• 한국항공운항학회지
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• 제20권2호
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• pp.58-63
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• 2012

An altitude chamber, also known as a hypobaric chamber, is a device used during aerospace or high terrestrial altitude research or training to simulate the effects of high altitude on the human body. Although data from altitude chamber researches using experimental animals have been accumulated, studies in the humans exposed to hypobaric conditions are seldomly reported. Despite the importance of altitude chamber flight training in the field of aviation physiology, the hematological analysis of post-flight physiological changes has rarely been performed. The aims of the present study were to investigate the alterations in blood components during altitude chamber flight and to determine whether the differences between pre- and post-flight values are significant. Sixty experienced pilots in the Republic of Korea Air Force were enrolled in the altitude chamber flight training. Venous blood samples were obtained before and immediately after the flight. Compared with the pre-flight values($6.32{\times}10^3/mm^3$, $5.02{\times}10^6/mm^3$, 15.61 g/dL, respectively), white blood cell count, red blood cell count and hemoglobin level were significantly increased after the flight($6.77{\times}10^3/mm^3$, $5.44{\times}10^6/mm^3$, 16.26 g/dL; p=0.006, p=0.012, p<0.001, respectively). These alterations may be attributable to the exposure to hypobaric hypoxia, 100% oxygen supply for denitrogenation, considerable rise and fall in altitude and psychophysical stress due to these factors. In further studies, experimental groups and methods should be individualized to ensure objectivity and diversification. In addition, multiple time-frame analyses regarding the changing pattern of each blood component are also required to elucidate the physiological process for adapting to the high terrestrial altitude exposure.

• 대한한방부인과학회지
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• 제25권2호
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• pp.120-130
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• 2012

Objectives: The purpose of this study is to investigate the symptoms accompanied with acne and HRV pattern of the acne patients. Methods: We reviewed 60 acne patients(age 15-38) who visited ${\bigcirc}{\bigcirc}$ hospital from January 2010 to October 2011. We investigated the symptoms accompanied with acne of 60 patients and evaluated HRV of 41 acne patients. The data were analyzed by Mann-Whitney test using SPSS/PC ver 13.0 program. Results: 1. Prevalence of female post-adolescent acne was 66.7% in this study. The symptoms accompanied with acne were dischezia(35%), gastric discomfort(28.3%) in all patients and dysmenorrhea(40%), leukorrhea(38%), irregular menstrual period (24%) in female patients. 2. SDNN, RMSSD, VLF and HF of female were significantly lower than male. 3. SDNN, TP and VLF of un-dysmenorrhea group were significantly lower than dysmenorrhea group. 4. PSI of under 6 months group was significantly higer than over 6 months group. 5. In postadolescent acne patients SDNN, RMSSD, TP, LF and HF were significantly lower and PSI was significantly higher than adolescent acne patients. Conclusions: There are many female post-adolescent acne pateints and the assessment of the symptoms accompanied with acne and stress degree is helpful in treating acne. The further research and development about the diagnostic and therapeutic methods of acne are needed in oriental obstetrics and gynecology field.

• 대한예방한의학회지
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• 제16권3호
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• pp.119-128
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• 2012

Objective : The aim of this study is to investigate the relationship between Yangsaeng and general health status. Methods : In this study, we used data from the combined 2008-2010 Korean National Health and Nutrition Examination Survey(KNHANES). Mental Yangsaeng was measured by stress recognition and depression. Food Yangsaeng was measured by breakfast skipping and mixed grain diet. Life style Yangsaeng was measured by sleeping time and working pattern. Exercise Yangsaeng was measured by walking and exercise. We defined general health status as EQ-5Dindex, EQ-5Dvas, frequency and day of lying in a sickbed in last one month and activity limitation. Results : Mental Yangsaeng, food Yangsaeng, life style Yangsaeng and exercise Yangsaeng have 8 factors. Most of factors significant correlation with EQ-5Dindex, EQ-5Dvas, frequency and day of lying in a sickbed in last one month and activity limitation. Conclusion : Yangsaeng and general health status have positive correlation.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 추계학술대회 논문집
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• pp.589-592
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• 2005

Micro-forming is a suited technology to manufacture very small metallic parts(several $mm{\sim}{\mu}m$). Micro-forming of $Zr_{62}Cu_{17}Ni_{13}Al_8$ bulk metallic glass(BMG) as a candidate material for this developing process are feasible at a relatively low stress in the supercooled liquid state without any crystallization during hot deformation. In this study, micro-formability of a representative bulk metallic glass, $Zr_{62}Cu_{17}Ni_{13}Al_8$, was investigated for micro-forging of U-shape pattern. Micro-formability was estimated by comparing $R_f$ values $(=A_f/A_g)$, where Ag is cross-sectional area of U groove, and $A_f$ the filled area by material. Microforging process was simulated and analyzed by applying finite element method. FEM simulation results should reasonable agreement with the experimental results when the material properties and simulation conditions such as top die speed, remeshing criteria and boundary conditions tightly controlled. The micro-formability of $Zr_{62}Cu_{17}Ni_{13}Al_8$ was increased with increasing load and time in the temperature range of the supercooled liquid state. Also, FEM Simulation using DEFORM was confirmed to be applicable for the micro-forming process simulation.

• 대한기계학회논문집A
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• 제26권4호
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• pp.787-793
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• 2002

In this study, a bar impact test of low velocity was carried out to gain an insight into the damage mechanism and sequence induced in alumina plates(AD 85 and AD 90) under impact conditions. An experimental setup utilizing an instrumented long bar impact was devised, that can measure directly the impact force applied to the specimen and supply a compressive contact pressure to the specimen. During the bar impact testing, the influences of the contact pressure applied along the impact direction to the specimen on the fracture behavior were investigated. The measured impact force profiles explained well the damage behavior induced in alumina plates. The higher contact pressure to the specimen led to the less damage due to the suppression of radial cracks due to the increase in the apparent flexural stiffness of plate. It had produced the change of damage pattern developed in the specimen; from the radial cracks to the local contact stress dominant damage. It would contribute to the improvement of the ballistic property in ceramic plates. The observed results showed the following sequence in damage developed: The development of cone crack at impact region, the formation of radial cracks from the rear surface of plate depending on the plate thickness, the occurrence of crushing within the cone envelope and the fragmentation.

• 생태와환경
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• 제48권2호
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• pp.86-94
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• 2015

Chironomous is aquatic insect belonging to order Diptera, family Chironomidae. Their larval stage can be found mainly in aquatic benthic environment, hence good model organism to study environmental toxicology assessments and consider as useful bio indicators of contamination of the aquatic environment. In this study, Chironomus Heat Shock Proteins, Cytochrome 450, Glutathione S-transferase, Serine-type endopeptidase gene expressions were compared between polluted field areas (Chironomus plumosus) and under laboratory conditions (Chironomus riparious) to investigate molecular indicators for environmental contaminant stress assessment. Heavy metal (Al, Fe, Mn, Cu, Cr, Zn, Se, Pb, As, Cd) concentrations in sediments collected from three study areas exceeded the reference values. Moreover, HSPs, CYP450 and GST gene expression except SP for C. plumosus showed higher expression than C. riparious gene expression. Similar gene expression pattern was observed in C. riparious that exposed environment waters up to 96 h when compared to C. plumosus exposed to waters that grown in lab conditions. In summary, this comparative gene expression analysis in Chironomous between field and laboratory condition gave useful information to select candidate molecular indicators in heavy metal contaminations in the environment.

• 한국가족복지학
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• 제54호
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• pp.225-262
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• 2016

본 연구의 목적은 아동보호서비스 개입사례의 재학대 특성을 확인하는 것이다. 이를 위해 국가아동학대정보시스템에 접근하여 2012년에 신고 접수된 전수를 추출하였고 이들 사례 중 아동학대로 판정된 사례를 중심으로 2014년까지 총 3년간의 데이터를 수집하여 해당기간 내 재학대가 발생한 사례들의 특성을 확인하였다. 재학대 특성은 생존분석을 통해 재학대 발생 시점 및 빈도를 중심으로 살펴보았다. 분석결과, 2012년에 학대판정을 받은 5,542사례 중 323사례가 이후 3년 이내에 재학대를 기록하였다. 대부분의 사례(93.5%)가 1회의 재학대를 기록하였지만 2회의 재학대를 기록한 사례도 21사례로 확인되었다. 또한 학대로 판정된 이후 1개월 이내에 가장 많은 재학대가 발생하였고, 이전 아동보호서비스 연루 유무, 중복학대 유무, 신체학대 포함 여부, 서비스 제공 유형 등에 따라 재학대 발생 시기 및 빈도가 다르게 나타났다. 아동의 연령 및 문제행동 수, 학대행위자의 스트레스 및 사회적 고립, 가족구성원인 학대행위자, 이전 아동보호서비스 연루 기록, 재신고 총 횟수 증가 등은 이후의 재학대 발생과 관련되었다. 본 연구는 이러한 분석결과를 토대로 아동학대의 재학대 예방을 위한 정책적, 실천적 함의를 논하고 관련 제언을 제시하였다.

• Structural Engineering and Mechanics
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• 제41권6호
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• pp.711-734
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• 2012

The foundation of a tall building frame resting on settable soil mass undergoes differential settlements which alter the forces in the structural members significantly. For tall buildings it is essential to consider seismic forces in analysis. The building frame, foundation and soil mass are considered to act as single integral compatible structural unit. The stress-strain characteristics of the supporting soil play a vital role in the interaction analysis. The resulting differential settlements of the soil mass are responsible for the redistribution of forces in the superstructure. In the present work, the nonlinear interaction analysis of a two-bay ten-storey plane building frame- layered soil system under seismic loading has been carried out using the coupled finite-infinite elements. The frame has been considered to act in linear elastic manner while the soil mass to act as nonlinear elastic manner. The subsoil in reality exists in layered formation and consists of various soil layers having different properties. Each individual soil layer in reality can be considered to behave in nonlinear manner. The nonlinear layered system as a whole will undergo differential settlements. Thus, it becomes essential to study the structural behaviour of a structure resting on such nonlinear composite layered soil system. The nonlinear constitutive hyperbolic soil model available in the literature is adopted to model the nonlinear behaviour of the soil mass. The structural behaviour of the interaction system is investigated as the shear forces and bending moments in superstructure get significantly altered due to differential settlements of the soil mass.

• 한국식품위생안전성학회지
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• 제36권5호
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• pp.440-446
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• 2021

GABA는 식물, 동물 및 미생물 등 자연계에 다양하게 존재하고 있으며, 항고혈압, 이뇨, 진정, 수면유도 및 항스트레스 등 다양한 효과가 있는 것으로 알려져 있어서 식품, 의약품 소재로 활용되고 있다. 본 연구에서는 김치로 부터 분리한 GABA 형성 유산균을 옥수수 수염 추출물에 적용하여 발효 특성과 발효물의 항산화 효과에 대해 분석하였다. 신규 L. plantarum LAB459의 분리와 동정은 생화학적 특성, 당자화성 및 16s rRNA 염기 서열 분석을 통해 확인되었다. 그리고 TLC와 HPLC 분석을 통해 분리된 L. plantarum LAB459가 GABA 생성능이 있는 것으로 나타났다. 그리고 탈지유가 포함된 옥수수 수염 열수 추출물에 대해 발효를 수행한 결과, 동결 건조된 발효물에 약 1 ㎍/mg 수준의 GABA가 형성된 것을 확인하였다. 또한 발효물에 대한 플라보노이드와 항산화 분석은 옥수수 수염 열수 추출물에 비해 더 높은 것으로 나타났다. 따라서 본 연구에서 분리된 L. plantarum LAB459는 다양한 식품 발효의 스타터 또는 식품 소재와 의약품 소재로 적용이 가능할 것으로 판단된다.

• Neonatal Medicine
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• 제28권1호
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• pp.41-47
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• 2021

Neonatal diabetes mellitus can be categorized as transient, permanent, or syndromic, and approximately half of the cases are transient. We present a case involving a term newborn who showed overt progression of transient neonatal diabetes mellitus, with complete remission within 6 months. On the second day of life, the patient presented with tachypnea, hyperglycemia, and decreased serum levels of C-peptide and insulin. Continuous subcutaneous infusion of insulin and continuous glucose monitoring were well tolerated. The patient showed a normal growth pattern, with no hyperglycemic or hypoglycemic episodes at 6 months of age. As it is rare and often asymptomatic, hyperglycemia may be attributed to various factors, including intrauterine environment, perinatal stress, and diverse genetic background. Therefore, consistent blood glucose monitoring and prompt early insulin therapy are crucial for any term newborns with persistent hyperglycemia, to prevent further diabetic complications. Moreover, continuous subcutaneous insulin infusion and the utilization of continuous glucose monitoring devices are the most effective and practical management strategies.