• 한국산림과학회지
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• 제109권3호
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• pp.259-270
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• 2020

최근 20년 동안 고온, 건조 등 이상기상 현상이 빈발해지면서 병해충으로 인한 피해가 아닌 생리적 스트레스로 인한 소나무 피해 사례가 지속적으로 보고되고 있다. 2014년도에는 울진 소광리 산림유전자원보호구역 내에 금강소나무(Pinus densiflora for. erecta Uyeki)의 집단고사가 발견되어 이에 대한 원인 구명과 산림관리방안 마련이 요구되었다. 이에 본 연구는 2008~2015년 항공사진에서 발견된 울진 소광리 금강소나무 고사 피해 발생 지역의 지형 및 임분 특성을 파악하여 고사 발생의 영향 요인을 도출하고 이를 기반으로 전체 지역의 고사피해 발생 위험지역을 예측하는 것을 목표로 하였다. 소나무 고사발생 지점 정보와 해발고도, 경사 등의 지형정보, 영급, 경급 등의 임분 정보 등 총 14개의 설명변수를 이용하여 고사발생 예측모델을 구축하였다. 모형 개발에는 Decision Tree, Random Forest (RF), Support Vector Machine (SVM) 등 기계학습 기법을 적용하였으며, RF와 SVM가 정확도 93% 이상으로 좋은 성능을 보였다. 소나무 고사와 관련된 주요 변수 분석 결과, 소나무 고사의 지형적인 취약지역은 해발고도가 높은 동시에 일사량이 높으며 수분 조건이 불리한 지역이었으며, 임분 특성 중에서는 특히 5~15m 높이의 수직적 임분밀도가 높은 소나무림, 그리고 영급이 높은 소나무림에서 고사 위험성이 높다고 평가되었다. RF와 SVM 모형 예측에 따라, 소나무 고사위험도가 높은 지역의 면적은 연구대상지 전체 소나무림 면적의 약 9.5%, 115ha로 평가되었다. 본 연구의 고사위험도 평가 결과는 금강소나무 취약지역의 현황을 조사하고 아직 피해가 발생하지 않은 취약지역에 대한 적극적인 기후변화 적응 산림관리를 수행하기 위한 기반자료로 활용될 수 있다.

• 한국농림기상학회지
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• 제18권4호
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• pp.188-198
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• 2016

본 연구는 콩 생육모형을 활용하여 우리나라에서 콩 재배기간 동안 발생할 수 있는 이상고온에서 파종일 이동에 따른 콩의 수량반응과 그 영향을 탐색하였다. 또한 미래 기후변화 시나리오(2041-2070년)에서도 파종일 이동이 잠재수량(yield potential)의 변화에 미칠 수 있는 영향을 분석하였다. 1981-2010년 동안 전주와 밀양 두 지점에서, 6월 10일의 파종일을 기준으로 5월 25일과 30일의 파종일 단축에 의한 상대적 잠재수량의 변화는 증가보다는 감소 경향으로 나타난 반면, 6월 5일의 파종일 단축에 의한 잠재수량은 증가(평균 +3%)하는 것으로 나타났다. 그러나, 6월 15일과 20일의 파종일 지연에 의한 잠재수량의 감소(평균 -5%)가 증가(평균 +2%)보다 큰 것으로 나타났다. 또한 두 지점의 최근 2003년부터 2010년 동안 정상온도의 해에서, 6월 10일의 파종일을 기준으로 전주의 5월 25일을 제외하고 파종일 이동에 의한 상대적 잠재수량의 변화에 큰 차이가 나타나지 않았다. 그러나 이상 고온의 해에서, 밀양의 경우 파종일 단축에 의한 상대적 잠재수량이 모두 증가하였지만 전주는 6월 5일의 파종일 단축을 제외하고 파종일 단축에서도 상대적 잠재수량의 감소가 나타났다. 파종일 지연에서는 두 지점 모두에서 상대적 잠재수량이 감소하는 것으로 나타났다. 두 지점에서 2041-2070년의 미래 기후변화 시나리오 전망에서 파종일 단축에 따른 잠재수량의 증감효과는 RCP 4.5에서 +7%/-13%(전주)와 +14%/-10%(밀양)로 나타났고, RCP 8.5에서 +10%/-9%(전주)와 +14%/-9%(밀양)로 나타났다. 또한 파종일 지연에 따른 잠재수량의 증감효과는 RCP 4.5에서 +5%/-13%(전주)와 +11%/-16%(밀양)로 나타났고, RCP 8.5에서는 +10%/-17%(전주)와 +10%/-29%(밀양)로 나타났다. 절대적인 값의 차이는 작지만 상대적 잠재수량의 변화에서 파종일 이동에 의한 영향이 RCP 8.5에서 더 반영된 것으로 판단된다.

• 한국조경학회지
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• 제44권4호
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• pp.100-108
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• 2016

최근에 관광기후지수가 생리등가온도(PET)와 범용열기후지수(UTCI)와 같은 완전한 인간 에너지 균형 모델들을 포함함으로써 발전되어 오고 있다. 이 연구는 해변에서의 조경계획 및 설계를 위해, 2015년 봄과 여름에 대한민국 제주특별자치도 월정리해변에서 인간 열환경지수 및 열쾌적성을 조사하였다. 미기후 측정과 국제표준화기구 10551을 바탕으로 만들어진 설문조사를 동시에 실시하였으며, 성인 869명이 참가하였다. 그 결과, 생리적인 요소만 고려된 '열환경 지각'과 '열환경 선호도'가 선형 회귀 분석에서 생리등가온도와 92.8과 87.6%의 높은 결정계수를 나타내었다. 그러나, 생리적 요소와 심리적 요소 둘 다 고려된 '열환경 평가', '열환경 수용도'와 '열환경 부담도'에서는 60.0, 21.1, 46.4%로 낮은 결정계수를 보였다. 그렇지만, 생리등가온도와의 상관성 분석에서는 모두 0.01 레벨에서 유의성이 있는 것으로 나타났다. 인간 열환경 지수를 나타내는 '열환경 지각'에서 덥지도 춥지도 않는 '중간'의 생리등가온도의 범위는 $25{\sim}27^{\circ}C$로 나타났으나, 미국의 냉온난방협회 표준 55에서 추천한 20% 이하의 불만족성 범위는 없었다. 다만, '열환경 평가'와 '열환경 부담도'에서 $21{\sim}32^{\circ}C$와 $17{\sim}37^{\circ}C$의 생리등가온도 범위들이 그 추천범위에 속하는 것으로 나타났다. 그러므로, $21{\sim}32^{\circ}C$의 생리등가온도를 해변지역의 조경계획 및 디자인뿐만 아니라 관광 및 레크리에이션 계획을 위한 인간 열쾌적성 범위로 적용될 수 있을 것이다. 해변에서의 열 스트레스 레벨들은 한국의 내륙들보다 $2{\sim}5^{\circ}C$ 높게 나타났으며, 대만과 나이지리아와 같은 열대지역과 유사한 높은 결과들을 보였고, 서 중유럽과 이스라엘의 텔아비브보다 높은 것으로 나타났다.

• 유통과학연구
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• 제9권3호
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• pp.5-14
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• 2011

본 연구에서는 전통적 유통과 차별되는 체험매장의 혁신적 속성에 대한 지각 (지각된 유용성, 지각된 용이성)이 소비자의 만족과 충성도에 어떠한 영향을 미치는가를 살펴보고, 이에 대한 소비자 특성의 조절효과를 살펴보았다. 그 결과, 지각된 유용성과 용이성은 소비자의 만족과 충성도에 긍정적인 영향을 미치는 것으로 나타났다. 지각된 용이성과 유용성 중 만족에 더 강한 긍정적인 영향을 미치는 요인은 용이성인 것으로 나타났다. 그러므로 체험매장의 마케팅과 프로모션에는 이 매장을 이용함으로써 더욱 빠르고 쉽게 원하는 제품을 구입할 수 있다는 편리함을 강조하는 것이 유리할 것이라 판단된다. 그리고 혁신적 속성에 대한 소비자 특성(월평균 스포츠 용품/의류 구입 금액, 스포츠 용품/의류를 구입하는 유통을 선택할 때 직접 제품을 체험해보는 것을 중요하게 생각하는 정도)의 조절효과는 검증되지 않았다. 이는 아직까지 우리나라에 체험매장 자체가 생소한 개념이므로 그에 대한 만족, 충성도 형성과정이 소비자의 특성에 따라 조절될 만큼 충분하게 경험되어지지 않았기 때문이라 풀이된다.

• 생명과학회지
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• 제31권6호
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• pp.550-558
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• 2021

양성 전립선 비대증(BPH)의 발병은 노화에 따른 남성 호르몬 수치의 변화와 연관된 내분비 기능 저하와 밀접한 관련이 있는 것으로 알려져 있다. 현재 BPH 치료를 위해 임상적으로 사용되는 약물은 다양한 부작용을 나타내므로 효과적인 대체 식의약 소재의 개발을 시급히 요구된다. 산수유나무의 열매인 산수유(Fructus Corni)는 오랫동안 다양한 질병의 예방 및 치료에 사용되어왔으며 최근 BPH의 진행을 억제할 수 있음이 밝혀졌다. 본 연구에서는 BPH에 대한 산수유 열수 추출물(CF)의 추가 효능을 평가하기 위해 비거세 및 거세 동물 모델에서 TP에 의한 BPH 유도에 미치는 효과를 조사하였으며, BPH 억제를 위한 양성대조군으로 FINA를 사용하였다. 본 연구의 결과에 의하면 CF 투여는 대조군 및 FINA 처리 그룹에 비하여 비거세 및 거세군 모두에서 전립선의 과도한 발달을 억제하였다. BPH에 대한 CF의 억제 효과는 BPH 유도에 관여하는 testosterone과 DHT의 발현 감소뿐만 아니라 HIF-1α, 5α-reductase type 2, SRC1, AR 및 PSA 발현의 과도한 발현 억제와 관련이 있었다. 또한, 스트레스 호르몬인 cortisol의 혈청 수준은 비거세 및 거세군 모두에서 TP에 의한 BPH 유도 동안 증가하였지만 CF 투여에 의하여 유의하게 감소되었다. 그러나 BPH 유도군에서 insulin 및 IGF-1은 증가되지 않았으며 CF에 의한 효과적인 결과는 나타나지 않았다. 이러한 결과는 AR 신호 전달 경로 활성의 억제를 통해 BPH에 대한 CF의 유익한 효과를 시사하며, 산수유가 BPH의 예방과 치료에 잠재적인 가능성을 가지고 있음을 시사한다.

• 마케팅과학연구
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• 제18권3호
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• pp.59-88
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• 2008

Digital Convergence means integration between industry, technology, and contents, and in marketing, it usually comes with creation of new types of product and service under the base of digital technology as digitalization progress in electro-communication industries including telecommunication, home appliance, and computer industries. One can see digital convergence not only in instruments such as PC, AV appliances, cellular phone, but also in contents, network, service that are required in production, modification, distribution, re-production of information. Convergence in contents started around 1990. Convergence in network and service begins as broadcasting and telecommunication integrates and DMB(digital multimedia broadcasting), born in May, 2005 is the symbolic icon in this trend. There are some positive and negative expectations about DMB. The reason why two opposite expectations exist is that DMB does not come out from customer's need but from technology development. Therefore, customers might have hard time to interpret the real meaning of DMB. Time is quite critical to a high tech product, like DMB because another product with same function from different technology can replace the existing product within short period of time. If DMB does not positioning well to customer's mind quickly, another products like Wibro, IPTV, or HSPDA could replace it before it even spreads out. Therefore, positioning strategy is critical for success of DMB product. To make correct positioning strategy, one needs to understand how consumer interprets DMB and how consumer's interpretation can be changed via communication strategy. In this study, we try to investigate how consumer perceives a new product, like DMB and how AD strategy change consumer's perception. More specifically, the paper segment consumers into sub-groups based on their DMB perceptions and compare their characteristics in order to understand how they perceive DMB. And, expose them different printed ADs that have messages guiding consumer think DMB in specific ways, either cellular phone or personal TV. Research Question 1: Segment consumers according to perceptions about DMB and compare characteristics of segmentations. Research Question 2: Compare perceptions about DMB after AD that induces categorization of DMB in direction for each segment. If one understand and predict a direction in which consumer perceive a new product, firm can select target customers easily. We segment consumers according to their perception and analyze characteristics in order to find some variables that can influence perceptions, like prior experience, usage, or habit. And then, marketing people can use this variables to identify target customers and predict their perceptions. If one knows how customer's perception is changed via AD message, communication strategy could be constructed properly. Specially, information from segmented customers helps to develop efficient AD strategy for segment who has prior perception. Research framework consists of two measurements and one treatment, O1 X O2. First observation is for collecting information about consumer's perception and their characteristics. Based on first observation, the paper segment consumers into two groups, one group perceives DMB similar to Cellular phone and the other group perceives DMB similar to TV. And compare characteristics of two segments in order to find reason why they perceive DMB differently. Next, we expose two kinds of AD to subjects. One AD describes DMB as Cellular phone and the other Ad describes DMB as personal TV. When two ADs are exposed to subjects, consumers don't know their prior perception of DMB, in other words, which subject belongs 'similar-to-Cellular phone' segment or 'similar-to-TV' segment? However, we analyze the AD's effect differently for each segment. In research design, final observation is for investigating AD effect. Perception before AD is compared with perception after AD. Comparisons are made for each segment and for each AD. For the segment who perceives DMB similar to TV, AD that describes DMB as cellular phone could change the prior perception. And AD that describes DMB as personal TV, could enforce the prior perception. For data collection, subjects are selected from undergraduate students because they have basic knowledge about most digital equipments and have open attitude about a new product and media. Total number of subjects is 240. In order to measure perception about DMB, we use indirect measurement, comparison with other similar digital products. To select similar digital products, we pre-survey students and then finally select PDA, Car-TV, Cellular Phone, MP3 player, TV, and PSP. Quasi experiment is done at several classes under instructor's allowance. After brief introduction, prior knowledge, awareness, and usage about DMB as well as other digital instruments is asked and their similarities and perceived characteristics are measured. And then, two kinds of manipulated color-printed AD are distributed and similarities and perceived characteristics for DMB are re-measured. Finally purchase intension, AD attitude, manipulation check, and demographic variables are asked. Subjects are given small gift for participation. Stimuli are color-printed advertising. Their actual size is A4 and made after several pre-test from AD professionals and students. As results, consumers are segmented into two subgroups based on their perceptions of DMB. Similarity measure between DMB and cellular phone and similarity measure between DMB and TV are used to classify consumers. If subject whose first measure is less than the second measure, she is classified into segment A and segment A is characterized as they perceive DMB like TV. Otherwise, they are classified as segment B, who perceives DMB like cellular phone. Discriminant analysis on these groups with their characteristics of usage and attitude shows that Segment A knows much about DMB and uses a lot of digital instrument. Segment B, who thinks DMB as cellular phone doesn't know well about DMB and not familiar with other digital instruments. So, consumers with higher knowledge perceive DMB similar to TV because launching DMB advertising lead consumer think DMB as TV. Consumers with less interest on digital products don't know well about DMB AD and then think DMB as cellular phone. In order to investigate perceptions of DMB as well as other digital instruments, we apply Proxscal analysis, Multidimensional Scaling technique at SPSS statistical package. At first step, subjects are presented 21 pairs of 7 digital instruments and evaluate similarity judgments on 7 point scale. And for each segment, their similarity judgments are averaged and similarity matrix is made. Secondly, Proxscal analysis of segment A and B are done. At third stage, get similarity judgment between DMB and other digital instruments after AD exposure. Lastly, similarity judgments of group A-1, A-2, B-1, and B-2 are named as 'after DMB' and put them into matrix made at the first stage. Then apply Proxscal analysis on these matrixes and check the positional difference of DMB and after DMB. The results show that map of segment A, who perceives DMB similar as TV, shows that DMB position closer to TV than to Cellular phone as expected. Map of segment B, who perceive DMB similar as cellular phone shows that DMB position closer to Cellular phone than to TV as expected. Stress value and R-square is acceptable. And, change results after stimuli, manipulated Advertising show that AD makes DMB perception bent toward Cellular phone when Cellular phone-like AD is exposed, and that DMB positioning move towards Car-TV which is more personalized one when TV-like AD is exposed. It is true for both segment, A and B, consistently. Furthermore, the paper apply correspondence analysis to the same data and find almost the same results. The paper answers two main research questions. The first one is that perception about a new product is made mainly from prior experience. And the second one is that AD is effective in changing and enforcing perception. In addition to above, we extend perception change to purchase intention. Purchase intention is high when AD enforces original perception. AD that shows DMB like TV makes worst intention. This paper has limitations and issues to be pursed in near future. Methodologically, current methodology can't provide statistical test on the perceptual change, since classical MDS models, like Proxscal and correspondence analysis are not probability models. So, a new probability MDS model for testing hypothesis about configuration needs to be developed. Next, advertising message needs to be developed more rigorously from theoretical and managerial perspective. Also experimental procedure could be improved for more realistic data collection. For example, web-based experiment and real product stimuli and multimedia presentation could be employed. Or, one can display products together in simulated shop. In addition, demand and social desirability threats of internal validity could influence on the results. In order to handle the threats, results of the model-intended advertising and other "pseudo" advertising could be compared. Furthermore, one can try various level of innovativeness in order to check whether it make any different results (cf. Moon 2006). In addition, if one can create hypothetical product that is really innovative and new for research, it helps to make a vacant impression status and then to study how to form impression in more rigorous way.

• 대한치과교정학회지
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• 제36권5호
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• pp.339-348
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• 2006

교정용 미니 임플랜트 고정원을 이용한 교정 치료가 보편화되며, SWA와 이를 이용한 on masse sliding retraction 은 임상에서 흔히 사용하는 치료법이 되었다. 그러나 고정원을 성공적으로 보존하려는 노력에 비해, 발치 공간 폐쇄시 전치부 치축 조절에 관여하는 요인에 대한 보고는 아직까지 부족한 실정이다. 본 연구에서는 제1소구치를 제거한 상악 치아와 치주 인대 그리고 치조골에 대한 3차원 유한요소 기준모델을 제작하였고, 제1대구치와 제2소구치 사이 주호선 10 mm 상방에 식립된 교정용 미니 임플랜트를 고정원으로 사용할 경우, 측절치-견치 사이의 견인 훅의 높이를 변화시키며 후상방 견인력을 가하거나, 주호선에 보상 만곡을 부여하는 것이 전치부 치축 조절에 어떤 영향을 미치는지 시뮬레이션 하였다. 또한 전치부 치축이 설측 경사된 모델을 같은 실험 조건으로 시뮬레이션 하여 발치 공간 페쇄 시 설측 경사된 전치부 치축을 유지하거나 개선할 수 있는 요인을 검토하였고, 다음과 같은 연구 결과를 얻었다. 2 mm 높이의 견인 훅에 대하여 후상방으로 견인력을 가할 경우 발생하는 함입력으로 인하여 전치부 설측 경사가 더 감소되지는 않았다. 견인 훅의 높이가 5 mm인 경우 후상방 견인력을 가하면, 측절치의 치관 순측 및 치근 설측 이동이 일어나고, 견치의 비조절성 후방 경사 이동이 심화되었다. 4 mm의 보상 만곡은 측절치의 치관 순측 및 치근 설측 이동을 일으키고, 견치의 비조절성 후방 경사 이동을 감소시켰다. 또한 전치부가 설측 경사된 모델을 기준모델과 같은 실험 조건으로 시뮬레이션 한 경우 치근면의 응력 분포와 25000배 확대된 그래프 상에서의 치아 이동 양상은 매우 유사하였다 이상의 결과는 미니 임플랜트-SWA sliding 생역학을 구사 시 견인 훅의 위치와 와이어 상의 보상 만곡의 유무에 의해 전치부의 치축 조절이 달라지며 실제 임상에서 가이드라인으로 활용될 수 있을 것이다. 따라 수용자들의 적극적 인식도 심화되었다고 결론지을 수 있을 것이다. 신문이 일제의 지배방식에 순응해 독자들에게 내선일체와 전쟁협력을 강요했다는 역사적 평가를 듣게 만들었다.사되었으며 그 다음은 근 현대가 18편으로 26.47%, 중세 7편 10.3%, 선사시대 5편 7.35%, 상고시대가 1편으로 1.47%로 나타나 고대 중세, 근 현대 순으로 선호하는 것으로 나타났다.기인계 농약의 특징인 불안정성에 의해 광분해 및 미생물 분해를 통해 이미 분해가 진행 중이어서 본래의 유기인 화합물이 검출되지 않았을 가능성이 있다. 그리고 유기인계 농약이 완전히 분해되어 생성된 유기인계 농약 기원의 영양염류가 저수지 내로 많은 양이 유입된다면, 부영양화에 기여할 가능성이 있다. 따라서 농업용 저수지에서 유기인계 농약의 농도 분포는 물론이고 중간 생성물과 그 독성, 광분해 및 미생물 분해의 메커니즘, 그리고 최종 산물에 대한 연구가 필요하다.삭감율은 BOD의 경우 Scenario 1-1(처리용량 1,500 $m^3$ $day^{-1}$인 인공습지), scenario 1-2 (처리용량 1,000 $m^3$ $day^{-1}$인 인공습지), scenario 2(면적 4.2ha인 저류지)가 각각 연평균 6.9%, 4.8%, 7.1%의 감소를 보였다. TN은 4.7%, 3.4%, 13.4%의 삭감율을 나타내었으며, TP는 5.6%, 3.9%, 7.3%의 삭감율을 나타내었다. 본 연구에서는 적용하지 못하였으나, 인공습지와 저류지의 적절한 연계시스템을 적용한다면 저감시설 설치 부지면적과 비용의 감소뿐만 아니라 보다 효과적인 수질개선효과를 가져올 수 있으리라 판단된다.다. 이상과 같이 조선시대 주식류의 종류 및 조리방법에 대한 문헌적 고찰을 분석한 결과로 조선시대로부터 현재까지 주식류의 변천과정을 파악할 수 있었으며 새롭게 문헌으로라도 복원된 전통음식인

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 1993년도 한국우주과학회보 제2권2호
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• pp.17-17
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• 1993

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70${\pm}$1.32mmHg/min)compared to CF dialyzers(4.32${\pm}$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500,550,570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500,550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100,300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3,000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.