• 한국어병학회지
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• 제22권3호
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• pp.253-262
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• 2009

병든 넙치에서 분리한 Streptococcus parauberis (FP2284)를 스트레스 조건을 달리하여 넙치, Paralichthys olivaceus에 인위감염한 후 조직 내 생균수 변화 및 병리조직학적 변화를 분석하였다. 인위감염 실험은 건강한 넙치 (평균 어체 중 40.4 g)에 $2{\times}10^{8}$ CFU/fish 농도로 복강주사하고 스트레스를 주지 않거나 하루 2번, 2분간 Netting 스트레스를 처리하였다. 스트레스를 주지 않은 그룹과 Netting 스트레스를 준 그룹의 누적 폐사율은 각각 70% 및 95%로 나타났다. 인위감염 시킨 넙치에서는 체색흑화와 심장의 염증이 주요 임상소견으로 나타났으며, 심장에서는 주로 심외막염, 심근염 및 심근의 섬유화가 관찰되었다. 인위감염 후 심장 조직의 세균수 변화를 측정한 결과, 주사 후 3주째까지 심장 1 g당 $10^{4}$ CFU의 세균수가 유지되는 것으로 나타났다. 스트레스 조건하에서 심장에서의 병리조직학적 변화가 더 심한 것으로 나타났으며, 심장 조직내 세균의 점차적인 감소가 지연되는 것으로 나타났다.

• Molecules and Cells
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• 제28권3호
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• pp.139-148
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• 2009

Cell death has been traditionally classified in apoptosis and necrosis. Apoptosis, known as programmed cell death, is an active form of cell death mechanism that is tightly regulated by multiple cellular signaling pathways and requires ATP for its appropriate process. Apoptotic death plays essential roles for successful development and maintenance of normal cellular homeostasis in mammalian. In contrast to apoptosis, necrosis is classically considered as a passive cell death process that occurs rather by accident in disastrous conditions, is not required for energy and eventually induces inflammation. Regardless of different characteristics between apoptosis and necrosis, it has been well defined that both are responsible for a wide range of human diseases. Glycogen storage disease type I (GSD-I) is a kind of human genetic disorders and is caused by the deficiency of a microsomal protein, glucose-6-phosphatase-${\alpha}$ ($G6Pase-{\alpha}$) or glucose-6-phosphate transporter (G6PT) responsible for glucose homeostasis, leading to GSD-Ia or GSD-Ib, respectively. This review summarizes cell deaths in GSD-I and mostly focuses on current knowledge of the neutrophil apoptosis in GSD-Ib based upon ER stress and redox signaling.

• 대한간호학회지
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• 제33권6호
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• pp.829-838
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• 2003

Purpose: In South Korea, as growing the need of psychological support in disaster situation psychological assessment on stress after disaster is important to find out the factors affecting coping, and to plan intervention in the community. Method: The volunteers of Korea Redcross who live around K city, and the research team visited all homes at Jirye town, one of the high-impact area, 4 month after the typhoon. One of the family members who is over 18 years old, answered the self-report questionnaire composed of disaster experience, damage, exposure to traumatic event, and posttraumatic stress with IES-K (Impact of Event Scale-korea) He also, described his family members symptom related to re-experiencing, hyper-arousal, and avoidance. Six hundreds households were surveyed. Result: The prevalence of moderate to severe PTSD symptom was 36% of the subjects. The severity of PTSD was affected by gender, economic status and affected by damaged property, physical injury, worsening existing disease, getting infectious disease, amount of experienced traumatic event before disaster, warning, taking shelter, and subjects revealed differences in somatization as severity of PTSD. According to the description, community members had re-experiencing, hyper-arousal and avoidance. Conclusion: At a rural area, South Korea, community members have suffered from psychological distress after disaster. So psychological interventions are required as affecting factors and also to plan for warning and shelter in disaster situation is needed for preventing PTSD.

• Biomolecules & Therapeutics
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• 제28권3호
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• pp.213-221
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• 2020

Acute kidney injury (AKI) is a common disease with a complex pathophysiology which significantly contributes to the development of chronic kidney disease and end stage kidney failure. Preventing AKI can consequently reduce mortality, morbidity, and healthcare burden. However, there are no effective drugs in use for either prevention or treatment of AKI. Developing therapeutic agents with pleiotropic effects covering multiple pathophysiological pathways are likely to be more effective in attenuating AKI. Fyn, a non-receptor tyrosine kinase, has been acknowledged to integrate multiple injurious stimuli in the kidney. Limited studies have shown increased Fyn transcription level and activation under experimental AKI. Activated Fyn kinase propagates various downstream signaling pathways associated to the progression of AKI, such as oxidative stress, inflammation, endoplasmic reticulum stress, as well as autophagy dysfunction. The versatility of Fyn kinase in mediating various pathophysiological pathways suggests that its inhibition can be a potential strategy in attenuating AKI.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6397-6400
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• 2015

Cervical cancer is the second most common gynecological malignancy worldwide. According to HPV Information Centre, Spain (Aug'2014), in India approximately 1,22,844 women are diagnosed with the disease every year and of them 67,477 die due to the disease. CaCx is said to be mediated by HPV but recent data published reveal the role of Oxidative Stress in different Cancers. Arsenic is also one of the agents for causing Oxidative Stress. Arsenic has been linked with different types of cancer. Arsenic is considered responsible for generation of free radicals and eventually for apoptosis. Early diagnosis of CaCx is presently a matter of concern and clinical presentation in advanced stages become difficult for complete clinical response. For determination of oxidative stress, Malondialdehyde (MDA) was taken as an identifier and arsenic estimation was performed with the help of Atomic Absorption Spectrometer (AAS). RBC count and Haemoglobin levels were performed according to standard protocol. MDA was in direct proportion with arsenic concentration and inversely proportional to RBC and Haemoglobin in CaCx patients. Arsenic is one of the major causative agents for oxidative stress and hence may be a risk factor leading to cancer including CaCx.

• 한국자원식물학회지
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• 제28권6호
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• pp.675-681
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• 2015

β amyloid protein (Aβ) plays a critical role in the pathogenesis of Alzheimer's disease (AD) and possibly in Aβ-induced mitochondrial dysfunction and oxidative stress. Aβ can directly cause reactive oxygen species (ROS) production. Overproduction of ROS is considered to be involved in the pathogenesis of neurodegeneration of AD. Here, we investigated 9 kinds of ramie (Boehmeria nivea, (L.) Gaud., BN; hereafter denoted as BN) for their protective action against oxidative stress in a cellular system using C6 glial cells. We observed loss of cell viability and high levels of ROS generation after treatment with hydrogen peroxide (H₂O₂) and Aβ_25-35. However, treatments with BN extracts led to an increase in cell viability and decrease in ROS production induced by H2O2 and Aβ25-35. In particular, the extracts of BN-01 (seobang variety from Seocheon) and BN-09 (local variety from Yeonggwang) showed excellent anti-oxidative properties. This indicates that BN extracts could prevent neurodegeneration by reducing oxidative stress in cells.

• 한국환경복원기술학회지
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• 제24권5호
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• pp.35-53
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• 2021

A field survey was carried out targeting 59 pine wilt disease control areas distributed in Andong, and the ecological characteristics of the areas affected by pine wilt disease were analyzed using vegetation information, ecological information, and land use information. Vegetation characteristics of Pine wilt disease affected forest area showed a 3-layer vegetation structure, high percentage of accidental occurrence species (37%) and secondary vegetation species (59.6%), appearing 12 taxa naturalized plants and 3 taxa ecosystem disturbance organisms designated by the Ministry of Environment. Ecological information of Pine wilt affected area showed frequent occurrence of water stress in south and west slopes, low lying grounds in mountains, and in well-drained soils. Also, surrounding the area has been used as roads, tombs, and cultivation where intensive human activities were the cause of disturbance and stress to the pine forest. It was analyzed that the pine forest in Andong city suffered extensive damage due to the onset of pine wilt disease while the pine trees were weakened due to continuous human activities. Conclusively, the spread and onset of pine wilt disease are worsened by artificial factors than natural environmental conditions.

• 한국인터넷방송통신학회논문지
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• 제23권4호
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• pp.127-135
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• 2023

요즘, 우울증 및 스트레스로 자살하는 환자가 급증하고 있다. 뿐만 아니라, 스트레스 및 우울증이 오래 지속되면, 심장병 및 뇌 질환, 고혈압 등을 유발할 수 있는 위험한 요소로 질환이다. 그러나, 아무리 현대 의학이 발전하였지만, 우울증 및 심장병 환자에게는 특별한 약이나 치료제가 없는 매우 난감한 상황이다. 그러므로, 세계 여러 나라에서, 심전도 및 산소포화도, 뇌파 분석 기능을 이용해서 우울증 위험환자 및 자살 위험환자를 조기에 판단하는 연구가 활발하게 이루어지고 있다. 본 논문에서는, 이러한 문제점을 분석하기 위해서, 심장병 가설데이터를 수립해서, 심장병 위험환자를 판단하는 컴퓨터 모의실험을 수행하였다. 특히, 심장병 발생 예측을 을 10% 이상 향상하게 시키기 위해서, 퍼지 추론을 사용하는 모의실험을 수행하였다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.232.2-232.2
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• 2003

Many neurodegenerative disorders such as stroke, Alzheimer's disease, and Parkinson's disease have been known to be associated with an excessive generation of reactive oxygen species (ROS) and oxidative stress. Therefore, the antioxidants have recently received much attention as therapeutic agent for the treatment of neurodegenerative disease. (omitted)

• 정신신체의학
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• 제9권1호
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• pp.93-102
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• 2001

이완반응은 갚은 휴식상태를 말하며, 소위 스트레스반응으로 불리는 투쟁-도피 반응의 생리적 변화와 반대되는 생리적 변화를 일으키게 된다. 따라서 인위적으로 이완반응을 일으킴으로써 이러한 스트레스 반응을 상쇄시킬 수 있다. 이러한 이완반응을 일으킬 수 있는 복식호흡, 명상, 점진적 근육이완기법, 자율이완훈련, 생체되먹이기법 등의 다양한 이완기법들이 제시되어 왔으며, 이들은 다양한 신체, 정신 질환뿐만 아니라 정상적인 스트레스 관리 프로그램에 있어서도 마음과 신체의 안녕을 위해 유익한 도움을 줄 수 있음이 알려져 있다. 이러한 이완기법들은 스트레스 관리를 위한 전체적 과정의 한 부분으로 이해되어야 할 것이며, 자신에 맞는 적절한 기법을 찾아 지속적인 훈련을 함으로써 효과적인 스트레스 관리 방법으로서의 역할을 할 수 있을 것이다. 이에 본 저자는 명상, 점진적 근육이완기법, 자율이완훈련 및 기타 이완기법에 대한 보다 구체적이고 실제적인 방법을 제시하고자 한다. 스트레스와 관련된 다양한 신체, 정신 질환들에 대한 치료적 접근을 함에 있어서, 전통적 치료 방법에 병합하여 이완기법을 사용함으로써 스트레스와 질병 사이의 조절자로 이용할 수 있을 것이다.