groups respond to reforming for oneself and social life. The difficult things during the stop to using drugs, all of them responed to family problems, friends problems and temptation and impulse. As for stop to using drug, they need good advise, understandable attitude and family love. But they do not need to be stigmatized, scolding, over protect and ridicule of friends. Also they entreat continuous understanding, advise, concern and the method for resolving stress. For the friends to want to use the drug, they will talk about the stories of their personal experiences and for the friends to stop to using the drug, they will consider for them how to stop. From the theses results, drug users understand personal problems due to drug using, and consider about why to stop and how to stop. Also drug users need to resolve the family problems, personal problems, stress and temptations or impulses. Accordingly this paper suggests that drug users in adolescents need understandable and acceptable atitudes, loving and tenderness, continuous advice and concern, and hopes for life.

• Journal of Chest Surgery
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• v.31 no.8
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• pp.776-780
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• 1998

Background: In patients with coronary artery disease, dysfunctional hypoperfused myocardium at rest may represent either nonviable or viable hibernating myocardium. Two-dimensional echocardiography can detect regional wall motion abnormalities resulting from myocardial ischemia by dobutamine infusion. The purpose of the present study was to identify the prediction of improvement of regional left ventricular(LV) function after surgical revascularization. Materials and methods: Sixteen patients with chronic regional LV dysfunction underwent dobutamine stress echocardiography(DSE) (dobutamine: baseline, 5, 10, 20$\mu$g/kg/min) before coronary artery bypass grafting(CABG) and underwent echocardiography at least 2 months after CABG. Results: All patients were male with mean age of 58 years ranging from 42 to 73 years. The mean LV ejection fraction was 41.8% with a range from 19% to 55%. During DSE, there were no complications, also, there were no operative morbidities or mortalities. Improvement of wall motion within the dysfunctional myocardium was found in 8(50%) of 16 patients in DSE. Among them, 6 patients(75%) showed functional recovery after CABG. Another 8 patients did not show improvement of wall motion in DSE. But among them, 3 patients(38%) showed functional recovery after CABG. 84 dysfunctional segments were found in 256 segments of 16 patients. Improvement of wall motion was found in 34 of 84 segments in DSE. Among them, 23 segments(74%) showed functional recovery after CABG. Another 53 segments did not show improvement of wall motion in DSE. But among them, 12 segments(23%) showed functional recovery after CABG. The sensitivity and specificity of DSE for the prediction of postoperative improvement of segmental wall motion were 66% and 84%, respectively. The positive and negative predictive value of DSE were 74% and 77%, respectively. In patients with chronic regional LV dysfunction, think that DSE is a good predictor of the improvement of dysfunctional segments after CABG.

• Journal of Power Electronics
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• v.15 no.5
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• pp.1190-1199
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• 2015

This paper presents a new resonant converter to achieve the soft switching of power devices. Two full-bridge converters are connected in series to clamp the voltage stress of power switches at V_in/2. Thus, power MOSFETs with a 500V voltage rating can be used for 800V input voltage applications. Two flying capacitors are connected on the AC side of the two full-bridge converters to automatically balance the two split input capacitor voltages in every switching cycle. Two resonant tanks are used in the proposed converter to share the load current and to reduce the current stress of the passive and active components. If the switching frequency is less than the series resonant frequency of the resonant tanks, the power MOSFETs can be turned on under zero voltage switching, and the rectifier diodes can be turned off under zero current switching. The switching losses on the power MOSFETs are reduced and the reverse recovery loss is improved. Experiments with a 1.5kW prototype are provided to demonstrate the performance of the proposed converter.

• Korean Journal of Materials Research
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• v.19 no.11
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• pp.619-624
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• 2009

Titanium alloys have been attractive due to a high ratio of strength to weight as well as good corrosion resistance. However, strengthening causes a decrease in ductility in Ti alloys, as is usual in other alloys. For enhanced strength without ductility reduction, grain refinement and tensile properties were investigated as functions of thickness reduction of cold rolling and annealing condition in Ti-15V-3Cr-3Sn-3Al alloy with a ${\beta}$ single phase. The average grain size of the specimen, which was cold-rolled by 90% and annealed at 700$^{\circ}C$ for 5 min, was decreased to approximately 19 ${\mu}m$. The grain refinement of 63 μm to 19 ${\mu}m$ increased yield stress by 90 MPa without a significant decrease in total elongation. The Ti-15-3 alloy exhibited very low work hardening during tensile test at a crosshead speed of 2 mm/min. This result was discussed based on dynamic recovery associated with dislocation annihilation in grain boundaries.

• Journal of Korean Academy of Nursing
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• v.32 no.1
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• pp.40-49
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• 2002

The purpose of this study was to investigate the influencing factors on health behavior among patients with coronary artery disease. Method: The subjects were 95 patients who visited the out-patient department of a university hospital for follow-up. The four health belief concepts (motivation, benefit, barrier, seriousness), general self-efficacy, health behaviors on medication, diet, exercise, stress management, smoking, and drinking were measured. Result: There were significant differences in the health behavior scores of subjects according to family support and the experience of surgical procedure. Subjects were found to have a high degree of compliance in taking medication. However subjects reported the lowest degree of compliance in regular exercise. In the multiple regression analysis, surgical procedure and motivation were significant predictors to explain diet. Motivation and barrier were significant predictors to explain exercise. Self-efficacy, motivation and family support were significant predictors to explain stress management. Family support and seriousness explained 16% of variance in drinking. Also, family support explained 30% of variance in smoking. Conclusion: Since predicting factors on each health behavior indicator were different, then nurses should consider these differences to construct strategy enhancing patient's recovery.

• The Korean Journal of Pain
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• v.19 no.1
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• pp.115-118
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• 2006

Among the sympathetic blocks used to treat various symptoms and diseases, including sympathetic dysfunction in pain clinics, a stellate ganglion block (SGB) is one of the easiest to apply. However, it is difficult to evaluate the effects of SGB due to the subjective nature of patient-reported data. A 26-year-old female, who presented with symptoms of coldness and sweating on both hands, received SGB 25 times on each side over a 2-month period. The effects of SGB were followed up using a cold stress test with thermography. Although the symptoms appeared again after 6 months, the recovery rate of the palmar temperature after the cold stress test improved significantly and was maintained for 18 months.